|
1
|
Geremia A, Biancheri P, Allan P, Corazza
GR and Di Sabatino A: Innate and adaptive immunity in inflammatory
bowel disease. Autoimmun Rev. 13:3–10. 2014.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Cosnes J, Gower-Rousseau C, Seksik P and
Cortot A: Epidemiology and natural history of inflammatory bowel
diseases. Gastroenterology. 140:1785–1794. 2011.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Roda G, Chien Ng S, Kotze PG, Argollo M,
Panaccione R, Spinelli A, Kaser A, Peyrin-Biroulet L and Danese S:
Crohn's disease. Nat Rev Dis Primer. 6(22)2020.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Dulai PS, Singh S, Vande Casteele N,
Boland BS, Rivera-Nieves J, Ernst PB, Eckmann L, Barrett KE, Chang
JT and Sandborn WJ: Should we divide Crohn's disease into
ileum-dominant and isolated colonic diseases? Clin Gastroenterol
Hepatol. 17:2634–2643. 2019.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Friedberg S and Rubin DT: Intestinal
cancer and dysplasia in Crohn's disease. Gastroenterol Clin North
Am. 51:369–379. 2022.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Friedman S: Cancer in Crohn's disease.
Gastroenterol Clin North Am. 35:621–639. 2006.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Baumgart DC and Sandborn WJ: Crohn's
disease. Lancet. 380:1590–1605. 2012.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Jiang X, Stockwell BR and Conrad M:
Ferroptosis: Mechanisms, biology and role in disease. Nat Rev Mol
Cell Biol. 22:266–282. 2021.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Li J, Cao F, Yin HL, Huang ZJ, Lin ZT, Mao
N, Sun B and Wang G: Ferroptosis: Past, present and future. Cell
Death Dis. 11(88)2020.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Xu C, Liu Z and Xiao J: Ferroptosis: A
double-edged sword in gastrointestinal disease. Int J Mol Sci.
22(12403)2021.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Vancamelbeke M, Vanuytsel T, Farré R,
Verstockt S, Ferrante M, Van Assche G, Rutgeerts P, Schuit F,
Vermeire S, Arijs I and Cleynen I: Genetic and transcriptomic bases
of intestinal epithelial barrier dysfunction in inflammatory bowel
disease. Inflamm Bowel Dis. 23:1718–1729. 2017.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Verstockt S, De Hertogh G, Van der Goten
J, Verstockt B, Vancamelbeke M, Machiels K, Van Lommel L, Schuit F,
Van Assche G, Rutgeerts P, et al: Gene and mirna regulatory
networks during different stages of Crohn's disease. J Crohns
Colitis. 13:916–930. 2019.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Kanehisa M, Furumichi M, Sato Y, Kawashima
M and Ishiguro-Watanabe M: KEGG for taxonomy-based analysis of
pathways and genomes. Nucleic Acids Res. 51:D587–D592.
2023.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Kanehisa M and Goto S: KEGG: Kyoto
encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30.
2000.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Kanehisa M: Toward understanding the
origin and evolution of cellular organisms. Protein. 28:1947–1951.
2019.PubMed/NCBI View
Article : Google Scholar
|
|
16
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408.
2001.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Yao B, Zhang Q, Yang Z, An F, Nie H, Wang
H, Yang C, Sun J, Chen K, Zhou J, et al: CircEZH2/miR-133b/IGF2BP2
aggravates colorectal cancer progression via enhancing the
stability of m6A-modified CREB1 mRNA. Mol Cancer.
21(140)2022.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Veauthier B and Hornecker JR: Crohn's
disease: Diagnosis and management. Am Fam Physician. 98:661–669.
2018.PubMed/NCBI
|
|
19
|
Chiba M, Morita N, Nakamura A, Tsuji K and
Harashima E: Increased incidence of inflammatory bowel disease in
association with dietary transition (westernization) in Japan. JMA
J. 4:347–357. 2021.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Chetcuti Zammit S, Ellul P and Sidhu R:
The role of small bowel endoscopy for Crohn's disease. Curr Opin
Gastroenterol. 35:223–234. 2019.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Wilkins T, Jarvis K and Patel J: Diagnosis
and management of Crohn's disease. Am Fam Physician. 84:1365–1375.
2011.PubMed/NCBI
|
|
22
|
Ambruzs JM and Larsen CP: Renal
manifestations of inflammatory bowel disease. Rheum Dis Clin North
Am. 44:699–714. 2018.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Prieto JMI, Andrade AR, Magro DO, Imbrizi
M, Nishitokukado I, Ortiz-Agostinho CL, Dos Santos FM, Luzia LA,
Rondo PHC, Leite AZA, et al: Nutritional global status and its
impact in Crohn's disease. J Can Assoc Gastroenterol. 4:290–295.
2021.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Wu X, Li Y, Zhang S and Zhou X:
Ferroptosis as a novel therapeutic target for cardiovascular
disease. Theranostics. 11:3052–3059. 2021.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Mahoney-Sánchez L, Bouchaoui H, Ayton S,
Devos D, Duce JA and Devedjian JC: Ferroptosis and its potential
role in the physiopathology of Parkinson's disease. Prog Neurobiol.
196(101890)2021.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Martin-Sanchez D, Fontecha-Barriuso M,
Martinez-Moreno JM, Ramos AM, Sanchez-Niño MD, Guerrero-Hue M,
Moreno JA, Ortiz A and Sanz AB: Ferroptosis and kidney disease.
Nefrologia (Engl Ed). 40:384–394. 2020.PubMed/NCBI View Article : Google Scholar : (In English,
Spanish).
|
|
27
|
Huang F, Zhang S, Li X, Huang Y, He S and
Luo L: STAT3-mediated ferroptosis is involved in ulcerative
colitis. Free Radic Biol Med. 188:375–385. 2022.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Sui X, Zhang R, Liu S, Duan T, Zhai L,
Zhang M, Han X, Xiang Y, Huang X, Lin H and Xie T: RSL3 drives
ferroptosis through GPX4 inactivation and ROS production in
colorectal cancer. Front Pharmacol. 9(1371)2018.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Liu W, Xu C, Zou Z, Weng Q and Xiao Y:
Sestrin2 suppresses ferroptosis to alleviate septic intestinal
inflammation and barrier dysfunction. Immunopharmacol
Immunotoxicol. 45:123–132. 2023.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Ma X, Xiao L, Liu L, Ye L, Su P, Bi E,
Wang Q, Yang M, Qian J and Yi Q: CD36-mediated ferroptosis dampens
intratumoral CD8+ T cell effector function and impairs
their antitumor ability. Cell Metab. 33:1001–1012.e5.
2021.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Xu H, Ye D, Ren M, Zhang H and Bi F:
Ferroptosis in the tumor microenvironment: Perspectives for
immunotherapy. Trends Mol Med. 27:856–867. 2021.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Yu Y, Yan Y, Niu F, Wang Y, Chen X, Su G,
Liu Y, Zhao X, Qian L, Liu P and Xiong Y: Ferroptosis: A cell death
connecting oxidative stress, inflammation and cardiovascular
diseases. Cell Death Discov. 7(193)2021.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Mancardi D, Mezzanotte M, Arrigo E,
Barinotti A and Roetto A: Iron overload, oxidative stress, and
ferroptosis in the failing heart and liver. Antioxidants (Basel).
10(1864)2021.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Reuter S, Gupta SC, Chaturvedi MM and
Aggarwal BB: Oxidative stress, inflammation, and cancer: How are
they linked? Free Radic Biol Med. 49:1603–1616. 2010.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Gu L, Ge Z, Wang Y, Shen M and Zhao P:
Activating transcription factor 3 promotes intestinal epithelial
cell apoptosis in Crohn's disease. Pathol Res Pract. 214:862–870.
2018.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Zhang J, Xu M, Zhou W, Li D, Zhang H, Chen
Y, Ning L, Zhang Y, Li S, Yu M, et al: Deficiency in the
anti-apoptotic protein DJ-1 promotes intestinal epithelial cell
apoptosis and aggravates inflammatory bowel disease via p53. J Biol
Chem. 295:4237–4251. 2020.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Melincovici CS, Boşca AB, Şuşman S,
Mărginean M, Mihu C, Istrate M, Moldovan IM, Roman AL and Mihu CM:
Vascular endothelial growth factor (VEGF)-key factor in normal and
pathological angiogenesis. Rom J Morphol Embryol. 59:455–467.
2018.PubMed/NCBI
|
|
38
|
Kvietys PR and Granger DN: Role of
reactive oxygen and nitrogen species in the vascular responses to
inflammation. Free Radic Biol Med. 52:556–592. 2012.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Fukai T and Ushio-Fukai M: Cross-talk
between nadph oxidase and mitochondria: Role in ros signaling and
angiogenesis. Cells. 9(1849)2020.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Su LJ, Zhang JH, Gomez H, Murugan R, Hong
X, Xu D, Jiang F and Peng ZY: Reactive oxygen species-induced lipid
peroxidation in apoptosis, autophagy, and ferroptosis. Oxid Med
Cell Longev. 2019(5080843)2019.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Scaldaferri F, Vetrano S, Sans M, Arena V,
Straface G, Stigliano E, Repici A, Sturm A, Malesci A, Panes J, et
al: VEGF-A links angiogenesis and inflammation in inflammatory
bowel disease pathogenesis. Gastroenterology. 136:585–95.e5.
2009.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Eder P, Korybalska K, Lykowska-Szuber L,
Krela-Kazmierczak I, Stawczyk-Eder K, Klimczak K, Szymczak A, Linke
K and Witowski J: Association of serum VEGF with clinical response
to anti-TNFα therapy for Crohn's disease. Cytokine. 76:288–293.
2015.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Bradley JR: TNF-mediated inflammatory
disease. J Pathol. 214:149–160. 2008.PubMed/NCBI View Article : Google Scholar
|
|
44
|
Iwakura Y, Ishigame H, Saijo S and Nakae
S: Functional specialization of interleukin-17 family members.
Immunity. 34:149–162. 2011.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Bishu S, El Zaatari M, Hayashi A, Hou G,
Bowers N, Kinnucan J, Manoogian B, Muza-Moons M, Zhang M and
Grasberger H: , et al: CD4+ tissue-resident memory T cells
expand and are a major source of mucosal tumour necrosis factor α
in active Crohn's disease. J Crohns Colitis. 13:905–915.
2019.PubMed/NCBI View Article : Google Scholar
|
|
46
|
Tanaka T, Narazaki M and Kishimoto T: IL-6
in inflammation, immunity, and disease. Cold Spring Harb Perspect
Biol. 6(a016295)2014.PubMed/NCBI View Article : Google Scholar
|
|
47
|
Shi YJ, Hu SJ, Zhao QQ, Liu XS, Liu C and
Wang H: Toll-like receptor 4 (TLR4) deficiency aggravates dextran
sulfate sodium (DSS)-induced intestinal injury by down-regulating
IL6, CCL2 and CSF3. Ann Transl Med. 7(713)2019.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Gross V, Andus T, Caesar I, Roth M and
Schölmerich J: Evidence for continuous stimulation of interleukin-6
production in Crohn's disease. Gastroenterology. 102:514–519.
1992.PubMed/NCBI View Article : Google Scholar
|
|
49
|
Han F, Li S, Yang Y and Bai Z:
Interleukin-6 promotes ferroptosis in bronchial epithelial cells by
inducing reactive oxygen species-dependent lipid peroxidation and
disrupting iron homeostasis. Bioengineered. 12:5279–5288.
2021.PubMed/NCBI View Article : Google Scholar
|
|
50
|
Li M, Jin S, Zhang Z, Ma H and Yang X:
Interleukin-6 facilitates tumor progression by inducing ferroptosis
resistance in head and neck squamous cell carcinoma. Cancer Lett.
527:28–40. 2022.PubMed/NCBI View Article : Google Scholar
|
|
51
|
Kunzmann AT, Murray LJ, Cardwell CR,
McShane CM, McMenamin UC and Cantwell MM: PTGS2 (Cyclooxygenase-2)
expression and survival among colorectal cancer patients: A
systematic review. Cancer Epidemiol Biomarkers Prev. 22:1490–1497.
2013.PubMed/NCBI View Article : Google Scholar
|
|
52
|
Roberts PJ, Morgan K, Miller R, Hunter JO
and Middleton SJ: Neuronal COX-2 expression in human myenteric
plexus in active inflammatory bowel disease. Gut. 48:468–472.
2001.PubMed/NCBI View Article : Google Scholar
|
|
53
|
Singer II, Kawka DW, Schloemann S, Tessner
T, Riehl T and Stenson WF: Cyclooxygenase 2 is induced in colonic
epithelial cells in inflammatory bowel disease. Gastroenterology.
115:297–306. 1998.PubMed/NCBI View Article : Google Scholar
|
|
54
|
Chiang SK, Chen SE and Chang LC: A dual
role of heme oxygenase-1 in cancer cells. Int J Mol Sci.
20(39)2018.PubMed/NCBI View Article : Google Scholar
|
|
55
|
Chen Y, Wang J, Li J, Zhu J, Wang R, Xi Q,
Wu H, Shi T and Chen W: Astragalus polysaccharide prevents
ferroptosis in a murine model of experimental colitis and human
Caco-2 cells via inhibiting NRF2/HO-1 pathway. Eur J Pharmacol.
911(174518)2021.PubMed/NCBI View Article : Google Scholar
|
|
56
|
Lipinski S, Till A, Sina C, Arlt A,
Grasberger H, Schreiber S and Rosenstiel P: DUOX2-derived reactive
oxygen species are effectors of NOD2-mediated antibacterial
responses. J Cell Sci. 122:3522–3530. 2009.PubMed/NCBI View Article : Google Scholar
|
|
57
|
Haberman Y, Tickle TL, Dexheimer PJ, Kim
MO, Tang D, Karns R, Baldassano RN, Noe JD, Rosh J, Markowitz J, et
al: Pediatric Crohn disease patients exhibit specific ileal
transcriptome and microbiome signature. J Clin Invest.
124:3617–3633. 2014.PubMed/NCBI View Article : Google Scholar
|
|
58
|
Gajendran M, Loganathan P, Catinella AP
and Hashash JG: A comprehensive review and update on Crohn's
disease. Dis Mon. 64:20–57. 2018.PubMed/NCBI View Article : Google Scholar
|
|
59
|
Rolak S and Kane SV: Conventional
therapies for Crohn's disease. Gastroenterol Clin North Am.
51:271–282. 2022.PubMed/NCBI View Article : Google Scholar
|
|
60
|
Bian Y, Dong Y, Sun J, Sun M, Hou Q, Lai Y
and Zhang B: Protective effect of kaempferol on LPS-induced
inflammation and barrier dysfunction in a coculture model of
intestinal epithelial cells and intestinal microvascular
endothelial cells. J Agric Food Chem. 68:160–167. 2020.PubMed/NCBI View Article : Google Scholar
|
|
61
|
Yuan Y, Zhai Y, Chen J, Xu X and Wang H:
Kaempferol ameliorates oxygen-glucose
deprivation/reoxygenation-induced neuronal ferroptosis by
activating Nrf2/SLC7A11/GPX4 axis. Biomolecules.
11(923)2021.PubMed/NCBI View Article : Google Scholar
|
