Deep lymph node enlargement and renal failure caused by hypercalcemia‑associated sarcoidosis: A case report

Liu,Zezhou; Tang,Zhigang; Yuan,Jingping; Su,Ke; Jian,Yonghong; Liu,Hongyan

doi:10.3892/etm.2024.12524

Deep lymph node enlargement and renal failure caused by hypercalcemia‑associated sarcoidosis: A case report

Authors:
- Zezhou Liu
- Zhigang Tang
- Jingping Yuan
- Ke Su
- Yonghong Jian
- Hongyan Liu
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Affiliations: Department of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Pancreatic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
Published online on: March 27, 2024 https://doi.org/10.3892/etm.2024.12524
Article Number: 235
Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Sarcoidosis is a rare disease that severely affects the lungs and superficial lymph nodes. In addition, this disease can also affect the skin, eyes and kidneys to varying degrees. The present report described a 32‑year‑old male patient who was admitted to Renmin Hospital of Wuhan University (Wuhan, China) due to joint pain in the extremities. He was diagnosed with uncorrectable hypercalcemia. A lymph node biopsy revealed the hypercalcemia to be associated with sarcoidosis, with the patient also demonstrating renal failure and lymph node enlargement. Administration of glucocorticoids provided benefits in terms of both primary and recurrent sarcoidosis, which also improved and preserved renal function. After being prescribed with oral prednisone treatment, blood calcium levels returned to normal, which indicated markedly improving renal function. However, the discontinuation of glucocorticoids for 2 months resulted in increased serum calcium and creatinine levels, both of which returned to abnormal levels. Overall, the present case report suggests that clinicians should actively perform sarcoidosis treatment in clinical practice to overcome any unexpected results associated with organ damage.

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