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Article

Angiogenic systemic response to the hypoxic microenvironment in prostate tumorigenesis: A pilot study

  • Authors:
    • Cosmin Ene
    • Ilinca Nicolae
    • Corina Daniela Ene
  • View Affiliations / Copyright

    Affiliations: Department of Urology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Research Laboratory, ‘Victor Babes’ Clinical Hospital of Infectious and Tropical Diseases, 030303 Bucharest, Romania, Department of Nephrology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania
  • Article Number: 483
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    Published online on: September 1, 2023
       https://doi.org/10.3892/etm.2023.12182
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Abstract

The present paper aimed to investigate the altered angiogenetic mechanisms in hypoxic conditions in patients with prostate tumours, in correlation with common clinicopathologic variables. A case‑control study was developed and included 87 patients with prostate tumours [40 diagnosed with benign prostatic hyperplasia (BPH) and 47 diagnosed with prostate cancer (PCa), using prostate transrectal biopsy] and 40 healthy subjects. The following parameters were evaluated in the serum of volunteers: Hypoxia‑inducible factor (HIF)‑1α, fibroblast growth factor (FGF)‑2, vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP)‑2 and ‑9, thrombospondin (TSP)‑1 and soluble VEGF‑1 receptor. Experimental data analysis demonstrated increasing amounts of inflammation in patients with PCa (IL‑6, 18.1±4.7 ng/ml) and BPH (IL‑6, 16.3±5.1 ng/ml) vs. control (IL‑6, 4.1±1.2 ng/ml); overregulation of HIF1α in patients with PCa (129.3±21.8 ng/ml) compared with patients with BPH (65.6±18.2 ng/ml) and control (61.3±12.7 ng/ml); angiogenesis abnormalities in patients with PCa (upregulation of FGF‑2, VEGF, MMP‑2 and ‑9, suppression of TSP‑1 and soluble VEGR‑1) and BPH (upregulation FGF‑2 and VEGF) compared with the control group. In conclusion, a greater understanding of the biological mechanism, the pathological roles and the clinical significance of various proangiogenic parameters and angiogenic‑suppressor proteins seem useful in clinical practice for establishing an early diagnosis of prostate pathology and finding an individualized therapeutic approach.
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Copy and paste a formatted citation
Spandidos Publications style
Ene C, Nicolae I and Ene CD: Angiogenic systemic response to the hypoxic microenvironment in prostate tumorigenesis: A pilot study. Exp Ther Med 26: 483, 2023.
APA
Ene, C., Nicolae, I., & Ene, C.D. (2023). Angiogenic systemic response to the hypoxic microenvironment in prostate tumorigenesis: A pilot study. Experimental and Therapeutic Medicine, 26, 483. https://doi.org/10.3892/etm.2023.12182
MLA
Ene, C., Nicolae, I., Ene, C. D."Angiogenic systemic response to the hypoxic microenvironment in prostate tumorigenesis: A pilot study". Experimental and Therapeutic Medicine 26.4 (2023): 483.
Chicago
Ene, C., Nicolae, I., Ene, C. D."Angiogenic systemic response to the hypoxic microenvironment in prostate tumorigenesis: A pilot study". Experimental and Therapeutic Medicine 26, no. 4 (2023): 483. https://doi.org/10.3892/etm.2023.12182
Copy and paste a formatted citation
x
Spandidos Publications style
Ene C, Nicolae I and Ene CD: Angiogenic systemic response to the hypoxic microenvironment in prostate tumorigenesis: A pilot study. Exp Ther Med 26: 483, 2023.
APA
Ene, C., Nicolae, I., & Ene, C.D. (2023). Angiogenic systemic response to the hypoxic microenvironment in prostate tumorigenesis: A pilot study. Experimental and Therapeutic Medicine, 26, 483. https://doi.org/10.3892/etm.2023.12182
MLA
Ene, C., Nicolae, I., Ene, C. D."Angiogenic systemic response to the hypoxic microenvironment in prostate tumorigenesis: A pilot study". Experimental and Therapeutic Medicine 26.4 (2023): 483.
Chicago
Ene, C., Nicolae, I., Ene, C. D."Angiogenic systemic response to the hypoxic microenvironment in prostate tumorigenesis: A pilot study". Experimental and Therapeutic Medicine 26, no. 4 (2023): 483. https://doi.org/10.3892/etm.2023.12182
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