|
1
|
Rubin LJ: Primary pulmonary hypertension.
N Engl J Med. 336:111–117. 1997.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Ghofrani HA, Reichenberger F, Kohstall MG,
Mrosek EH, Seeger T, Olschewski H, Seeger W and Grimminger F:
Sildenafil increased exercise capacity during hypoxia at low
altitudes and at Mount Everest base camp: A randomized,
double-blind, placebo-controlled crossover trial. Ann Intern Med.
141:169–177. 2004.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Hsu AR, Barnholt KE, Grundmann NK, Lin JH,
McCallum SW and Friedlander AL: Sildenafil improves cardiac output
and exercise performance during acute hypoxia, but not normoxia. J
Appl Physiol (1985). 100:2031–2040. 2006.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Ricart A, Maristany J, Fort N, Leal C,
Pagés T and Viscor G: Effects of sildenafil on the human response
to acute hypoxia and exercise. High Alt Med Biol. 6:43–49.
2005.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Richalet JP, Gratadour P, Robach P, Pham
I, Déchaux M, Joncquiert-Latarjet A, Mollard P, Brugniaux J and
Cornolo J: Sildenafil inhibits altitude-induced hypoxemia and
pulmonary hypertension. Am J Respir Crit Care Med. 171:275–281.
2005.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Weitzenblum E: Chronic cor pulmonale.
Heart. 89:225–230. 2003.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Dorrington KL, Clar C, Young JD, Jonas M,
Tansley JG and Robbins PA: Time course of the human pulmonary
vascular response to 8 hours of isocapnic hypoxia. Am J Physiol.
273:H1126–H1134. 1997.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Scherrer U, Allemann Y, Rexhaj E, Rimoldi
SF and Sartori C: Mechanisms and drug therapy of pulmonary
hypertension at high altitude. High Alt Med Biol. 14:126–133.
2013.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Humbert M, Morrell NW, Archer SL, Stenmark
KR, MacLean MR, Lang IM, Christman BW, Weir EK, Eickelberg O,
Voelkel NF and Rabinovitch M: Cellular and molecular pathobiology
of pulmonary arterial hypertension. J Am Coll Cardiol 43(12 Suppl
S). 43:S13–S24. 2004.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Andersson KE: PDE5 inhibitors-pharmacology
and clinical applications 20 years after sildenafil discovery. Br J
Pharmacol. 175:2554–2565. 2018.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Jin B, Luo XP, Ni HC and Shi HM:
Phosphodiesterase type 5 inhibitors for high-altitude pulmonary
hypertension: A meta-analysis. Clin Drug Investig. 30:259–265.
2010.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Barst RJ, Ivy DD, Gaitan G, Szatmari A,
Rudzinski A, Garcia AE, Sastry BK, Pulido T, Layton GR,
Serdarevic-Pehar M and Wessel DL: A randomized, double-blind,
placebo-controlled, dose-ranging study of oral sildenafil citrate
in treatment-naive children with pulmonary arterial hypertension.
Circulation. 125:324–334. 2012.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Kjaergaard J, Snyder EM, Hassager C, Olson
TP, Oh JK, Johnson BD and Frantz RP: Right ventricular function
with hypoxic exercise: Effects of sildenafil. Eur J Appl Physiol.
102:87–95. 2007.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Xu Y, Liu Y, Liu J and Qian G:
Meta-analysis of clinical efficacy of sildenafil, a
phosphodiesterase type-5 inhibitor on high altitude hypoxia and its
complications. High Alt Med Biol. 15:46–51. 2014.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Zhao L, Mason NA, Morrell NW, Kojonazarov
B, Sadykov A, Maripov A, Mirrakhimov MM, Aldashev A and Wilkins MR:
Sildenafil inhibits hypoxia-induced pulmonary hypertension.
Circulation. 104:424–428. 2001.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Kressler J, Stoutenberg M, Roos BA,
Friedlander AL, Perry AC, Signorile JF and Jacobs KA: Sildenafil
does not improve steady state cardiovascular hemodynamics, peak
power, or 15-km time trial cycling performance at simulated
moderate or high altitudes in men and women. Eur J Appl Physiol.
111:3031–3040. 2011.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Faoro V, Lamotte M, Deboeck G, Pavelescu
A, Huez S, Guenard H, Martinot JB and Naeije R: Effects of
sildenafil on exercise capacity in hypoxic normal subjects. High
Alt Med Biol. 8:155–163. 2007.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Calbet JA, Boushel R, Rådegran G,
Søndergaard H, Wagner PD and Saltin B: Determinants of maximal
oxygen uptake in severe acute hypoxia. Am J Physiol Regul Integr
Comp Physio. 284:R291–R303. 2003.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Fulco CS, Rock PB and Cymerman A: Maximal
and submaximal exercise performance at altitude. Aviat Space
Environ Med. 69:793–801. 1998.PubMed/NCBI
|
|
20
|
Reichenberger F, Kohstall MG, Seeger T,
Olschewski H, Grimminger F, Seeger W and Ghofrani HA: Effect of
sildenafil on hypoxia-induced changes in pulmonary circulation and
right ventricular function. Respir Physiol Neurobiol. 159:196–201.
2007.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Moher D, Pham B, Jones A, Cook DJ, Jadad
AR, Moher M, Tugwell P and Klassen TP: Does quality of reports of
randomised trials affect estimates of intervention efficacy
reported in meta-analyses? Lancet. 352:609–613. 1998.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Higgins JP, Thompson SG, Deeks JJ and
Altman DG: Measuring inconsistency in meta-analyses. BMJ.
327:557–560. 2003.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Altman DG and Bland JM: Standard
deviations and standard errors. BMJ. 331(903)2005.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Hozo SP, Djulbegovic B and Hozo I:
Estimating the mean and variance from the median, range, and the
size of a sample. BMC Med Res Methodol. 5(13)2005.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Snyder EM, Olson TP, Johnson BD and Frantz
RP: Influence of sildenafil on lung diffusion during exposure to
acute hypoxia at rest and during exercise in healthy humans. Eur J
Appl Physiol. 103:421–430. 2008.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Lalande S, Snyder EM, Olson TP, Hulsebus
ML, Orban M, Somers VK, Johnson BD and Frantz RP: The effects of
sildenafil and acetazolamide on breathing efficiency and
ventilatory control during hypoxic exercise. Eur J Appl Physiol.
106:509–515. 2009.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Olfert IM, Loeckinger A, Treml B,
Faulhaber M, Flatz M, Burtscher M, Truebsbach S and Kleinsasser A:
Sildenafil and bosentan improve arterial oxygenation during acute
hypoxic exercise: A controlled laboratory trial. Wilderness Environ
Med. 22:211–221. 2011.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Toro-Salinas AH, Fort N, Torrella JR,
Pagès T, Javierre C and Viscor G: Sildenafil does not improve
exercise capacity under acute hypoxia exposure. Int J Sports Med.
37:785–791. 2016.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Jacobs KA, Kressler J, Stoutenberg M, Roos
BA and Friedlander AL: Sildenafil has little influence on
cardiovascular hemodynamics or 6-km time trial performance in
trained men and women at simulated high altitude. High Alt Med
Biol. 12:215–222. 2011.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Cornolo J, Mollard P, Brugniaux JV, Robach
P and Richalet JP: Autonomic control of the cardiovascular system
during acclimatization to high altitude: Effects of sildenafil. J
Appl Physiol. 97:935–940. 2004.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Hainsworth R, Drinkhill MJ and
Rivera-Chira M: The autonomic nervous system at high altitude. Clin
Auton Res. 17:13–19. 2007.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Vogel JA, Hansen JE and Harris CW:
Cardiovascular responses in man during exhaustive work at sea level
and high altitude. J Appl Physiol. 23:531–539. 1967.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Vogel JA and Harris CW: Cardiopulmonary
responses of resting man during early exposure to high altitude. J
Appl Physiol. 22:1124–1128. 1967.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Coppel J, Hennis P, Gilbert-Kawai E and
Grocott MP: The physiological effects of hypobaric hypoxia versus
normobaric hypoxia: A systematic review of crossover trials. Extrem
Physiol Med. 4(2)2015.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Netzer N, Strohl K, Faulhaber M, Gatterer
H and Burtscher M: Hypoxia-related altitude illnesses. J Travel
Med. 20:247–255. 2013.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Swenson ER: Hypoxic pulmonary
vasoconstriction. High Alt Med Biol. 14:101–110. 2013.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Ghofrani HA, Wiedemann R, Rose F,
Olschewski H, Schermuly RT, Weissmann N, Seeger W and Grimminger F:
Combination therapy with oral sildenafil and inhaled iloprost for
severe pulmonary hypertension. Ann Intern Med. 136:515–522.
2002.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Wilkens H, Guth A, König J, Forestier N,
Cremers B, Hennen B, Böhm M and Sybrecht GW: Effect of inhaled
iloprost plus oral sildenafil in patients with primary pulmonary
hypertension. Circulation. 104:1218–1222. 2001.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Sastry BK, Narasimhan C, Reddy NK, Anand
B, Prakash GS, Raju PR and Kumar DN: A study of clinical efficacy
of sildenafil in patients with primary pulmonary hypertension.
Indian Heart J. 54:410–414. 2002.PubMed/NCBI
|
|
40
|
Carter EA, Lohse K, Sheel W and Koehle M:
Sildenafil does not reliably improve exercise performance in
hypoxia: A systematic review. BMJ Open Sport Exerc Med.
5(e000526)2019.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Rodway GW, Lovelace AJ, Lanspa MJ,
McIntosh SE, Bell J, Briggs B, Weaver LK, Yanowitz F and Grissom
CK: Sildenafil and exercise capacity in the elderly at moderate
altitude. Wilderness Environ Med. 27:307–315. 2016.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Bates MG, Thompson AA, Baillie JK,
Sutherland AI, Irving JB, Hirani N and Webb DJ: Sildenafil citrate
for the prevention of high altitude hypoxic pulmonary hypertension:
double blind, randomized, placebo-controlled trial. High Alt Med
Biol. 12:207–214. 2011.PubMed/NCBI View Article : Google Scholar
|
