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Case Report Open Access

Cryobiopsy for diagnosing acute fibrinous and organizing pneumonia during breast cancer treatment: A case report

  • Authors:
    • Susumu Tsunoda
    • Takahiro Mitsumura
    • Tatsuya Kato
    • Hiroshi Nakahama
    • Yuichiro Nei
    • Shigeo Hanada
    • Atsushi Miyamoto
    • Hironori Uruga
    • Takeshi Fujii
    • Yoko Kobayashi
    • Meiyo Tamaoka
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital, Minato‑ku, Tokyo 105‑8470, Japan, Department of Diagnostic Pathology, Toranomon Hospital, Minato‑ku, Tokyo 105‑8470, Japan, Department of Breast and Endocrinology Surgery, Toranomon Hospital, Minato‑ku, Tokyo 105‑8470, Japan
    Copyright: © Tsunoda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 115
    |
    Published online on: April 8, 2025
       https://doi.org/10.3892/etm.2025.12865
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Abstract

Current standard treatments for breast cancer have the potential to induce interstitial pneumonia. The present report describes a case of acute fibrinous and organizing pneumonia (AFOP) in a 52‑year‑old female patient undergoing adjuvant therapy with abemaciclib following breast cancer surgery. The patient received abemaciclib after completion of radiation therapy. On the 85th day of abemaciclib administration and 157th day after radiation therapy initiation, the patient presented with dyspnea. CT findings were indicative of interstitial pneumonitis, warranting hospitalization. During hospitalization, transbronchial lung cryobiopsy (TBLC) was performed, which revealed pathological findings consistent with AFOP. Following two 3‑day doses of 1 g intravenous methylprednisolone therapy, tacrolimus (2 mg/day) was administered and the patient was switched to oral prednisolone. The patient was discharged on the 25th day of hospitalization. Advances in bronchoscopic techniques, including TBLC, may aid in diagnosing lung injuries.
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1 

Johnston SRD, Harbeck N, Hegg R, Toi M, Martin M, Shao ZM, Zhang QY, Martinez Rodriguez JL, Campone M, Hamilton E, et al: Abemaciclib combined with endocrine therapy for the adjuvant treatment of HR+, HER2-, node-positive, high-risk, early breast cancer (monarchE). J Clin Oncol. 38:3987–3998. 2020.PubMed/NCBI View Article : Google Scholar

2 

Goetz MP, Toi M, Campone M, Sohn J, Paluch-Shimon S, Huober J, Park IH, Trédan O, Chen SC, Manso L, et al: MONARCH 3: Abemaciclib as initial therapy for advanced breast cancer. J Clin Oncol. 35:3638–3646. 2017.PubMed/NCBI View Article : Google Scholar

3 

Johnston S, Martin M, Di Leo A, Im SA, Awada A, Forrester T, Frenzel M, Hardebeck MC, Cox J, Barriga S, et al: MONARCH 3 final PFS: A randomized study of abemaciclib as initial therapy for advanced breast cancer. NPJ Breast Cancer. 17(5)2019.PubMed/NCBI View Article : Google Scholar

4 

Johnston S, O'Shaughnessy J, Martin M, Huober J, Toi M, Sohn J, André VAM, Martin HR, Hardebeck MC and Goetz MP: Abemaciclib as initial therapy for advanced breast cancer: MONARCH 3 updated results in prognostic subgroups. NPJ Breast Cancer. 7(80)2021.PubMed/NCBI View Article : Google Scholar

5 

Santos C, Oliveira RC, Serra P, Baptista JP, Sousa E, Casanova P, Pimentel J and Carvalho L: Pathophysiology of acute fibrinous and organizing pneumonia-Clinical and morphological spectra. Pathophysiology. 26:213–217. 2019.PubMed/NCBI View Article : Google Scholar

6 

Zhao X, Cheng Y, Xiong Y and Wang G: Pulmonary tuberculosis associated acute fibrinous and organizing pneumonia: A case report and literature review. Clin Respir J. 17:499–506. 2023.PubMed/NCBI View Article : Google Scholar

7 

Epler GR and Kelly EM: Systematic review of postradiotherapy bronchiolitis obliterans organizing pneumonia in women with breast cancer. Oncologist. 19:1216–1226. 2014.PubMed/NCBI View Article : Google Scholar

8 

Vasiljevic D, Arnold C, Neuman D, Fink K, Popovscaia M, Kvitsaridze I, Nevinny-Stickel M, Glatzer M, Lukas P and Seppi T: Occurrence of pneumonitis following radiotherapy of breast cancer-A prospective study. Strahlenther Onkol. 194:520–532. 2018.PubMed/NCBI View Article : Google Scholar

9 

Eggert MC, Yu NY and Rades D: Radiation dermatitis and pneumonitis in patients irradiated for breast cancer. In Vivo. 37:2654–2661. 2023.PubMed/NCBI View Article : Google Scholar

10 

Werner EM, Eggert MC, Bohnet S and Rades D: Prevalence and characteristics of pneumonitis following irradiation of breast cancer. Anticancer Res. 39:6355–6358. 2019.PubMed/NCBI View Article : Google Scholar

11 

Abdeltawab AA, Ali SA, Mostafa HG and Hassan MA: Predictive factors increasing the risk of radiation toxicity in patients with early breast cancer. Asian Pac J Cancer Prev. 22:145–149. 2021.PubMed/NCBI View Article : Google Scholar

12 

Sato H, Ebi J, Tamaki T, Yukawa A, Nakajima M, Ohtake T and Suzuki Y: Incidence of organizing pneumonia after whole-breast radiotherapy for breast cancer, and risk factor analysis. J Radiat Res. 298–302. 2018.PubMed/NCBI View Article : Google Scholar

13 

Wen G, Tan YT, Lan XW, He ZC, Huang JH, Shi JT, Lin X and Huang XB: New clinical features and dosimetric predictor identification for symptomatic radiation pneumonitis after tangential irradiation in breast cancer patients. J Cancer. 8:3795–3802. 2017.PubMed/NCBI View Article : Google Scholar

14 

Yu TK, Whitman GJ, Thames HD, Buzdar AU, Strom EA, Perkins GH, Schechter NR, McNeese MD and Kau SW: Clinically relevant pneumonitis after sequential paclitaxel-based chemotherapy and radiotherapy in breast cancer patients. J Natl Cancer Inst. 96:1676–1681. 2004.PubMed/NCBI View Article : Google Scholar

15 

Dörr W, Bertmann S and Herrmann T: Radiation induced lung reactions in breast cancer therapy: Modulating factors and consequential effects. Strahlenther Onkol. 181:567–573. 2005.PubMed/NCBI View Article : Google Scholar

16 

Jeba J, Isiah R, Subhashini J, Backianathan S, Thangakunam B and Christopher DJ: Radiation pneumonitis after conventional radiotherapy for breast cancer: A prospective study. J Clin Diagn Res. 9:XC01–XC05. 2015.PubMed/NCBI View Article : Google Scholar

17 

Zaizen Y, Tachibana Y, Ozasa M, Yamano Y, Takei R, Kohashi Y, Kataoka K, Saito Y, Tabata K, Okamoto M, et al: Sensitivity of transbronchial lung cryobiopsy in the diagnosis of different interstitial lung diseases. Sci Rep. 12(22037)2022.PubMed/NCBI View Article : Google Scholar

18 

Ramaswamy A, Homer R, Killam J, Pisani MA, Murphy TE, Araujo K and Puchalski J: Comparison of transbronchial and cryobiopsies in evaluation of diffuse parenchymal lung disease. J Bronchology Interv Pulmonol. 23:14–21. 2016.PubMed/NCBI View Article : Google Scholar

19 

Mathew N, Joel A, Andrews AG, John AO and Singh A: CDK 4/6 inhibitor induced lung injury: A case report and review of literature. Ecancermedicalscience. 15(1245)2021.PubMed/NCBI View Article : Google Scholar

20 

Kuza C, Matheos T, Kathman D and Heard SO: Life after acute fibrinous and organizing pneumonia: A case report of a patient 30 months after diagnosis and review of the literature. J Crit Care. 31:255–261. 2016.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Tsunoda S, Mitsumura T, Kato T, Nakahama H, Nei Y, Hanada S, Miyamoto A, Uruga H, Fujii T, Kobayashi Y, Kobayashi Y, et al: Cryobiopsy for diagnosing acute fibrinous and organizing pneumonia during breast cancer treatment: A case report. Exp Ther Med 29: 115, 2025.
APA
Tsunoda, S., Mitsumura, T., Kato, T., Nakahama, H., Nei, Y., Hanada, S. ... Tamaoka, M. (2025). Cryobiopsy for diagnosing acute fibrinous and organizing pneumonia during breast cancer treatment: A case report. Experimental and Therapeutic Medicine, 29, 115. https://doi.org/10.3892/etm.2025.12865
MLA
Tsunoda, S., Mitsumura, T., Kato, T., Nakahama, H., Nei, Y., Hanada, S., Miyamoto, A., Uruga, H., Fujii, T., Kobayashi, Y., Tamaoka, M."Cryobiopsy for diagnosing acute fibrinous and organizing pneumonia during breast cancer treatment: A case report". Experimental and Therapeutic Medicine 29.6 (2025): 115.
Chicago
Tsunoda, S., Mitsumura, T., Kato, T., Nakahama, H., Nei, Y., Hanada, S., Miyamoto, A., Uruga, H., Fujii, T., Kobayashi, Y., Tamaoka, M."Cryobiopsy for diagnosing acute fibrinous and organizing pneumonia during breast cancer treatment: A case report". Experimental and Therapeutic Medicine 29, no. 6 (2025): 115. https://doi.org/10.3892/etm.2025.12865
Copy and paste a formatted citation
x
Spandidos Publications style
Tsunoda S, Mitsumura T, Kato T, Nakahama H, Nei Y, Hanada S, Miyamoto A, Uruga H, Fujii T, Kobayashi Y, Kobayashi Y, et al: Cryobiopsy for diagnosing acute fibrinous and organizing pneumonia during breast cancer treatment: A case report. Exp Ther Med 29: 115, 2025.
APA
Tsunoda, S., Mitsumura, T., Kato, T., Nakahama, H., Nei, Y., Hanada, S. ... Tamaoka, M. (2025). Cryobiopsy for diagnosing acute fibrinous and organizing pneumonia during breast cancer treatment: A case report. Experimental and Therapeutic Medicine, 29, 115. https://doi.org/10.3892/etm.2025.12865
MLA
Tsunoda, S., Mitsumura, T., Kato, T., Nakahama, H., Nei, Y., Hanada, S., Miyamoto, A., Uruga, H., Fujii, T., Kobayashi, Y., Tamaoka, M."Cryobiopsy for diagnosing acute fibrinous and organizing pneumonia during breast cancer treatment: A case report". Experimental and Therapeutic Medicine 29.6 (2025): 115.
Chicago
Tsunoda, S., Mitsumura, T., Kato, T., Nakahama, H., Nei, Y., Hanada, S., Miyamoto, A., Uruga, H., Fujii, T., Kobayashi, Y., Tamaoka, M."Cryobiopsy for diagnosing acute fibrinous and organizing pneumonia during breast cancer treatment: A case report". Experimental and Therapeutic Medicine 29, no. 6 (2025): 115. https://doi.org/10.3892/etm.2025.12865
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