Open Access

Immune myocarditis induced by sintilimab therapy: A case report

  • Authors:
    • Yu Li
    • Baowei Zhai
    • Ben Yang
    • Bin Wang
    • Yubing Wang
    • Meihua Qu
    • Yuanyuan Tang
  • View Affiliations

  • Published online on: June 25, 2024     https://doi.org/10.3892/etm.2024.12622
  • Article Number: 333
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Immunotherapy is a potent tool used in cancer treatment, but the occurrence of immune‑related adverse events induced by immune checkpoint inhibitors (ICIs) cannot be overlooked. This is particularly true for rare but potentially fatal cardiovascular complications, such as myocarditis; heart muscle inflammation may lead to heart dysfunction and arrhythmia. The present case is a 68‑year‑old female breast cancer patient who developed palpitations and elevated cardiac enzyme levels after 1 day of ICI therapy, and the patient was eventually diagnosed with immune myocarditis. After receiving hormonal shock therapy, Ctn I, CK, CK‑MB and other cardiac enzyme‑related markers improved significantly, and electrocardiogram test returned to normal, and the patient recovered during hospitalization without any major adverse cardiac events. Furthermore, the present study reviewed the mechanism of immune myocarditis induced by ICI therapy, with the aim of providing a clinical foundation for the prevention and diagnosis of cardiovascular adverse events in ICI therapy.
View Figures
View References

Related Articles

Journal Cover

August-2024
Volume 28 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Zhai B, Yang B, Wang B, Wang Y, Qu M and Tang Y: Immune myocarditis induced by sintilimab therapy: A case report. Exp Ther Med 28: 333, 2024.
APA
Li, Y., Zhai, B., Yang, B., Wang, B., Wang, Y., Qu, M., & Tang, Y. (2024). Immune myocarditis induced by sintilimab therapy: A case report. Experimental and Therapeutic Medicine, 28, 333. https://doi.org/10.3892/etm.2024.12622
MLA
Li, Y., Zhai, B., Yang, B., Wang, B., Wang, Y., Qu, M., Tang, Y."Immune myocarditis induced by sintilimab therapy: A case report". Experimental and Therapeutic Medicine 28.2 (2024): 333.
Chicago
Li, Y., Zhai, B., Yang, B., Wang, B., Wang, Y., Qu, M., Tang, Y."Immune myocarditis induced by sintilimab therapy: A case report". Experimental and Therapeutic Medicine 28, no. 2 (2024): 333. https://doi.org/10.3892/etm.2024.12622