Role of co‑inhibitory molecules in the treatment of psoriasis (Review)

  • Authors:
    • Yue Yao
    • Linxi Zeng
    • Xin Huang
    • Jinfang Zhang
    • Guoqiang Zhang
    • Ling Wang
  • View Affiliations

  • Published online on: March 19, 2024     https://doi.org/10.3892/etm.2024.12497
  • Article Number: 209
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Abstract

Psoriasis is a common chronic inflammatory skin disease characterized by abnormal activation and infiltration of T‑cells and excessive proliferation of keratinocytes (KCs). Its pathogenesis is complex and frequently accompanied by the imbalance of T‑cell subpopulations, contributing to its development and further exacerbation. Therefore, the immune system, especially T‑cells, is mainly involved in the pathogenesis of psoriasis. While T‑cell activation not only requires the first recognition of T‑cell receptor and major histocompatibility complex peptide, co‑stimulatory and co‑inhibitory pathways are reported to promote or dampen T‑cell responses through a variety of mechanisms. In recent years, immuno‑related agents have been applied in the treatment of numerous clinical diseases, including psoriasis, and are starting to show promising and potential therapy prospects in autoimmune skin diseases. The present review outlined the role of co‑inhibitory molecules in the pathogenesis of psoriasis and their application in the treatment of psoriasis.
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May-2024
Volume 27 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Yao Y, Zeng L, Huang X, Zhang J, Zhang G and Wang L: Role of co‑inhibitory molecules in the treatment of psoriasis (Review). Exp Ther Med 27: 209, 2024
APA
Yao, Y., Zeng, L., Huang, X., Zhang, J., Zhang, G., & Wang, L. (2024). Role of co‑inhibitory molecules in the treatment of psoriasis (Review). Experimental and Therapeutic Medicine, 27, 209. https://doi.org/10.3892/etm.2024.12497
MLA
Yao, Y., Zeng, L., Huang, X., Zhang, J., Zhang, G., Wang, L."Role of co‑inhibitory molecules in the treatment of psoriasis (Review)". Experimental and Therapeutic Medicine 27.5 (2024): 209.
Chicago
Yao, Y., Zeng, L., Huang, X., Zhang, J., Zhang, G., Wang, L."Role of co‑inhibitory molecules in the treatment of psoriasis (Review)". Experimental and Therapeutic Medicine 27, no. 5 (2024): 209. https://doi.org/10.3892/etm.2024.12497