Open Access

Sex differences in diabetes‑induced hepatic and renal damage

  • Authors:
    • Linghuan Gao
    • Xindi Wang
    • Lei Guo
    • Wenli Zhang
    • Gengyin Wang
    • Shuying Han
    • Yuxin Zhang
  • View Affiliations

  • Published online on: February 19, 2024     https://doi.org/10.3892/etm.2024.12436
  • Article Number: 148
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Diabetes mellitus (DM) is a disease that affects millions of individuals worldwide and is characterized by abnormal glucose metabolism that can induce severe damage to numerous organs throughout the body. Sex differences have been demonstrated in a number of factors associated with diabetes and its complications, such as diabetic kidney disease and diabetic liver disease. To investigate the sex differences in DM further, the changes in the weight, food and water intake, and blood sugar of mice were recorded for 8 weeks in the present study. Hematoxylin and eosin staining, Masson's trichrome staining and transmission electron microscopy were used to observe the pathological changes of liver and kidney tissues. There is no significant difference in the water intake and blood glucose concentration between db/db female and male mice was observed. However, sex differences in liver and kidney damage including glomerular injury and hepatic fibrosis were found. In conclusion, the present study characterized the features of liver and kidney damage in db/db mice and indicated that sex differences should be taken into account in experiments using female and male experimental animals. Furthermore, sex differences should be taken into account in the selection of drug interventions in experiments and in clinical drug therapy.
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April-2024
Volume 27 Issue 4

Print ISSN: 1792-0981
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Copy and paste a formatted citation
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Spandidos Publications style
Gao L, Wang X, Guo L, Zhang W, Wang G, Han S and Zhang Y: Sex differences in diabetes‑induced hepatic and renal damage. Exp Ther Med 27: 148, 2024
APA
Gao, L., Wang, X., Guo, L., Zhang, W., Wang, G., Han, S., & Zhang, Y. (2024). Sex differences in diabetes‑induced hepatic and renal damage. Experimental and Therapeutic Medicine, 27, 148. https://doi.org/10.3892/etm.2024.12436
MLA
Gao, L., Wang, X., Guo, L., Zhang, W., Wang, G., Han, S., Zhang, Y."Sex differences in diabetes‑induced hepatic and renal damage". Experimental and Therapeutic Medicine 27.4 (2024): 148.
Chicago
Gao, L., Wang, X., Guo, L., Zhang, W., Wang, G., Han, S., Zhang, Y."Sex differences in diabetes‑induced hepatic and renal damage". Experimental and Therapeutic Medicine 27, no. 4 (2024): 148. https://doi.org/10.3892/etm.2024.12436