Open Access

Selected markers of ovarian cancer and their relation to targeted therapy (Review)

  • Authors:
    • Anna Markowska
    • Zbigniew Kojs
    • Damian Twardawa
    • Joanna Pietras
    • Janina Markowska
  • View Affiliations

  • Published online on: March 27, 2024     https://doi.org/10.3892/etm.2024.12523
  • Article Number: 236
  • Copyright: © Markowska et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Despite advances in surgical treatment techniques and chemotherapy‑including anti‑angiogenic and immune poly (ADP‑ribose) polymerase inhibitors, the 5‑year survival rate in ovarian cancer (OC) remains low. The reasons for this are the diagnosis of cancer in advanced clinical stages, chemoresistance and cancer recurrence. New therapeutic approaches are being developed, including the search for new biomarkers that are also targets for targeted therapy. The present review describes new molecular markers with relevance to targeted therapy, which to date have been studied only in experimental research. These include the angiogenic protein angiopoietin‑2, the transmembrane glycoprotein ectonucleotide pyrophosphatase/phosphodiesterase 1, the adhesion protein E‑cadherin, the TIMP metallopeptidase inhibitor 1 and Kruppel‑like factor 7. Drugs affecting cancer stem cells (CSCs) in OC, such as metformin and salinomycin, as well as inhibitors of CSCs markers aldehyde dehydrogenase 1 (with the drug ATRA) and the transcription factor Nanog homeobox (microRNA) are also discussed. A new approach to prevention and possible therapies under investigation such as development of vaccines containing a subpopulation of CD117(+) and CD44(+) stem cells with a promising option for use in women with OC was described.
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May-2024
Volume 27 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Markowska A, Kojs Z, Twardawa D, Pietras J and Markowska J: Selected markers of ovarian cancer and their relation to targeted therapy (Review). Exp Ther Med 27: 236, 2024
APA
Markowska, A., Kojs, Z., Twardawa, D., Pietras, J., & Markowska, J. (2024). Selected markers of ovarian cancer and their relation to targeted therapy (Review). Experimental and Therapeutic Medicine, 27, 236. https://doi.org/10.3892/etm.2024.12523
MLA
Markowska, A., Kojs, Z., Twardawa, D., Pietras, J., Markowska, J."Selected markers of ovarian cancer and their relation to targeted therapy (Review)". Experimental and Therapeutic Medicine 27.5 (2024): 236.
Chicago
Markowska, A., Kojs, Z., Twardawa, D., Pietras, J., Markowska, J."Selected markers of ovarian cancer and their relation to targeted therapy (Review)". Experimental and Therapeutic Medicine 27, no. 5 (2024): 236. https://doi.org/10.3892/etm.2024.12523