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Case Report Open Access

Immune myocarditis induced by sintilimab therapy: A case report

  • Authors:
    • Yu Li
    • Baowei Zhai
    • Ben Yang
    • Bin Wang
    • Yubing Wang
    • Meihua Qu
    • Yuanyuan Tang
  • View Affiliations / Copyright

    Affiliations: Translational Medical Center, Weifang Second People's Hospital, Weifang Respiratory Disease Hospital, Weifang, Shandong 261041, P.R. China, Department of Cardiology, Weifang Second People's Hospital, Weifang Respiratory Disease Hospital, Weifang, Shandong 261041, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 333
    |
    Published online on: June 25, 2024
       https://doi.org/10.3892/etm.2024.12622
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Abstract

Immunotherapy is a potent tool used in cancer treatment, but the occurrence of immune‑related adverse events induced by immune checkpoint inhibitors (ICIs) cannot be overlooked. This is particularly true for rare but potentially fatal cardiovascular complications, such as myocarditis; heart muscle inflammation may lead to heart dysfunction and arrhythmia. The present case is a 68‑year‑old female breast cancer patient who developed palpitations and elevated cardiac enzyme levels after 1 day of ICI therapy, and the patient was eventually diagnosed with immune myocarditis. After receiving hormonal shock therapy, Ctn I, CK, CK‑MB and other cardiac enzyme‑related markers improved significantly, and electrocardiogram test returned to normal, and the patient recovered during hospitalization without any major adverse cardiac events. Furthermore, the present study reviewed the mechanism of immune myocarditis induced by ICI therapy, with the aim of providing a clinical foundation for the prevention and diagnosis of cardiovascular adverse events in ICI therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Zhai B, Yang B, Wang B, Wang Y, Qu M and Tang Y: Immune myocarditis induced by sintilimab therapy: A case report. Exp Ther Med 28: 333, 2024.
APA
Li, Y., Zhai, B., Yang, B., Wang, B., Wang, Y., Qu, M., & Tang, Y. (2024). Immune myocarditis induced by sintilimab therapy: A case report. Experimental and Therapeutic Medicine, 28, 333. https://doi.org/10.3892/etm.2024.12622
MLA
Li, Y., Zhai, B., Yang, B., Wang, B., Wang, Y., Qu, M., Tang, Y."Immune myocarditis induced by sintilimab therapy: A case report". Experimental and Therapeutic Medicine 28.2 (2024): 333.
Chicago
Li, Y., Zhai, B., Yang, B., Wang, B., Wang, Y., Qu, M., Tang, Y."Immune myocarditis induced by sintilimab therapy: A case report". Experimental and Therapeutic Medicine 28, no. 2 (2024): 333. https://doi.org/10.3892/etm.2024.12622
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Zhai B, Yang B, Wang B, Wang Y, Qu M and Tang Y: Immune myocarditis induced by sintilimab therapy: A case report. Exp Ther Med 28: 333, 2024.
APA
Li, Y., Zhai, B., Yang, B., Wang, B., Wang, Y., Qu, M., & Tang, Y. (2024). Immune myocarditis induced by sintilimab therapy: A case report. Experimental and Therapeutic Medicine, 28, 333. https://doi.org/10.3892/etm.2024.12622
MLA
Li, Y., Zhai, B., Yang, B., Wang, B., Wang, Y., Qu, M., Tang, Y."Immune myocarditis induced by sintilimab therapy: A case report". Experimental and Therapeutic Medicine 28.2 (2024): 333.
Chicago
Li, Y., Zhai, B., Yang, B., Wang, B., Wang, Y., Qu, M., Tang, Y."Immune myocarditis induced by sintilimab therapy: A case report". Experimental and Therapeutic Medicine 28, no. 2 (2024): 333. https://doi.org/10.3892/etm.2024.12622
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