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Serum cell division cycle 42 reflects the development and progression of diabetic nephropathy in patients with diabetes mellitus

  • Authors:
    • Hongyu Yu
    • Jian Ma
    • Yueru Gu
    • Wei Zou
    • Na Zhao
  • View Affiliations / Copyright

    Affiliations: Clinic of Integrated Traditional and Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China, Department of Endocrinology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China, Department of Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 185
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    Published online on: March 7, 2024
       https://doi.org/10.3892/etm.2024.12473
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Abstract

Cell division cycle 42 (CDC42) regulates podocyte apoptosis to take part in the development and progression of diabetic nephropathy (DN), but currently the clinical evidence is limited. The aim of the present study was to investigate the capability of serum CDC42 expression level to estimate the development and progression of DN in patients with diabetes mellitus (DM). Patients with type 2 DM (n=306) were enrolled and divided into normoalbuminuria (n=185), microalbuminuria (n=72) and macroalbuminuria (n=49) groups based on the urinary albumin‑to‑creatinine ratio. Serum CDC42 was measured in all subjects using enzyme‑linked immunosorbent assay. The median (interquartile range) CDC42 in patients with DM was 0.461 (0.314‑0.690) ng/ml (range, 0.087‑1.728 ng/ml). CDC42 was positively associated with the estimated glomerular filtration rate (P<0.001), but negatively correlated with body mass index, systolic blood pressure, hemoglobin A1c, serum creatine, serum uric acid and C reactive protein (all P<0.050). CDC42 levels were lowest in the macroalbuminuria group, followed by the microalbuminuria group, and were highest in the normoalbuminuria group (P<0.001). CDC42 indicated that it was a favorable estimator for the presence of albuminuria [area under the curve (AUC), 0.792; 95% confidence interval (CI), 0.736‑0.848] and macroalbuminuria (AUC, 0.845; 95% CI, 0.775‑0.915). By analyses in four different multivariate logistic regression models, increased CDC42 was independently associated with the presence of microalbuminuria (all P<0.001), macroalbuminuria (most P<0.001) and microalbuminuria + macroalbuminuria (all P<0.001). Serum CDC42 level negatively correlated with microalbuminuria and macroalbuminuria in patients with DM, suggesting its ability for estimating the development and progression of DN.
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1 

Schleicher E, Gerdes C, Petersmann A, Muller-Wieland D, Muller UA, Freckmann G, Heinemann L, Nauck M and Landgraf R: Definition, Classification and Diagnosis of Diabetes Mellitus. Exp Clin Endocrinol Diabetes. 130(S 01):S1–S8. 2022.PubMed/NCBI View Article : Google Scholar

2 

Lovic D, Piperidou A, Zografou I, Grassos H, Pittaras A and Manolis A: The growing epidemic of diabetes mellitus. Curr Vasc Pharmacol. 18:104–109. 2020.PubMed/NCBI View Article : Google Scholar

3 

Yeram PB and Kulkarni YA: Glycosides and vascular complications of diabetes. Chem Biodivers. 19(e202200067)2022.PubMed/NCBI View Article : Google Scholar

4 

Eid S, Sas KM, Abcouwer SF, Feldman EL, Gardner TW, Pennathur S and Fort PE: New insights into the mechanisms of diabetic complications: Role of lipids and lipid metabolism. Diabetologia. 62:1539–1549. 2019.PubMed/NCBI View Article : Google Scholar

5 

Deng Y, Li N, Wu Y, Wang M, Yang S, Zheng Y, Deng X, Xiang D, Zhu Y, Xu P, et al: Global, Regional, and National Burden of diabetes-related chronic kidney disease from 1990 to 2019. Front Endocrinol (Lausanne). 12(672350)2021.PubMed/NCBI View Article : Google Scholar

6 

Natesan V and Kim SJ: Diabetic Nephropathy-a review of risk factors, progression, mechanism, and dietary management. Biomol Ther (Seoul). 29:365–372. 2021.PubMed/NCBI View Article : Google Scholar

7 

Kopel J, Pena-Hernandez C and Nugent K: Evolving spectrum of diabetic nephropathy. World J Diabetes. 10:269–279. 2019.PubMed/NCBI View Article : Google Scholar

8 

Sagoo MK and Gnudi L: Diabetic nephropathy: An overview. Methods Mol Biol. 2067:3–7. 2020.PubMed/NCBI View Article : Google Scholar

9 

Faselis C, Katsimardou A, Imprialos K, Deligkaris P, Kallistratos M and Dimitriadis K: Microvascular complications of type 2 diabetes mellitus. Curr Vasc Pharmacol. 18:117–124. 2020.PubMed/NCBI View Article : Google Scholar

10 

Selby NM and Taal MW: An updated overview of diabetic nephropathy: Diagnosis, prognosis, treatment goals and latest guidelines. Diabetes Obes Metab. 22 (Suppl 1):S3–S15. 2020.PubMed/NCBI View Article : Google Scholar

11 

Huang QY, Lai XN, Qian XL, Lv LC, Li J, Duan J, Xiao XH and Xiong LX: Cdc42: A novel regulator of insulin secretion and diabetes-associated diseases. Int J Mol Sci. 20(179)2019.PubMed/NCBI View Article : Google Scholar

12 

Tackenberg H, Moller S, Filippi MD and Laskay T: The Small GTPase Cdc42 is a major regulator of neutrophil effector functions. Front Immunol. 11(1197)2020.PubMed/NCBI View Article : Google Scholar

13 

Moller LLV, Klip A and Sylow L: Rho GTPases-Emerging regulators of glucose homeostasis and metabolic health. Cells. 8(434)2019.PubMed/NCBI View Article : Google Scholar

14 

Xiao XH, Huang QY, Qian XL, Duan J, Jiao XQ, Wu LY, Huang QY, Li J, Lai XN, Shi YB and Xiong LX: Cdc42 Promotes ADSC-Derived IPC induction, proliferation, and insulin secretion via wnt/beta-catenin signaling. Diabetes Metab Syndr Obes. 12:2325–2339. 2019.PubMed/NCBI View Article : Google Scholar

15 

Duan J, Qian XL, Li J, Xiao XH, Lu XT, Lv LC, Huang QY, Ding W, Zhang HY and Xiong LX: miR-29a negatively affects glucose-stimulated insulin secretion and MIN6 cell proliferation via Cdc42/β-Catenin signaling. Int J Endocrinol. 2019(5219782)2019.PubMed/NCBI View Article : Google Scholar

16 

He XQ, Wang N, Zhao JJ, Wang D, Wang CJ, Xie L, Zheng HY, Shi SZ, He J, Zhou J, et al: Specific deletion of CDC42 in pancreatic beta cells attenuates glucose-induced insulin expression and secretion in mice. Mol Cell Endocrinol. 518(111004)2020.PubMed/NCBI View Article : Google Scholar

17 

Huang Z, Zhang L, Chen Y, Zhang H, Zhang Q, Li R, Ma J, Li Z, Yu C, Lai Y, et al: Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp/stress fibers/YAP pathway. Cell Death Dis. 7(e2142)2016.PubMed/NCBI View Article : Google Scholar

18 

Jiang S, Xu CM, Yao S, Zhang R, Li XZ, Zhang RZ, Xie TY, Xing YQ, Zhang Q, Zhou XJ, et al: Cdc42 upregulation under high glucose induces podocyte apoptosis and impairs β-cell insulin secretion. Front Endocrinol (Lausanne). 13(905703)2022.PubMed/NCBI View Article : Google Scholar

19 

American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 35 (Suppl 1):S64–S71. 2012.PubMed/NCBI View Article : Google Scholar

20 

Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF III, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, et al: A new equation to estimate glomerular filtration rate. Ann Intern Med. 150:604–612. 2009.PubMed/NCBI View Article : Google Scholar

21 

Tabur S, Oztuzcu S, Oguz E, Korkmaz H, Eroglu S, Ozkaya M and Demiryurek AT: Association of Rho/Rho-kinase gene polymorphisms and expressions with obesity-related metabolic syndrome. Eur Rev Med Pharmacol Sci. 19:1680–1688. 2015.PubMed/NCBI

22 

Rastogi D, Nico J, Johnston AD, Tobias TAM, Jorge Y, Macian F and Greally JM: CDC42-related genes are upregulated in helper T cells from obese asthmatic children. J Allergy Clin Immunol. 141:539–548 e7. 2018.PubMed/NCBI View Article : Google Scholar

23 

Feng Q, Guo J, Hou A, Guo Z, Zhang Y, Guo Y, Liu S, Cheng Z, Sun L, Meng L and Han S: The clinical role of serum cell division control 42 in coronary heart disease. Scand J Clin Lab Invest. 83:45–50. 2023.PubMed/NCBI View Article : Google Scholar

24 

Ahmadian E, Eftekhari A, Atakishizada S, Valiyeva M, Ardalan M, Khalilov R and Kavetskyy T: Podocytopathy: The role of actin cytoskeleton. Biomed Pharmacother. 156(113920)2022.PubMed/NCBI View Article : Google Scholar

25 

Sun Y, Cui S, Hou Y and Yi F: The updates of podocyte lipid metabolism in proteinuric kidney disease. Kidney Dis (Basel). 7:438–451. 2021.PubMed/NCBI View Article : Google Scholar

26 

Elias BC, Das A, Parekh DV, Mernaugh G, Adams R, Yang Z, Brakebusch C, Pozzi A, Marciano DK, Carroll TJ and Zent R: Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development. J Cell Sci. 128:4293–4305. 2015.PubMed/NCBI View Article : Google Scholar

27 

Raij L, Tian R, Wong JS, He JC and Campbell KN: Podocyte injury: The role of proteinuria, urinary plasminogen, and oxidative stress. Am J Physiol Renal Physiol. 311:F1308–F1317. 2016.PubMed/NCBI View Article : Google Scholar

28 

Steichen C, Herve C, Hauet T and Bourmeyster N: Rho GTPases in kidney physiology and diseases. Small GTPases. 13:141–161. 2022.PubMed/NCBI View Article : Google Scholar

29 

Choi SY, Chacon-Heszele MF, Huang L, McKenna S, Wilson FP, Zuo X and Lipschutz JH: Cdc42 deficiency causes ciliary abnormalities and cystic kidneys. J Am Soc Nephrol. 24:1435–1450. 2013.PubMed/NCBI View Article : Google Scholar

30 

Nofer JR, Feuerborn R, Levkau B, Sokoll A, Seedorf U and Assmann G: Involvement of Cdc42 signaling in apoA-I-induced cholesterol efflux. J Biol Chem. 278:53055–53062. 2003.PubMed/NCBI View Article : Google Scholar

31 

Cinar Y, Senyol AM and Duman K: Blood viscosity and blood pressure: Role of temperature and hyperglycemia. Am J Hypertens. 14 (5 Pt 1):433–438. 2001.PubMed/NCBI View Article : Google Scholar

32 

Volpe A, Ye C, Hanley AJ, Connelly PW, Zinman B and Retnakaran R: Changes over time in uric acid in relation to changes in insulin sensitivity, beta-cell function, and glycemia. J Clin Endocrinol Metab. 105:e651–e659. 2020.PubMed/NCBI View Article : Google Scholar

33 

Li Y, Yang W and Wang F: The relationship of blood CDC42 level with Th1 cells, Th17 cells, inflammation markers, disease risk/activity, and treatment efficacy of rheumatoid arthritis. Ir J Med Sci. 191:2155–2161. 2022.PubMed/NCBI View Article : Google Scholar

34 

Bai S, Zeng R, Zhou Q, Liao W, Zhang Y, Xu C, Han M, Pei G, Liu L, Liu X, et al: Cdc42-interacting protein-4 promotes TGF-B1-induced epithelial-mesenchymal transition and extracellular matrix deposition in renal proximal tubular epithelial cells. Int J Biol Sci. 8:859–869. 2012.PubMed/NCBI View Article : Google Scholar

35 

Lee YH, Kim KP, Kim YG, Moon JY, Jung SW, Park E, Kim JS, Jeong KH, Lee TW, Ihm CG, et al: Clinicopathological features of diabetic and nondiabetic renal diseases in type 2 diabetic patients with nephrotic-range proteinuria. Medicine (Baltimore). 96(e8047)2017.PubMed/NCBI View Article : Google Scholar

36 

Wada T, Shimizu M, Toyama T, Hara A, Kaneko S and Furuichi K: Clinical impact of albuminuria in diabetic nephropathy. Clin Exp Nephrol. 16:96–101. 2012.PubMed/NCBI View Article : Google Scholar

37 

Blattner SM, Hodgin JB, Nishio M, Wylie SA, Saha J, Soofi AA, Vining C, Randolph A, Herbach N, Wanke R, et al: Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury. Kidney Int. 84:920–930. 2013.PubMed/NCBI View Article : Google Scholar

38 

Rico-Fontalvo J, Aroca G, Cabrales J, Daza-Arnedo R, Yanez-Rodriguez T, Martinez-Avila MC, Uparella-Gulfo I and Raad-Sarabia M: Molecular mechanisms of diabetic kidney disease. Int J Mol Sci. 23(8668)2022.PubMed/NCBI View Article : Google Scholar

39 

Samsu N: Diabetic nephropathy: Challenges in pathogenesis, diagnosis, and treatment. Biomed Res Int. 2021(1497449)2021.PubMed/NCBI View Article : Google Scholar

40 

Jia Y, Zheng Z, Xue M, Zhang S, Hu F, Li Y, Yang Y, Zou M, Li S, Wang L, et al: Extracellular vesicles from albumin-induced tubular epithelial cells promote the M1 macrophage phenotype by targeting klotho. Mol Ther. 27:1452–1466. 2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Yu H, Ma J, Gu Y, Zou W and Zhao N: Serum cell division cycle 42 reflects the development and progression of diabetic nephropathy in patients with diabetes mellitus. Exp Ther Med 27: 185, 2024.
APA
Yu, H., Ma, J., Gu, Y., Zou, W., & Zhao, N. (2024). Serum cell division cycle 42 reflects the development and progression of diabetic nephropathy in patients with diabetes mellitus. Experimental and Therapeutic Medicine, 27, 185. https://doi.org/10.3892/etm.2024.12473
MLA
Yu, H., Ma, J., Gu, Y., Zou, W., Zhao, N."Serum cell division cycle 42 reflects the development and progression of diabetic nephropathy in patients with diabetes mellitus". Experimental and Therapeutic Medicine 27.5 (2024): 185.
Chicago
Yu, H., Ma, J., Gu, Y., Zou, W., Zhao, N."Serum cell division cycle 42 reflects the development and progression of diabetic nephropathy in patients with diabetes mellitus". Experimental and Therapeutic Medicine 27, no. 5 (2024): 185. https://doi.org/10.3892/etm.2024.12473
Copy and paste a formatted citation
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Spandidos Publications style
Yu H, Ma J, Gu Y, Zou W and Zhao N: Serum cell division cycle 42 reflects the development and progression of diabetic nephropathy in patients with diabetes mellitus. Exp Ther Med 27: 185, 2024.
APA
Yu, H., Ma, J., Gu, Y., Zou, W., & Zhao, N. (2024). Serum cell division cycle 42 reflects the development and progression of diabetic nephropathy in patients with diabetes mellitus. Experimental and Therapeutic Medicine, 27, 185. https://doi.org/10.3892/etm.2024.12473
MLA
Yu, H., Ma, J., Gu, Y., Zou, W., Zhao, N."Serum cell division cycle 42 reflects the development and progression of diabetic nephropathy in patients with diabetes mellitus". Experimental and Therapeutic Medicine 27.5 (2024): 185.
Chicago
Yu, H., Ma, J., Gu, Y., Zou, W., Zhao, N."Serum cell division cycle 42 reflects the development and progression of diabetic nephropathy in patients with diabetes mellitus". Experimental and Therapeutic Medicine 27, no. 5 (2024): 185. https://doi.org/10.3892/etm.2024.12473
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