Open Access

Paclitaxel mediates the PI3K/AKT/mTOR pathway to reduce proliferation of FLT3‑ITD+ AML cells and promote apoptosis

  • Authors:
    • Yanyun Su
    • Meiqing Wu
    • Baowen Zhou
    • Ziwen Bai
    • Ruli Pang
    • Zhenfang Liu
    • Weihua Zhao
  • View Affiliations

  • Published online on: February 23, 2024     https://doi.org/10.3892/etm.2024.12449
  • Article Number: 161
  • Copyright: © Su et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Acute myeloid leukemia (AML) with internal tandem duplication (ITD) mutations in the FLT3 tyrosine kinase tend to have a poor prognosis. FLT3‑ITD can promote the progress of AML by activating the PI3K/AKT/mTOR pathway. Paclitaxel (PTX) is a natural anticancer drug that has been widely used in chemotherapy for multiple malignancies. The present study used the CCK‑8 assay, flow cytometry, PCR and western blotting to explore the anti‑leukemia effect and possible mechanisms of PTX on MV4‑11 cells with the FLT3‑ITD mutation and the underlying mechanism. As a result, it was found that PTX could inhibit proliferation of MV4‑11 cells and promoted apoptosis by inhibiting the PI3K/AKT/mTOR pathway.
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April-2024
Volume 27 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Su Y, Wu M, Zhou B, Bai Z, Pang R, Liu Z and Zhao W: Paclitaxel mediates the PI3K/AKT/mTOR pathway to reduce proliferation of FLT3‑ITD<sup>+</sup> AML cells and promote apoptosis. Exp Ther Med 27: 161, 2024
APA
Su, Y., Wu, M., Zhou, B., Bai, Z., Pang, R., Liu, Z., & Zhao, W. (2024). Paclitaxel mediates the PI3K/AKT/mTOR pathway to reduce proliferation of FLT3‑ITD<sup>+</sup> AML cells and promote apoptosis. Experimental and Therapeutic Medicine, 27, 161. https://doi.org/10.3892/etm.2024.12449
MLA
Su, Y., Wu, M., Zhou, B., Bai, Z., Pang, R., Liu, Z., Zhao, W."Paclitaxel mediates the PI3K/AKT/mTOR pathway to reduce proliferation of FLT3‑ITD<sup>+</sup> AML cells and promote apoptosis". Experimental and Therapeutic Medicine 27.4 (2024): 161.
Chicago
Su, Y., Wu, M., Zhou, B., Bai, Z., Pang, R., Liu, Z., Zhao, W."Paclitaxel mediates the PI3K/AKT/mTOR pathway to reduce proliferation of FLT3‑ITD<sup>+</sup> AML cells and promote apoptosis". Experimental and Therapeutic Medicine 27, no. 4 (2024): 161. https://doi.org/10.3892/etm.2024.12449