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Examining the effect of Kuntai capsule combined with HRT in the treatment of premature ovarian insufficiency: A systematic review and meta‑analysis

  • Authors:
    • Fengning Lin
    • Junyu Lian
    • Lijing Wu
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350000, P.R. China
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 116
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    Published online on: April 9, 2025
       https://doi.org/10.3892/etm.2025.12866
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Abstract

While Chinese herbal medicines have been used to treat premature ovarian insufficiency (POI), their efficacy is currently unclear. The present study aimed to review and evaluate the efficacy of the Kuntai capsule combined with hormone replacement therapy (HRT) in treating POI. The China National Knowledge Infrastructure, WanFang, Chinese Biomedical Literature, PubMed, Embase and Cochrane Library databases were searched from the inception of the database to 25th October 2020, for studies comparing the therapeutic effect of Kuntai capsule combined with HRT vs. HRT alone in women with POI. The Cochrane Risk of Bias assessment tool was used to assess the quality of the studies, and the results were reported as weighted mean differences (MD) with 95% confidence intervals (CI). The present study included 10 trials involving 742 women with POI. When compared with HRT alone, HRT combined with Kuntai capsule significantly increased the number of antral follicles (AFC) (MD=0.88; 95% CI, 0.48‑1.29; P<0.00001), anti‑Müllerian hormone (AMH) levels (MD=0.24, 95% CI, 0.13 to 0.35, P<0.00001) and significantly improved peri‑menopausal symptoms [MD=‑2.26; 95% CI, ‑3.77‑(‑0.75); P=0.003]. The combined treatment regimen significantly decreased the levels of follicle‑stimulating hormone [MD=‑5.60; 95% CI, ‑7.98‑(‑3.22); P<0.00001] and luteinizing hormone [MD=‑2.42; 95% CI, ‑3.40‑(‑1.44), P<0.00001] and significantly increased the level of estradiol (MD=13.94; 95% CI, 4.16‑23.71; P<0.00001). Therefore, the Kuntai capsule combined with HRT could potentially be used as a supplementary therapy to alleviate menstrual disorders and peri‑menopausal symptoms and improve serum sex hormone levels in women with POI. The observed increase in the number of AFC in patients with POI treated with the combined therapy was indicative of improved ovarian reserve function. Therefore, combining the Kuntai capsule and HRT had am improved curative effect for POI treatment compared with HRT alone. However, as the present study was limited by the quality of the included reports, additional high‑quality studies with extensive sample sizes are required to verify the findings.
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Copy and paste a formatted citation
Spandidos Publications style
Lin F, Lian J and Wu L: Examining the effect of Kuntai capsule combined with HRT in the treatment of premature ovarian insufficiency: A systematic review and meta‑analysis. Exp Ther Med 29: 116, 2025.
APA
Lin, F., Lian, J., & Wu, L. (2025). Examining the effect of Kuntai capsule combined with HRT in the treatment of premature ovarian insufficiency: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 29, 116. https://doi.org/10.3892/etm.2025.12866
MLA
Lin, F., Lian, J., Wu, L."Examining the effect of Kuntai capsule combined with HRT in the treatment of premature ovarian insufficiency: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 29.6 (2025): 116.
Chicago
Lin, F., Lian, J., Wu, L."Examining the effect of Kuntai capsule combined with HRT in the treatment of premature ovarian insufficiency: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 29, no. 6 (2025): 116. https://doi.org/10.3892/etm.2025.12866
Copy and paste a formatted citation
x
Spandidos Publications style
Lin F, Lian J and Wu L: Examining the effect of Kuntai capsule combined with HRT in the treatment of premature ovarian insufficiency: A systematic review and meta‑analysis. Exp Ther Med 29: 116, 2025.
APA
Lin, F., Lian, J., & Wu, L. (2025). Examining the effect of Kuntai capsule combined with HRT in the treatment of premature ovarian insufficiency: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 29, 116. https://doi.org/10.3892/etm.2025.12866
MLA
Lin, F., Lian, J., Wu, L."Examining the effect of Kuntai capsule combined with HRT in the treatment of premature ovarian insufficiency: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 29.6 (2025): 116.
Chicago
Lin, F., Lian, J., Wu, L."Examining the effect of Kuntai capsule combined with HRT in the treatment of premature ovarian insufficiency: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 29, no. 6 (2025): 116. https://doi.org/10.3892/etm.2025.12866
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