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Article

Role of right/left ventricular diameter ratio in therapy selection for high and low intermediate‑risk pulmonary embolism in the Emergency Department

  • Authors:
    • Emir Karakaya
    • Bedriye Müge Sönmez
    • Gülsen Cigsar
    • Ilker Sirin
    • Ihsaniye Süer Dogan
  • View Affiliations / Copyright

    Affiliations: Department of Emergency Medicine, University of Health Sciences Dışkapı Ankara Dışkapı Yıldırım Beyazıt Training and Research Hospital, 06110 Ankara, Turkey, Department of Radiology, University of Health Sciences Ankara Dışkapı Yıldırım Beyazıt Training and Research Hospital, 06110 Ankara, Turkey
  • Article Number: 73
    |
    Published online on: February 12, 2025
       https://doi.org/10.3892/etm.2025.12823
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Abstract

Patients with intermediate‑risk pulmonary embolism (PE) comprise a significant patient population. Computerized tomographic pulmonary angiography (CTPA) plays a crucial role in diagnosis and determining the prognosis. Right ventricular diameter/left ventricular diameter (RVD/LVD) ratio measured through CTPA provides insight into right ventricular overload. The aim of the present study was to determine the role of RVD/LVD ratio on decision of treatment between high and low intermediate‑risk PE. A retrospective observational study was conducted between May 2018 and May 2022 on patients with intermediate‑risk PE at the Emergency Department (ED) of a tertiary care hospital. The demographic information, risk factors, vital signs at presentation, laboratory data, CTPA images and treatment modality of the patients were obtained. RVD/LVD was calculated from the CTPA images. All‑cause mortality at 24 h, 7 and 30 days were recorded. A total of 127 patients were included. In total, 52 (40.9%) patients were in the low‑intermediate risk group, and 75 (59.1%) patients were in the intermediate‑high risk group. A total of 54 patients were administered thrombolytic therapy while 73 patients were not. The mean RVD/LVD was 1.35±0.25 in patients who were administered thrombolytic therapy and 1.17±0.34 in those who were not. A significant association was identified between RVD/LVD and the administration of thrombolytic therapy (P<0.001). RVD/LVD and mortality were not significantly correlated (P=0.248). No significant association was found between the administration of thrombolytic therapy and mortality (P=0.569). RVD/LVD assessed through CTPA was found to be significantly decisive for administering thrombolytic therapy but not significantly predictive for mortality in intermediate‑risk patients with PE presenting to the ED.
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1 

Konstantinides SV, Meyer G, Becattini C, Bueno H, Geersing GJ, Harjola VP, Huisman MV, Humbert M, Jennings CS, Jiménez D, et al: 2019 ESC guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European respiratory society (ERS). Eur Heart J. 41:543–603. 2020.PubMed/NCBI View Article : Google Scholar

2 

Balakrishna AM, Reddi V, Belford PM, Alvarez M, Jaber WA, Zhao DX and Vallabhajosyula S: Intermediate-Risk pulmonary embolism: A review of contemporary diagnosis, risk stratification and management. Medicina (Kaunas). 58(1186)2022.PubMed/NCBI View Article : Google Scholar

3 

Zimmermann L, Laufs U, Petros S and Lenk K: Outcome after thrombolysis in patients with intermediate high-risk pulmonary embolism: A propensity score analysis. J Emerg Med. 62:378–389. 2022.PubMed/NCBI View Article : Google Scholar

4 

Meyer G, Vicaut E, Danays T, Agnelli G, Becattini C, Beyer-Westendorf J, Bluhmki E, Bouvaist H, Brenner B, Couturaud F, et al: Fibrinolysis for patients with intermediate-risk pulmonary embolism. N Engl J Med. 370:1402–1411. 2014.PubMed/NCBI View Article : Google Scholar

5 

Kagima J, Stolbrink M, Masheti S, Mbaiyani C, Munubi A, Joekes E, Mortimer K, Rylance J and Morton B: Diagnostic accuracy of combined thoracic and cardiac sonography for the diagnosis of pulmonary embolism: A systematic review and meta-analysis. PLoS One. 15(e0235940)2020.PubMed/NCBI View Article : Google Scholar

6 

Thomas SE, Weinberg I, Schainfeld RM, Rosenfield K and Parmar GM: Diagnosis of pulmonary embolism: A review of evidence-based approaches. J Clin Med. 13(3722)2024.PubMed/NCBI View Article : Google Scholar

7 

Kang DK, Thilo C, Schoepf UJ, Barraza JM Jr, Nance JW Jr, Bastarrika G, Abro JA, Ravenel JG, Costello P and Goldhaber SZ: CT signs of right ventricular dysfunction: Prognostic role in acute pulmonary embolism. JACC Cardiovasc Imaging. 4:841–849. 2011.PubMed/NCBI View Article : Google Scholar

8 

Miyagawa M, Okumura Y, Fukamachi D, Fukuda I, Nakamura M, Yamada N, Takayama M, Maeda H, Yamashita T, Ikeda T, et al: Clinical implication of the right ventricular/left ventricular diameter ratio in patients with pulmonary thromboembolism. Int Heart J. 63:255–263. 2022.PubMed/NCBI View Article : Google Scholar

9 

Wang J, Guan W, Chen D, Han Y, Xu Z, Qiang J, Chen W, Li N and Gao W: The value of CTPA for diagnosing acute pulmonary thromboembolism and the ensuing right ventricular dysfunction. Cell Biochem Biophys. 69:517–522. 2014.PubMed/NCBI View Article : Google Scholar

10 

Pastré J, Sanchis-Borja M and Benlounes M: Risk stratification and treatment of pulmonary embolism with intermediate-risk of mortality. Curr Opin Pulm Med. 28:375–383. 2022.PubMed/NCBI View Article : Google Scholar

11 

Tapson VF: Thrombolytic therapy in acute pulmonary embolism. Curr Opin Cardiol. 27:585–591. 2012.PubMed/NCBI View Article : Google Scholar

12 

Keller K, Beule J, Balzer JO and Dippold W: D-Dimer and thrombus burden in acute pulmonary embolism. Am J Emerg Med. 36:1613–1618. 2018.PubMed/NCBI View Article : Google Scholar

13 

Hu J, Tian X, Liu XW, Liu YZ, Gao BL and Li CY: Markers of right ventricular dysfunction predict 30-day adverse prognosis of pulmonary embolism on pulmonary computed tomographic angiography. Medicine (Baltimore). 102(e34304)2023.PubMed/NCBI View Article : Google Scholar

14 

Brunton N, McBane R, Casanegra AI, Houghton DE, Balanescu DV, Ahmad S, Caples S, Motiei A and Henkin S: Risk stratification and management of intermediate-risk acute pulmonary embolism. J Clin Med. 13(257)2024.PubMed/NCBI View Article : Google Scholar

15 

Park JR, Chang SA, Jang SY, No HJ, Park SJ, Choi SH, Park SW, Kim H, Choe YH, Lee KS, et al: Evaluation of right ventricular dysfunction and prediction of clinical outcomes in acute pulmonary embolism by chest computed tomography: Comparisons with echocardiography. Int J Cardiovasc Imaging. 28:979–987. 2012.PubMed/NCBI View Article : Google Scholar

16 

Ayöz S, Erol S, Kul M, Kaya AG, Çoruh AG, Savaş İ, Aydın Ö and Kaya A: Using RV/LV ratio and cardiac biomarkers to define the risk of mortality from pulmonary embolism. Tuberk Toraks. 69:297–306. 2021.PubMed/NCBI View Article : Google Scholar

17 

Ammari Z, Hasnie AA, Ruzieh M, Dasa O, Al-Sarie M, Shastri P, Ashcherkin N, Brewster PS, Cooper CJ and Gupta R: Prognostic value of computed tomography versus echocardiography derived right to left ventricular diameter ratio in acute pulmonary embolism. Am J Med Sci. 361:445–450. 2021.PubMed/NCBI View Article : Google Scholar

18 

Moore AJE, Wachsmann J, Chamarthy MR, Panjikaran L, Tanabe Y and Rajiah P: Imaging of acute pulmonary embolism: An update. Cardiovasc Diagn Ther. 8:225–243. 2018.PubMed/NCBI View Article : Google Scholar

19 

Nasser MF, Jabri A, Limaye S, Sharma S, Hamade H, Mhanna M, Aneja A and Gandhi S: Echocardiographic evaluation of pulmonary embolism: A review. J Am Soc Echocardiogr. 36:906–912. 2023.PubMed/NCBI View Article : Google Scholar

20 

Yamashita Y, Morimoto T, Amano H, Takase T, Hiramori S, Kim K, Oi M, Akao M, Kobayashi Y, Toyofuku M, et al: Validation of simplified PESI score for identification of low-risk patients with pulmonary embolism: From the COMMAND VTE registry. Eur Heart J Acute Cardiovasc Care. 9:262–270. 2020.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Karakaya E, Sönmez B, Cigsar G, Sirin I and Süer Dogan I: Role of right/left ventricular diameter ratio in therapy selection for high and low intermediate‑risk pulmonary embolism in the Emergency Department. Exp Ther Med 29: 73, 2025.
APA
Karakaya, E., Sönmez, B., Cigsar, G., Sirin, I., & Süer Dogan, I. (2025). Role of right/left ventricular diameter ratio in therapy selection for high and low intermediate‑risk pulmonary embolism in the Emergency Department. Experimental and Therapeutic Medicine, 29, 73. https://doi.org/10.3892/etm.2025.12823
MLA
Karakaya, E., Sönmez, B., Cigsar, G., Sirin, I., Süer Dogan, I."Role of right/left ventricular diameter ratio in therapy selection for high and low intermediate‑risk pulmonary embolism in the Emergency Department". Experimental and Therapeutic Medicine 29.4 (2025): 73.
Chicago
Karakaya, E., Sönmez, B., Cigsar, G., Sirin, I., Süer Dogan, I."Role of right/left ventricular diameter ratio in therapy selection for high and low intermediate‑risk pulmonary embolism in the Emergency Department". Experimental and Therapeutic Medicine 29, no. 4 (2025): 73. https://doi.org/10.3892/etm.2025.12823
Copy and paste a formatted citation
x
Spandidos Publications style
Karakaya E, Sönmez B, Cigsar G, Sirin I and Süer Dogan I: Role of right/left ventricular diameter ratio in therapy selection for high and low intermediate‑risk pulmonary embolism in the Emergency Department. Exp Ther Med 29: 73, 2025.
APA
Karakaya, E., Sönmez, B., Cigsar, G., Sirin, I., & Süer Dogan, I. (2025). Role of right/left ventricular diameter ratio in therapy selection for high and low intermediate‑risk pulmonary embolism in the Emergency Department. Experimental and Therapeutic Medicine, 29, 73. https://doi.org/10.3892/etm.2025.12823
MLA
Karakaya, E., Sönmez, B., Cigsar, G., Sirin, I., Süer Dogan, I."Role of right/left ventricular diameter ratio in therapy selection for high and low intermediate‑risk pulmonary embolism in the Emergency Department". Experimental and Therapeutic Medicine 29.4 (2025): 73.
Chicago
Karakaya, E., Sönmez, B., Cigsar, G., Sirin, I., Süer Dogan, I."Role of right/left ventricular diameter ratio in therapy selection for high and low intermediate‑risk pulmonary embolism in the Emergency Department". Experimental and Therapeutic Medicine 29, no. 4 (2025): 73. https://doi.org/10.3892/etm.2025.12823
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