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Case Report Open Access

A long‑term complete response to namodenoson in liver cancer with Child‑Pugh B cirrhosis: A case report

  • Authors:
    • Ioana Adriana Ciurescu
    • Riccardo Lencioni
    • Salomon M. Stemmer
    • Motti Farbstein
    • Zivit Harpaz
    • Avital Bareket-Samish
    • Michael H. Silverman
    • Pnina Fishman
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, S.C. Pelican Impex SRL, Oradea 410450, Romania, Department of Radiology, Pisa University School of Medicine, I-56126 Pisa, Italy, Rabin Medical Center, Petah Tikva 4941492, Israel, Can-Fite BioPharma Ltd., Petah Tikva 49170, Israel, BioInsight Ltd., Binyamina 3056814, Israel
    Copyright: © Ciurescu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 263
    |
    Published online on: April 24, 2024
       https://doi.org/10.3892/etm.2024.12551
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Abstract

Established treatments for advanced hepatocellular carcinoma (HCC) with Child‑Pugh cirrhosis B (CPB, moderate hepatic dysfunction) are lacking. A recently published randomized phase 2 study in CPB HCC investigating the safety and efficacy of namodenoson (25 mg BID), an A3 adenosine‑receptor agonist vs. placebo, suggested a favorable safety profile and a positive efficacy signal in patients with HCC with a CPB score of 7 (CPB7). The present study reports a 61‑year‑old woman with CPB7 HCC who received namodenoson for over 6 years through this study and its open‑label extension. Computed tomography scans demonstrated partial and complete responses after 7 weeks and 4 years of treatment, respectively. Low albumin levels (31 g/l) and elevated baseline levels of alanine transaminase and aspartate aminotransferase (68 U/l and 44 U/l, respectively) were reported. After 4 weeks of treatment, these levels normalized and were stable for over 6 years. No treatment‑emergent adverse events were noted. At the time of reporting, the response is ongoing as manifested by imaging studies and liver function evaluation.
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Copy and paste a formatted citation
Spandidos Publications style
Ciurescu IA, Lencioni R, Stemmer SM, Farbstein M, Harpaz Z, Bareket-Samish A, Silverman MH and Fishman P: A long‑term complete response to namodenoson in liver cancer with Child‑Pugh B cirrhosis: A case report. Exp Ther Med 27: 263, 2024.
APA
Ciurescu, I.A., Lencioni, R., Stemmer, S.M., Farbstein, M., Harpaz, Z., Bareket-Samish, A. ... Fishman, P. (2024). A long‑term complete response to namodenoson in liver cancer with Child‑Pugh B cirrhosis: A case report. Experimental and Therapeutic Medicine, 27, 263. https://doi.org/10.3892/etm.2024.12551
MLA
Ciurescu, I. A., Lencioni, R., Stemmer, S. M., Farbstein, M., Harpaz, Z., Bareket-Samish, A., Silverman, M. H., Fishman, P."A long‑term complete response to namodenoson in liver cancer with Child‑Pugh B cirrhosis: A case report". Experimental and Therapeutic Medicine 27.6 (2024): 263.
Chicago
Ciurescu, I. A., Lencioni, R., Stemmer, S. M., Farbstein, M., Harpaz, Z., Bareket-Samish, A., Silverman, M. H., Fishman, P."A long‑term complete response to namodenoson in liver cancer with Child‑Pugh B cirrhosis: A case report". Experimental and Therapeutic Medicine 27, no. 6 (2024): 263. https://doi.org/10.3892/etm.2024.12551
Copy and paste a formatted citation
x
Spandidos Publications style
Ciurescu IA, Lencioni R, Stemmer SM, Farbstein M, Harpaz Z, Bareket-Samish A, Silverman MH and Fishman P: A long‑term complete response to namodenoson in liver cancer with Child‑Pugh B cirrhosis: A case report. Exp Ther Med 27: 263, 2024.
APA
Ciurescu, I.A., Lencioni, R., Stemmer, S.M., Farbstein, M., Harpaz, Z., Bareket-Samish, A. ... Fishman, P. (2024). A long‑term complete response to namodenoson in liver cancer with Child‑Pugh B cirrhosis: A case report. Experimental and Therapeutic Medicine, 27, 263. https://doi.org/10.3892/etm.2024.12551
MLA
Ciurescu, I. A., Lencioni, R., Stemmer, S. M., Farbstein, M., Harpaz, Z., Bareket-Samish, A., Silverman, M. H., Fishman, P."A long‑term complete response to namodenoson in liver cancer with Child‑Pugh B cirrhosis: A case report". Experimental and Therapeutic Medicine 27.6 (2024): 263.
Chicago
Ciurescu, I. A., Lencioni, R., Stemmer, S. M., Farbstein, M., Harpaz, Z., Bareket-Samish, A., Silverman, M. H., Fishman, P."A long‑term complete response to namodenoson in liver cancer with Child‑Pugh B cirrhosis: A case report". Experimental and Therapeutic Medicine 27, no. 6 (2024): 263. https://doi.org/10.3892/etm.2024.12551
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