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Review Open Access

Current clinical application of lutetium‑177 in solid tumors (Review)

  • Authors:
    • Tingting Niu
    • Mi Fan
    • Binwei Lin
    • Feng Gao
    • Bangxian Tan
    • Xiaobo Du
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Mianyang Central Hospital, Mianyang, Sichuan 621000, P.R. China, Department of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China
    Copyright: © Niu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 225
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    Published online on: March 26, 2024
       https://doi.org/10.3892/etm.2024.12514
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Abstract

Radionuclide‑based therapy represents a novel treatment regimen for tumors. Among these therapies, lutetium‑177 (177Lu) has gained significant attention due to its stability and safety, as well as its ability to emit both γ and β rays, allowing for both imaging with single photon emission computed tomography and tumor treatment. As a result, 177Lu can be used for both diagnosis and treatment for diseases such as prostatic and gastric cancer. Therefore, based on the available data, the present review provides a brief overview of the clinical applications of 177Lu‑targeted radionuclide therapy in metastatic prostate cancer, neuroendocrine tumors and other types of solid tumors, and highlights the current therapeutic effect, reduction in damage to normal tissues and future research directions, including the development of new nuclides and the application of more nuclides in different tumors. In the future, such treatments could be used in more tumors.
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Copy and paste a formatted citation
Spandidos Publications style
Niu T, Fan M, Lin B, Gao F, Tan B and Du X: Current clinical application of lutetium‑177 in solid tumors (Review). Exp Ther Med 27: 225, 2024.
APA
Niu, T., Fan, M., Lin, B., Gao, F., Tan, B., & Du, X. (2024). Current clinical application of lutetium‑177 in solid tumors (Review). Experimental and Therapeutic Medicine, 27, 225. https://doi.org/10.3892/etm.2024.12514
MLA
Niu, T., Fan, M., Lin, B., Gao, F., Tan, B., Du, X."Current clinical application of lutetium‑177 in solid tumors (Review)". Experimental and Therapeutic Medicine 27.5 (2024): 225.
Chicago
Niu, T., Fan, M., Lin, B., Gao, F., Tan, B., Du, X."Current clinical application of lutetium‑177 in solid tumors (Review)". Experimental and Therapeutic Medicine 27, no. 5 (2024): 225. https://doi.org/10.3892/etm.2024.12514
Copy and paste a formatted citation
x
Spandidos Publications style
Niu T, Fan M, Lin B, Gao F, Tan B and Du X: Current clinical application of lutetium‑177 in solid tumors (Review). Exp Ther Med 27: 225, 2024.
APA
Niu, T., Fan, M., Lin, B., Gao, F., Tan, B., & Du, X. (2024). Current clinical application of lutetium‑177 in solid tumors (Review). Experimental and Therapeutic Medicine, 27, 225. https://doi.org/10.3892/etm.2024.12514
MLA
Niu, T., Fan, M., Lin, B., Gao, F., Tan, B., Du, X."Current clinical application of lutetium‑177 in solid tumors (Review)". Experimental and Therapeutic Medicine 27.5 (2024): 225.
Chicago
Niu, T., Fan, M., Lin, B., Gao, F., Tan, B., Du, X."Current clinical application of lutetium‑177 in solid tumors (Review)". Experimental and Therapeutic Medicine 27, no. 5 (2024): 225. https://doi.org/10.3892/etm.2024.12514
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