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Comparative efficiency of differential diagnostic methods for the identification of BRAF V600E gene mutation in papillary thyroid cancer (Review)

  • Authors:
    • Qian Liu
    • Xue Jiang
    • Wenling Tu
    • Lina Liu
    • Ying Huang
    • Yuxiao Xia
    • Xuliang Xia
    • Yuhong Shi
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan 610000, P.R. China, Department of General Surgery, The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan 610000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 149
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    Published online on: February 20, 2024
       https://doi.org/10.3892/etm.2024.12437
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Abstract

V‑Raf murine sarcoma viral oncogene homolog B1 (BRAF) encodes a serine‑threonine kinase. The V600E point mutation in the BRAF gene is the most common mutation, predominantly occurring in melanoma, and colorectal, thyroid and non‑small cell lung cancer. Particularly in the context of thyroid cancer research, it is routinely employed as a molecular biomarker to assist in diagnosing and predicting the prognosis of papillary thyroid cancer (PTC), and to formulate targeted therapeutic strategies. Currently, several methods are utilized in clinical settings to detect BRAF V600E mutations in patients with PTC. However, the sensitivity and specificity of various detection techniques vary significantly, resulting in diverse detection outcomes. The present review highlights the advantages and disadvantages of the methods currently employed in medical practice, with the aim of guiding clinicians and researchers in selecting the most suitable detection approach for its high sensitivity, reproducibility and potential to develop targeted therapeutic regimens for patients with BRAF gene mutation‑associated PTC.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Q, Jiang X, Tu W, Liu L, Huang Y, Xia Y, Xia X and Shi Y: Comparative efficiency of differential diagnostic methods for the identification of BRAF V600E gene mutation in papillary thyroid cancer (Review). Exp Ther Med 27: 149, 2024.
APA
Liu, Q., Jiang, X., Tu, W., Liu, L., Huang, Y., Xia, Y. ... Shi, Y. (2024). Comparative efficiency of differential diagnostic methods for the identification of BRAF V600E gene mutation in papillary thyroid cancer (Review). Experimental and Therapeutic Medicine, 27, 149. https://doi.org/10.3892/etm.2024.12437
MLA
Liu, Q., Jiang, X., Tu, W., Liu, L., Huang, Y., Xia, Y., Xia, X., Shi, Y."Comparative efficiency of differential diagnostic methods for the identification of BRAF V600E gene mutation in papillary thyroid cancer (Review)". Experimental and Therapeutic Medicine 27.4 (2024): 149.
Chicago
Liu, Q., Jiang, X., Tu, W., Liu, L., Huang, Y., Xia, Y., Xia, X., Shi, Y."Comparative efficiency of differential diagnostic methods for the identification of BRAF V600E gene mutation in papillary thyroid cancer (Review)". Experimental and Therapeutic Medicine 27, no. 4 (2024): 149. https://doi.org/10.3892/etm.2024.12437
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Q, Jiang X, Tu W, Liu L, Huang Y, Xia Y, Xia X and Shi Y: Comparative efficiency of differential diagnostic methods for the identification of BRAF V600E gene mutation in papillary thyroid cancer (Review). Exp Ther Med 27: 149, 2024.
APA
Liu, Q., Jiang, X., Tu, W., Liu, L., Huang, Y., Xia, Y. ... Shi, Y. (2024). Comparative efficiency of differential diagnostic methods for the identification of BRAF V600E gene mutation in papillary thyroid cancer (Review). Experimental and Therapeutic Medicine, 27, 149. https://doi.org/10.3892/etm.2024.12437
MLA
Liu, Q., Jiang, X., Tu, W., Liu, L., Huang, Y., Xia, Y., Xia, X., Shi, Y."Comparative efficiency of differential diagnostic methods for the identification of BRAF V600E gene mutation in papillary thyroid cancer (Review)". Experimental and Therapeutic Medicine 27.4 (2024): 149.
Chicago
Liu, Q., Jiang, X., Tu, W., Liu, L., Huang, Y., Xia, Y., Xia, X., Shi, Y."Comparative efficiency of differential diagnostic methods for the identification of BRAF V600E gene mutation in papillary thyroid cancer (Review)". Experimental and Therapeutic Medicine 27, no. 4 (2024): 149. https://doi.org/10.3892/etm.2024.12437
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