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Efficacy of mechanical against manual method in cardiopulmonary resuscitation for out‑of‑hospital cardiac arrest: A meta‑analysis

  • Authors:
    • Xinqing Zhu
    • Jun Fu
  • View Affiliations / Copyright

    Affiliations: Department of Emergency Medicine, Shandong Provincial Third Hospital, Shandong University, Jinan, Shandong 250031, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 458
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    Published online on: October 16, 2024
       https://doi.org/10.3892/etm.2024.12748
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Abstract

Out‑of‑hospital cardiac arrest (OHCA) remains a leading cause of mortality worldwide, with the efficacy of cardiopulmonary resuscitation (CPR) methods playing a crucial role in patient outcomes. The present study aimed to compare the effectiveness of mechanical and manual CPR in OHCA, focusing on three outcomes: Return of spontaneous circulation (ROSC), survival to admission and survival till discharge. A comprehensive meta‑analysis was conducted, incorporating 39 studies for ROSC, 28 for survival to admission, and 30 for survival till discharge, totalling 144,430, 130,499 and 162,088 participants, respectively. The quality of evidence was evaluated using the GRADE approach, assessing risk of bias, inconsistency, indirectness, imprecision and publication bias. Statistical analysis included pooled odds ratios (ORs) with 95% confidence intervals (CIs) and sensitivity analyses. For ROSC, the pooled OR was 1.09 (95% CI: 0.92‑1.29), demonstrating no significant difference between mechanical and manual CPR. Survival to admission favoured mechanical CPR with a pooled OR of 1.25 (95% CI: 1.09‑1.43). No conclusive difference was found for survival till discharge, with a pooled OR of 0.79 (95% CI: 0.61‑1.02). Substantial heterogeneity was observed across outcomes. Evidence of potential publication bias was noted, particularly in the survival to admission outcome. The overall quality of evidence was graded as very low, mainly due to high heterogeneity and indirectness of evidence. The study suggests that mechanical CPR may improve short‑term outcomes such as survival to admission in patients with OHCA but does not demonstrate a significant long‑term survival benefit over manual CPR.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu X and Fu J: Efficacy of mechanical against manual method in cardiopulmonary resuscitation for out‑of‑hospital cardiac arrest: A meta‑analysis. Exp Ther Med 28: 458, 2024.
APA
Zhu, X., & Fu, J. (2024). Efficacy of mechanical against manual method in cardiopulmonary resuscitation for out‑of‑hospital cardiac arrest: A meta‑analysis. Experimental and Therapeutic Medicine, 28, 458. https://doi.org/10.3892/etm.2024.12748
MLA
Zhu, X., Fu, J."Efficacy of mechanical against manual method in cardiopulmonary resuscitation for out‑of‑hospital cardiac arrest: A meta‑analysis". Experimental and Therapeutic Medicine 28.6 (2024): 458.
Chicago
Zhu, X., Fu, J."Efficacy of mechanical against manual method in cardiopulmonary resuscitation for out‑of‑hospital cardiac arrest: A meta‑analysis". Experimental and Therapeutic Medicine 28, no. 6 (2024): 458. https://doi.org/10.3892/etm.2024.12748
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu X and Fu J: Efficacy of mechanical against manual method in cardiopulmonary resuscitation for out‑of‑hospital cardiac arrest: A meta‑analysis. Exp Ther Med 28: 458, 2024.
APA
Zhu, X., & Fu, J. (2024). Efficacy of mechanical against manual method in cardiopulmonary resuscitation for out‑of‑hospital cardiac arrest: A meta‑analysis. Experimental and Therapeutic Medicine, 28, 458. https://doi.org/10.3892/etm.2024.12748
MLA
Zhu, X., Fu, J."Efficacy of mechanical against manual method in cardiopulmonary resuscitation for out‑of‑hospital cardiac arrest: A meta‑analysis". Experimental and Therapeutic Medicine 28.6 (2024): 458.
Chicago
Zhu, X., Fu, J."Efficacy of mechanical against manual method in cardiopulmonary resuscitation for out‑of‑hospital cardiac arrest: A meta‑analysis". Experimental and Therapeutic Medicine 28, no. 6 (2024): 458. https://doi.org/10.3892/etm.2024.12748
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