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Case Report Open Access

Pathophysiological mechanisms and benefits of SGLT‑2 inhibitors in a patient with cerebral artery aneurysm: A case report

  • Authors:
    • Oana-Andreea Parlițeanu
    • Roxana-Maria Nemes
    • Mara Amalia Balteanu
    • Daniel Radu
    • George Gherlan
  • View Affiliations

    Affiliations: Department of Diabetes, ‘Marius Nasta’ National Institute of Pneumology, 050159 Bucharest, Romania, Department of Pneumology, ‘Marius Nasta’ National Institute of Pneumology, 050159 Bucharest, Romania, Department of Emergency, Ilfov County Emergency Clinical Hospital, 022104 Bucharest, Romania, Department of Gastroenterology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania
  • Published online on: April 4, 2025     https://doi.org/10.3892/etm.2025.12862
  • Article Number: 112
  • Copyright: © Parlițeanu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study described the case of a 50‑year‑old male patient. The patient had type 2 diabetes since the age of 38 years (in 2013) with an initial elevated glycated hemoglobin A1c of 7.2%, with a significant cardiovascular (CV) history consisting of an aneurysm of the anterior communicating artery that had been operated on in 1998 and a ruptured basilar artery tip aneurysm embolized with a stent in 2013; the case was also associated with bronchiectasis (since 2020), non‑alcoholic fatty liver disease (since 2018), diabetic neuropathy (since 2023) and obesity with a body mass index of 31.72 kg/m2 (since 2010). Over the years the patient exhibited good metabolic control, initially treated with Metformin and managed through a change of diet. However, due to intolerance to Metformin, the patient stopped receiving treatments and only managed his diet. Since diabetes is by definition a condition that implies a high CV risk by itself, the primary focus with this patient was to provide additional CV protection, particularly secondary protection against any other potential future, and possibly fatal, CV events. After a brief introduction regarding the available therapeutic options, the case is presented along with the medical history, concomitant medications and evolution after 1 year. In the discussion section, similar documented cases in the literature were compared with the present case, and the potential effects of the therapeutic intervention in the present study were compared.
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Copy and paste a formatted citation
Spandidos Publications style
Parlițeanu O, Nemes R, Balteanu MA, Radu D and Gherlan G: Pathophysiological mechanisms and benefits of SGLT‑2 inhibitors in a patient with cerebral artery aneurysm: A case report. Exp Ther Med 29: 112, 2025.
APA
Parlițeanu, O., Nemes, R., Balteanu, M.A., Radu, D., & Gherlan, G. (2025). Pathophysiological mechanisms and benefits of SGLT‑2 inhibitors in a patient with cerebral artery aneurysm: A case report. Experimental and Therapeutic Medicine, 29, 112. https://doi.org/10.3892/etm.2025.12862
MLA
Parlițeanu, O., Nemes, R., Balteanu, M. A., Radu, D., Gherlan, G."Pathophysiological mechanisms and benefits of SGLT‑2 inhibitors in a patient with cerebral artery aneurysm: A case report". Experimental and Therapeutic Medicine 29.6 (2025): 112.
Chicago
Parlițeanu, O., Nemes, R., Balteanu, M. A., Radu, D., Gherlan, G."Pathophysiological mechanisms and benefits of SGLT‑2 inhibitors in a patient with cerebral artery aneurysm: A case report". Experimental and Therapeutic Medicine 29, no. 6 (2025): 112. https://doi.org/10.3892/etm.2025.12862
Copy and paste a formatted citation
x
Spandidos Publications style
Parlițeanu O, Nemes R, Balteanu MA, Radu D and Gherlan G: Pathophysiological mechanisms and benefits of SGLT‑2 inhibitors in a patient with cerebral artery aneurysm: A case report. Exp Ther Med 29: 112, 2025.
APA
Parlițeanu, O., Nemes, R., Balteanu, M.A., Radu, D., & Gherlan, G. (2025). Pathophysiological mechanisms and benefits of SGLT‑2 inhibitors in a patient with cerebral artery aneurysm: A case report. Experimental and Therapeutic Medicine, 29, 112. https://doi.org/10.3892/etm.2025.12862
MLA
Parlițeanu, O., Nemes, R., Balteanu, M. A., Radu, D., Gherlan, G."Pathophysiological mechanisms and benefits of SGLT‑2 inhibitors in a patient with cerebral artery aneurysm: A case report". Experimental and Therapeutic Medicine 29.6 (2025): 112.
Chicago
Parlițeanu, O., Nemes, R., Balteanu, M. A., Radu, D., Gherlan, G."Pathophysiological mechanisms and benefits of SGLT‑2 inhibitors in a patient with cerebral artery aneurysm: A case report". Experimental and Therapeutic Medicine 29, no. 6 (2025): 112. https://doi.org/10.3892/etm.2025.12862
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