|
1
|
Mani V, Durmus C, Khushaim W, Ferreira DC,
Timur S, Arduini F and Salama KN: Multiplexed sensing techniques
for cardiovascular disease biomarkers-A review. Biosens
Bioelectron. 216(114680)2022.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Khatana C, Saini NK, Chakrabarti S, Saini
V, Sharma A, Saini RV and Saini AK: Mechanistic insights into the
oxidized low-density lipoprotein-induced atherosclerosis. Oxid Med
Cell Longev. 2020(5245308)2020.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Heo KS, Fujiwara K and Abe JI: Shear
stress and atherosclerosis. Mol Cells. 37:435–440. 2014.PubMed/NCBI View Article : Google Scholar
|
|
4
|
J M, L N, A V, E C, V L, K BS, L L, T G, M
P and P M: Wall shear stress alteration: A local risk factor of
atherosclerosis. Curr Atheroscler Rep. 24:143–151. 2022.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Singh P and Ali SA: Multifunctional role
of S100 protein family in the immune system: An update. Cells.
11(2274)2022.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Schiopu A and Cotoi OS: S100A8 and S100A9:
DAMPs at the crossroads between innate immunity, traditional risk
factors, and cardiovascular disease. Mediators Inflamm.
2013(828354)2013.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Averill MM, Kerkhoff C and Bornfeldt KE:
S100A8 and S100A9 in cardiovascular biology and disease.
Arterioscler Thromb Vasc Biol. 32:223–229. 2012.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Tietge UJF: Hyperlipidemia and
cardiovascular disease: Inflammation, dyslipidemia, and
atherosclerosis. Curr Opin Lipidol. 25:94–95. 2014.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Ross R and Harker L: Hyperlipidemia and
atherosclerosis. Science. 193:1094–1100. 1976.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Bornfeldt KE and Tabas I: Insulin
resistance, hyperglycemia, and atherosclerosis. Cell Metab.
14:575–585. 2011.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Aronson D and Rayfield EJ: How
hyperglycemia promotes atherosclerosis: Molecular mechanisms.
Cardiovasc Diabetol. 1(1)2002.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Zhang L and Lei S: Changes of junctions of
endothelial cells in coronary sclerosis: A review. Chronic Dis
Transl Med. 2:22–26. 2016.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Chistiakov DA, Orekhov AN and Bobryshev
YV: Endothelial barrier and its abnormalities in cardiovascular
disease. Front Physiol. 6(365)2015.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Chistiakov DA, Bobryshev YV and Orekhov
AN: Macrophage-mediated cholesterol handling in atherosclerosis. J
Cell Mol Med. 20:17–28. 2016.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Chistiakov DA, Melnichenko AA, Myasoedova
VA, Grechko AV and Orekhov AN: Mechanisms of foam cell formation in
atherosclerosis. J Mol Med (Berl). 95:1153–1165. 2017.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Falk E: Pathogenesis of atherosclerosis. J
Am Coll Cardiol. 47 (8 Suppl):C7–C12. 2006.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Rahman K: Garlic and aging: New insights
into an old remedy. Ageing Res Rev. 2:39–56. 2003.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Kodera Y, Kurita M, Nakamoto M and
Matsutomo T: Chemistry of aged garlic: Diversity of constituents in
aged garlic extract and their production mechanisms via the
combination of chemical and enzymatic reactions. Exp Ther Med.
19:1574–1584. 2020.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Allison GL, Lowe GM and Rahman K: Aged
garlic extract and its constituents inhibit platelet aggregation
through multiple mechanisms. J Nutr. 136 (3 Suppl):782S–788S.
2006.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Hoshino T, Kashimoto N and Kasuga S:
Effects of garlic preparations on the gastrointestinal mucosa. J
Nutr. 131 (3S):1109S–1113S. 2001.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Sumiyoshi H, Kanezawa A, Masamoto K,
Harada H, Nakagami S, Yokota A, Nishikawa M and Nakagawa S: Chronic
toxicity test of garlic extract in rats. J Toxicol Sci. 9:61–75.
1984.PubMed/NCBI View Article : Google Scholar : (In Japanese).
|
|
22
|
Efendy JL, Simmons DL, Campbell GR and
Campbell JH: The effect of the aged garlic extract, ‘Kyolic’, on
the development of experimental atherosclerosis. Atherosclerosis.
132:37–42. 1997.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Weiss N, Ide N, Abahji T, Nill L, Keller C
and Hoffmann U: Aged garlic extract improves homocysteine-induced
endothelial dysfunction in macro- and microcirculation. J Nutr. 136
(3 Suppl):750S–754S. 2006.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Shaikh K, Kinninger A, Cherukuri L,
Birudaraju D, Nakanishi R, Almeida S, Jayawardena E, Shekar C,
Flores F, Hamal S, et al: Aged garlic extract reduces low
attenuation plaque in coronary arteries of patients with diabetes:
A randomized, double-blind, placebo-controlled study. Exp Ther Med.
19:1457–1461. 2020.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Gómez-Arbeláez D, Lahera V, Oubiña P,
Valero-Muñoz M, de Las Heras N, Rodríguez Y, García RG, Camacho PA
and López-Jaramillo P: Aged garlic extract improves adiponectin
levels in subjects with metabolic syndrome: A double-blind,
placebo-controlled, randomized, crossover study. Mediators Inflamm.
2013(285795)2013.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Matsumoto S, Nakanishi R, Li D, Alani A,
Rezaeian P, Prabhu S, Abraham J, Fahmy MA, Dailing C, Flores F, et
al: Aged garlic extract reduces low attenuation plaque in coronary
arteries of patients with metabolic syndrome in a prospective
randomized double-blind study. J Nutr. 146:427S–432S.
2016.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Wlosinska M, Nilsson AC, Hlebowicz J,
Hauggaard A, Kjellin M, Fakhro M and Lindstedt S: The effect of
aged garlic extract on the atherosclerotic process-a randomized
double-blind placebo-controlled trial. BMC Complement Med Ther.
20(132)2020.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Williams MJA, Sutherland WHF, McCormick
MP, Yeoman DJ and de Jong SA: Aged garlic extract improves
endothelial function in men with coronary artery disease. Phytother
Res. 19:314–319. 2005.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Budoff M: Aged garlic extract retards
progression of coronary artery calcification. J Nutr. 136 (3
Suppl):741S–744S. 2006.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Hom C, Budoff M and Luo Y: The effects of
aged garlic extract on coronary artery calcification progression
and blood pressure. J Am Coll Cardiol. 65(A1472)2015.
|
|
31
|
Budoff MJ, Takasu J, Flores FR, Niihara Y,
Lu B, Lau BH, Rosen RT and Amagase H: Inhibiting progression of
coronary calcification using aged garlic extract in patients
receiving statin therapy: A preliminary study. Prev Med.
39:985–991. 2004.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Zeb I, Ahmadi N, Flores F and Budoff MJ:
Randomized trial evaluating the effect of aged garlic extract with
supplements versus placebo on adipose tissue surrogates for
coronary atherosclerosis progression. Coron Artery Dis. 29:325–328.
2018.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Ahmadi N, Nabavi V, Hajsadeghi F, Zeb I,
Flores F, Ebrahimi R and Budoff M: Aged garlic extract with
supplement is associated with increase in brown adipose, decrease
in white adipose tissue and predict lack of progression in coronary
atherosclerosis. Int J Cardiol. 168:2310–2314. 2013.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Larijani VN, Ahmadi N, Zeb I, Khan F,
Flores F and Budoff M: Beneficial effects of aged garlic extract
and coenzyme Q10 on vascular elasticity and endothelial function:
The FAITH randomized clinical trial. Nutrition. 29:71–75.
2013.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Zeb I, Ahmadi N, Nasir K, Kadakia J,
Larijani VN, Flores F, Li D and Budoff MJ: Aged garlic extract and
coenzyme Q10 have favorable effect on inflammatory markers and
coronary atherosclerosis progression: A randomized clinical trial.
J Cardiovasc Dis Res. 3:185–190. 2012.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Budoff MJ, Ahmadi N, Gul KM, Liu ST,
Flores FR, Tiano J, Takasu J, Miller E and Tsimikas S: Aged garlic
extract supplemented with B vitamins, folic acid and L-arginine
retards the progression of subclinical atherosclerosis: A
randomized clinical trial. Prev Med. 49:101–107. 2009.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Yeh YY and Yeh SM: Homocysteine-lowering
action is another potential cardiovascular protective factor of
aged garlic extract. J Nutr. 136 (3 Suppl):745S–749S.
2006.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Miki S, Suzuki JI, Takashima M, Ishida M,
Kokubo H and Yoshizumi M: S-1-Propenylcysteine promotes
IL-10-induced M2c macrophage polarization through prolonged
activation of IL-10R/STAT3 signaling. Sci Rep.
11(22469)2021.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Morihara N, Hino A, Miki S, Takashima M
and Suzuki JI: Aged garlic extract suppresses inflammation in
apolipoprotein E-knockout mice. Mol Nutr Food Res.
61(1700308)2017.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Morihara N, Hino A, Yamaguchi T and Suzuki
JI: Aged garlic extract suppresses the development of
atherosclerosis in apolipoprotein E-knockout mice. J Nutr.
146:460S–463S. 2016.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Li X, Li C, Zhang W, Wang Y, Qian P and
Huang H: Inflammation and aging: Signaling pathways and
intervention therapies. Signal Transduct Target Ther.
8(239)2023.PubMed/NCBI View Article : Google Scholar
|
|
42
|
He Y, Chen Y, Yao L, Wang J, Sha X and
Wang Y: The inflamm-aging model identifies key risk factors in
atherosclerosis. Front Genet. 13(865827)2022.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Raj R, Thomas S and Gorantla V:
Accelerated atherosclerosis in rheumatoid arthritis: A systematic
review. F1000Res. 11(466)2022.PubMed/NCBI View Article : Google Scholar
|
|
44
|
Adawi M, Firas S and Blum A: Rheumatoid
Arthritis and Atherosclerosis. IMAJ. 21:460–463. 2019.PubMed/NCBI
|
|
45
|
Sreejit G, Abdel Latif A, Murphy AJ and
Nagareddy PR: Emerging roles of neutrophil-borne S100A8/A9 in
cardiovascular inflammation. Pharmacol Res.
161(105212)2020.PubMed/NCBI View Article : Google Scholar
|
|
46
|
Roh JS and Sohn DH: Damage-associated
molecular patterns in inflammatory diseases. Immune Netw.
18(e27)2018.PubMed/NCBI View Article : Google Scholar
|
|
47
|
Wlosinska M, Nilsson AC, Hlebowicz J,
Fakhro M, Malmsjö M and Lindstedt S: Aged garlic extract reduces
IL-6: A double-blind placebo-controlled trial in females with a low
risk of cardiovascular disease. Evid Based Complement Alternat Med.
2021(6636875)2021.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Xu C, Mathews AE, Rodrigues C, Eudy BJ,
Rowe CA, O'Donoughue A and Percival SS: Aged garlic extract
supplementation modifies inflammation and immunity of adults with
obesity: A randomized, double-blind, placebo-controlled clinical
trial. Clin Nutr ESPEN. 24:148–155. 2018.PubMed/NCBI View Article : Google Scholar
|
|
49
|
Lee HH, Han MH, Hwang HJ, Kim GY, Moon SK,
Hyun JW, Kim WJ and Choi YH: Diallyl trisulfide exerts
anti-inflammatory effects in lipopolysaccharide-stimulated RAW
264.7 macrophages by suppressing the Toll-like receptor 4/nuclear
factor-κB pathway. Int J Mol Med. 35:487–495. 2015.PubMed/NCBI View Article : Google Scholar
|
|
50
|
Lee HH, Jeong JW, Hong SH, Park C, Kim BW
and Choi YH: Diallyl trisulfide suppresses the production of
lipopolysaccharide-induced inflammatory mediators in BV2 microglia
by decreasing the NF-κB pathway activity associated with toll-like
Receptor 4 and CXCL12/CXCR4 pathway blockade. J Cancer Prev.
23:134–140. 2018.PubMed/NCBI View Article : Google Scholar
|
|
51
|
Suzuki JI, Kodera Y, Miki S, Ushijima M,
Takashima M, Matsutomo T and Morihara N: Anti-inflammatory action
of cysteine derivative S-1-propenylcysteine by inducing MyD88
degradation. Sci Rep. 8(14148)2018.PubMed/NCBI View Article : Google Scholar
|
|
52
|
Suzuki J, Miki S, Ushijima M and Kodera Y:
Regulation of immune response by S-1-propenylcysteine through
autophagy-mediated protein degradation. Exp Ther Med. 19:1570–1573.
2020.PubMed/NCBI View Article : Google Scholar
|
|
53
|
Chen Y, Xue R, Jin X and Tan X:
Antiarthritic activity of diallyl disulfide against freund's
adjuvant-induced arthritic rat model. J Environ Pathol Toxicol
Oncol. 37:291–303. 2018.PubMed/NCBI View Article : Google Scholar
|
|
54
|
Cao S, Li Y, Song R, Meng X, Fuchs M,
Liang C, Kachler K, Meng X, Wen J, Schlötzer-Schrehardt U, et al:
L-arginine metabolism inhibits arthritis and inflammatory bone
loss. Ann Rheum Dis. 83:72–87. 2024.PubMed/NCBI View Article : Google Scholar
|
|
55
|
Prasad K and Mishra M: Mechanism of
hypercholesterolemia-induced atherosclerosis. Rev Cardiovasc Med.
23(212)2022.PubMed/NCBI View Article : Google Scholar
|
|
56
|
Davis CE, Rifkind BM, Brenner H and Gordon
DJ: A single cholesterol measurement underestimates the risk of
coronary heart disease. An empirical example from the lipid
research clinics mortality follow-up study. JAMA. 264:3044–3046.
1990.PubMed/NCBI
|
|
57
|
Minatel IO, Francisqueti FV, Corrêa CR and
Pereira Lima GPP: Antioxidant activity of Ƴ-oryzanol: A complex
network of interactions. Int J Mol Sci. 17(1107)2016.PubMed/NCBI View Article : Google Scholar
|
|
58
|
Ranneh Y, Ali F, Akim AM, Hamid HA,
Khazaai H and Fadel A: Crosstalk between reactive oxygen species
and pro-inflammatory markers in developing various chronic
diseases: A review. Appl Biol Chem. 60:327–338. 2017.
|
|
59
|
Yeh YY and Liu L: Cholesterol-lowering
effect of garlic extracts and organosulfur compounds: Human and
animal studies. J Nutr. 131 (3S):989S–993S. 2001.PubMed/NCBI View Article : Google Scholar
|
|
60
|
Steiner M, Khan AH, Holbert D and Lin RIS:
A double-blind crossover study in moderately hypercholesterolemic
men that compared the effect of aged garlic extract and placebo
administration on blood lipids. Am J Clin Nutr. 64:866–870.
1996.PubMed/NCBI View Article : Google Scholar
|
|
61
|
Lau BHS: Suppression of LDL oxidation by
garlic compounds is a possible mechanism of cardiovascular health
benefit. J Nutr. 136 (3 Suppl):765S–768S. 2006.PubMed/NCBI View Article : Google Scholar
|
|
62
|
Poznyak AV, Sadykhov NK, Kartuesov AG,
Borisov EE, Melnichenko AA, Grechko AV and Orekhov AN: Hypertension
as a risk factor for atherosclerosis: Cardiovascular risk
assessment. Front Cardiovasc Med. 9(959285)2022.PubMed/NCBI View Article : Google Scholar
|
|
63
|
Visseren F, Mach F, Smulders YM, Carballo
D, Koskinas KC, Bäck M, Benetos A, Biffi A, Boavida JM, Capodanno
D, et al: 2021 ESC guidelines on cardiovascular disease prevention
in clinical practice. Eur Heart J. 42:3227–3337. 2021.PubMed/NCBI View Article : Google Scholar
|
|
64
|
Maraj I, Makaryus JN, Ashkar A, McFarlane
SI and Makaryus AN: Hypertension management in the high
cardiovascular risk population. Int J Hypertens.
2013(382802)2013.PubMed/NCBI View Article : Google Scholar
|
|
65
|
Ried K, Frank OR and Stocks NP: Aged
garlic extract reduces blood pressure in hypertensives: A
dose-response trial. Eur J Clin Nutr. 67:64–70. 2013.PubMed/NCBI View Article : Google Scholar
|
|
66
|
Ried K, Travica N and Sali A: The effect
of aged garlic extract on blood pressure and other cardiovascular
risk factors in uncontrolled hypertensives: The AGE at heart trial.
Integr Blood Press Control. 9:9–21. 2016.PubMed/NCBI View Article : Google Scholar
|
|
67
|
Ried K, Travica N and Sali A: The effect
of kyolic aged garlic extract on gut microbiota, inflammation, and
cardiovascular markers in hypertensives: The GarGIC trial. Front
Nutr. 5(122)2018.PubMed/NCBI View Article : Google Scholar
|
|
68
|
Matsutomo T, Ushijima M, Kodera Y,
Nakamoto M, Takashima M, Morihara N and Tamura K: Metabolomic study
on the antihypertensive effect of S-1-propenylcysteine in
spontaneously hypertensive rats using liquid chromatography coupled
with quadrupole-orbitrap mass spectrometry. J Chromatogr B Analyt
Technol Biomed Life Sci. 1046:147–155. 2017.PubMed/NCBI View Article : Google Scholar
|
|
69
|
Matsutomo T, Ushijima M, Kunimura K and
Ohtani M: Metabolomic study reveals the acute hypotensive effect of
S-1-propenylcysteine accompanied by alteration of the plasma
histidine level in spontaneously hypertensive rats. J Pharm Biomed
Anal. 168:148–154. 2019.PubMed/NCBI View Article : Google Scholar
|
|
70
|
Ushijima M, Takashima M, Kunimura K,
Kodera Y, Morihara N and Tamura K: Effects of S-1-propenylcysteine,
a sulfur compound in aged garlic extract, on blood pressure and
peripheral circulation in spontaneously hypertensive rats. J Pharm
Pharmacol. 70:559–565. 2018.PubMed/NCBI View Article : Google Scholar
|
|
71
|
Cruz C, Correa-Rotter R, Sánchez-González
DJ, Hernández-Pando R, Maldonado PD, Martínez-Martínez CM,
Medina-Campos ON, Tapia E, Aguilar D, Chirino YI and
Pedraza-Chaverri J: Renoprotective and antihypertensive effects of
S-allylcysteine in 5/6 nephrectomized rats. Am J Physiol Renal
Physiol. 293:F1691–F1698. 2007.PubMed/NCBI View Article : Google Scholar
|
|
72
|
Halim RM, Kamisah Y, Aziz NF, Sudirman UM,
Ahmad NAN, Kok-Yong C and Zainalabidin S: Pakistan veterinary
journal S-allylcysteine supplementation effects on vascular and
bone health in ovariectomized wistar rats. Pakistan Vet J.
41(507)2021.
|
|
73
|
Trimm E and Red-Horse K: Vascular
endothelial cell development and diversity. Nat Rev Cardiol.
20:197–210. 2023.PubMed/NCBI View Article : Google Scholar
|
|
74
|
Badimon L, Peña E, Arderiu G, Padró T,
Slevin M, Vilahur G and Chiva-Blanch G: C-reactive protein in
atherothrombosis and angiogenesis. Front Immunol.
9(430)2018.PubMed/NCBI View Article : Google Scholar
|
|
75
|
Čejková S, Králová-Lesná I and Poledne R:
Monocyte adhesion to the endothelium is an initial stage of
atherosclerosis development. Cor Vasa. 58:e419–e425. 2016.
|
|
76
|
Glass CK and Witztum JL: Atherosclerosis.
The road ahead. Cell. 104:503–516. 2001.PubMed/NCBI View Article : Google Scholar
|
|
77
|
Schiopu A, Nadig SN, Cotoi OS, Hester J,
Van Rooijen N and Wood KJ: Inflammatory Ly-6C(hi) monocytes play an
important role in the development of severe transplant
arteriosclerosis in hyperlipidemic recipients. Atherosclerosis.
223:291–298. 2012.PubMed/NCBI View Article : Google Scholar
|
|
78
|
Woollard KJ and Geissmann F: Monocytes in
atherosclerosis: Subsets and functions. Nat Rev Cardiol. 7:77–86.
2010.PubMed/NCBI View Article : Google Scholar
|
|
79
|
Hilgendorf I, Swirski FK and Robbins CS:
Monocyte fate in atherosclerosis. Arterioscler Thromb Vasc Biol.
35:272–279. 2015.PubMed/NCBI View Article : Google Scholar
|
|
80
|
Pang J, Maienschein-Cline M and Koh TJ:
Enhanced proliferation of Ly6C+ monocytes/macrophages
contributes to chronic inflammation in skin wounds of diabetic
mice. J Immunol. 206:621–630. 2021.PubMed/NCBI View Article : Google Scholar
|
|
81
|
Ho SE, Ide N and Lau BH: S-allyl cysteine
reduces oxidant load in cells involved in the atherogenic process.
Phytomedicine. 8:39–46. 2001.PubMed/NCBI View Article : Google Scholar
|
|
82
|
Ide N and Lau BH: S-allylcysteine
attenuates oxidative stress in endothelial cells. Drug Dev Ind
Pharm. 25:619–624. 1999.PubMed/NCBI View Article : Google Scholar
|
|
83
|
Ide N and Lau BH: Garlic compounds
minimize intracellular oxidative stress and inhibit nuclear
factor-kappa b activation. J Nutr. 131 (3S):1020S–1026S.
2001.PubMed/NCBI View Article : Google Scholar
|
|
84
|
Ide N and Lau BH: Garlic compounds protect
vascular endothelial cells from oxidized low density
lipoprotein-induced injury. J Pharm Pharmacol. 49:908–911.
1997.PubMed/NCBI View Article : Google Scholar
|
|
85
|
Ide N, Lau BH, Ryu K, Matsuura H and
Itakura Y: Antioxidant effects of fructosyl arginine, a Maillard
reaction product in aged garlic extract. J Nutr Biochem.
10:372–376. 1999.PubMed/NCBI View Article : Google Scholar
|
|
86
|
Hiramatsu K, Tsuneyoshi T, Ogawa T and
Morihara N: Aged garlic extract enhances heme oxygenase-1 and
glutamate-cysteine ligase modifier subunit expression via the
nuclear factor erythroid 2-related factor 2-antioxidant response
element signaling pathway in human endothelial cells. Nutr Res.
36:143–149. 2016.PubMed/NCBI View Article : Google Scholar
|
|
87
|
Tsuneyoshi T, Kunimura K and Morihara N:
S-1-Propenylcysteine augments BACH1 degradation and heme oxygenase
1 expression in a nitric oxide-dependent manner in endothelial
cells. Nitric Oxide. 84:22–29. 2019.PubMed/NCBI View Article : Google Scholar
|
|
88
|
Tsuneyoshi T: BACH1 mediates the
antioxidant properties of aged garlic extract. Exp Ther Med.
19:1500–1503. 2020.PubMed/NCBI View Article : Google Scholar
|
|
89
|
Kim KM, Chun SB, Koo MS, Choi WJ, Kim TW,
Kwon YG, Chung HT, Billiar TR and Kim YM: Differential regulation
of NO availability from macrophages and endothelial cells by the
garlic component S-allyl cysteine. Free Radic Biol Med. 30:747–756.
2001.PubMed/NCBI View Article : Google Scholar
|
|
90
|
Geddo F, Querio G, Asteggiano A,
Antoniotti S, Porcu A, Occhipinti A, Medana C and Gallo MP:
Improving endothelial health with food-derived H2S
donors: An in vitro study with S-allyl cysteine and with a
black-garlic extract enriched in sulfur-containing compounds. Food
Funct. 14:4163–4172. 2023.PubMed/NCBI View Article : Google Scholar
|
|
91
|
Tsuneyoshi T, Kanamori Y, Matsutomo T and
Morihara N: Dehydrodiconiferyl alcohol suppresses monocyte adhesion
to endothelial cells by attenuation of JNK signaling pathway.
Biochem Biophys Res Commun. 465:408–413. 2015.PubMed/NCBI View Article : Google Scholar
|
|
92
|
Lei YP, Chen HW, Sheen LY and Lii CK:
Diallyl disulfide and diallyl trisulfide suppress oxidized
LDL-induced vascular cell adhesion molecule and E-selectin
expression through protein kinase A- and B-dependent signaling
pathways. J Nutr. 138:996–1003. 2008.PubMed/NCBI View Article : Google Scholar
|
|
93
|
Miki S, Inokuma KI, Takashima M, Nishida
M, Sasaki Y, Ushijima M, Suzuki JI and Morihara N: Aged garlic
extract suppresses the increase of plasma glycated albumin level
and enhances the AMP-activated protein kinase in adipose tissue in
TSOD mice. Mol Nutr Food Res. 61(1600797)2017.PubMed/NCBI View Article : Google Scholar
|
|
94
|
Adams MR, Jessup W, Hailstones D and
Celermajer DS: L-arginine reduces human monocyte adhesion to
vascular endothelium and endothelial expression of cell adhesion
molecules. Circulation. 95:662–668. 1997.PubMed/NCBI View Article : Google Scholar
|
|
95
|
Cooke JP, Singer AH, Tsao P, Zera P, Rowan
RA and Billingham ME: Antiatherogenic effects of L-arginine in the
hypercholesterolemic rabbit. J Clin Invest. 90:1168–1172.
1992.PubMed/NCBI View Article : Google Scholar
|
|
96
|
Tsao PS, McEvoy LM, Drexler H, Butcher EC
and Cooke JP: Enhanced endothelial adhesiveness in
hypercholesterolemia is attenuated by L-arginine. Circulation.
89:2176–2182. 1994.PubMed/NCBI View Article : Google Scholar
|
|
97
|
Kunimura K, Miki S, Takashima M and Suzuki
JI: S-1-propenylcysteine improves TNF-α-induced vascular
endothelial barrier dysfunction by suppressing the GEF-H1/RhoA/Rac
pathway. Cell Commun Signal. 19(17)2021.PubMed/NCBI View Article : Google Scholar
|
|
98
|
Mehta JL, Sanada N, Hu CP, Chen J,
Dandapat A, Sugawara F, Satoh H, Inoue K, Kawase Y, Jishage K, et
al: Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice
fed high cholesterol diet. Circ Res. 100:1634–1642. 2007.PubMed/NCBI View Article : Google Scholar
|
|
99
|
Febbraio M, Podrez EA, Smith JD, Hajjar
DP, Hazen SL, Hoff HF, Sharma K and Silverstein RL: Targeted
disruption of the class B scavenger receptor CD36 protects against
atherosclerotic lesion development in mice. J Clin Invest.
105:1049–1056. 2000.PubMed/NCBI View Article : Google Scholar
|
|
100
|
Kunjathoor VV, Febbraio M, Podrez EA,
Moore KJ, Andersson L, Koehn S, Rhee JS, Silverstein R, Hoff HF and
Freeman MW: Scavenger receptors class A-I/II and CD36 are the
principal receptors responsible for the uptake of modified low
density lipoprotein leading to lipid loading in macrophages. J Biol
Chem. 277:49982–49988. 2002.PubMed/NCBI View Article : Google Scholar
|
|
101
|
Morihara N, Ide N and Weiss N: Aged garlic
extract inhibits CD36 expression in human macrophages via
modulation of the PPARgamma pathway. Phytother Res. 24:602–608.
2010.PubMed/NCBI View Article : Google Scholar
|
|
102
|
Ide N, Keller C and Weiss N: Aged garlic
extract inhibits homocysteine-induced CD36 expression and foam cell
formation in human macrophages. J Nutr. 136 (3 Suppl):755S–758S.
2006.PubMed/NCBI View Article : Google Scholar
|
|
103
|
Morihara N, Ide N and Weiss N: Aged garlic
extract inhibits homocysteine-induced scavenger receptor CD36
expression and oxidized low-density lipoprotein cholesterol uptake
in human macrophages in vitro. J Ethnopharmacol. 134:711–716.
2011.PubMed/NCBI View Article : Google Scholar
|
|
104
|
Matsuo M: ABCA1 and ABCG1 as potential
therapeutic targets for the prevention of atherosclerosis. J
Pharmacol Sci. 148:197–203. 2022.PubMed/NCBI View Article : Google Scholar
|
|
105
|
Malekpour-Dehkordi Z, Javadi E, Doosti M,
Paknejad M, Nourbakhsh M, Yassa N, Gerayesh-Nejad S and Heshmat R:
S-Allylcysteine, a garlic compound, increases ABCA1 expression in
human THP-1 macrophages. Phytother Res. 27:357–361. 2013.PubMed/NCBI View Article : Google Scholar
|
|
106
|
Lammers B, Zhao Y, Foks AC, Hildebrand RB,
Kuiper J, van Berkel TJC and van Eck M: Leukocyte ABCA1 remains
atheroprotective in splenectomized LDL receptor knockout mice. PLoS
One. 7(e48080)2012.PubMed/NCBI View Article : Google Scholar
|
|
107
|
Yvan-Charvet L, Ranalletta M, Wang N, Han
S, Terasaka N, Li R, Welch C and Tall AR: Combined deficiency of
ABCA1 and ABCG1 promotes foam cell accumulation and accelerates
atherosclerosis in mice. J Clin Invest. 117:3900–3908.
2007.PubMed/NCBI View Article : Google Scholar
|
|
108
|
Wang X, Collins HL, Ranalletta M, Fuki IV,
Billheimer JT, Rothblat GH, Tall AR and Rader DJ: Macrophage ABCA1
and ABCG1, but not SR-BI, promote macrophage reverse cholesterol
transport in vivo. J Clin Invest. 117:2216–2224. 2007.PubMed/NCBI View Article : Google Scholar
|
|
109
|
Van Eck M, Singaraja RR, Ye D, Hildebrand
RB, James ER, Hayden MR and Van Berkel TJ: Macrophage ATP-binding
cassette transporter A1 overexpression inhibits atherosclerotic
lesion progression in low-density lipoprotein receptor knockout
mice. Arterioscler Thromb Vasc Biol. 26:929–934. 2006.PubMed/NCBI View Article : Google Scholar
|
|
110
|
Wu J, He S, Song Z, Chen S, Lin X, Sun H,
Zhou P, Peng Q, Du S, Zheng S and Liu X: Macrophage polarization
states in atherosclerosis. Front Immunol.
14(1185587)2023.PubMed/NCBI View Article : Google Scholar
|
|
111
|
Bisgaard LS, Mogensen CK, Rosendahl A,
Cucak H, Nielsen LB, Rasmussen SE and Pedersen TX: Bone
marrow-derived and peritoneal macrophages have different
inflammatory response to oxLDL and M1/M2 marker
expression-implications for atherosclerosis research. Sci Rep.
6(35234)2016.PubMed/NCBI View Article : Google Scholar
|
|
112
|
Khallou-Laschet J, Varthaman A, Fornasa G,
Compain C, Gaston AT, Clement M, Dussiot M, Levillain O,
Graff-Dubois S, Nicoletti A and Caligiuri G: Macrophage plasticity
in experimental atherosclerosis. PLoS One. 5(e8852)2010.PubMed/NCBI View Article : Google Scholar
|
|
113
|
Seifert R, Kuhlmann MT, Eligehausen S,
Kiefer F, Hermann S and Schäfers M: Molecular imaging of MMP
activity discriminates unstable from stable plaque phenotypes in
shear-stress induced murine atherosclerosis. PLoS One.
13(e0204305)2018.PubMed/NCBI View Article : Google Scholar
|
|
114
|
Li J, Lei HT, Cao L, Mi YN, Li S and Cao
YX: Crocin alleviates coronary atherosclerosis via inhibiting lipid
synthesis and inducing M2 macrophage polarization. Int
Immunopharmacol. 55:120–127. 2018.PubMed/NCBI View Article : Google Scholar
|
|
115
|
Aharoni S, Lati Y, Aviram M and Fuhrman B:
Pomegranate juice polyphenols induce a phenotypic switch in
macrophage polarization favoring a M2 anti-inflammatory state.
Biofactors. 41:44–51. 2015.PubMed/NCBI View Article : Google Scholar
|
|
116
|
Bi Y, Chen J, Hu F, Liu J, Li M and Zhao
L: M2 macrophages as a potential target for antiatherosclerosis
treatment. Neural Plast. 2019(6724903)2019.PubMed/NCBI View Article : Google Scholar
|
|
117
|
Zhang XN, Zhao N, Guo FF, Wang YR, Liu SX
and Zeng T: Diallyl disulfide suppresses the
lipopolysaccharide-driven inflammatory response of macrophages by
activating the Nrf2 pathway. Food Chem Toxicol.
159(112760)2022.PubMed/NCBI View Article : Google Scholar
|
|
118
|
Xiang AH, Peters RK, Kjos SL, Ochoa C,
Marroquin A, Goico J, Tan S, Wang C, Azen SP, Liu CR, et al: Effect
of thiazolidinedione treatment on progression of subclinical
atherosclerosis in premenopausal women at high risk for type 2
diabetes. J Clin Endocrinol Metab. 90:1986–1991. 2005.PubMed/NCBI View Article : Google Scholar
|
|
119
|
Pioglitazone inhibits progression of
atherosclerosis. Nat Clin Pract Cardiovasc Med. 5(512)2008.
|
|
120
|
Nakayama T, Komiyama N, Yokoyama M,
Namikawa S, Kuroda N, Kobayashi Y and Komuro I: Pioglitazone
induces regression of coronary atherosclerotic plaques in patients
with type 2 diabetes mellitus or impaired glucose tolerance: A
randomized prospective study using intravascular ultrasound. Int J
Cardiol. 138:157–165. 2010.PubMed/NCBI View Article : Google Scholar
|
|
121
|
Chen R, McVey DG, Shen D, Huang X and Ye
S: Phenotypic switching of vascular smooth muscle cells in
atherosclerosis. J Am Heart Assoc. 12(e031121)2023.PubMed/NCBI View Article : Google Scholar
|
|
122
|
Durham AL, Speer MY, Scatena M, Giachelli
CM and Shanahan CM: Role of smooth muscle cells in vascular
calcification: Implications in atherosclerosis and arterial
stiffness. Cardiovasc Res. 114:590–600. 2018.PubMed/NCBI View Article : Google Scholar
|
|
123
|
Hom C, Luo Y and Budoff MJ: The effects of
aged garlic extract on coronary artery calcification progression. J
Nutr Food Sci. S5(005)2015.
|
|
124
|
Yamakawa T, Matsutomo T, Hofmann T and
Kodera Y: Aged garlic extract and one of the constituent,
(+)-(2S,3R)-dehydrodiconiferyl alcohol, inhibits alkaline
phosphatase activity induced by inflammation factors in human
vascular smooth muscle cells. Food Nutr Sci. 5:177–184. 2014.
|
|
125
|
Jackson SP: The growing complexity of
platelet aggregation. Blood. 109:5087–5095. 2007.PubMed/NCBI View Article : Google Scholar
|
|
126
|
Bye AP, Unsworth AJ and Gibbins JM:
Platelet signaling: A complex interplay between inhibitory and
activatory networks. J Thromb Haemost. 14:918–930. 2016.PubMed/NCBI View Article : Google Scholar
|
|
127
|
Asada Y, Yamashita A, Sato Y and
Hatakeyama K: Pathophysiology of atherothrombosis: Mechanisms of
thrombus formation on disrupted atherosclerotic plaques. Pathol
Int. 70:309–322. 2020.PubMed/NCBI View Article : Google Scholar
|
|
128
|
Steiner M and Li W: Aged garlic extract, a
modulator of cardiovascular risk factors: A dose-finding study on
the effects of AGE on platelet functions. J Nutr. 131
(3S):980S–984S. 2001.PubMed/NCBI View Article : Google Scholar
|
|
129
|
Rahman K and Billington D: Dietary
supplementation with aged garlic extract inhibits ADP-induced
platelet aggregation in humans. J Nutr. 130:2662–2665.
2000.PubMed/NCBI View Article : Google Scholar
|
|
130
|
Macan H, Uykimpang R, Alconcel M, Takasu
J, Razon R, Amagase H and Niihara Y: Aged garlic extract may be
safe for patients on warfarin therapy. J Nutr. 136 (3
Suppl):793S–795S. 2006.PubMed/NCBI View Article : Google Scholar
|
|
131
|
Li Z, Delaney MK, O'Brien KA and Du X:
Signaling during platelet adhesion and activation. Arterioscler
Thromb Vasc Biol. 30:2341–2349. 2010.PubMed/NCBI View Article : Google Scholar
|
|
132
|
Yacoub D, Théorêt JF, Villeneuve L,
Abou-Saleh H, Mourad W, Allen BG and Merhi Y: Essential role of
protein kinase C delta in platelet signaling, alpha IIb beta 3
activation, and thromboxane A2 release. J Biol Chem.
281:30024–30035. 2006.PubMed/NCBI View Article : Google Scholar
|
|
133
|
Lannan KL, Sahler J, Kim N, Spinelli SL,
Maggirwar SB, Garraud O, Cognasse F, Blumberg N and Phipps RP:
Breaking the mold: Transcription factors in the anucleate platelet
and platelet-derived microparticles. Front Immunol.
6(48)2015.PubMed/NCBI View Article : Google Scholar
|
|
134
|
Morihara N and Hino A: Aged garlic extract
suppresses platelet aggregation by changing the functional property
of platelets. J Nat Med. 71:249–256. 2017.PubMed/NCBI View Article : Google Scholar
|
|
135
|
Allison GL, Lowe GM and Rahman K: Aged
garlic extract may inhibit aggregation in human platelets by
suppressing calcium mobilization. J Nutr. 136 (3 Suppl):789S–792S.
2006.PubMed/NCBI View Article : Google Scholar
|
|
136
|
Rahman K, Lowe GM and Smith S: Aged garlic
extract inhibits human platelet aggregation by altering
intracellular signaling and platelet shape change. J Nutr.
146:410S–415S. 2016.PubMed/NCBI View Article : Google Scholar
|
|
137
|
Allison GL, Lowe GM and Rahman K: Aged
garlic extract inhibits platelet activation by increasing
intracellular cAMP and reducing the interaction of GPIIb/IIIa
receptor with fibrinogen. Life Sci. 91:1275–1280. 2012.PubMed/NCBI View Article : Google Scholar
|
|
138
|
Qi R, Liao F, Inoue K, Yatomi Y, Sato K
and Ozaki Y: Inhibition by diallyl trisulfide, a garlic component,
of intracellular Ca(2+) mobilization without affecting
inositol-1,4, 5-trisphosphate [IP(3)] formation in activated
platelets. Biochem Pharmacol. 60:1475–1483. 2000.
|
|
139
|
Tian KJ, Yang Y, Chen GS, Deng NH, Tian Z,
Bai R, Zhang F and Jiang ZS: Omics research in atherosclerosis. Mol
Cell Biochem: Oct 24, 2024 (Epub ahead of print).
|
|
140
|
Duan M, Zhao WL, Zhou L, Novák P, Zhu X
and Yin K: Omics research in vascular calcification. Clin Chim
Acta. 511:319–328. 2020.PubMed/NCBI View Article : Google Scholar
|
|
141
|
Wu X and Zhang H: Omics approaches
unveiling the biology of human atherosclerotic plaques. Am J
Pathol. 194:482–498. 2024.PubMed/NCBI View Article : Google Scholar
|
|
142
|
Das V, Zhang X, Djordjevic D, Bergman Q,
Narayanan S, Shungin D, Chemaly M, Karadimou G, Vuckovic S, Prasad
I, et al: Multi-omics integration from a large human biobank
identifies key molecular mechanisms and signatures of
atherosclerotic plaque instability. Atherosclerosis. 395 (Suppl
1)(S117757)2024.
|
|
143
|
Sánchez-Cabo F, Fuster V, Silla-Castro JC,
González G, Lorenzo-Vivas E, Alvarez R, Callejas S, Benguría A, Gil
E, Núñez E, et al: Subclinical atherosclerosis and accelerated
epigenetic age mediated by inflammation: A multi-omics study. Eur
Heart J. 44:2698–2709. 2023.PubMed/NCBI View Article : Google Scholar
|
|
144
|
Kardassis D, Vindis C, Stancu CS, Toma L,
Gafencu AV, Georgescu A, Alexandru-Moise N, Molica F, Kwak BR,
Burlacu A, et al: Unravelling molecular mechanisms in
atherosclerosis using cellular models and omics technologies.
Vascul Pharmacol. 158(107452)2024.PubMed/NCBI View Article : Google Scholar : (Epub ahead of
print).
|