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Comparative quantitative analysis of optical coherence tomography angiography in varied morphologies of macular neovascularization following intravitreal conbercept and ranibizumab treatments for neovascular age‑related macular degeneration

  • Authors:
    • Jing Li
    • Zhufang Yang
    • Xueying Li
    • Di Li
    • Jin Yang
    • Meijia Dang
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    Affiliations: Department of Ophthalmology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, P.R. China, Xi'an Medical College, Xi'an, Shaanxi 710021, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 214
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    Published online on: March 20, 2024
       https://doi.org/10.3892/etm.2024.12501
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Abstract

The present study aimed to examine the optical coherence tomography angiography (OCTA) parameters associated with macular neovascularization (MNV) in patients diagnosed with neovascular age‑related macular degeneration (nAMD) and treated with either intravitreal conbercept (IVC) or ranibizumab (IVR). It enrolled 39 nAMD patients presenting with MNV, including 23 in the IVC group and 16 in the IVR group. All participants were treatment‑naïve with intravitreal therapy and they underwent treatment following a ‘3+PRN’ regimen. The MNV patterns identified through OCTA were categorized as Medusa, tangled, seafan and other variations. Key outcome measures encompassed best‑corrected visual acuity (BCVA), MNV vascular area (MNV‑VA), MNV vascular density (MNV‑VD) ratio and central macular thickness (CMT). In the present study, 44 eyes were included, with 28 eyes undergoing treatment with IVC and 18 eyes with IVR. On day 90, there was a statistically significant improvement in mean BCVA from baseline among all patients treated with IVC (P=0.002). Notably, improved outcomes were observed in those with the ‘tangled’ pattern compared with the other three patterns (P=0.007). CMT exhibited a significant decrease from baseline (P=0.007), with consistent improvement observed across all four patterns (P=0.052) on day 90. The mean MNV‑VA decreased in all patients, reaching statistical significance for the Medusa pattern (P=0.008), although the improvement in visual acuity was deemed unsatisfactory. Patients with the seafan pattern treated with IVR improved significantly in BCVA (P=0.042). The mean CMT significantly improved from baseline (P=0.001), consistent across the four patterns (P=0.114). Significant improvements were noted in the mean MNV‑VA for the seafan pattern and in the mean MNV‑VD ratio for the other patterns. The two regimens had no significant differences regarding BCVA, CMT, and MNV parameters. Conbercept emerged as a viable treatment option for patients presenting with tangled MNV patterns. On the other hand, ranibizumab might be considered an effective intervention for individuals with seafan MNV patterns. Notably, the Medusa MNV pattern was associated with a morphologic configuration indicative of a poor prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Li J, Yang Z, Li X, Li D, Yang J and Dang M: Comparative quantitative analysis of optical coherence tomography angiography in varied morphologies of macular neovascularization following intravitreal conbercept and ranibizumab treatments for neovascular age‑related macular degeneration. Exp Ther Med 27: 214, 2024.
APA
Li, J., Yang, Z., Li, X., Li, D., Yang, J., & Dang, M. (2024). Comparative quantitative analysis of optical coherence tomography angiography in varied morphologies of macular neovascularization following intravitreal conbercept and ranibizumab treatments for neovascular age‑related macular degeneration. Experimental and Therapeutic Medicine, 27, 214. https://doi.org/10.3892/etm.2024.12501
MLA
Li, J., Yang, Z., Li, X., Li, D., Yang, J., Dang, M."Comparative quantitative analysis of optical coherence tomography angiography in varied morphologies of macular neovascularization following intravitreal conbercept and ranibizumab treatments for neovascular age‑related macular degeneration". Experimental and Therapeutic Medicine 27.5 (2024): 214.
Chicago
Li, J., Yang, Z., Li, X., Li, D., Yang, J., Dang, M."Comparative quantitative analysis of optical coherence tomography angiography in varied morphologies of macular neovascularization following intravitreal conbercept and ranibizumab treatments for neovascular age‑related macular degeneration". Experimental and Therapeutic Medicine 27, no. 5 (2024): 214. https://doi.org/10.3892/etm.2024.12501
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Yang Z, Li X, Li D, Yang J and Dang M: Comparative quantitative analysis of optical coherence tomography angiography in varied morphologies of macular neovascularization following intravitreal conbercept and ranibizumab treatments for neovascular age‑related macular degeneration. Exp Ther Med 27: 214, 2024.
APA
Li, J., Yang, Z., Li, X., Li, D., Yang, J., & Dang, M. (2024). Comparative quantitative analysis of optical coherence tomography angiography in varied morphologies of macular neovascularization following intravitreal conbercept and ranibizumab treatments for neovascular age‑related macular degeneration. Experimental and Therapeutic Medicine, 27, 214. https://doi.org/10.3892/etm.2024.12501
MLA
Li, J., Yang, Z., Li, X., Li, D., Yang, J., Dang, M."Comparative quantitative analysis of optical coherence tomography angiography in varied morphologies of macular neovascularization following intravitreal conbercept and ranibizumab treatments for neovascular age‑related macular degeneration". Experimental and Therapeutic Medicine 27.5 (2024): 214.
Chicago
Li, J., Yang, Z., Li, X., Li, D., Yang, J., Dang, M."Comparative quantitative analysis of optical coherence tomography angiography in varied morphologies of macular neovascularization following intravitreal conbercept and ranibizumab treatments for neovascular age‑related macular degeneration". Experimental and Therapeutic Medicine 27, no. 5 (2024): 214. https://doi.org/10.3892/etm.2024.12501
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