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Article

Upregulated expression of glucose transporter isoform 1 in invasive and metastatic extramammary Paget's disease

  • Authors:
    • Mika Matsumoto
    • Daiki Rokunohe
    • Takanori Sasaki
    • Yasushi Matsuzaki
    • Hajime Nakano
    • Hiroki Mizukami
    • Eijiro Akasaka
    • Daisuke Sawamura
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036‑8562, Japan, Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036‑8562, Japan
  • Article Number: 228
    |
    Published online on: March 26, 2024
       https://doi.org/10.3892/etm.2024.12516
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Abstract

Glucose transporter isoform 1 (GLUT1), which is upregulated in a variety of malignant tumors, facilitates cellular glucose uptake to boost rapid tumor growth and progression. In several types of cancer, inhibition of GLUT1 suppresses tumor proliferation and metastasis, indicating that GLUT1 is a potential target of anticancer therapy. The present study performed immunohistochemistry to analyze GLUT1 expression levels in 51 patients with extramammary Paget's disease (EMPD), including 23 with only intraepidermal lesions and 28 with dermal‑invasive lesions. Of the 28 patients with dermal invasion, nine had available samples of lymph node metastasis. GLUT1 staining scores were significantly higher in dermal‑invasive (P<0.0001) and metastatic lesions (P=0.0008) compared with in intraepidermal lesions. GLUT1 is upregulated during the transition from preinvasive to invasive or metastatic tumor in EMPD. Moreover, GLUT1 staining scores were statistically higher in intraepidermal tumor cells of dermal‑invasive EMPD compared with tumor cells of only in situ EMPD (P=0.0338). GLUT1 is upregulated even during the preinvasive phase in patients with invasive EMPD, suggesting that GLUT1 immunostaining can predict the risk of dermal invasion. The present study provides novel evidence to pursue in vitro and in vivo studies to confirm that upregulated expression of GLUT1 enhances tumor aggressiveness in EMPD.
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Copy and paste a formatted citation
Spandidos Publications style
Matsumoto M, Rokunohe D, Sasaki T, Matsuzaki Y, Nakano H, Mizukami H, Akasaka E and Sawamura D: Upregulated expression of glucose transporter isoform 1 in invasive and metastatic extramammary Paget's disease. Exp Ther Med 27: 228, 2024.
APA
Matsumoto, M., Rokunohe, D., Sasaki, T., Matsuzaki, Y., Nakano, H., Mizukami, H. ... Sawamura, D. (2024). Upregulated expression of glucose transporter isoform 1 in invasive and metastatic extramammary Paget's disease. Experimental and Therapeutic Medicine, 27, 228. https://doi.org/10.3892/etm.2024.12516
MLA
Matsumoto, M., Rokunohe, D., Sasaki, T., Matsuzaki, Y., Nakano, H., Mizukami, H., Akasaka, E., Sawamura, D."Upregulated expression of glucose transporter isoform 1 in invasive and metastatic extramammary Paget's disease". Experimental and Therapeutic Medicine 27.5 (2024): 228.
Chicago
Matsumoto, M., Rokunohe, D., Sasaki, T., Matsuzaki, Y., Nakano, H., Mizukami, H., Akasaka, E., Sawamura, D."Upregulated expression of glucose transporter isoform 1 in invasive and metastatic extramammary Paget's disease". Experimental and Therapeutic Medicine 27, no. 5 (2024): 228. https://doi.org/10.3892/etm.2024.12516
Copy and paste a formatted citation
x
Spandidos Publications style
Matsumoto M, Rokunohe D, Sasaki T, Matsuzaki Y, Nakano H, Mizukami H, Akasaka E and Sawamura D: Upregulated expression of glucose transporter isoform 1 in invasive and metastatic extramammary Paget's disease. Exp Ther Med 27: 228, 2024.
APA
Matsumoto, M., Rokunohe, D., Sasaki, T., Matsuzaki, Y., Nakano, H., Mizukami, H. ... Sawamura, D. (2024). Upregulated expression of glucose transporter isoform 1 in invasive and metastatic extramammary Paget's disease. Experimental and Therapeutic Medicine, 27, 228. https://doi.org/10.3892/etm.2024.12516
MLA
Matsumoto, M., Rokunohe, D., Sasaki, T., Matsuzaki, Y., Nakano, H., Mizukami, H., Akasaka, E., Sawamura, D."Upregulated expression of glucose transporter isoform 1 in invasive and metastatic extramammary Paget's disease". Experimental and Therapeutic Medicine 27.5 (2024): 228.
Chicago
Matsumoto, M., Rokunohe, D., Sasaki, T., Matsuzaki, Y., Nakano, H., Mizukami, H., Akasaka, E., Sawamura, D."Upregulated expression of glucose transporter isoform 1 in invasive and metastatic extramammary Paget's disease". Experimental and Therapeutic Medicine 27, no. 5 (2024): 228. https://doi.org/10.3892/etm.2024.12516
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