Open Access

Proteinase‑3‑antineutrophil cytoplasmic antibody‑associated vasculitis secondary to subacute infective endocarditis: A case report

  • Authors:
    • Hui Lu
    • Zhao Cui
    • Xu-Jie Zhou
    • Ying Yang
    • Xiao-Ning Han
    • Xi-Hui Li
    • Fu-De Zhou
    • Ming-Hui Zhao
  • View Affiliations

  • Published online on: March 20, 2024     https://doi.org/10.3892/etm.2024.12504
  • Article Number: 216
  • Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

A 58‑year‑old male patient was admitted to Peking University First Hospital (Beijing, China) due to recurrent hematuria, proteinuria and kidney dysfunction. The patient was positive for proteinase‑3 (PR3)‑antineutrophil cytoplasmic antibody (ANCA). Pathology of the kidney showed focal proliferative necrotizing glomerulonephritis with crescent formation and immune complex‑mediated glomerulonephritis. The patient was diagnosed with PR3‑ANCA‑associated vasculitis (AAV), received intensive immunosuppressive therapy and experienced two relapses within 1 year. After admission, aortic valve vegetation was observed via echocardiography. The patient subsequently received antibiotic treatment and valve replacement, and achieved complete remission of kidney and cardiac function. The present case emphasized the importance of identifying secondary reasons for ANCA formation, especially infective endocarditis in patients with PR3‑AAV.
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May-2024
Volume 27 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Lu H, Cui Z, Zhou X, Yang Y, Han X, Li X, Zhou F and Zhao M: Proteinase‑3‑antineutrophil cytoplasmic antibody‑associated vasculitis secondary to subacute infective endocarditis: A case report. Exp Ther Med 27: 216, 2024
APA
Lu, H., Cui, Z., Zhou, X., Yang, Y., Han, X., Li, X. ... Zhao, M. (2024). Proteinase‑3‑antineutrophil cytoplasmic antibody‑associated vasculitis secondary to subacute infective endocarditis: A case report. Experimental and Therapeutic Medicine, 27, 216. https://doi.org/10.3892/etm.2024.12504
MLA
Lu, H., Cui, Z., Zhou, X., Yang, Y., Han, X., Li, X., Zhou, F., Zhao, M."Proteinase‑3‑antineutrophil cytoplasmic antibody‑associated vasculitis secondary to subacute infective endocarditis: A case report". Experimental and Therapeutic Medicine 27.5 (2024): 216.
Chicago
Lu, H., Cui, Z., Zhou, X., Yang, Y., Han, X., Li, X., Zhou, F., Zhao, M."Proteinase‑3‑antineutrophil cytoplasmic antibody‑associated vasculitis secondary to subacute infective endocarditis: A case report". Experimental and Therapeutic Medicine 27, no. 5 (2024): 216. https://doi.org/10.3892/etm.2024.12504