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Selected markers of ovarian cancer and their relation to targeted therapy (Review)

  • Authors:
    • Anna Markowska
    • Zbigniew Kojs
    • Damian Twardawa
    • Joanna Pietras
    • Janina Markowska
  • View Affiliations / Copyright

    Affiliations: Department of Perinatology and Women's Diseases, Poznan University of Medical Sciences, 60‑535 Poznan, Poland, Department of Gynecology and Obstetrics with Gynecologic Oncology, Ludwik Rydygier Memorial Specialized Hospital, 31‑826 Kraków, Poland, Medical Department, Bausch Health Poland, 02‑674 Warsaw, Poland, Gynecological Oncology Center Poznań, 60‑850 Poznan, Poland
    Copyright: © Markowska et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 236
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    Published online on: March 27, 2024
       https://doi.org/10.3892/etm.2024.12523
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Abstract

Despite advances in surgical treatment techniques and chemotherapy‑including anti‑angiogenic and immune poly (ADP‑ribose) polymerase inhibitors, the 5‑year survival rate in ovarian cancer (OC) remains low. The reasons for this are the diagnosis of cancer in advanced clinical stages, chemoresistance and cancer recurrence. New therapeutic approaches are being developed, including the search for new biomarkers that are also targets for targeted therapy. The present review describes new molecular markers with relevance to targeted therapy, which to date have been studied only in experimental research. These include the angiogenic protein angiopoietin‑2, the transmembrane glycoprotein ectonucleotide pyrophosphatase/phosphodiesterase 1, the adhesion protein E‑cadherin, the TIMP metallopeptidase inhibitor 1 and Kruppel‑like factor 7. Drugs affecting cancer stem cells (CSCs) in OC, such as metformin and salinomycin, as well as inhibitors of CSCs markers aldehyde dehydrogenase 1 (with the drug ATRA) and the transcription factor Nanog homeobox (microRNA) are also discussed. A new approach to prevention and possible therapies under investigation such as development of vaccines containing a subpopulation of CD117(+) and CD44(+) stem cells with a promising option for use in women with OC was described.
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Copy and paste a formatted citation
Spandidos Publications style
Markowska A, Kojs Z, Twardawa D, Pietras J and Markowska J: Selected markers of ovarian cancer and their relation to targeted therapy (Review). Exp Ther Med 27: 236, 2024.
APA
Markowska, A., Kojs, Z., Twardawa, D., Pietras, J., & Markowska, J. (2024). Selected markers of ovarian cancer and their relation to targeted therapy (Review). Experimental and Therapeutic Medicine, 27, 236. https://doi.org/10.3892/etm.2024.12523
MLA
Markowska, A., Kojs, Z., Twardawa, D., Pietras, J., Markowska, J."Selected markers of ovarian cancer and their relation to targeted therapy (Review)". Experimental and Therapeutic Medicine 27.5 (2024): 236.
Chicago
Markowska, A., Kojs, Z., Twardawa, D., Pietras, J., Markowska, J."Selected markers of ovarian cancer and their relation to targeted therapy (Review)". Experimental and Therapeutic Medicine 27, no. 5 (2024): 236. https://doi.org/10.3892/etm.2024.12523
Copy and paste a formatted citation
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Spandidos Publications style
Markowska A, Kojs Z, Twardawa D, Pietras J and Markowska J: Selected markers of ovarian cancer and their relation to targeted therapy (Review). Exp Ther Med 27: 236, 2024.
APA
Markowska, A., Kojs, Z., Twardawa, D., Pietras, J., & Markowska, J. (2024). Selected markers of ovarian cancer and their relation to targeted therapy (Review). Experimental and Therapeutic Medicine, 27, 236. https://doi.org/10.3892/etm.2024.12523
MLA
Markowska, A., Kojs, Z., Twardawa, D., Pietras, J., Markowska, J."Selected markers of ovarian cancer and their relation to targeted therapy (Review)". Experimental and Therapeutic Medicine 27.5 (2024): 236.
Chicago
Markowska, A., Kojs, Z., Twardawa, D., Pietras, J., Markowska, J."Selected markers of ovarian cancer and their relation to targeted therapy (Review)". Experimental and Therapeutic Medicine 27, no. 5 (2024): 236. https://doi.org/10.3892/etm.2024.12523
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