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Paeoniflorin improves ulcerative colitis via regulation of PI3K‑AKT based on network pharmacology analysis

  • Authors:
    • Qifang Li
    • Shuyue Zheng
    • Kai Niu
    • Yi Qiao
    • Yuan Liu
    • Ying Zhang
    • Bingbing Li
    • Canlei Zheng
    • Bin Yu
  • View Affiliations / Copyright

    Affiliations: Department of Traditional Chinese Medicine, Affiliated Hospital of Jining Medical University, Jining, Shandong 272069, P.R. China, College of Integrated Chinese and Western Medicine, Jining Medical University, Jining, Shandong 272067, P.R. China, School of Public Health, Jining Medical University, Jining, Shandong 272067, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 125
    |
    Published online on: February 5, 2024
       https://doi.org/10.3892/etm.2024.12414
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Abstract

Paeoniflorin (PF) is the primary component derived from Paeonia lactiflora and white peony root and has been used widely for the treatment of ulcerative colitis (UC) in China. UC primarily manifests as a chronic inflammatory response in the intestine. In the present study, a network pharmacology approach was used to explore the specific effects and underlying mechanisms of action of PF in the treatment of UC. A research strategy based on network pharmacology, combining target prediction, network construction, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, and molecular docking simulation was used to predict the targets of PF. A total of 288 potential targets of PF and 599 UC‑related targets were identified. A total of 60 therapeutic targets of PF against UC were identified. Of these, 20 core targets were obtained by protein‑protein interaction network construction. GO and KEGG pathway analyses showed that PF alleviated UC through EGFR tyrosine kinase inhibitor resistance, the IL‑17 signaling pathway, and the PI3K/AKT signaling pathway. Molecular docking simulation showed that AKT1 and EGFR had good binding energy with PF. Animal‑based experiments revealed that the administration of PF ameliorated the colonic pathological damage in a dextran sulfate sodium‑induced mouse model, resulting in lower levels of proinflammatory cytokines including IL‑1β, IL‑6, and TNF‑α, and higher levels of IL‑10 and TGF‑β. PF decreased the mRNA and protein expression levels of AKT1, EGFR, mTOR, and PI3K. These findings suggested that PF plays a therapeutic protective role in the treatment of UC by regulating the PI3K/AKT signaling pathway.
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1 

Feuerstein JD, Moss AC and Farraye FA: Ulcerative colitis. Mayo Clin Proc. 94:1357–1373. 2019.PubMed/NCBI View Article : Google Scholar

2 

Neurath MF and Leppkes M: Resolution of ulcerative colitis. Semin Immunopathol. 41:747–756. 2019.PubMed/NCBI View Article : Google Scholar

3 

Krishna M, Britto S, Qian J, Ihekweazu F, Rodriguez JR and Kellermayer R: Diagnostic delay and colectomy risk in pediatric ulcerative colitis. J Pediatr Surg. 55:403–405. 2020.PubMed/NCBI View Article : Google Scholar

4 

Danese S and Fiocchi C: Ulcerative colitis. N Engl J Med. 365:1713–1725. 2011.PubMed/NCBI View Article : Google Scholar

5 

Loftus EV Jr: Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology. 126:1504–1517. 2004.PubMed/NCBI View Article : Google Scholar

6 

Langholz E, Munkholm P, Nielsen OH, Kreiner S and Binder V: Incidence and prevalence of ulcerative colitis in Copenhagen county from 1962 to 1987. Scand J Gastroenterol. 26:1247–1256. 1991.PubMed/NCBI View Article : Google Scholar

7 

Kaistha A and Levine J: Inflammatory bowel disease: The classic gastrointestinal autoimmune disease. Curr Probl Pediatr Adolesc Health Care. 44:328–334. 2014.PubMed/NCBI View Article : Google Scholar

8 

Miyamoto Y, Suyama K and Baba H: Recent advances in targeting the EGFR signaling pathway for the treatment of metastatic colorectal cancer. Int J Mol Sci. 18(752)2017.PubMed/NCBI View Article : Google Scholar

9 

Gisbert JP and Chaparro M: Acute severe ulcerative colitis: State of the art treatment. Best Pract Res Clin Gastroenterol. 32-33:59–69. 2018.PubMed/NCBI View Article : Google Scholar

10 

Duijvestein M, Battat R, Vande Casteele N, D'Haens GR, Sandborn WJ, Khanna R, Jairath V and Feagan BG: Novel therapies and treatment strategies for patients with inflammatory bowel disease. Curr Treat Options Gastroenterol. 16:129–146. 2018.PubMed/NCBI View Article : Google Scholar

11 

Wang YN, Li J, Zheng WY, Wu D, Yang H, Li Y, Lv H, Tan B, Shu HJ, Sun XY, et al: Clinical characteristics of ulcerative colitis-related colorectal cancer in Chinese patients. J Dig Dis. 18:684–690. 2017.PubMed/NCBI View Article : Google Scholar

12 

Bezzio C, Furfaro F, de Franchis R, Maconi G, Asthana AK and Ardizzone S: Ulcerative colitis: Current pharmacotherapy and future directions. Expert Opin Pharmacother. 15:1659–1670. 2014.PubMed/NCBI View Article : Google Scholar

13 

Kobayashi T, Siegmund B, Le Berre C, Wei SC, Ferrante M, Shen B, Bernstein CN, Danese S, Peyrin-Biroulet L and Hibi T: Ulcerative colitis. Nat Rev Dis Primers. 6(74)2020.PubMed/NCBI View Article : Google Scholar

14 

Gao Q, Tian W, Yang H, Hu H, Zheng J, Yao X, Hu B and Liu H: Shen-Ling-Bai-Zhu-San alleviates the imbalance of intestinal homeostasis in dextran sodium sulfate-induced colitis mice by regulating gut microbiota and inhibiting the NLRP3 inflammasome activation. J Ethnopharmacol. 319(117136)2024.PubMed/NCBI View Article : Google Scholar

15 

Chen K, Lou Y and Zhu Y: Tong Xie Yao Fang: A classic Chinese medicine prescription with potential for the treatment of ulcerative colitis. Evid Based Complement Alternat Med. 2021(5548764)2021.PubMed/NCBI View Article : Google Scholar

16 

Niu C, Hu XL, Yuan ZW, Xiao Y, Ji P, Wei YM and Hua YL: Pulsatilla decoction improves DSS-induced colitis via modulation of fecal-bacteria-related short-chain fatty acids and intestinal barrier integrity. J Ethnopharmacol. 300(115741)2023.PubMed/NCBI View Article : Google Scholar

17 

He Z, Zhou Q, Wen K, Wu B, Sun X, Wang X and Chen Y: Huangkui Lianchang decoction ameliorates DSS-induced ulcerative colitis in mice by inhibiting the NF-kappaB signaling pathway. Evid Based Complement Alternat Med. 2019(1040847)2019.PubMed/NCBI View Article : Google Scholar

18 

Li R, Chen Y, Shi M, Xu X, Zhao Y, Wu X and Zhang Y: Gegen Qinlian decoction alleviates experimental colitis via suppressing TLR4/NF-κB signaling and enhancing antioxidant effect. Phytomedicine. 23:1012–1020. 2016.PubMed/NCBI View Article : Google Scholar

19 

Ye Q, Hu Z, Yang M, Qin K and Zhou Y: Effects and mechanisms of Chinese herbal medicine for ulcerative colitis: Protocol for a systematic review and meta-analysis. Medicine (Baltimore). 99(e19768)2020.PubMed/NCBI View Article : Google Scholar

20 

Zhang HY, Zeng HR, Wei HZ, Chu XY, Zhu HT, Zhao B and Zhang Y: Tongxie-Yaofang formula regulated macrophage polarization to ameliorate DSS-induced colitis via NF-κB/NLRP3 signaling pathway. Phytomedicine. 107(154455)2022.PubMed/NCBI View Article : Google Scholar

21 

Zhu Y, Li Q, Li H, Xie Y, Sun M, Zheng C and Yu B: Effect of Tongxie Yaofang on the expression of inflammatory factors in rats of stagnation of liver and spleen deficiency syndrome. Lishizhen Med Mater Med Res. 29:1053–1057. 2018.

22 

Zheng K, Jia J, Yan S, Shen H, Zhu P and Yu J: Paeoniflorin ameliorates ulcerative colitis by modulating the dendritic cell-mediated TH17/Treg balance. Inflammopharmacology. 28:1705–1716. 2020.PubMed/NCBI View Article : Google Scholar

23 

Zhao DD, Jiang LL, Li HY, Yan PF and Zhang YL: Chemical components and pharmacological activities of terpene natural products from the genus paeonia. Molecules. 21(1362)2016.PubMed/NCBI View Article : Google Scholar

24 

Ma X, Zhang W, Jiang Y, Wen J, Wei S and Zhao Y: Paeoniflorin, a natural product with multiple targets in liver diseases-a mini review. Front Pharmacol. 11(531)2020.PubMed/NCBI View Article : Google Scholar

25 

Zhai A, Zhang Z and Kong X: Paeoniflorin alleviates H2O2-induced oxidative injury through down-regulation of MicroRNA-135a in HT-22 cells. Neurochem Res. 44:2821–2831. 2019.PubMed/NCBI View Article : Google Scholar

26 

Xin Q, Yuan R, Shi W, Zhu Z, Wang Y and Cong W: A review for the anti-inflammatory effects of paeoniflorin in inflammatory disorders. Life Sci. 237(116925)2019.PubMed/NCBI View Article : Google Scholar

27 

Wang Y, Zhou Y, Lin H, Chen H and Wang S: Paeoniflorin inhibits the proliferation and metastasis of ulcerative colitis-associated colon cancer by targeting EGFL7. J Oncol. 2022(7498771)2022.PubMed/NCBI View Article : Google Scholar

28 

Luo TT, Lu Y, Yan SK, Xiao X, Rong XL and Guo J: Network pharmacology in research of chinese medicine formula: Methodology, application and prospective. Chin J Integr Med. 26:72–80. 2020.PubMed/NCBI View Article : Google Scholar

29 

Zhou Z, Chen B, Chen S, Lin M, Chen Y, Jin S, Chen W and Zhang Y: Applications of network pharmacology in traditional chinese medicine research. Evid Based Complement Alternat Med. 2020(1646905)2020.PubMed/NCBI View Article : Google Scholar

30 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003.PubMed/NCBI View Article : Google Scholar

31 

Chin CH, Chen SH, Wu HH, Ho CW, Ko MT and Lin CY: cytoHubba: Identifying hub objects and sub-networks from complex interactome. BMC Syst Biol. 8 (Suppl 4)(S11)2014.PubMed/NCBI View Article : Google Scholar

32 

Assenov Y, Ramírez F, Schelhorn SE, Lengauer T and Albrecht M: Computing topological parameters of biological networks. Bioinformatics. 24:282–284. 2008.PubMed/NCBI View Article : Google Scholar

33 

Yu G, Wang LG, Han Y and He QY: clusterProfiler: An R package for comparing biological themes among gene clusters. OMICS. 16:284–287. 2012.PubMed/NCBI View Article : Google Scholar

34 

RStudio Team: RStudio: Integrated development for R. RStudio, PBC., Boston MA, 2015.

35 

Team RC: R: A language and Environment for Statistical Computing. MSOR connections, pp1, 2014.

36 

The Gene Ontology Consortium. The gene ontology resource: 20 Years and still GOing strong. Nucleic Acids Res. 47:D330–D338. 2019.PubMed/NCBI View Article : Google Scholar

37 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The gene ontology consortium. Nat Genet. 25:25–29. 2000.PubMed/NCBI View Article : Google Scholar

38 

Kanehisa M: Post-Genome Informatics. Oxford University Press, Oxford, 2000.

39 

Morris GM, Huey R, Lindstrom W, Sanner MF, Belew RK, Goodsell DS and Olson AJ: AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. J Comput Chem. 30:2785–2791. 2009.PubMed/NCBI View Article : Google Scholar

40 

Trott O and Olson AJ: AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem. 31:455–461. 2010.PubMed/NCBI View Article : Google Scholar

41 

Wang K, Li YF, Lv Q, Li XM, Dai Y and Wei FZ: Bergenin, acting as an agonist of PPARγ, ameliorates experimental colitis in mice through improving expression of SIRT1, and therefore inhibiting NF-κB-mediated macrophage activation. Front Pharmacol. 8(981)2018.PubMed/NCBI View Article : Google Scholar

42 

Xie X, Liu P, Wu H, Li H, Tang Y, Chen X, Xu C, Liu X and Dai G: miR-21 antagonist alleviates colitis and angiogenesis via the PTEN/PI3K/AKT pathway in colitis mice induced by TNBS. Ann Transl Med. 10(413)2022.PubMed/NCBI View Article : Google Scholar

43 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

44 

Wang Y and Ouyang Q: APDW 2004 Chinese IBD working group. Ulcerative colitis in China: Retrospective analysis of 3100 hospitalized patients. J Gastroenterol Hepatol. 22:1450–1455. 2007.PubMed/NCBI View Article : Google Scholar

45 

Jiang XL and Cui HF: An analysis of 10218 ulcerative colitis cases in China. World J Gastroenterol. 8:158–161. 2002.PubMed/NCBI View Article : Google Scholar

46 

Yang H, Zhou R, Bai X, Guo M, Ruan G, Wang L and Qian J: Trend and geographic variation in incidence and prevalence of inflammatory bowel disease in regions across China: A nationwide employee study between 2013 and 2016. Front Med (Lausanne). 9(900251)2022.PubMed/NCBI View Article : Google Scholar

47 

Han Z, Tan X, Sun J, Wang T, Yan G, Wang C and Ma K: Systems pharmacology and transcriptomics reveal the mechanisms of Sanhuang decoction enema in the treatment of ulcerative colitis with additional Candida albicans infection. Chin Med. 16(75)2021.PubMed/NCBI View Article : Google Scholar

48 

Ananthakrishnan AN, Bernstein CN, Iliopoulos D, Macpherson A, Neurath MF, Ali RAR, Vavricka SR and Fiocchi C: Environmental triggers in IBD: A review of progress and evidence. Nat Rev Gastroenterol Hepatol. 15:39–49. 2018.PubMed/NCBI View Article : Google Scholar

49 

Burri E, Maillard MH, Schoepfer AM, Seibold F, Van Assche G, Rivière P, Laharie D and Manz M: Swiss IBDnet, an official working group of the Swiss Society of Gastroenterology. Treatment algorithm for mild and moderate-to-severe ulcerative colitis: An update. Digestion. 101 (Suppl 1):S2–S15. 2020.PubMed/NCBI View Article : Google Scholar

50 

Segal JP, LeBlanc JF and Hart AL: Ulcerative colitis: An update. Clin Med (Lond). 21:135–139. 2021.PubMed/NCBI View Article : Google Scholar

51 

Hirten RP and Sands BE: New therapeutics for ulcerative colitis. Annu Rev Med. 72:199–213. 2021.PubMed/NCBI View Article : Google Scholar

52 

Azab A, Nassar A and Azab AN: Anti-inflammatory activity of natural products. Molecules. 21(1321)2016.PubMed/NCBI View Article : Google Scholar

53 

An J, Chen B, Kang X, Zhang R, Guo Y, Zhao J and Yang H: Neuroprotective effects of natural compounds on LPS-induced inflammatory responses in microglia. Am J Transl Res. 12:2353–2378. 2020.PubMed/NCBI

54 

Wei M, Li H, Li Q, Qiao Y, Ma Q, Xie R, Wang R, Liu Y, Wei C, Li B, et al: Based on network pharmacology to explore the molecular targets and mechanisms of Gegen Qinlian decoction for the treatment of ulcerative colitis. Biomed Res Int. 2020(5217405)2020.PubMed/NCBI View Article : Google Scholar

55 

Bindman AB and Cox DF: Changes in health care costs and mortality associated with transitional care management services after a discharge among medicare beneficiaries. JAMA Intern Med. 178:1165–1171. 2018.PubMed/NCBI View Article : Google Scholar

56 

Deng X, Xing X, Sun G, Xu X, Wu H, Li G and Sun X: Guanxin danshen formulation protects against myocardial ischemia reperfusion injury-induced left ventricular remodeling by upregulating estrogen receptor β. Front Pharmacol. 8(777)2017.PubMed/NCBI View Article : Google Scholar

57 

Wei J, Guo F, Zhang M, Xian M, Wang T, Gao J, Wu H, Song L, Zhang Y, Li D, et al: Signature-oriented investigation of the efficacy of multicomponent drugs against heart failure. FASEB J. 33:2187–2198. 2019.PubMed/NCBI View Article : Google Scholar

58 

Cao C, Zhao W, Chen X, Shen B, Wang T, Wu C and Rong X: Deciphering the action mechanism of paeoniflorin in suppressing pancreatic cancer: A network pharmacology study and experimental validation. Front Pharmacol. 13(1032282)2022.PubMed/NCBI View Article : Google Scholar

59 

Sun X, Wang X, Zhao Z, Chen J, Li C and Zhao G: Paeoniflorin inhibited nod-like receptor protein-3 inflammasome and NF-κB-mediated inflammatory reactions in diabetic foot ulcer by inhibiting the chemokine receptor CXCR2. Drug Dev Res. 82:404–411. 2021.PubMed/NCBI View Article : Google Scholar

60 

Zhang L and Wei W: Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony. Pharmacol Ther. 207(107452)2020.PubMed/NCBI View Article : Google Scholar

61 

Chang Y, Zhai L, Peng J, Wu H, Bian Z and Xiao H: Phytochemicals as regulators of Th17/Treg balance in inflammatory bowel diseases. Biomed Pharmacother. 141(111931)2021.PubMed/NCBI View Article : Google Scholar

62 

Wu XX, Huang XL, Chen RR, Li T, Ye HJ, Xie W, Huang ZM and Cao GZ: Paeoniflorin prevents intestinal barrier disruption and inhibits lipopolysaccharide (LPS)-induced inflammation in Caco-2 cell monolayers. Inflammation. 42:2215–2225. 2019.PubMed/NCBI View Article : Google Scholar

63 

Chen M, Cao L, Luo Y, Feng X, Sun L, Wen M and Peng S: Paeoniflorin protects against concanavalin A-induced hepatitis in mice. Int Immunopharmacol. 24:42–49. 2015.PubMed/NCBI View Article : Google Scholar

64 

Chen Z, Ma X, Zhu Y, Zhao Y, Wang J, Li R, Chen C, Wei S, Jiao W, Zhang Y, et al: Paeoniflorin ameliorates ANIT-induced cholestasis by activating Nrf2 through an PI3K/Akt-dependent pathway in rats. Phytother Res. 29:1768–1775. 2015.PubMed/NCBI View Article : Google Scholar

65 

Li N, Sun W, Zhou X, Gong H, Chen Y, Chen D and Xiang F: Dihydroartemisinin protects against dextran sulfate sodium-induced colitis in mice through inhibiting the PI3K/AKT and NF-κB signaling pathways. Biomed Res Int. 2019(1415809)2019.PubMed/NCBI View Article : Google Scholar

66 

Huang XL, Xu J, Zhang XH, Qiu BY, Peng L, Zhang M and Gan HT: PI3K/Akt signaling pathway is involved in the pathogenesis of ulcerative colitis. Inflamm Res. 60:727–734. 2011.PubMed/NCBI View Article : Google Scholar

67 

Setia S, Nehru B and Sanyal SN: Upregulation of MAPK/Erk and PI3K/Akt pathways in ulcerative colitis-associated colon cancer. Biomed Pharmacother. 68:1023–1029. 2014.PubMed/NCBI View Article : Google Scholar

68 

Chen Q, Duan X, Fan H, Xu M, Tang Q, Zhang L, Shou Z, Liu X, Zuo D, Yang J, et al: Oxymatrine protects against DSS-induced colitis via inhibiting the PI3K/AKT signaling pathway. Int Immunopharmacol. 53:149–157. 2017.PubMed/NCBI View Article : Google Scholar

69 

Wei J and Feng J: Signaling pathways associated with inflammatory bowel disease. Recent Pat Inflamm Allergy Drug Discov. 4:105–117. 2010.PubMed/NCBI View Article : Google Scholar

70 

Vetuschi A, Latella G, Sferra R, Caprilli R and Gaudio E: Increased proliferation and apoptosis of colonic epithelial cells in dextran sulfate sodium-induced colitis in rats. Dig Dis Sci. 47:1447–1457. 2002.PubMed/NCBI View Article : Google Scholar

71 

Laukoetter MG, Nava P, Lee WY, Severson EA, Capaldo CT, Babbin BA, Williams IR, Koval M, Peatman E, Campbell JA, et al: JAM-A regulates permeability and inflammation in the intestine in vivo. J Exp Med. 204:3067–3076. 2007.PubMed/NCBI View Article : Google Scholar

72 

Panés J and Granger DN: Leukocyte-endothelial cell interactions: Implications for the pathogenesis and treatment of gastrointestinal disease. Dig Dis. 12:232–241. 1994.PubMed/NCBI View Article : Google Scholar

73 

Sturm A, de Souza HS and Fiocchi C: Mucosal T cell proliferation and apoptosis in inflammatory bowel disease. Current Drug Targets. 9:381–387. 2008.PubMed/NCBI View Article : Google Scholar

74 

Brown SJ and Mayer L: The immune response in inflammatory bowel disease. Am J Gastroenterol. 102:2058–2069. 2007.PubMed/NCBI View Article : Google Scholar

75 

Bisping G, Lügering N, Lütke-Brintrup S, Pauels HG, Schürmann G, Domschke W and Kucharzik T: Patients with inflammatory bowel disease (IBD) reveal increased induction capacity of intracellular interferon-gamma (IFN-gamma) in peripheral CD8+ lymphocytes co-cultured with intestinal epithelial cells. Clin Exp Immunol. 123:15–22. 2001.PubMed/NCBI View Article : Google Scholar

76 

Atreya I, Atreya R and Neurath MF: NF-kappaB in inflammatory bowel disease. J Intern Med. 263:591–596. 2008.PubMed/NCBI View Article : Google Scholar

77 

Patil DT, Moss AC and Odze RD: Role of histologic inflammation in the natural history of ulcerative colitis. Gastrointest Endosc Clin N Am. 26:629–640. 2016.PubMed/NCBI View Article : Google Scholar

78 

Jentzer A, Veyrard P, Roblin X, Saint-Sardos P, Rochereau N, Paul S, Bourlet T, Pozzetto B and Pillet S: Cytomegalovirus and inflammatory bowel diseases (IBD) with a special focus on the link with ulcerative colitis (UC). Microorganisms. 8(1078)2020.PubMed/NCBI View Article : Google Scholar

79 

Ben-Horin S, Kopylov U and Chowers Y: Optimizing anti-TNF treatments in inflammatory bowel disease. Autoimmun Rev. 13:24–30. 2014.PubMed/NCBI View Article : Google Scholar

80 

Yamamoto-Furusho JK, Santiago-Hernández JJ, Pérez-Hernández N, Ramírez-Fuentes S, Fragoso JM and Vargas-Alarcón G: Interleukin 1 β (IL-1B) and IL-1 antagonist receptor (IL-1RN) gene polymorphisms are associated with the genetic susceptibility and steroid dependence in patients with ulcerative colitis. J Clin Gastroenterol. 45:531–535. 2011.PubMed/NCBI View Article : Google Scholar

81 

Bernardo D, Vallejo-Díez S, Mann ER, Al-Hassi HO, Martínez-Abad B, Montalvillo E, Tee CT, Murugananthan AU, Núñez H, Peake ST, et al: IL-6 promotes immune responses in human ulcerative colitis and induces a skin-homing phenotype in the dendritic cells and Tcells they stimulate. Eur J Immunol. 42:1337–1353. 2012.PubMed/NCBI View Article : Google Scholar

82 

Tao YE, Wen Z, Song Y and Wang H: Paeoniflorin attenuates hepatic ischemia/reperfusion injury via anti-oxidative, anti-inflammatory and anti-apoptotic pathways. Exp Ther Med. 11:263–268. 2016.PubMed/NCBI View Article : Google Scholar

83 

Chen TF, Hsu JT, Wu KC, Hsiao CF, Lin JA, Cheng YH, Liu YH, Lee DY, Chang HH, Cho DY and Hsu JL: A systematic identification of anti-inflammatory active components derived from Mu Dan Pi and their applications in inflammatory bowel disease. Sci Rep. 10(17238)2020.PubMed/NCBI View Article : Google Scholar

84 

Zhao Y, Ma X, Wang J, Zhu Y, Li R, Wang J, He X, Shan L, Wang R, Wang L, et al: Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway. Fitoterapia. 99:318–327. 2014.PubMed/NCBI View Article : Google Scholar

85 

Li J, Ren S, Li M, Bi J, Yang G and Li E: Paeoniflorin protects against dextran sulfate sodium (DSS)-induced colitis in mice through inhibition of inflammation and eosinophil infiltration. Int Immunopharmacol. 97(107667)2021.PubMed/NCBI View Article : Google Scholar

86 

Hu B, Xu G, Zhang X, Xu L, Zhou H, Ma Z, Shen X, Zhu J and Shen R: Paeoniflorin attenuates inflammatory pain by inhibiting microglial activation and Akt-NF-κB signaling in the central nervous system. Cell Physiol Biochem. 47:842–850. 2018.PubMed/NCBI View Article : Google Scholar

87 

Wang D, Liu L, Li S and Wang C: Effects of paeoniflorin on neurobehavior, oxidative stress, brain insulin signaling, and synaptic alterations in intracerebroventricular streptozotocin-induced cognitive impairment in mice. Physiol Behav. 191:12–20. 2018.PubMed/NCBI View Article : Google Scholar

88 

Wang G and Cheng N: Paeoniflorin inhibits mast cell-mediated allergic inflammation in allergic rhinitis. J Cell Biochem. 119:8636–8642. 2018.PubMed/NCBI View Article : Google Scholar

89 

Cao XY, Ni JH, Wang X, Feng GZ, Li HD, Bao WL, Wang YR, You KY, Weng HB and Shen XY: Total glucosides of paeony restores intestinal barrier function through inhibiting Lyn/Snail signaling pathway in colitis mice. Phytomedicine. 87(153590)2021.PubMed/NCBI View Article : Google Scholar

90 

Ola MS, Nawaz M and Ahsan H: Role of Bcl-2 family proteins and caspases in the regulation of apoptosis. Mol Cell Biochem. 351:41–58. 2011.PubMed/NCBI View Article : Google Scholar

91 

Sun J, Zhang H, Guan L, Zhou H and Sun M: Alpha-lipoic acid attenuates trinitrobenzene sulfonic acid-induced ulcerative colitis in mice. Int J Clin Exp Med. 8:358–367. 2015.PubMed/NCBI

92 

Gu P, Zhu L, Liu Y, Zhang L, Liu J and Shen H: Protective effects of paeoniflorin on TNBS-induced ulcerative colitis through inhibiting NF-kappaB pathway and apoptosis in mice. Int Immunopharmacol. 50:152–160. 2017.PubMed/NCBI View Article : Google Scholar

93 

Lee G, Goretsky T, Managlia E, Dirisina R, Singh AP, Brown JB, May R, Yang GY, Ragheb JW, Evers BM, et al: Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis. Gastroenterology. 139:869–881.e1-e9. 2010.PubMed/NCBI View Article : Google Scholar

94 

Karar J and Maity A: PI3K/AKT/mTOR pathway in angiogenesis. Front Mol Neurosci. 4(51)2011.PubMed/NCBI View Article : Google Scholar

95 

Lu N, Wang L, Cao H, Liu L, Van Kaer L, Washington MK, Rosen MJ, Dubé PE, Wilson KT, Ren X, et al: Activation of the epidermal growth factor receptor in macrophages regulates cytokine production and experimental colitis. J Immunol. 192:1013–1023. 2014.PubMed/NCBI View Article : Google Scholar

96 

Yao J, Cao X, Zhang R, Li YX, Xu ZL, Zhang DG, Wang LS and Wang JY: Protective effect of baicalin against experimental colitis via suppression of oxidant stress and apoptosis. Pharmacogn Mag. 12:225–234. 2016.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Li Q, Zheng S, Niu K, Qiao Y, Liu Y, Zhang Y, Li B, Zheng C and Yu B: Paeoniflorin improves ulcerative colitis via regulation of PI3K‑AKT based on network pharmacology analysis. Exp Ther Med 27: 125, 2024.
APA
Li, Q., Zheng, S., Niu, K., Qiao, Y., Liu, Y., Zhang, Y. ... Yu, B. (2024). Paeoniflorin improves ulcerative colitis via regulation of PI3K‑AKT based on network pharmacology analysis. Experimental and Therapeutic Medicine, 27, 125. https://doi.org/10.3892/etm.2024.12414
MLA
Li, Q., Zheng, S., Niu, K., Qiao, Y., Liu, Y., Zhang, Y., Li, B., Zheng, C., Yu, B."Paeoniflorin improves ulcerative colitis via regulation of PI3K‑AKT based on network pharmacology analysis". Experimental and Therapeutic Medicine 27.4 (2024): 125.
Chicago
Li, Q., Zheng, S., Niu, K., Qiao, Y., Liu, Y., Zhang, Y., Li, B., Zheng, C., Yu, B."Paeoniflorin improves ulcerative colitis via regulation of PI3K‑AKT based on network pharmacology analysis". Experimental and Therapeutic Medicine 27, no. 4 (2024): 125. https://doi.org/10.3892/etm.2024.12414
Copy and paste a formatted citation
x
Spandidos Publications style
Li Q, Zheng S, Niu K, Qiao Y, Liu Y, Zhang Y, Li B, Zheng C and Yu B: Paeoniflorin improves ulcerative colitis via regulation of PI3K‑AKT based on network pharmacology analysis. Exp Ther Med 27: 125, 2024.
APA
Li, Q., Zheng, S., Niu, K., Qiao, Y., Liu, Y., Zhang, Y. ... Yu, B. (2024). Paeoniflorin improves ulcerative colitis via regulation of PI3K‑AKT based on network pharmacology analysis. Experimental and Therapeutic Medicine, 27, 125. https://doi.org/10.3892/etm.2024.12414
MLA
Li, Q., Zheng, S., Niu, K., Qiao, Y., Liu, Y., Zhang, Y., Li, B., Zheng, C., Yu, B."Paeoniflorin improves ulcerative colitis via regulation of PI3K‑AKT based on network pharmacology analysis". Experimental and Therapeutic Medicine 27.4 (2024): 125.
Chicago
Li, Q., Zheng, S., Niu, K., Qiao, Y., Liu, Y., Zhang, Y., Li, B., Zheng, C., Yu, B."Paeoniflorin improves ulcerative colitis via regulation of PI3K‑AKT based on network pharmacology analysis". Experimental and Therapeutic Medicine 27, no. 4 (2024): 125. https://doi.org/10.3892/etm.2024.12414
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