Open Access

Effects of dapagliflozin on body weight in patients with type 2 diabetes mellitus: Evidence‑based practice

  • Authors:
    • Yan Han
    • Ya-Feng Li
    • Chao-Wei Ye
    • Yao-Yang Gu
    • Xiao Chen
    • Qian Gu
    • Qiang-Qiang Xu
    • Xian-Ming Wang
    • Su-Mei He
    • Dong-Dong Wang
  • View Affiliations

  • Published online on: February 28, 2024     https://doi.org/10.3892/etm.2024.12461
  • Article Number: 173
  • Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The dose‑dependent pharmacological response to dapagliflozin in patients with type 2 diabetes mellitus (T2DM) with regard to weight loss remain unknown. The aim of the present study was to investigate the effects of dapagliflozin on weight loss in patients with T2DM. A total of 8,545 patients with T2DM from 24 randomized controlled trials reported in the literature were selected for inclusion in the study. Data from these trials were analyzed using maximal effect (Emax) models with nonlinear mixed effects modeling; the evaluation index was the body weight change rate from baseline values. Patients treated with 2.5 mg/day dapagliflozin exhibited an Emax of ‑3.04%, and the time taken for therapy to reach half of the Emax (ET50) was estimated to be 30.8 weeks for patients treated with this dose. Patients treated with 5, 10 and 20 mg/day dapagliflozin exhibited Emax values of ‑6.57, ‑4.12 and ‑3.23%, respectively, and their ET50 values were estimated to be 27.3, 20.4 and 4.23 weeks, respectively. The data indicated ideal linear relationships between individual predictions and observations, suggesting the optimal fitting of the final models. The present study is the first systematic analysis of the effect of dapagliflozin on weight loss in patients with T2DM. The application of dapagliflozin at 5 mg/day exhibited a greater weight loss effect compared with the other doses used, and the weight loss onset time shortened as the dose of dapagliflozin increased.
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April-2024
Volume 27 Issue 4

Print ISSN: 1792-0981
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Copy and paste a formatted citation
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Spandidos Publications style
Han Y, Li Y, Ye C, Gu Y, Chen X, Gu Q, Xu Q, Wang X, He S, Wang D, Wang D, et al: Effects of dapagliflozin on body weight in patients with type 2 diabetes mellitus: Evidence‑based practice. Exp Ther Med 27: 173, 2024
APA
Han, Y., Li, Y., Ye, C., Gu, Y., Chen, X., Gu, Q. ... Wang, D. (2024). Effects of dapagliflozin on body weight in patients with type 2 diabetes mellitus: Evidence‑based practice. Experimental and Therapeutic Medicine, 27, 173. https://doi.org/10.3892/etm.2024.12461
MLA
Han, Y., Li, Y., Ye, C., Gu, Y., Chen, X., Gu, Q., Xu, Q., Wang, X., He, S., Wang, D."Effects of dapagliflozin on body weight in patients with type 2 diabetes mellitus: Evidence‑based practice". Experimental and Therapeutic Medicine 27.4 (2024): 173.
Chicago
Han, Y., Li, Y., Ye, C., Gu, Y., Chen, X., Gu, Q., Xu, Q., Wang, X., He, S., Wang, D."Effects of dapagliflozin on body weight in patients with type 2 diabetes mellitus: Evidence‑based practice". Experimental and Therapeutic Medicine 27, no. 4 (2024): 173. https://doi.org/10.3892/etm.2024.12461