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Tumor immunity: A brief overview of tumor‑infiltrating immune cells and research advances into tumor‑infiltrating lymphocytes in gynecological malignancies (Review)

  • Authors:
    • Zi-Tao Wang
    • Zhi-Min Deng
    • Fang-Fang Dai
    • Meng-Qin Yuan
    • Shi-Yi Liu
    • Bing-Shu Li
    • Yan-Xiang Cheng
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 166
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    Published online on: February 26, 2024
       https://doi.org/10.3892/etm.2024.12453
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Abstract

Tumor immunity is a promising topic in the area of cancer therapy. The ‘soil’ function of the tumor microenvironment (TME) for tumor growth has attracted wide attention from scientists. Tumor‑infiltrating immune cells in the TME, especially the tumor‑infiltrating lymphocytes (TILs), serve a key role in cancer. Firstly, relevant literature was searched in the PubMed and Web of Science databases with the following key words: ‘Tumor microenvironment’; ‘TME’; ‘tumor‑infiltrating immunity cells’; ‘gynecologic malignancies’; ‘the adoptive cell therapy (ACT) of TILs’; and ‘TIL‑ACT’ (https://pubmed.ncbi.nlm.nih.gov/). According to the title and abstract of the articles, relevant items were screened out in the preliminary screening. The most relevant selected items were of two types: All kinds of tumor‑infiltrating immune cells; and advanced research on TILs in gynecological malignancies. The results showed that the subsets of TILs were various and complex, while each subpopulation influenced each other and their effects on tumor prognosis were diverse. Moreover, the related research and clinical trials on TILs were mostly concentrated in melanoma and breast cancer, but relatively few focused on gynecological tumors. In conclusion, the present review summarized the biological classification of TILs and the mechanisms of their involvement in the regulation of the immune microenvironment, and subsequently analyzed the development of tumor immunotherapy for TILs. Collectively, the present review provides ideas for the current treatment dilemma of gynecological tumor immune checkpoints, such as adverse reactions, safety, personal specificity and efficacy.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Z, Deng Z, Dai F, Yuan M, Liu S, Li B and Cheng Y: Tumor immunity: A brief overview of tumor‑infiltrating immune cells and research advances into tumor‑infiltrating lymphocytes in gynecological malignancies (Review). Exp Ther Med 27: 166, 2024.
APA
Wang, Z., Deng, Z., Dai, F., Yuan, M., Liu, S., Li, B., & Cheng, Y. (2024). Tumor immunity: A brief overview of tumor‑infiltrating immune cells and research advances into tumor‑infiltrating lymphocytes in gynecological malignancies (Review). Experimental and Therapeutic Medicine, 27, 166. https://doi.org/10.3892/etm.2024.12453
MLA
Wang, Z., Deng, Z., Dai, F., Yuan, M., Liu, S., Li, B., Cheng, Y."Tumor immunity: A brief overview of tumor‑infiltrating immune cells and research advances into tumor‑infiltrating lymphocytes in gynecological malignancies (Review)". Experimental and Therapeutic Medicine 27.4 (2024): 166.
Chicago
Wang, Z., Deng, Z., Dai, F., Yuan, M., Liu, S., Li, B., Cheng, Y."Tumor immunity: A brief overview of tumor‑infiltrating immune cells and research advances into tumor‑infiltrating lymphocytes in gynecological malignancies (Review)". Experimental and Therapeutic Medicine 27, no. 4 (2024): 166. https://doi.org/10.3892/etm.2024.12453
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Z, Deng Z, Dai F, Yuan M, Liu S, Li B and Cheng Y: Tumor immunity: A brief overview of tumor‑infiltrating immune cells and research advances into tumor‑infiltrating lymphocytes in gynecological malignancies (Review). Exp Ther Med 27: 166, 2024.
APA
Wang, Z., Deng, Z., Dai, F., Yuan, M., Liu, S., Li, B., & Cheng, Y. (2024). Tumor immunity: A brief overview of tumor‑infiltrating immune cells and research advances into tumor‑infiltrating lymphocytes in gynecological malignancies (Review). Experimental and Therapeutic Medicine, 27, 166. https://doi.org/10.3892/etm.2024.12453
MLA
Wang, Z., Deng, Z., Dai, F., Yuan, M., Liu, S., Li, B., Cheng, Y."Tumor immunity: A brief overview of tumor‑infiltrating immune cells and research advances into tumor‑infiltrating lymphocytes in gynecological malignancies (Review)". Experimental and Therapeutic Medicine 27.4 (2024): 166.
Chicago
Wang, Z., Deng, Z., Dai, F., Yuan, M., Liu, S., Li, B., Cheng, Y."Tumor immunity: A brief overview of tumor‑infiltrating immune cells and research advances into tumor‑infiltrating lymphocytes in gynecological malignancies (Review)". Experimental and Therapeutic Medicine 27, no. 4 (2024): 166. https://doi.org/10.3892/etm.2024.12453
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