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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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June-2025 Volume 29 Issue 6

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Case Report

Lung cancer with diabetes mellitus and polymyalgia rheumatica during long‑term nivolumab treatment: A case report

  • Authors:
    • Makoto Nakao
    • Ayami Hirano
    • Masato Nakai
    • Syuntaro Hayashi
    • Mamiko Kuriyama
    • Norihisa Takeda
    • Hideki Muramatsu
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Kainan Hospital Aichi Prefectural Welfare Federation of Agricultural Cooperatives, Yatomi, Aichi 498‑8502, Japan
  • Article Number: 109
    |
    Published online on: April 2, 2025
       https://doi.org/10.3892/etm.2025.12859
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Abstract

A 54‑year‑old man was referred to Kainan hospital (Yatomi, Japan) in June 2014 with a chief complaint of right hip pain. Computed tomography showed a pelvic tumor and a nodule in the right upper lobe of the lung. After transbronchial lung tumor biopsy and full‑body screening, the patient was diagnosed with stage IV lung cancer. Epidermal growth factor receptor mutation and anaplastic lymphoma kinase fusion gene were not detected, and programmed cell death ligand 1 was negative. From July 2014, while undergoing radiotherapy to the right pelvic region, the patient also received combination therapy with carboplatin, paclitaxel and bevacizumab. The patient subsequently received pemetrexed monotherapy and docetaxel monotherapy, as well as radiotherapy, for right adrenal metastasis. From February 2019, the patient was administered nivolumab, which was effective, but 3 years and 3 months after the start of nivolumab treatment, he developed diabetes mellitus and insulin therapy was started. Then, 4 years and 5 months after the start of nivolumab, the patient developed polymyalgia rheumatica and was treated with prednisolone. The present study reports a rare case of diabetes mellitus and polymyalgia rheumatica in a patient with lung cancer who had received nivolumab treatment for more than 4 years.
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Copy and paste a formatted citation
Spandidos Publications style
Nakao M, Hirano A, Nakai M, Hayashi S, Kuriyama M, Takeda N and Muramatsu H: Lung cancer with diabetes mellitus and polymyalgia rheumatica during long‑term nivolumab treatment: A case report. Exp Ther Med 29: 109, 2025.
APA
Nakao, M., Hirano, A., Nakai, M., Hayashi, S., Kuriyama, M., Takeda, N., & Muramatsu, H. (2025). Lung cancer with diabetes mellitus and polymyalgia rheumatica during long‑term nivolumab treatment: A case report. Experimental and Therapeutic Medicine, 29, 109. https://doi.org/10.3892/etm.2025.12859
MLA
Nakao, M., Hirano, A., Nakai, M., Hayashi, S., Kuriyama, M., Takeda, N., Muramatsu, H."Lung cancer with diabetes mellitus and polymyalgia rheumatica during long‑term nivolumab treatment: A case report". Experimental and Therapeutic Medicine 29.6 (2025): 109.
Chicago
Nakao, M., Hirano, A., Nakai, M., Hayashi, S., Kuriyama, M., Takeda, N., Muramatsu, H."Lung cancer with diabetes mellitus and polymyalgia rheumatica during long‑term nivolumab treatment: A case report". Experimental and Therapeutic Medicine 29, no. 6 (2025): 109. https://doi.org/10.3892/etm.2025.12859
Copy and paste a formatted citation
x
Spandidos Publications style
Nakao M, Hirano A, Nakai M, Hayashi S, Kuriyama M, Takeda N and Muramatsu H: Lung cancer with diabetes mellitus and polymyalgia rheumatica during long‑term nivolumab treatment: A case report. Exp Ther Med 29: 109, 2025.
APA
Nakao, M., Hirano, A., Nakai, M., Hayashi, S., Kuriyama, M., Takeda, N., & Muramatsu, H. (2025). Lung cancer with diabetes mellitus and polymyalgia rheumatica during long‑term nivolumab treatment: A case report. Experimental and Therapeutic Medicine, 29, 109. https://doi.org/10.3892/etm.2025.12859
MLA
Nakao, M., Hirano, A., Nakai, M., Hayashi, S., Kuriyama, M., Takeda, N., Muramatsu, H."Lung cancer with diabetes mellitus and polymyalgia rheumatica during long‑term nivolumab treatment: A case report". Experimental and Therapeutic Medicine 29.6 (2025): 109.
Chicago
Nakao, M., Hirano, A., Nakai, M., Hayashi, S., Kuriyama, M., Takeda, N., Muramatsu, H."Lung cancer with diabetes mellitus and polymyalgia rheumatica during long‑term nivolumab treatment: A case report". Experimental and Therapeutic Medicine 29, no. 6 (2025): 109. https://doi.org/10.3892/etm.2025.12859
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