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Case Report Open Access

A rare and challenging pediatric case of drug toxicity and immune reconstitution inflammatory syndrome during the treatment of intracranial tuberculoma: A case report

  • Authors:
    • Fatma Tuğba Çetin
    • Ümmühan Çay
    • Fatma Kilinç
    • Ömer Kaya
    • Nisanur Tapaç
    • Emel Bakanoğlu
    • Asena Ünal
    • Özlem Özgür Gündeşli̇oğlu
    • Arzu Demir
    • Derya Alabaz
  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Infection, Faculty of Medicine, Cukurova University, Balcalı Hospital, Sarıçam, 01790 Adana, Turkey, Department of Radiology, Faculty of Medicine, Cukurova University, Balcalı Hospital, Sarıçam, 01790 Adana, Turkey, Department of Medical Pathology, Faculty of Medicine, Cukurova University, Balcalı Hospital, Sarıçam, 01790 Adana, Turkey
    Copyright: © Çetin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 66
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    Published online on: February 5, 2025
       https://doi.org/10.3892/etm.2025.12815
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Abstract

Intracranial tuberculoma represents one of the most severe complications of central nervous system tuberculosis (TB), with an incidence that is relatively low. In cases of intracranial tuberculoma, patients may develop drug toxicity and/or immune reconstitution inflammatory syndrome (IRIS) while receiving anti‑TB treatment. The current study presented the case of a seven‑year‑old female patient with intracranial tuberculoma who developed drug‑induced hepatotoxicity and IRIS during the course of treatment. During the follow‑up of the patient, anti‑TB drug‑induced hepatitis developed, which led to the discontinuation of the drug twice. In the seventh month of treatment, cranial MRI showed the progression of tuberculoma lesions. The possibility of IRIS or treatment failure was considered and the treatment was restarted with steroids and non‑hepatotoxic anti‑TB drugs. With steroid and anti‑TB treatment, the lesions regressed almost completely and the neurological deficit regressed. Patients receiving treatment should be followed up closely due to the possible side effects of anti‑TB drugs, especially IRIS, which develops as an immune restructuring response during the recovery of the immune system.
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Copy and paste a formatted citation
Spandidos Publications style
Çetin FT, Çay Ü, Kilinç F, Kaya Ö, Tapaç N, Bakanoğlu E, Ünal A, Gündeşli̇oğlu ÖÖ, Demir A, Alabaz D, Alabaz D, et al: A rare and challenging pediatric case of drug toxicity and immune reconstitution inflammatory syndrome during the treatment of intracranial tuberculoma: A case report. Exp Ther Med 29: 66, 2025.
APA
Çetin, F.T., Çay, Ü., Kilinç, F., Kaya, Ö., Tapaç, N., Bakanoğlu, E. ... Alabaz, D. (2025). A rare and challenging pediatric case of drug toxicity and immune reconstitution inflammatory syndrome during the treatment of intracranial tuberculoma: A case report. Experimental and Therapeutic Medicine, 29, 66. https://doi.org/10.3892/etm.2025.12815
MLA
Çetin, F. T., Çay, Ü., Kilinç, F., Kaya, Ö., Tapaç, N., Bakanoğlu, E., Ünal, A., Gündeşli̇oğlu, Ö. Ö., Demir, A., Alabaz, D."A rare and challenging pediatric case of drug toxicity and immune reconstitution inflammatory syndrome during the treatment of intracranial tuberculoma: A case report". Experimental and Therapeutic Medicine 29.4 (2025): 66.
Chicago
Çetin, F. T., Çay, Ü., Kilinç, F., Kaya, Ö., Tapaç, N., Bakanoğlu, E., Ünal, A., Gündeşli̇oğlu, Ö. Ö., Demir, A., Alabaz, D."A rare and challenging pediatric case of drug toxicity and immune reconstitution inflammatory syndrome during the treatment of intracranial tuberculoma: A case report". Experimental and Therapeutic Medicine 29, no. 4 (2025): 66. https://doi.org/10.3892/etm.2025.12815
Copy and paste a formatted citation
x
Spandidos Publications style
Çetin FT, Çay Ü, Kilinç F, Kaya Ö, Tapaç N, Bakanoğlu E, Ünal A, Gündeşli̇oğlu ÖÖ, Demir A, Alabaz D, Alabaz D, et al: A rare and challenging pediatric case of drug toxicity and immune reconstitution inflammatory syndrome during the treatment of intracranial tuberculoma: A case report. Exp Ther Med 29: 66, 2025.
APA
Çetin, F.T., Çay, Ü., Kilinç, F., Kaya, Ö., Tapaç, N., Bakanoğlu, E. ... Alabaz, D. (2025). A rare and challenging pediatric case of drug toxicity and immune reconstitution inflammatory syndrome during the treatment of intracranial tuberculoma: A case report. Experimental and Therapeutic Medicine, 29, 66. https://doi.org/10.3892/etm.2025.12815
MLA
Çetin, F. T., Çay, Ü., Kilinç, F., Kaya, Ö., Tapaç, N., Bakanoğlu, E., Ünal, A., Gündeşli̇oğlu, Ö. Ö., Demir, A., Alabaz, D."A rare and challenging pediatric case of drug toxicity and immune reconstitution inflammatory syndrome during the treatment of intracranial tuberculoma: A case report". Experimental and Therapeutic Medicine 29.4 (2025): 66.
Chicago
Çetin, F. T., Çay, Ü., Kilinç, F., Kaya, Ö., Tapaç, N., Bakanoğlu, E., Ünal, A., Gündeşli̇oğlu, Ö. Ö., Demir, A., Alabaz, D."A rare and challenging pediatric case of drug toxicity and immune reconstitution inflammatory syndrome during the treatment of intracranial tuberculoma: A case report". Experimental and Therapeutic Medicine 29, no. 4 (2025): 66. https://doi.org/10.3892/etm.2025.12815
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