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Proteinase‑3‑antineutrophil cytoplasmic antibody‑associated vasculitis secondary to subacute infective endocarditis: A case report

  • Authors:
    • Hui Lu
    • Zhao Cui
    • Xu-Jie Zhou
    • Ying Yang
    • Xiao-Ning Han
    • Xi-Hui Li
    • Fu-De Zhou
    • Ming-Hui Zhao
  • View Affiliations / Copyright

    Affiliations: Renal Division, Department of Medicine, Peking University First Hospital, Beijing 100034, P.R. China, Renal Division, Department of Medicine, Peking University First Hospital, Beijing 100034, P.R. China, Department of Cardiology, Peking University First Hospital, Beijing 100034, P.R. China, Department of Cardiology, Peking University First Hospital, Beijing 100034, P.R. China, Department of Cardiac Surgery, Peking University First Hospital, Beijing 100034, P.R. China
    Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 216
    |
    Published online on: March 20, 2024
       https://doi.org/10.3892/etm.2024.12504
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Abstract

A 58‑year‑old male patient was admitted to Peking University First Hospital (Beijing, China) due to recurrent hematuria, proteinuria and kidney dysfunction. The patient was positive for proteinase‑3 (PR3)‑antineutrophil cytoplasmic antibody (ANCA). Pathology of the kidney showed focal proliferative necrotizing glomerulonephritis with crescent formation and immune complex‑mediated glomerulonephritis. The patient was diagnosed with PR3‑ANCA‑associated vasculitis (AAV), received intensive immunosuppressive therapy and experienced two relapses within 1 year. After admission, aortic valve vegetation was observed via echocardiography. The patient subsequently received antibiotic treatment and valve replacement, and achieved complete remission of kidney and cardiac function. The present case emphasized the importance of identifying secondary reasons for ANCA formation, especially infective endocarditis in patients with PR3‑AAV.
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Copy and paste a formatted citation
Spandidos Publications style
Lu H, Cui Z, Zhou X, Yang Y, Han X, Li X, Zhou F and Zhao M: Proteinase‑3‑antineutrophil cytoplasmic antibody‑associated vasculitis secondary to subacute infective endocarditis: A case report. Exp Ther Med 27: 216, 2024.
APA
Lu, H., Cui, Z., Zhou, X., Yang, Y., Han, X., Li, X. ... Zhao, M. (2024). Proteinase‑3‑antineutrophil cytoplasmic antibody‑associated vasculitis secondary to subacute infective endocarditis: A case report. Experimental and Therapeutic Medicine, 27, 216. https://doi.org/10.3892/etm.2024.12504
MLA
Lu, H., Cui, Z., Zhou, X., Yang, Y., Han, X., Li, X., Zhou, F., Zhao, M."Proteinase‑3‑antineutrophil cytoplasmic antibody‑associated vasculitis secondary to subacute infective endocarditis: A case report". Experimental and Therapeutic Medicine 27.5 (2024): 216.
Chicago
Lu, H., Cui, Z., Zhou, X., Yang, Y., Han, X., Li, X., Zhou, F., Zhao, M."Proteinase‑3‑antineutrophil cytoplasmic antibody‑associated vasculitis secondary to subacute infective endocarditis: A case report". Experimental and Therapeutic Medicine 27, no. 5 (2024): 216. https://doi.org/10.3892/etm.2024.12504
Copy and paste a formatted citation
x
Spandidos Publications style
Lu H, Cui Z, Zhou X, Yang Y, Han X, Li X, Zhou F and Zhao M: Proteinase‑3‑antineutrophil cytoplasmic antibody‑associated vasculitis secondary to subacute infective endocarditis: A case report. Exp Ther Med 27: 216, 2024.
APA
Lu, H., Cui, Z., Zhou, X., Yang, Y., Han, X., Li, X. ... Zhao, M. (2024). Proteinase‑3‑antineutrophil cytoplasmic antibody‑associated vasculitis secondary to subacute infective endocarditis: A case report. Experimental and Therapeutic Medicine, 27, 216. https://doi.org/10.3892/etm.2024.12504
MLA
Lu, H., Cui, Z., Zhou, X., Yang, Y., Han, X., Li, X., Zhou, F., Zhao, M."Proteinase‑3‑antineutrophil cytoplasmic antibody‑associated vasculitis secondary to subacute infective endocarditis: A case report". Experimental and Therapeutic Medicine 27.5 (2024): 216.
Chicago
Lu, H., Cui, Z., Zhou, X., Yang, Y., Han, X., Li, X., Zhou, F., Zhao, M."Proteinase‑3‑antineutrophil cytoplasmic antibody‑associated vasculitis secondary to subacute infective endocarditis: A case report". Experimental and Therapeutic Medicine 27, no. 5 (2024): 216. https://doi.org/10.3892/etm.2024.12504
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