Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May-2024 Volume 27 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2024 Volume 27 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

New treatment strategies for uterine sarcoma using secreted frizzled‑related proteins

  • Authors:
    • Tomohiro Kagawa
    • Ayuka Mineda
    • Tomotaka Nakagawa
    • Ayaka Shinohara
    • Ryosuke Arakaki
    • Hiroaki Inui
    • Hiroki Noguchi
    • Atsuko Yoshida
    • Riyo Kinouchi
    • Yuri Yamamoto
    • Kanako Yoshida
    • Takashi Kaji
    • Masato Nishimura
    • Takeshi Iwasa
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770‑8503, Japan
  • Article Number: 231
    |
    Published online on: March 26, 2024
       https://doi.org/10.3892/etm.2024.12520
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Secreted frizzled‑related proteins (SFRPs) are involved in the development of various types of cancer and function by suppressing the Wnt signaling pathway. To elucidate the clinical implications of SFRPs in uterine sarcoma, SFRP expression levels and their effects on uterine leiomyosarcoma cells were examined. Immunostaining for SFRP4 was performed on uterine smooth muscle, uterine fibroid and uterine leiomyosarcoma tissues. Additionally, the effects of SFRP4 administration on cell viability, migration and adhesion were evaluated in uterine leiomyosarcoma SKN cells using the WST‑1 assay (Roche Diagnostics) and the CytoSelect™ 24‑well Cell Migration Assay Kit and the CytoSelect™ 48‑well Cell Adhesion Assay Kit. The expression levels of SFRP4 in uterine leiomyosarcoma tissues were lower than those in normal smooth muscle and uterine fibroid tissues. In addition, SFRP4 suppressed the viability and migration, and increased the adhesion ability of uterine leiomyosarcoma cells compared with in the control group. In conclusion, SFRP4 may suppress the viability and migration, and enhance the adhesion of sarcoma cells. These results suggested that SFRP4 could be considered as a novel therapeutic target for uterine sarcoma.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Nakata E, Fujiwara T, Kunisada T, Ito T, Takihira S and Ozaki T: Immunotherapy for sarcomas. Jpn J Clin Oncol. 51:523–537. 2021.PubMed/NCBI View Article : Google Scholar

2 

Mineda A, Nishimura M, Kagawa T, Takiguchi E, Kawakita T, Abe A and Irahara M: Resveratrol suppresses proliferation and induces apotosis of uterine sarcoma cells by inhibiting the Wnt signaling pathway. Exp Ther Med. 17:2242–2246. 2019.PubMed/NCBI View Article : Google Scholar

3 

Zou Y, Yang J and Jiang D: Resveratrol inhibits canonical Wnt signaling in human MG-63 osteosarcoma cells. Mol Med Rep. 12:7221–7226. 2015.PubMed/NCBI View Article : Google Scholar

4 

Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Farnsworth NR, Kinghorn AD, Mehta RG, et al: Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 275:218–220. 1997.PubMed/NCBI View Article : Google Scholar

5 

Logan CY and Nusse R: The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol. 20:781–810. 2004.PubMed/NCBI View Article : Google Scholar

6 

Lavergne E, Hendaoui I, Coulouarn C, Ribault C, Leseur J, Eliat PA, Mebarki S, Corlu A, Clément B and Musso O: Blocking Wnt signaling by SFRP-like molecules inhibits in vivo cell proliferation and tumor growth in cells carrying active β-catenin. Oncogene. 30:423–433. 2011.PubMed/NCBI View Article : Google Scholar

7 

Wu Q, Xu C, Zeng X, Zhang Z, Yang B and Rao Z: Tumor suppressor role of sFRP-4 in hepatocellular carcinoma via the Wnt/β-catenin signaling pathway. Mol Med Rep. 23(336)2021.PubMed/NCBI View Article : Google Scholar

8 

De La Cruz MS and Buchanan EM: Uterine fibroids: Diagnosis and treatment. Am Fam Physician. 95:100–107. 2017.PubMed/NCBI

9 

Pridgeon MG, Grohar PJ, Steensma MR and Williams BO: Wnt signaling in ewing sarcoma, osteosarcoma, and malignant peripheral nerve sheath tumors. Curr Osteoporos Rep. 15:239–246. 2017.PubMed/NCBI View Article : Google Scholar

10 

Singla A, Wang J, Yang R, Geller DS, Loeb DM and Hoang BH: Wnt signaling in osteosarcoma. Adv Exp Med Biol. 1258:125–139. 2020.PubMed/NCBI View Article : Google Scholar

11 

Ford CE, Jary E, Ma SSQ, Nixdorf S, Heinzelmann-Schwarz VA and Ward RL: The Wnt gatekeeper SFRP4 modulates EMT, cell migration and downstream Wnt signalling in serous ovarian cancer cells. PLoS One. 8(e54362)2013.PubMed/NCBI View Article : Google Scholar

12 

Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT and Horwitz AR: Cell migration: Integrating signals from front to back. Science. 302:1704–1709. 2003.PubMed/NCBI View Article : Google Scholar

13 

Kikuchi A, Yamamoto H and Kishida S: Multiple of the interactions of Wnt proteins and their receptors. Cell Signal. 19:659–671. 2007.PubMed/NCBI View Article : Google Scholar

14 

Fang F, VanCleave A, Helmuth R, Torres H, Rickel K, Wollenzien H, Sun H, Zeng E, Zhao J and Tao J: Targeting the Wnt/β-catenin pathway in human osteosarcoma cells. Oncotarget. 9:36780–36792. 2018.PubMed/NCBI View Article : Google Scholar

15 

Rattner A, Hsieh JC, Smallwood PM, Gilbert DJ, Copeland NG, Jenkins NA and Nathans J: A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci USA. 94:2859–2863. 1997.PubMed/NCBI View Article : Google Scholar

16 

Suzuki H, Watkins DN, Jair KW, Schuebel KE, Markowitz SD, Chen WD, Pretlow TP, Yang B, Akiyama Y, Van Engeland M, et al: Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet. 36:417–422. 2004.PubMed/NCBI View Article : Google Scholar

17 

Ko J, Ryu KS, Lee YH, Na DS, Kim YS, Oh YM, Kim IS and Kim JW: Human secreted frizzled-related protein is down-regulated and induces apoptosis in human cervical cancer. Exp Cell Res. 280:280–287. 2002.PubMed/NCBI View Article : Google Scholar

18 

Chung MT, Lai HC, Sytwu HK, Yan MD, Shih YL, Chang CC, Yu MH, Liu HS, Chu DW and Lin YW: SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway. Gynecol Oncol. 112:646–653. 2009.PubMed/NCBI View Article : Google Scholar

19 

Lin YW, Chung MT, Lai HC, Yan MD, Shih YL, Chang CC and Yu MH: Methylation analysis of SFRP genes family in cervical adenocarcinoma. J Cancer Res Clin Oncol. 135:1665–1674. 2009.PubMed/NCBI View Article : Google Scholar

20 

Jacob F, Ukegjini K, Nixdorf S, Ford CE, Olivier J, Caduff R, Scurry JP, Guertler R, Hornung D, Mueller R, et al: Loss of secreted frizzled-related protein 4 correlates with an aggressive phenotype and predicts poor outcome in ovarian cancer patients. PLoS One. 7(e31885)2012.PubMed/NCBI View Article : Google Scholar

21 

Kawauchi T: Cell adhesion and its endocytic regulation in cell migration during neural development and cancer metastasis. Int J Mol Sci. 13:4564–4590. 2012.PubMed/NCBI View Article : Google Scholar

22 

Mei J, Jin LP, Ding D, Li MQ, Li DJ and Zhu XY: Inhibition of IDO1 suppresses cyclooxygenase-2 and matrix metalloproteinase-9 expression and decreases proliferation, adhesion and invasion of endometrial stromal cells. Mol Hum Reprod. 18:467–476. 2012.PubMed/NCBI View Article : Google Scholar

23 

Tsukamoto H, Kondo S, Mukudai Y, Nagumo T, Yasuda A, Kurihara Y, Kamatani T and Shintani S: Evaluation of anticancer activities of benzo[c]phenanthridine alkaloid sanguinarine in oral squamous cell carcinoma cell line. Anticancer Res. 31:2841–2846. 2011.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kagawa T, Mineda A, Nakagawa T, Shinohara A, Arakaki R, Inui H, Noguchi H, Yoshida A, Kinouchi R, Yamamoto Y, Yamamoto Y, et al: New treatment strategies for uterine sarcoma using secreted frizzled‑related proteins. Exp Ther Med 27: 231, 2024.
APA
Kagawa, T., Mineda, A., Nakagawa, T., Shinohara, A., Arakaki, R., Inui, H. ... Iwasa, T. (2024). New treatment strategies for uterine sarcoma using secreted frizzled‑related proteins. Experimental and Therapeutic Medicine, 27, 231. https://doi.org/10.3892/etm.2024.12520
MLA
Kagawa, T., Mineda, A., Nakagawa, T., Shinohara, A., Arakaki, R., Inui, H., Noguchi, H., Yoshida, A., Kinouchi, R., Yamamoto, Y., Yoshida, K., Kaji, T., Nishimura, M., Iwasa, T."New treatment strategies for uterine sarcoma using secreted frizzled‑related proteins". Experimental and Therapeutic Medicine 27.5 (2024): 231.
Chicago
Kagawa, T., Mineda, A., Nakagawa, T., Shinohara, A., Arakaki, R., Inui, H., Noguchi, H., Yoshida, A., Kinouchi, R., Yamamoto, Y., Yoshida, K., Kaji, T., Nishimura, M., Iwasa, T."New treatment strategies for uterine sarcoma using secreted frizzled‑related proteins". Experimental and Therapeutic Medicine 27, no. 5 (2024): 231. https://doi.org/10.3892/etm.2024.12520
Copy and paste a formatted citation
x
Spandidos Publications style
Kagawa T, Mineda A, Nakagawa T, Shinohara A, Arakaki R, Inui H, Noguchi H, Yoshida A, Kinouchi R, Yamamoto Y, Yamamoto Y, et al: New treatment strategies for uterine sarcoma using secreted frizzled‑related proteins. Exp Ther Med 27: 231, 2024.
APA
Kagawa, T., Mineda, A., Nakagawa, T., Shinohara, A., Arakaki, R., Inui, H. ... Iwasa, T. (2024). New treatment strategies for uterine sarcoma using secreted frizzled‑related proteins. Experimental and Therapeutic Medicine, 27, 231. https://doi.org/10.3892/etm.2024.12520
MLA
Kagawa, T., Mineda, A., Nakagawa, T., Shinohara, A., Arakaki, R., Inui, H., Noguchi, H., Yoshida, A., Kinouchi, R., Yamamoto, Y., Yoshida, K., Kaji, T., Nishimura, M., Iwasa, T."New treatment strategies for uterine sarcoma using secreted frizzled‑related proteins". Experimental and Therapeutic Medicine 27.5 (2024): 231.
Chicago
Kagawa, T., Mineda, A., Nakagawa, T., Shinohara, A., Arakaki, R., Inui, H., Noguchi, H., Yoshida, A., Kinouchi, R., Yamamoto, Y., Yoshida, K., Kaji, T., Nishimura, M., Iwasa, T."New treatment strategies for uterine sarcoma using secreted frizzled‑related proteins". Experimental and Therapeutic Medicine 27, no. 5 (2024): 231. https://doi.org/10.3892/etm.2024.12520
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team