Meningioma‑associated parkinsonism related to basal ganglia and cerebellar motor circuits: A case report and literature review

Takeda,Shintaro; Nagasaka,Shohei; Suzuki,Kohei; Futatsuya,Koichiro; Yamamoto,Junkoh

doi:10.3892/etm.2024.12742

December-2024 Volume 28 Issue 6

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

December-2024 Volume 28 Issue 6

Full Size Image

Case Report

Meningioma‑associated parkinsonism related to basal ganglia and cerebellar motor circuits: A case report and literature review

Authors:
- Shintaro Takeda
- Shohei Nagasaka
- Kohei Suzuki
- Koichiro Futatsuya
- Junkoh Yamamoto
View Affiliations / Copyright

Affiliations: Department of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 807‑8555, Japan, Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 807‑8555, Japan
Article Number: 452
|
Published online on: October 9, 2024

https://doi.org/10.3892/etm.2024.12742
Expand metrics +

Abstract

Parkinsonism can be caused by a variety of factors, such as drugs, vascular disease, toxicity, infection, and autoimmune, neoplastic, metabolic and functional diseases. Parkinsonism is associated with both motor and nonmotor clinical symptoms. Notably, the accurate diagnosis of Parkinson's disease and parkinsonism remains challenging. Meningioma is the most common type of extraparenchymal brain tumor, which typically presents with headaches, focal symptoms and cranial nerve symptoms. Parkinsonism is a rare initial symptom of meningioma. The present report describes an unusual case of a 70‑year‑old man who presented with tremors, pill‑rolling tremors and left‑sided rigidity. In addition, the patient exhibited asymmetrical bradykinesia (left > right) and mild postural instability. Magnetic resonance imaging (MRI) revealed a homogeneously enhanced cerebral falx meningioma and dilated tortuous veins. Dopamine transporter single‑photon emission computed tomography revealed decreased ¹²³I‑ioflupane uptake in the right striatum. The patient underwent two surgical interventions due to tumor growth and symptom deterioration. Pathological examination revealed transitional meningioma. Postoperatively, the symptoms of the patient improved, and MRI revealed a residual tumor without basal ganglia mechanical compression or venous congestion. It was hypothesized that involuntary movements, including parkinsonism in the present case, were associated with the disruption of the cortico‑cerebellar‑cortical and the dentato‑rubro‑olivary pathways (the Guillain‑Mollaret triangle) due to tumor mechanical compression and venous congestion. Meningioma, which is a type of extraparenchymal tumor, is more likely to cause mechanical compression and venous congestion than the infiltration of the basal ganglia circuit, leading to symptom improvement after surgical removal. This case highlights the importance of considering meningioma as a rare cause of lateral parkinsonism and its potential for symptom improvement after surgical intervention.

View Figures

View References

1	Kim J-I, Choi JK, Lee J-W and Hong JY: Intracranial meningioma-induced parkinsonism. J Lifestyle Med. 4:101–103. 2014.PubMed/NCBI View Article : Google Scholar
2	Hayes MT: Parkinson's disease and parkinsonism. Am J Med. 132:802–807. 2019.PubMed/NCBI View Article : Google Scholar
3	Tolosa E, Garrido A, Scholz SW and Poewe W: Challenges in the diagnosis of Parkinson's disease. Lancet Neurol. 20:385–397. 2021.PubMed/NCBI View Article : Google Scholar
4	Sveinbjornsdottir S: The clinical symptoms of Parkinson's disease. J Neurochem. 139 (Suppl):318–324. 2016.PubMed/NCBI View Article : Google Scholar
5	Ostrom QT, Price M, Neff C, Cioffi G, Waite KA, Kruchko C and Barnholtz-Sloan JS: CBTRUS statistical report: Primary brain and other central nervous system tumors diagnosed in the United States in 2015-2019. Neuro Oncol. 24 (Suppl):v1–v95. 2022.PubMed/NCBI View Article : Google Scholar
6	Cedergren Weber G, Timpka J, Rydelius A, Bengzon J and Odin P: Tumoral parkinsonism-Parkinsonism secondary to brain tumors, paraneoplastic syndromes, intracranial malformations, or oncological intervention, and the effect of dopaminergic treatment. Brain Behav. 13(e3151)2023.PubMed/NCBI View Article : Google Scholar
7	Defebvre L and Krystkowiak P: Movement disorders and stroke. Rev Neurol (Paris). 172:483–487. 2016.PubMed/NCBI View Article : Google Scholar
8	Choi S-M: Movement disorders following cerebrovascular lesions in cerebellar circuits. J Mov Disord. 9:80–88. 2016.PubMed/NCBI View Article : Google Scholar
9	Krauss JK, Paduch T, Mundinger F and Seeger W: Parkinsonism and rest tremor secondary to supratentorial tumours sparing the basal ganglia. Acta Neurochir. 133:22–29. 1995.PubMed/NCBI View Article : Google Scholar
10	Choi K-H, Choi S-M, Nam T-S and Lee M-C: Astrocytoma in the third ventricle and hypothalamus presenting with parkinsonism. J Korean Neurosurg Soc. 51:144–146. 2012.PubMed/NCBI View Article : Google Scholar
11	Merrill S, Mauler DJ, Richter KR, Raghunathan A, Leis JF and Mrugala MM: Parkinsonism as a late presentation of lymphomatosis cerebri following high-dose chemotherapy with autologous stem cell transplantation for primary central nervous system lymphoma. J Neurol. 267:2239–2244. 2020.PubMed/NCBI View Article : Google Scholar
12	Okano R, Suzuki K, Nakano Y and Yamamoto J: Primary central nervous system lymphoma presenting with Parkinsonism as an initial manifestation: A case report and literature review. Mol Clin Oncol. 14(95)2021.PubMed/NCBI View Article : Google Scholar
13	Rodriguez W, Fedorova M and Chand P: Levodopa-responsive parkinsonian syndrome secondary to a compressive craniopharyngioma: A case report. Cureus. 15(e35621)2023.PubMed/NCBI View Article : Google Scholar
14	Diyora B, Kukreja S and Sharma A: Cerebral meningioma presenting as dystonic head tremor. Mov Disord. 29(40)2014.PubMed/NCBI View Article : Google Scholar
15	Kleib AS, Sid'Ahmed E, Salihy SM, Boukhrissi N, Diagana M and Soumaré O: Hemiparkinsonism secondary to sphenoid wing meningioma. Neurochirurgie. 62:281–283. 2016.PubMed/NCBI View Article : Google Scholar
16	Fong M, Ghahreman A, Masters L and Huynh W: Large intracranial meningioma masquerading as Parkinson's disease. J Neurol Neurosurg Psychiatry. 87(1251)2016.PubMed/NCBI View Article : Google Scholar
17	Labate A, Nisticò R, Cherubini A and Quattrone A: Midbrain meningioma causing subacute parkinsonism. Neurol Clin Pract. 8:166–168. 2018.PubMed/NCBI View Article : Google Scholar
18	Al-Janabi WSA, Zaman I and Memon AB: Secondary parkinsonism due to a large anterior cranial fossa meningioma. Eur J Case Rep Intern Med. 6(001055)2019.PubMed/NCBI View Article : Google Scholar
19	Inoue H, Yamamura R, Yamada K, Hamasaki T, Inoue N and Mukasa A: Hemichorea induced by a sphenoid ridge meningioma. Surg Neurol Int. 12(201)2021.PubMed/NCBI View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Meningioma‑associated parkinsonism related to basal ganglia and cerebellar motor circuits: A case report and literature review

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Figure 4

Related Articles