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Article

Immune profile of patients‑a new approach in management of sepsis and septic shock?

  • Authors:
    • Anca Bacârea
    • Oana Coman
    • Vladimir Constantin Bacârea
    • Anca Meda Văsieșiu
    • Irina Săplăcan
    • Raluca Ștefania Fodor
    • Bianca Liana Grigorescu
  • View Affiliations / Copyright

    Affiliations: Department of Pathophysiology, University of Medicine, Pharmacy, Science and Technology ‘George Emil Palade’, Târgu Mureș, Mureș 540142, Romania, Department of Simulation Applied in Medicine, University of Medicine, Pharmacy, Science and Technology ‘George Emil Palade’, Târgu Mureș, Mureș 540142, Romania, Department of Scientific Research Methodology, University of Medicine, Pharmacy, Science and Technology ‘George Emil Palade’, Târgu Mureș, Mureș 540142, Romania, Department of Infectious Disease, University of Medicine, Pharmacy, Science and Technology ‘George Emil Palade’, Târgu Mureș, Mureș 540142, Romania, Clinic of Anesthesiology and Intensive Care, Emergency County Hospital, Târgu Mureș, Mureș 540136, Romania, Department of Anesthesiology and Intensive Therapy, University of Medicine, Pharmacy, Science and Technology ‘George Emil Palade’, Târgu Mureș, Mureș 540142, Romania
  • Article Number: 203
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    Published online on: March 15, 2024
       https://doi.org/10.3892/etm.2024.12489
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Abstract

The present study was a prospective observational single center study, enrolling 102 patients with sepsis, admitted in the Intensive Care Unit of the County Emergency Clinical Hospital in Târgu Mureș (Mureș, Romania). The main goal of the present study was to compare the changes of the following parameters on day 1 compared with day 5, in sepsis compared with septic shock, as well as in survivors compared with non‑survivors: Cell blood count parameters, neutrophil‑lymphocyte ratio, platelet‑lymphocyte ratio and systemic inflammation index, C reactive protein (CRP), ferritin, procalcitonin (PCT), CD 3+ T cells, CD4+ T cells, CD8+ T cells, CD16+CD56+/CD3‑NK cells and CD19+ B cells. The relationship between the subcategories of lymphocytes with the inflammatory markers was evaluated. The serum concentration of CRP and PCT was significantly lower on day 5 compared with day 1 and serum ferritin was significantly higher in patients with septic shock. The percentage of cytotoxic T lymphocytes was significantly decreased and the percentage of NK lymphocytes was significantly increased in patients who developed septic shock. The results indicated a negative significant correlation between the proportion of T lymphocytes and PCT concentration and a positive significant correlation between the proportion of B lymphocytes and PCT concentration.
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Copy and paste a formatted citation
Spandidos Publications style
Bacârea A, Coman O, Bacârea VC, Văsieșiu AM, Săplăcan I, Fodor RȘ and Grigorescu BL: Immune profile of patients‑a new approach in management of sepsis and septic shock?. Exp Ther Med 27: 203, 2024.
APA
Bacârea, A., Coman, O., Bacârea, V.C., Văsieșiu, A.M., Săplăcan, I., Fodor, R.Ș., & Grigorescu, B.L. (2024). Immune profile of patients‑a new approach in management of sepsis and septic shock?. Experimental and Therapeutic Medicine, 27, 203. https://doi.org/10.3892/etm.2024.12489
MLA
Bacârea, A., Coman, O., Bacârea, V. C., Văsieșiu, A. M., Săplăcan, I., Fodor, R. Ș., Grigorescu, B. L."Immune profile of patients‑a new approach in management of sepsis and septic shock?". Experimental and Therapeutic Medicine 27.5 (2024): 203.
Chicago
Bacârea, A., Coman, O., Bacârea, V. C., Văsieșiu, A. M., Săplăcan, I., Fodor, R. Ș., Grigorescu, B. L."Immune profile of patients‑a new approach in management of sepsis and septic shock?". Experimental and Therapeutic Medicine 27, no. 5 (2024): 203. https://doi.org/10.3892/etm.2024.12489
Copy and paste a formatted citation
x
Spandidos Publications style
Bacârea A, Coman O, Bacârea VC, Văsieșiu AM, Săplăcan I, Fodor RȘ and Grigorescu BL: Immune profile of patients‑a new approach in management of sepsis and septic shock?. Exp Ther Med 27: 203, 2024.
APA
Bacârea, A., Coman, O., Bacârea, V.C., Văsieșiu, A.M., Săplăcan, I., Fodor, R.Ș., & Grigorescu, B.L. (2024). Immune profile of patients‑a new approach in management of sepsis and septic shock?. Experimental and Therapeutic Medicine, 27, 203. https://doi.org/10.3892/etm.2024.12489
MLA
Bacârea, A., Coman, O., Bacârea, V. C., Văsieșiu, A. M., Săplăcan, I., Fodor, R. Ș., Grigorescu, B. L."Immune profile of patients‑a new approach in management of sepsis and septic shock?". Experimental and Therapeutic Medicine 27.5 (2024): 203.
Chicago
Bacârea, A., Coman, O., Bacârea, V. C., Văsieșiu, A. M., Săplăcan, I., Fodor, R. Ș., Grigorescu, B. L."Immune profile of patients‑a new approach in management of sepsis and septic shock?". Experimental and Therapeutic Medicine 27, no. 5 (2024): 203. https://doi.org/10.3892/etm.2024.12489
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