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Article Open Access

Risk factors and predictive model for mortality in patients undergoing allogeneic hematopoietic stem cell transplantation admitted to the intensive care unit

  • Authors:
    • Peihua Wu
    • Wenxuan Huo
    • Huiying Zhao
    • Jie Lv
    • Shan Lv
    • Youzhong An
  • View Affiliations / Copyright

    Affiliations: Department of Critical Care Medicine, Peking University People's Hospital, Beijing 100044, P.R. China, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Peking University People's Hospital, Beijing 100044, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 168
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    Published online on: February 27, 2024
       https://doi.org/10.3892/etm.2024.12457
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Abstract

Hematological malignant tumors represent a group of major diseases carrying a substantial risk to the lives of affected patients. Risk factors for mortality in critically ill patients have garnered substantial attention in recent research endeavors. The present research aimed to identify factors predicting intensive care unit (ICU) mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (allo‑HSCT). Furthermore, the present study analyzed and compared the mortality rate between patients undergoing haploidentical hematopoietic stem cell transplantation (Haplo‑SCT) and those undergoing identical sibling donor (ISD) transplantation. A total of 108 patients were included in the present research, 83 (76.9%) of whom underwent Haplo‑SCT. ICU mortality was reported in 58 (53.7%) patients, with the values of 55.4 and 48.0% associated with Haplo‑SCT and ISD, respectively (P=0.514). The mortality rate of patients undergoing Haplo‑SCT was comparable to that of patients undergoing ISD transplantation. The present study found that reduced hemoglobin, elevated total bilirubin, elevated brain natriuretic peptide, elevated fibrinogen degradation products, need for vasoactive drugs at ICU admission, need for invasive mechanical ventilation and elevated APACHE II scores were independent risk factors for ICU mortality. Among patients presenting with 5‑7 risk factors, the ICU mortality reached 100%, significantly exceeding that of other patients. The present research revealed that ICU mortality rates remain elevated among patients who underwent allo‑HSCT, especially those presenting multiple risk factors. However, the outcome of patients undergoing Haplo‑SCT were comparable to those of patients undergoing ISD transplants.
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Spandidos Publications style
Wu P, Huo W, Zhao H, Lv J, Lv S and An Y: Risk factors and predictive model for mortality in patients undergoing allogeneic hematopoietic stem cell transplantation admitted to the intensive care unit. Exp Ther Med 27: 168, 2024.
APA
Wu, P., Huo, W., Zhao, H., Lv, J., Lv, S., & An, Y. (2024). Risk factors and predictive model for mortality in patients undergoing allogeneic hematopoietic stem cell transplantation admitted to the intensive care unit. Experimental and Therapeutic Medicine, 27, 168. https://doi.org/10.3892/etm.2024.12457
MLA
Wu, P., Huo, W., Zhao, H., Lv, J., Lv, S., An, Y."Risk factors and predictive model for mortality in patients undergoing allogeneic hematopoietic stem cell transplantation admitted to the intensive care unit". Experimental and Therapeutic Medicine 27.4 (2024): 168.
Chicago
Wu, P., Huo, W., Zhao, H., Lv, J., Lv, S., An, Y."Risk factors and predictive model for mortality in patients undergoing allogeneic hematopoietic stem cell transplantation admitted to the intensive care unit". Experimental and Therapeutic Medicine 27, no. 4 (2024): 168. https://doi.org/10.3892/etm.2024.12457
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Spandidos Publications style
Wu P, Huo W, Zhao H, Lv J, Lv S and An Y: Risk factors and predictive model for mortality in patients undergoing allogeneic hematopoietic stem cell transplantation admitted to the intensive care unit. Exp Ther Med 27: 168, 2024.
APA
Wu, P., Huo, W., Zhao, H., Lv, J., Lv, S., & An, Y. (2024). Risk factors and predictive model for mortality in patients undergoing allogeneic hematopoietic stem cell transplantation admitted to the intensive care unit. Experimental and Therapeutic Medicine, 27, 168. https://doi.org/10.3892/etm.2024.12457
MLA
Wu, P., Huo, W., Zhao, H., Lv, J., Lv, S., An, Y."Risk factors and predictive model for mortality in patients undergoing allogeneic hematopoietic stem cell transplantation admitted to the intensive care unit". Experimental and Therapeutic Medicine 27.4 (2024): 168.
Chicago
Wu, P., Huo, W., Zhao, H., Lv, J., Lv, S., An, Y."Risk factors and predictive model for mortality in patients undergoing allogeneic hematopoietic stem cell transplantation admitted to the intensive care unit". Experimental and Therapeutic Medicine 27, no. 4 (2024): 168. https://doi.org/10.3892/etm.2024.12457
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