1
|
Shah AP, Mourad MM and Bramhall SR: Acute
pancreatitis: Current perspectives on diagnosis and management. J
Inflamm Res. 11:77–85. 2018.PubMed/NCBI View Article : Google Scholar
|
2
|
Feng S, Wei Q, Hu Q, Huang X, Zhou X, Luo
G, Deng M and Lu M: Research progress on the relationship between
acute pancreatitis and calcium overload in acinar cells. Dig Dis
Sci. 64:25–38. 2019.PubMed/NCBI View Article : Google Scholar
|
3
|
Pandol SJ and Gottlieb RA: Calcium,
mitochondria and the initiation of acute pancreatitis.
Pancreatology. 22:838–845. 2022.PubMed/NCBI View Article : Google Scholar
|
4
|
Hegyi P, Pandol S, Venglovecz V and
Rakonczay Z Jr: The acinar-ductal tango in the pathogenesis of
acute pancreatitis. Gut. 60:544–552. 2011.PubMed/NCBI View Article : Google Scholar
|
5
|
Maleth J and Hegyi P: Calcium signaling in
pancreatic ductal epithelial cells: An old friend and a nasty
enemy. Cell Calcium. 55:337–345. 2014.PubMed/NCBI View Article : Google Scholar
|
6
|
Hegyi P and Rakonczay Z Jr: The role of
pancreatic ducts in the pathogenesis of acute pancreatitis.
Pancreatology. 15 (Suppl 4):S13–S17. 2015.PubMed/NCBI View Article : Google Scholar
|
7
|
Wen L, Javed TA, Yimlamai D, Mukherjee A,
Xiao X and Husain SZ: Transient high pressure in pancreatic ducts
promotes inflammation and alters tight junctions via calcineurin
signaling in mice. Gastroenterology. 155:1250–1263.e5.
2018.PubMed/NCBI View Article : Google Scholar
|
8
|
Yang H, Liang Z, Xie J, Wu Q, Qin Y, Zhang
S and Tang G: Gelsolin inhibits autophagy by regulating actin
depolymerization in pancreatic ductal epithelial cells in acute
pancreatitis. Braz J Med Biol Res. 56(e12279)2023.PubMed/NCBI View Article : Google Scholar
|
9
|
Yang HY, Liang ZH, Xie JL, Wu Q, Qin YY,
Zhang SY and Tang GD: Gelsolin impairs barrier function in
pancreatic ductal epithelial cells by actin filament
depolymerization in hypertriglyceridemia-induced pancreatitis in
vitro. Exp Ther Med. 23(290)2022.PubMed/NCBI View Article : Google Scholar
|
10
|
Konok GP and Thompson AG: Pancreatic
ductal mucosa as a protective barrier in the pathogenesis of
pancreatitis. Am J Surg. 117:18–23. 1969.PubMed/NCBI View Article : Google Scholar
|
11
|
Freedman SD, Kern HF and Scheele GA:
Pancreatic acinar cell dysfunction in CFTR(-/-) mice is associated
with impairments in luminal pH and endocytosis. Gastroenterology.
121:950–957. 2001.PubMed/NCBI View Article : Google Scholar
|
12
|
Bhoomagoud M, Jung T, Atladottir J,
Kolodecik TR, Shugrue C, Chaudhuri A, Thrower EC and Gorelick FS:
Reducing extracellular pH sensitizes the acinar cell to
secretagogue-induced pancreatitis responses in rats.
Gastroenterology. 137:1083–1092. 2009.PubMed/NCBI View Article : Google Scholar
|
13
|
Onishi M, Yamano K, Sato M, Matsuda N and
Okamoto K: Molecular mechanisms and physiological functions of
mitophagy. EMBO J. 40(e104705)2021.PubMed/NCBI View Article : Google Scholar
|
14
|
Perrone M, Patergnani S, Di Mambro T,
Palumbo L, Wieckowski MR, Giorgi C and Pinton P: Calcium
homeostasis in the control of mitophagy. Antioxid Redox Signal.
38:581–598. 2023.PubMed/NCBI View Article : Google Scholar
|
15
|
Zhang J, Huang W, He Q, Deng T, Wu B,
Huang F, Bi J, Jin Y, Sun H, Zhang Q and Shi K: PINK1/PARK2
dependent mitophagy effectively suppresses NLRP3 inflammasome to
alleviate acute pancreatitis. Free Radic Biol Med. 166:147–164.
2021.PubMed/NCBI View Article : Google Scholar
|
16
|
Vanasco V, Ropolo A, Grasso D, Ojeda DS,
García MN, Vico TA, Orquera T, Quarleri J, Alvarez S and Vaccaro
MI: Mitochondrial Dynamics and VMP1-Related Selective mitophagy in
experimental acute pancreatitis. Front Cell Dev Biol.
9(640094)2021.PubMed/NCBI View Article : Google Scholar
|
17
|
Mukherjee R, Mareninova OA, Odinokova IV,
Huang W, Murphy J, Chvanov M, Javed MA, Wen L, Booth DM, Cane MC,
et al: Mechanism of mitochondrial permeability transition pore
induction and damage in the pancreas: Inhibition prevents acute
pancreatitis by protecting production of ATP. Gut. 65:1333–1346.
2016.PubMed/NCBI View Article : Google Scholar
|
18
|
Baughman JM, Perocchi F, Girgis HS,
Plovanich M, Belcher-Timme CA, Sancak Y, Bao XR, Strittmatter L,
Goldberger O, Bogorad RL, et al: Integrative genomics identifies
MCU as an essential component of the mitochondrial calcium
uniporter. Nature. 476:341–345. 2011.PubMed/NCBI View Article : Google Scholar
|
19
|
Guan L, Che Z, Meng X, Yu Y, Li M, Yu Z,
Shi H, Yang D and Yu M: MCU Up-regulation contributes to myocardial
ischemia-reperfusion Injury through calpain/OPA-1-mediated
mitochondrial fusion/mitophagy Inhibition. J Cell Mol Med.
23:7830–7843. 2019.PubMed/NCBI View Article : Google Scholar
|
20
|
Chen Z, Zhou Q, Chen J, Yang Y, Chen W,
Mao H, Ouyang X, Zhang K, Tang M, Yan J, et al: MCU-dependent
mitochondrial calcium uptake-induced mitophagy contributes to
apelin-13-stimulated VSMCs proliferation. Vascul Pharmacol.
144(106979)2022.PubMed/NCBI View Article : Google Scholar
|
21
|
Qin Y, Yang H, Wu Q, Xie J, Meng N, Lei Y
and Tang G: Effects of inhibiting the mitochondrial calcium
uniporter on the oxidative stress in rats with acute pancreatitis.
China J Modern Med. 32:1–7. 2022.
|
22
|
Lerch MM and Gorelick FS: Models of acute
and chronic pancreatitis. Gastroenterology. 144:1180–1193.
2013.PubMed/NCBI View Article : Google Scholar
|
23
|
Wei B, Gong Y, Yang H, Zhou J, Su Z and
Liang Z: Role of tumor necrosis factor receptorassociated factor 6
in pyroptosis during acute pancreatitis. Mol Med Rep.
24(848)2021.PubMed/NCBI View Article : Google Scholar
|
24
|
Wang J, Qin M, Wu Q, Yang H, Wei B, Xie J,
Qin Y, Liang Z and Huang J: Effects of lipolysis-stimulated
lipoprotein receptor on tight junctions of pancreatic ductal
epithelial cells in hypertriglyceridemic acute pancreatitis. Biomed
Res Int. 2022(4234186)2022.PubMed/NCBI View Article : Google Scholar
|
25
|
Marta K, Hasan P, Rodriguez-Prados M,
Paillard M and Hajnoczky G: Pharmacological inhibition of the
mitochondrial Ca(2+) uniporter: Relevance for pathophysiology and
human therapy. J Mol Cell Cardiol. 151:135–144. 2021.PubMed/NCBI View Article : Google Scholar
|
26
|
Colombo PM and Rascio N: Ruthenium red
staining for electron microscopy of plant material. J Ultrastruct
Res. 60:135–139. 1977.PubMed/NCBI View Article : Google Scholar
|
27
|
Hajnóczky G, Csordás G, Das S,
Garcia-Perez C, Saotome M, Sinha Roy S and Yi M: Mitochondrial
calcium signalling and cell death: Approaches for assessing the
role of mitochondrial Ca2+ uptake in apoptosis. Cell Calcium.
40:553–560. 2006.PubMed/NCBI View Article : Google Scholar
|
28
|
Oxenoid K, Dong Y, Cao C, Cui T, Sancak Y,
Markhard AL, Grabarek Z, Kong L, Liu Z, Ouyang B, et al:
Architecture of the mitochondrial calcium uniporter. Nature.
533:269–273. 2016.PubMed/NCBI View Article : Google Scholar
|
29
|
Wen E, Xin G, Su W, Li S, Zhang Y, Dong Y,
Yang X, Wan C, Chen Z, Yu X, et al: Activation of TLR4 induces
severe acute pancreatitis-associated spleen injury via
ROS-disrupted mitophagy pathway. Mol Immunol. 142:63–75.
2022.PubMed/NCBI View Article : Google Scholar
|
30
|
Piplani H, Marek-Iannucci S, Sin J, Hou J,
Takahashi T, Sharma A, de Freitas Germano J, Waldron RT,
Saadaeijahromi H, Song Y, et al: Simvastatin induces autophagic
flux to restore cerulein-impaired phagosome-lysosome fusion in
acute pancreatitis. Biochim Biophys Acta Mol Basis Dis.
1865(165530)2019.PubMed/NCBI View Article : Google Scholar
|
31
|
Chvanov M, Voronina S, Zhang X, Telnova S,
Chard R, Ouyang Y, Armstrong J, Tanton H, Awais M, Latawiec D, et
al: Knockout of the mitochondrial calcium uniporter strongly
suppresses stimulus-metabolism coupling in pancreatic acinar cells
but does not reduce severity of experimental acute pancreatitis.
Cells. 9(1407)2020.PubMed/NCBI View Article : Google Scholar
|
32
|
Yu X, Dai C, Zhao X, Huang Q, He X, Zhang
R, Lin Z and Shen Y: Ruthenium red attenuates acute pancreatitis by
inhibiting MCU and improving mitochondrial function. Biochem
Biophys Res Commun. 635:236–243. 2022.PubMed/NCBI View Article : Google Scholar
|
33
|
Kirichok Y, Krapivinsky G and Clapham DE:
The mitochondrial calcium uniporter is a highly selective ion
channel. Nature. 427:360–364. 2004.PubMed/NCBI View Article : Google Scholar
|
34
|
Jiang C, Shen J, Wang C, Huang Y, Wang L,
Yang Y, Hu W, Li P and Wu H: Mechanism of aconitine mediated
neuronal apoptosis induced by mitochondrial calcium overload caused
by MCU. Toxicol Lett. 384:86–95. 2023.PubMed/NCBI View Article : Google Scholar
|
35
|
Rodríguez-Prados M, Huang KT, Márta K,
Paillard M, Csordás G, Joseph SK and Hajnóczky G: MICU1 controls
the sensitivity of the mitochondrial Ca2+ uniporter to
activators and inhibitors. Cell Chem Biol. 30:606–617.e4.
2023.PubMed/NCBI View Article : Google Scholar
|
36
|
Biczo G, Vegh ET, Shalbueva N, Mareninova
OA, Elperin J, Lotshaw E, Gretler S, Lugea A, Malla SR, Dawson D,
et al: Mitochondrial dysfunction, through impaired autophagy, leads
to endoplasmic reticulum stress, deregulated lipid metabolism, and
pancreatitis in animal models. Gastroenterology. 154:689–703.
2018.PubMed/NCBI View Article : Google Scholar
|
37
|
Shalbueva N, Mareninova OA, Gerloff A,
Yuan J, Waldron RT, Pandol SJ and Gukovskaya AS: Effects of
oxidative alcohol metabolism on the mitochondrial permeability
transition pore and necrosis in a mouse model of alcoholic
pancreatitis. Gastroenterology. 144:437–446 e6. 2013.PubMed/NCBI View Article : Google Scholar
|
38
|
Mizushima N and Komatsu M: Autophagy:
Renovation of cells and tissues. Cell. 147:728–741. 2011.PubMed/NCBI View Article : Google Scholar
|
39
|
Barth S, Glick D and Macleod KF:
Autophagy: Assays and artifacts. J Pathol. 221:117–124.
2010.PubMed/NCBI View Article : Google Scholar
|
40
|
Liu WJ, Ye L, Huang WF, Guo LJ, Xu ZG, Wu
HL, Yang C and Liu HF: p62 links the autophagy pathway and the
ubiqutin-proteasome system upon ubiquitinated protein degradation.
Cell Mol Biol Lett. 21(29)2016.PubMed/NCBI View Article : Google Scholar
|
41
|
Liu C, Li HJ, Duan WX, Duan Y, Yu Q, Zhang
T, Sun YP, Li YY, Liu YS and Xu SC: MCU upregulation overactivates
mitophagy by promoting VDAC1 dimerization and ubiquitination in the
hepatotoxicity of cadmium. Adv Sci (Weinh).
10(e2203869)2023.PubMed/NCBI View Article : Google Scholar
|
42
|
Yu S, Zheng S, Leng J, Wang S, Zhao T and
Liu J: Inhibition of mitochondrial calcium uniporter protects
neurocytes from ischemia/reperfusion injury via the inhibition of
excessive mitophagy. Neurosci Lett. 628:24–29. 2016.PubMed/NCBI View Article : Google Scholar
|
43
|
Shirihai OS, Song M and Dorn GW II: How
mitochondrial dynamism orchestrates mitophagy. Circ Res.
116:1835–1849. 2015.PubMed/NCBI View Article : Google Scholar
|
44
|
Nguyen TN, Padman BS and Lazarou M:
Deciphering the molecular signals of PINK1/Parkin mitophagy. Trends
Cell Biol. 26:733–744. 2016.PubMed/NCBI View Article : Google Scholar
|
45
|
Sidarala V, Pearson GL, Parekh VS,
Thompson B, Christen L, Gingerich MA, Zhu J, Stromer T, Ren J, Reck
EC, et al: Mitophagy protects β cells from inflammatory damage in
diabetes. JCI Insight. 5(e141138)2020.PubMed/NCBI View Article : Google Scholar
|
46
|
Rademaker G, Boumahd Y, Peiffer R, Anania
S, Wissocq T, Liegeois M, Luis G, Sounni NE, Agirman F,
Maloujahmoum N, et al: Myoferlin targeting triggers mitophagy and
primes ferroptosis in pancreatic cancer cells. Redox Biol.
53(102324)2022.PubMed/NCBI View Article : Google Scholar
|
47
|
Kang SU, Kim DH, Lee YS, Huang M, Byeon
HK, Lee SH, Baek SJ and Kim CH: DIM-C-pPhtBu induces lysosomal
dysfunction and unfolded protein response-mediated cell death via
excessive mitophagy. Cancer Lett. 504:23–36. 2021.PubMed/NCBI View Article : Google Scholar
|
48
|
Pasquier B: Autophagy inhibitors. Cell Mol
Life Sci. 73:985–1001. 2016.PubMed/NCBI View Article : Google Scholar
|
49
|
Green DR: Caspase activation and
inhibition. Cold Spring Harb Perspect Biol.
14(a041020)2022.PubMed/NCBI View Article : Google Scholar
|
50
|
Cao L and Mu W: Necrostatin-1 and
necroptosis inhibition: Pathophysiology and therapeutic
implications. Pharmacol Res. 163(105297)2021.PubMed/NCBI View Article : Google Scholar
|
51
|
Qin Y YH and Tang G: Effects of activated
mitochondrial calcium uniporter on acute pancreatitis induced by
caerulein in rats. Electronic Journal of Clinical Medical
Literature. 8:8–11. 2021.
|
52
|
Ma J: Block by ruthenium red of the
ryanodine-activated calcium release channel of skeletal muscle. J
Gen Physiol. 102:1031–1056. 1993.PubMed/NCBI View Article : Google Scholar
|