Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
January-2024 Volume 27 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2024 Volume 27 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis

  • Authors:
    • Zhou Sun
    • Kejing Zhu
    • Guofu Liang
    • Fu Yan
    • Sheng Chao
    • Lei Jia
    • Yulin Niu
  • View Affiliations / Copyright

    Affiliations: Department of Organ Transplantation, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 30
    |
    Published online on: November 23, 2023
       https://doi.org/10.3892/etm.2023.12318
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The effect of vitamin K on clinical outcomes in patients receiving kidney transplantation is contested according to previous studies. This meta‑analysis aimed to summarize the impact of vitamin K on all‑cause mortality, renal function, inflammation, and vascular/bone health in patients receiving kidney transplantation. EMBASE, PubMed, and Cochrane were searched for literature concerning the effect of vitamin K on clinical outcomes of patients receiving kidney transplantation until December 2022. Normal vitamin K status/vitamin K supplementation was considered as the experimental group; while vitamin K deficiency/no vitamin K supplementation was considered as the control group. All‑cause mortality, renal function indexes, C‑reactive protein (CRP), and vascular/bone health indexes were extracted and analyzed. A total of seven studies with 1,101 patients in the experimental group and 651 patients in the control group were included. All‑cause mortality was decreased in the experimental group vs. the control group [relative risk (95% confidence interval (CI)]: 0.72 (0.60‑0.86), P<0.001]. Regarding renal function indexes, the estimated glomerular filtration rate was increased in the experimental group vs. the control group [mean difference (95% CI): 9.87 (1.48‑18.26), P=0.021]; while creatinine and albumin remained unchanged between the two groups (both P>0.05). Moreover, CRP, systolic blood pressure, diastolic blood pressure, triglycerides, hemoglobin, calcium, and 25‑hydroxyvitamin D were unchanged between the two groups (all P>0.05). Publication bias was low, and the robustness assessed by sensitivity analysis was generally acceptable. Thus vitamin K exerted a potential implication in reducing all‑cause mortality and improving renal function in patients receiving kidney transplantation.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Wouk N: End-stage renal disease: Medical management. Am Fam Physician. 104:493–499. 2021.PubMed/NCBI

2 

Wang Y, Hemmelder MH, Bos WJW, Snoep JD, de Vries APJ, Dekker FW and Meuleman Y: Mapping health-related quality of life after kidney transplantation by group comparisons: A systematic review. Nephrol Dial Transplant. 36:2327–2339. 2021.PubMed/NCBI View Article : Google Scholar

3 

Axelrod DA, Schnitzler MA, Xiao H, Irish W, Tuttle-Newhall E, Chang SH, Kasiske BL, Alhamad T and Lentine KL: An economic assessment of contemporary kidney transplant practice. Am J Transplant. 18:1168–1176. 2018.PubMed/NCBI View Article : Google Scholar

4 

Agrawal A, Ison MG and Danziger-Isakov L: Long-term infectious complications of kidney transplantation. Clin J Am Soc Nephrol. 17:286–295. 2022.PubMed/NCBI View Article : Google Scholar

5 

Sotomayor CG, Benjamens S, Gomes-Neto AW, Pol RA, Groothof D, Te Velde-Keyzer CA, Chong G, Glaudemans AWJM, Berger SP, Bakker SJL and Slart RHJA: Bone mineral density and aortic calcification: evidence for a bone-vascular axis after kidney transplantation. Transplantation. 105:231–239. 2021.PubMed/NCBI View Article : Google Scholar

6 

Ponticelli C, Favi E and Ferraresso M: New-onset diabetes after kidney transplantation. Medicina (Kaunas). 57(250)2021.PubMed/NCBI View Article : Google Scholar

7 

Ponticelli C, Reggiani F and Moroni G: Delayed graft function in kidney transplant: Risk factors, Consequences and prevention strategies. J Pers Med. 12:2022.PubMed/NCBI View Article : Google Scholar

8 

Bahl D, Haddad Z, Datoo A and Qazi YA: Delayed graft function in kidney transplantation. Curr Opin Organ Transplant. 24:82–86. 2019.PubMed/NCBI View Article : Google Scholar

9 

Haberal M, Boyvat F, Akdur A, Kirnap M, Ozcelik U and Yarbug Karakayali F: Surgical complications after kidney transplantation. Exp Clin Transplant. 14:587–595. 2016.PubMed/NCBI

10 

Ammi M, Daligault M, Sayegh J, Abraham P, Papon X, Enon B and Picquet J: Evaluation of the vascular surgical complications of renal transplantation. Ann Vasc Surg. 33:23–30. 2016.PubMed/NCBI View Article : Google Scholar

11 

Ghadiani MH, Peyrovi S, Mousavinasab SN and Jalalzadeh M: Delayed graft function, allograft and patient srvival in kidney transplantation. Arab J Nephrol Transplant. 5:19–24. 2012.PubMed/NCBI

12 

Cozzolino M, Mangano M, Galassi A, Ciceri P, Messa P and Nigwekar S: Vitamin K in chronic kidney disease. Nutrients. 11(168)2019.PubMed/NCBI View Article : Google Scholar

13 

Eelderink C, Kremer D, Riphagen IJ, Knobbe TJ, Schurgers LJ, Pasch A, Mulder DJ, Corpeleijn E, Navis G, Bakker SJL, et al: Effect of vitamin K supplementation on serum calcification propensity and arterial stiffness in vitamin K-deficient kidney transplant recipients: A double-blind, randomized, placebo-controlled clinical trial. Am J Transplant. 23:520–530. 2023.PubMed/NCBI View Article : Google Scholar

14 

Boxma PY, van den Berg E, Geleijnse JM, Laverman GD, Schurgers LJ, Vermeer C, Kema IP, Muskiet FA, Navis G, Bakker SJ and de Borst MH: Vitamin K intake and plasma desphospho-uncarboxylated matrix Gla-protein levels in kidney transplant recipients. PLoS One. 7(e47991)2012.PubMed/NCBI View Article : Google Scholar

15 

Keyzer CA, Vermeer C, Joosten MM, Knapen MH, Drummen NE, Navis G, Bakker SJ and de Borst MH: Vitamin K status and mortality after kidney transplantation: A cohort study. Am J Kidney Dis. 65:474–483. 2015.PubMed/NCBI View Article : Google Scholar

16 

Mansour AG, Hariri E, Daaboul Y, Korjian S, El Alam A, Protogerou AD, Kilany H, Karam A, Stephan A and Bahous SA: Vitamin K2 supplementation and arterial stiffness among renal transplant recipients-a single-arm, single-center clinical trial. J Am Soc Hypertens. 11:589–597. 2017.PubMed/NCBI View Article : Google Scholar

17 

Evenepoel P, Claes K, Meijers B, Laurent M, Bammens B, Naesens M, Sprangers B, Pottel H, Cavalier E and Kuypers D: Poor vitamin K status is associated with low bone mineral density and increased fracture risk in end-stage renal disease. J Bone Miner Res. 34:262–269. 2019.PubMed/NCBI View Article : Google Scholar

18 

van Ballegooijen AJ, Beulens JWJ, Keyzer CA, Navis GJ, Berger SP, de Borst MH, Vervloet MG and Bakker SJL: Joint association of vitamins D and K status with long-term outcomes in stable kidney transplant recipients. Nephrol Dial Transplant. 35:706–714. 2020.PubMed/NCBI View Article : Google Scholar

19 

Lees JS, Rankin AJ, Gillis KA, Zhu LY, Mangion K, Rutherford E, Roditi GH, Witham MD, Chantler D, Panarelli M, et al: The ViKTORIES trial: A randomized, double-blind, placebo-controlled trial of vitamin K supplementation to improve vascular health in kidney transplant recipients. Am J Transplant. 21:3356–3368. 2021.PubMed/NCBI View Article : Google Scholar

20 

Kremer D, Groothof D, Keyzer CA, Eelderink C, Knobbe TJ, Post A, van Londen M, Eisenga MF, TransplantLines Investigators, Schurgers LJ, et al: Kidney function-dependence of vitamin K-status parameters: Results from the transplantlines biobank and cohort studies. Nutrients. 13(3069)2021.PubMed/NCBI View Article : Google Scholar

21 

Wells GA, Shea B, O'Connell D, je Peterson, Welch V, Losos M and Tugwell P: The newcastle-ottawa scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses. Ottawa Hospital Research Institute, Ottawa, ON, 2015.

22 

Higgins JP, Thompson SG, Deeks JJ and Altman DG: Measuring inconsistency in meta-analyses. BMJ. 327:557–560. 2003.PubMed/NCBI View Article : Google Scholar

23 

R Core Team: A language and environment for statistical computing. R foundation for statistical computing, Vienna, 2013. http://www.R-project.org/.

24 

RStudio Team: RStudio: Integrated development for R. RStudio, Inc., Boston MA. 2015. http://www.rstudio.com/.

25 

Shioi A, Morioka T, Shoji T and Emoto M: The inhibitory roles of vitamin K in progression of vascular calcification. Nutrients. 12(583)2020.PubMed/NCBI View Article : Google Scholar

26 

Roumeliotis S, Duni A, Vaios V, Kitsos A, Liakopoulos V and Dounousi E: Vitamin K supplementation for prevention of vascular calcification in chronic kidney disease patients: Are we there yet? Nutrients. 14(925)2022.PubMed/NCBI View Article : Google Scholar

27 

Alonso N, Meinitzer A, Fritz-Petrin E, Enko D and Herrmann M: Role of vitamin K in bone and muscle metabolism. Calcif Tissue Int. 112:178–196. 2023.PubMed/NCBI View Article : Google Scholar

28 

Fusaro M, Cianciolo G, Brandi ML, Ferrari S, Nickolas TL, Tripepi G, Plebani M, Zaninotto M, Iervasi G, La Manna G, et al: Vitamin K and osteoporosis. Nutrients. 12(3625)2020.PubMed/NCBI View Article : Google Scholar

29 

Bellone F, Cinquegrani M, Nicotera R, Carullo N, Casarella A, Presta P, Andreucci M, Squadrito G, Mandraffino G, Prunestì M, et al: Role of vitamin K in chronic kidney disease: A focus on bone and cardiovascular health. Int J Mol Sci. 23(5282)2022.PubMed/NCBI View Article : Google Scholar

30 

Wei FF, Drummen NE, Thijs L, Jacobs L, Herfs M, Van't Hoofd C, Vermeer C and Staessen JA: Vitamin-K-dependent protection of the renal microvasculature: Histopathological studies in normal and diseased kidneys. Pulse (Basel). 4:85–91. 2016.PubMed/NCBI View Article : Google Scholar

31 

Ohsaki Y, Shirakawa H, Miura A, Giriwono PE, Sato S, Ohashi A, Iribe M, Goto T and Komai M: Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activation of nuclear factor κB through the repression of IKKα/β phosphorylation. J Nutr Biochem. 21:1120–1126. 2010.PubMed/NCBI View Article : Google Scholar

32 

Bordoloi J, Dihingia A, Kalita J and Manna P: Implication of a novel vitamin K dependent protein, GRP/Ucma in the pathophysiological conditions associated with vascular and soft tissue calcification, osteoarthritis, inflammation, and carcinoma. Int J Biol Macromol. 113:309–316. 2018.PubMed/NCBI View Article : Google Scholar

33 

Vermeer C, Shearer MJ, Zittermann A, Bolton-Smith C, Szulc P, Hodges S, Walter P, Rambeck W, Stöcklin E and Weber P: Beyond deficiency: Potential benefits of increased intakes of vitamin K for bone and vascular health. Eur J Nutr. 43:325–335. 2004.PubMed/NCBI View Article : Google Scholar

34 

Kluch M, Bednarkiewicz P, Orzechowska M, Grzelak P and Kurnatowska I: Vitamin K1 and K2 in the diet of patients in the long term after kidney transplantation. Nutrients. 14(5070)2022.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sun Z, Zhu K, Liang G, Yan F, Chao S, Jia L and Niu Y: Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis. Exp Ther Med 27: 30, 2024.
APA
Sun, Z., Zhu, K., Liang, G., Yan, F., Chao, S., Jia, L., & Niu, Y. (2024). Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis. Experimental and Therapeutic Medicine, 27, 30. https://doi.org/10.3892/etm.2023.12318
MLA
Sun, Z., Zhu, K., Liang, G., Yan, F., Chao, S., Jia, L., Niu, Y."Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis". Experimental and Therapeutic Medicine 27.1 (2024): 30.
Chicago
Sun, Z., Zhu, K., Liang, G., Yan, F., Chao, S., Jia, L., Niu, Y."Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis". Experimental and Therapeutic Medicine 27, no. 1 (2024): 30. https://doi.org/10.3892/etm.2023.12318
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Z, Zhu K, Liang G, Yan F, Chao S, Jia L and Niu Y: Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis. Exp Ther Med 27: 30, 2024.
APA
Sun, Z., Zhu, K., Liang, G., Yan, F., Chao, S., Jia, L., & Niu, Y. (2024). Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis. Experimental and Therapeutic Medicine, 27, 30. https://doi.org/10.3892/etm.2023.12318
MLA
Sun, Z., Zhu, K., Liang, G., Yan, F., Chao, S., Jia, L., Niu, Y."Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis". Experimental and Therapeutic Medicine 27.1 (2024): 30.
Chicago
Sun, Z., Zhu, K., Liang, G., Yan, F., Chao, S., Jia, L., Niu, Y."Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis". Experimental and Therapeutic Medicine 27, no. 1 (2024): 30. https://doi.org/10.3892/etm.2023.12318
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team