|
1
|
Torre LA, Bray F, Siegel RL, Ferlay J,
Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA
Cancer J Clin. 65:87–108. 2015.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Wang Y, Zhao Z, Zhuang J, Wu X, Wang Z,
Zhang B, Gao G, Zhang Y, Guo C and Xia Q: Prognostic value of
autophagy, microsatellite instability, and KRAS mutations in
colorectal cancer. J Cancer. 12:3515–3528. 2021.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Hammond WA, Swaika A and Mody K:
Pharmacologic resistance in colorectal cancer: A review. Ther Adv
Med Oncol. 8:57–84. 2016.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Bignell GR, Greenman CD, Davies H, Butler
AP, Edkins S, Andrews JM, Buck G, Chen L, Beare D, Latimer C, et
al: Signatures of mutation and selection in the cancer genome.
Nature. 463:893–898. 2010.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Du L, Kim JJ, Shen J, Chen B and Dai N:
KRAS and TP53 mutations in inflammatory bowel disease-associated
colorectal cancer: A meta-analysis. Oncotarget. 8:22175–22186.
2017.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Inoue A, Robinson FS, Minelli R, Tomihara
H, Rizi BS, Rose JL, Kodama T, Srinivasan S, Harris AL, Zuniga AM,
et al: Sequential administration of XPO1 and ATR inhibitors
enhances therapeutic response in TP53-mutated colorectal cancer.
Gastroenterology. 161:196–210. 2021.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Koustas E, Sarantis P, Theoharis S, Saetta
AA, Chatziandreou I, Kyriakopoulou G, Giannopoulou I, Michelli M,
Schizas D, Papavassiliou AG and Karamouzis MV: Autophagy-related
proteins as a prognostic factor of patients with colorectal cancer.
Am J Clin Oncol. 42:767–776. 2019.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Wu S, Sun C, Tian D, Li Y, Gao X, He S and
Li T: Expression and clinical significances of Beclin1, LC3 and
mTOR in colorectal cancer. Int J Clin Exp Pathol. 8:3882–3891.
2015.PubMed/NCBI
|
|
9
|
Levine B and Kroemer G: Autophagy in the
pathogenesis of disease. Cell. 132:27–42. 2008.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Rabinowitz JD and White E: Autophagy and
metabolism. Science. 330:1344–1348. 2010.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Kimmelman AC: The dynamic nature of
autophagy in cancer. Genes Dev. 25:1999–2010. 2011.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Hanahan D and Weinberg RA: Hallmarks of
cancer: The next generation. Cell. 144:646–674. 2011.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Kabeya Y, Mizushima N, Ueno T, Yamamoto A,
Kirisako T, Noda T, Kominami E, Ohsumi Y and Yoshimori T: LC3, a
mammalian homologue of yeast Apg8p, is localized in autophagosome
membranes after processing. EMBO J. 19:5720–5728. 2000.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Pankiv S, Clausen TH, Lamark T, Brech A,
Bruun JA, Outzen H, Øvervatn A, Bjørkøy G and Johansen T:
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of
ubiquitinated protein aggregates by autophagy. J Biol Chem.
282:24131–24145. 2007.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Klionsky DJ, Abdalla F, Abeliovich H,
Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M,
Agostinis P, Aguirre-Ghiso JA, et al: Guidelines for the use and
interpretation of assays for monitoring autophagy. Autophagy.
8:445–544. 2012.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Maruyama Y, Sou YS, Kageyama S, Takahashi
T, Ueno T, Tanaka K, Komatsu M and Ichimura Y: LC3B is
indispensable for selective autophagy of p62 but not basal
autophagy. Biochem Biophys Res Commun. 446:309–315. 2014.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Wu DH, Jia CC, Chen J, Lin ZX, Ruan DY, Li
X, Lin Q, Min-Dong Ma XK, Wan XB, et al: Autophagic LC3B
overexpression correlates with malignant progression and predicts a
poor prognosis in hepatocellular carcinoma. Tumour Biol.
35:12225–12233. 2014.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Ghavami S, Shojaei S, Yeganeh B, Ande SR,
Jangamreddy JR, Mehrpour M, Christoffersson J, Chaabane W, Moghadam
AR, Kashani HH, et al: Autophagy and apoptosis dysfunction in
neurodegenerative disorders. Prog Neurobiol. 112:24–49.
2014.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Segala G, David M, de Medina P, Poirot MC,
Serhan N, Vergez F, Mougel A, Saland E, Carayon K, Leignadier J, et
al: Dendrogenin A drives LXR to trigger lethal autophagy in
cancers. Nat Commun. 8(1903)2017.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Cj P, Hv E, Vijayakurup V, R Menon G, Nair
S and Gopala S: High LC3/Beclin expression correlates with poor
survival in glioma: A definitive role for autophagy as evidenced by
in vitro autophagic flux. Pathol Oncol Res. 25:137–148.
2019.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Zhu W, Pan X, Li F, Zhang Y and Lu X:
Expression of Beclin 1 and LC3 in FIGO stage I-II cervical squamous
cell carcinoma and relationship to survival. Tumour Biol.
33:1653–1659. 2012.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Meng YC, Lou XL, Yang LY, Li D and Hou YQ:
Role of the autophagy-related marker LC3 expression in
hepatocellular carcinoma: A meta-analysis. J Cancer Res Clin Oncol.
146:1103–1113. 2020.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Li JX, Yan Q, Liu N, Zheng WJ, Hu M, Yu
ZM, Zhou YD, Wang XW, Liang FX and Chen R: The prognostic value of
autophagy-related markers bclin-1 and LC-3 in colorectal cancers: A
systematic review and meta-analysis. Evid Based Complement Alternat
Med. 2020(8475840)2020.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Stang A: Critical evaluation of the
Newcastle-Ottawa scale for the assessment of the quality of
nonrandomized studies in meta-analyses. Eur J Epidemiol.
25:603–605. 2010.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Park JM, Huang S, Wu TT, Foster NR and
Sinicrope FA: Prognostic impact of Beclin 1, p62/sequestosome 1 and
LC3 protein expression in colon carcinomas from patients receiving
5-fluorouracil as adjuvant chemotherapy. Cancer Biol Ther.
14:100–107. 2013.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Choi JH, Cho YS, Ko YH, Hong SU, Park JH
and Lee MA: Absence of autophagy-related proteins expression is
associated with poor prognosis in patients with colorectal
adenocarcinoma. Gastroenterol Res Pract.
2014(179586)2014.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Shim BY, Sun S, Won HS, Lee MA, Hong SU,
Jung JH, Cho HM and Ko YH: Role of autophagy-related protein
expression in patients with rectal cancer treated with neoadjuvant
chemoradiotherapy. BMC Cancer. 16(207)2016.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Schmitz KJ, Ademi C, Bertram S, Schmid KW
and Baba HA: Prognostic relevance of autophagy-related markers LC3,
p62/sequestosome 1, Beclin-1 and ULK1 in colorectal cancer patients
with respect to KRAS mutational status. World J Surg Oncol.
14(189)2016.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Zhao H, Yang M and Zhao B: Beclin 1 and
LC3 as predictive biomarkers for metastatic colorectal carcinoma.
Oncotarget. 8:59058–59067. 2017.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Guo GF, Wang YX, Zhang YJ, Chen XX, Lu JB,
Wang HH, Jiang C, Qiu HQ and Xia LP: Predictive and prognostic
implications of 4E-BP1, Beclin-1, and LC3 for cetuximab treatment
combined with chemotherapy in advanced colorectal cancer with
wild-type KRAS: Analysis from real-world data. World J
Gastroenterol. 25:1840–1853. 2019.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Sui YQ and Feng YZ: Expression and
significance of autophagy related genes LC3 and Beclin-1 and
apoptosis related genes p53 and Bcl-2 in colorectal cancer. J Clin
Exp pathol. 28:282–286. 2012.
|
|
32
|
Li SM: Expression and significance of
Tricellulin, LC3 and Beclin1 in colorectal cancer. Shandong Med.
58:1–5. 2018.
|
|
33
|
Morgan E, Arnold M, Gini A, Lorenzoni V,
Cabasag CJ, Laversanne M, Vignat J, Ferlay J, Murphy N and Bray F:
Global burden of colorectal cancer in 2020 and 2040: Incidence and
mortality estimates from GLOBOCAN. Gut. 72:338–344. 2023.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Brenner H, Kloor M and Pox CP: Colorectal
cancer. Lancet. 383:1490–1502. 2014.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Chen Z, Li Y, Zhang C, Yi H, Wu C, Wang J,
Liu Y, Tan J and Wen J: Downregulation of Beclin 1 and impairment
of autophagy in a small population of colorectal cancer. Dig Dis
Sci. 58:2887–2894. 2013.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Giatromanolaki A, Koukourakis MI, Harris
AL, Polychronidis A, Gatter KC and Sivridis E: Prognostic relevance
of light chain 3 (LC3A) autophagy patterns in colorectal
adenocarcinomas. J Clin Pathol. 63:867–872. 2010.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Sato K, Tsuchihara K, Fujii S, Sugiyama M,
Goya T, Atomi Y, Ueno T, Ochiai A and Esumi H: Autophagy is
activated in colorectal cancer cells and contributes to the
tolerance to nutrient deprivation. Cancer Res. 67:9677–9684.
2007.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Nagelkerke A, Bussink J, Geurts-Moespot A,
Sweep FC and Span PN: Therapeutic targeting of autophagy in cancer.
Part II: Pharmacological modulation of treatment-induced autophagy.
Semin Cancer Biol. 31:99–105. 2015.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Degenhardt K, Mathew R, Beaudoin B, Bray
K, Anderson D, Chen G, Mukherjee C, Shi Y, Gélinas C, Fan Y, et al:
Autophagy promotes tumor cell survival and restricts necrosis,
inflammation, and tumorigenesis. Cancer Cell. 10:51–64.
2006.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Kim JC, Lee KH, Yu CS, Kim HC, Kim JR,
Chang HM, Kim JH, Kim JS and Kim TW: The clinicopathological
significance of inferior mesenteric lymph node metastasis in
colorectal cancer. Eur J Surg Oncol. 30:271–279. 2004.PubMed/NCBI View Article : Google Scholar
|
