|
1
|
Mitchell P, Liew G, Gopinath B and Wong
TY: Age-related macular degeneration. Lancet. 392:1147–1159.
2018.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Ma X, Takahashi Y, Wu W, Chen J, Dehdarani
M, Liang W, Shin YH, Benyajati S and Ma JX: Soluble very
low-density lipoprotein receptor (sVLDLR) inhibits fibrosis in
neovascular age-related macular degeneration. FASEB J.
35(e22058)2021.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Zhou L, Shi DP, Chu WJ, Yang LL and Xu HF:
LRG1 promotes epithelial-mesenchymal transition of retinal pigment
epithelium cells by activating NOX4. Int J Ophthalmol. 14:349–355.
2021.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Zhang C, Qin S, Xie H, Qiu Q, Wang H and
Zhang J, Luo D and Zhang J: RO4929097, a selective γ-secretase
inhibitor, inhibits subretinal fibrosis via suppressing notch and
ERK1/2 signaling in laser-induced mouse model. Invest Ophthalmol
Vis Sci. 63(14)2022.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Tenbrock L, Wolf J, Boneva S, Schlecht A,
Agostini H, Wieghofer P, Schlunck G and Lange C: Subretinal
fibrosis in neovascular age-related macular degeneration: Current
concepts, therapeutic avenues, and future perspectives. Cell Tissue
Res. 387:361–375. 2022.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Mueller-Buehl AM, Doepper H, Grauthoff S,
Kiebler T, Peters L, Hurst J, Kuehn S, Bartz-Schmidt KU, Dick HB,
Joachim SC and Schnichels S: Oxidative stress-induced retinal
damage is prevented by mild hypothermia in an ex vivo model of
cultivated porcine retinas. Clin Exp Ophthalmol. 48:666–681.
2020.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Flory J and Lipska K: Metformin in 2019.
JAMA. 321:1926–1927. 2019.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Han J, Li Y, Liu X, Zhou T, Sun H, Edwards
P, Gao H, Yu FS and Qiao X: Metformin suppresses retinal
angiogenesis and inflammation in vitro and in vivo. PLoS One.
13(e0193031)2018.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Wang G, Chen S, Shao Z, Li Y, Wang W, Mao
L, Li J and Mei X: Metformin alleviates hydrogen peroxide-induced
inflammation and oxidative stress via inhibiting P2X7R signaling in
spinal cord tissue cells neurons. Can J Physiol Pharmacol.
99:768–774. 2021.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Rangarajan S, Bone NB, Zmijewska AA, Jiang
S, Park DW, Bernard K, et al: Metformin reverses established lung
fibrosis in a bleomycin model. Nature Medicine. 24:1121–7.
2018.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Lv Z and Guo Y: Metformin and its benefits
for various diseases. Front Endocrinol (Lausanne).
11(191)2020.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Blitzer AL, Ham SA, Colby KA and Skondra
D: Association of metformin use with age-related macular
degeneration: A case-control study. JAMA Ophthalmol. 139:302–309.
2021.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Romdhoniyyah DF, Harding SP, Cheyne CP and
Beare NAV: Metformin, a potential role in age-related macular
degeneration: A systematic review and meta-analysis. Ophthalmol
Ther. 10:245–260. 2021.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Zhang L, Chen T, Yin Y, Zhang CY and Zhang
YL: Dietary microRNA-A novel functional component of food. Adv
Nutr. 10:711–721. 2019.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Askou AL, Alsing S, Holmgaard A, Bek T and
Corydon TJ: Dissecting microRNA dysregulation in age-related
macular degeneration: New targets for eye gene therapy. Acta
Ophthalmol. 96:9–23. 2018.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Yi M, Li Y, Wang D, Zhang Q, Yang L and
Yang C: KCNQ1OT1 exacerbates ischemia-reperfusion injury through
targeted inhibition of miR-140-3P. Inflammation. 43:1832–1845.
2020.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Al-Modawi RN, Brinchmann JE and Karlsen
TA: Multi-pathway protective effects of MicroRNAs on human
chondrocytes in an in vitro model of osteoarthritis. Mol Ther
Nucleic Acids. 17:776–790. 2019.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Wu SM, Li TH, Yun H, Ai HW and Zhang KH:
miR-140-3p knockdown suppresses cell proliferation and fibrogenesis
in hepatic stellate cells via PTEN-mediated AKT/mTOR signaling.
Yonsei Med J. 60:561–569. 2019.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Zhou J, Ng SB and Chng WJ: LIN28/LIN28B:
An emerging oncogenic driver in cancer stem cells. Int J Biochem
Cell Biol. 45:973–978. 2013.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Huang Q, Niu Y, Song L, Huang J, Wang C
and Ma T: Does LIN28B gene dysregulation make women more likely to
abort? Reprod Fertil. 2:211–220. 2021.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Liang H, Liu S, Chen Y, Bai X, Liu L, Dong
Y, Hu M, Su X, Chen Y, Huangfu L, et al: miR-26a suppresses EMT by
disrupting the Lin28B/let-7d axis: Potential cross-talks among
miRNAs in IPF. J Mol Med (Berl). 94:655–665. 2016.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Zhang W and Sui Y: CircBPTF knockdown
ameliorates high glucose-induced inflammatory injuries and
oxidative stress by targeting the miR-384/LIN28B axis in human
umbilical vein endothelial cells. Mol Cell Biochem. 471:101–111.
2020.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Miyazaki T, Bub JD and Iwamoto Y: c-Jun
NH(2)-terminal kinase mediates leptin-stimulated
androgen-independent prostate cancer cell proliferation via signal
transducer and activator of transcription 3 and Akt. Biochim
Biophys Acta. 1782:593–604. 2008.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Guo ZL, Li JZ, Ma YY, Qian D, Zhong JY,
Jin MM, Huang P, Che LY, Pan B, Wang Y, et al: Shikonin sensitizes
A549 cells to TRAIL-induced apoptosis through the JNK, STAT3 and
AKT pathways. BMC Cell Biol. 19(29)2018.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Yang L, Besschetnova TY, Brooks CR, Shah
JV and Bonventre JV: Epithelial cell cycle arrest in G2/M mediates
kidney fibrosis after injury. Nat Med. 16:535–543, 1p, 143.
2010.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Du GS, Qiu Y, Wang WS, Peng K, Zhang ZC,
Li XS, Xiao WD and Yang H: Knockdown on aPKC-ι inhibits
epithelial-mesenchymal transition, migration and invasion of
colorectal cancer cells through Rac1-JNK pathway. Exp Mol Pathol.
107:57–67. 2019.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Zhao J, Qi YF and Yu YR: STAT3: A key
regulator in liver fibrosis. Ann Hepatol. 21(100224)2021.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Zhao WP, Wang HW, Liu J, Tan PP, Lin L and
Zhou BH: JNK/STAT signalling pathway is involved in
fluoride-induced follicular developmental dysplasia in female mice.
Chemosphere. 209:88–95. 2018.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Ishikawa K, Kannan R and Hinton DR:
Molecular mechanisms of subretinal fibrosis in age-related macular
degeneration. Exp Eye Res. 142:19–25. 2016.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408.
2001.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Wynn TA and Ramalingam TR: Mechanisms of
fibrosis: Therapeutic translation for fibrotic disease. Nat Med.
18:1028–1040. 2012.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Yi C, Liu J, Deng W, Luo C, Qi J, Chen M
and Xu H: Macrophage elastase (MMP12) critically contributes to the
development of subretinal fibrosis. J Neuroinflammation.
19(78)2022.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Li D, Zhang J, Liu Z, Gong Y and Zheng Z:
Human umbilical cord mesenchymal stem cell-derived exosomal miR-27b
attenuates subretinal fibrosis via suppressing
epithelial-mesenchymal transition by targeting HOXC6. Stem Cell Res
Ther. 12(24)2021.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Wu M, Xu H, Liu J, Tan X, Wan S, Guo M,
Long Y and Xu Y: Metformin and fibrosis: A review of existing
evidence and mechanisms. J Diabetes Res.
2021(6673525)2021.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Khateeb J, Fuchs E and Khamaisi M:
Diabetes and lung disease: A neglected relationship. Rev Diabet
Stud. 15:1–15. 2019.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Kheirollahi V, Wasnick RM, Biasin V,
Vazquez-Armendariz AI, Chu X, Moiseenko A, Weiss A, Wilhelm J,
Zhang JS, Kwapiszewska G, et al: Metformin induces lipogenic
differentiation in myofibroblasts to reverse lung fibrosis. Nat
Commun. 10(2987)2019.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Feng Y, Wang S, Zhang Y and Xiao H:
Metformin attenuates renal fibrosis in both AMPKα2-dependent and
independent manners. Clin Exp Pharmacol Physiol. 44:648–655.
2017.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Haura EB, Turkson J and Jove R: Mechanisms
of disease: Insights into the emerging role of signal transducers
and activators of transcription in cancer. Nat Clin Pract Oncol.
2:315–324. 2005.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Wang Y, He G, Tang H, Shi Y, Kang X, Lyu
J, Zhu M, Zhou M, Yang M, Mu M, et al: Aspirin inhibits
inflammation and scar formation in the injury tendon healing
through regulating JNK/STAT-3 signalling pathway. Cell Prolif.
52(e12650)2019.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Yan QL, Wang XY, Bai M, Zhang X, Song SJ
and Yao GD: Sesquiterpene lactones from Elephantopus scaber exhibit
cytotoxic effects on glioma cells by targeting GSTP1. Bioorg Chem.
129(106183)2022.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Dong G, Ma M, Lin X, Liu H, Gao D, Cui J,
Ren Z and Chen R: Treatment-damaged hepatocellular carcinoma
promotes activities of hepatic stellate cells and fibrosis through
GDF15. Exp Cell Res. 370:468–477. 2018.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Ghafouri-Fard S, Abak A, Talebi SF,
Shoorei H, Branicki W, Taheri M and Akbari Dilmaghani N: Role of
miRNA and lncRNAs in organ fibrosis and aging. Biomed Pharmacother.
143(112132)2021.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Zhang QY, Men CJ and Ding XW: Upregulation
of microRNA-140-3p inhibits epithelial-mesenchymal transition,
invasion, and metastasis of hepatocellular carcinoma through
inactivation of the MAPK signaling pathway by targeting GRN. J Cell
Biochem. 120:14885–14898. 2019.PubMed/NCBI View Article : Google Scholar
|
|
44
|
McDaniel K, Huang L, Sato K, Wu N, Annable
T, Zhou T, Ramos-Lorenzo S, Wan Y, Huang Q, Francis H, et al: The
let-7/Lin28 axis regulates activation of hepatic stellate cells in
alcoholic liver injury. J Biol Chem. 292:11336–11347.
2017.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Lu YY, Lin Y, Ding DX, Su S, Chi QQ, Zhang
YC, Sun J, Zhang X, Zhu HM, Huang QS, et al: MiR-26a functions as a
tumor suppressor in ambient particulate matter-bound
metal-triggered lung cancer cell metastasis by targeting
LIN28B-IL6-STAT3 axis. Arch Toxicol. 92:1023–1035. 2018.PubMed/NCBI View Article : Google Scholar
|
