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Fenofibrate prevents myocardial inflammation and fibrosis via PPARα/IκBζ signaling pathway in rat autoimmune myocarditis

  • Authors:
    • He Chang
    • Yue Wang
    • Yang Wu
    • Song-Lin Shi
    • Zhi Qi
  • View Affiliations / Copyright

    Affiliations: Department of Geriatrics, Xiang'an Hospital of Xiamen University, Xiamen, Fujian 361100, P.R. China, Department of Basic Medical Sciences, School of Medicine, Xiamen University, Xiamen, Fujian 361102, P.R. China
    Copyright: © Chang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 128
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    Published online on: May 6, 2025
       https://doi.org/10.3892/etm.2025.12879
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Abstract

Fenofibrate is a peroxisome proliferator‑activated receptor α (PPARα) agonist currently utilized clinically to reduce lipid levels. Experimental autoimmune myocarditis (EAM) is a T cell‑mediated autoimmune myocarditis with histopathological evidence of extensive inflammatory cells infiltrated into the myocardium, resulting in myocardial fibrosis. Previously, the authors demonstrated that long‑term fenofibrate could alleviate rat EAM; however, the underlying mechanism remains unclear. In the present study, EAM was induced in rats and fenofibrate was administered to evaluate its short‑term effects. The CD4(+) T cells were purified from rats with EAM and PPARα (‑/‑) mice and determined the levels of IκBζ, pNF‑κBp65 and IL‑6. The findings of the present study revealed that fenofibrate treatment improved the progression of EAM in rats, as evidenced by a decreased ratio of the heart weight to body weight, reduced inflammatory cell infiltration, and relieved cardiac function. It also inhibited the transcription levels of T helper 17 (Th17)‑related inflammatory cytokines, fibrosis‑associated factors, and the expression of IκBζ, and dose‑dependently downregulated IκBζ expression in differentiated Th17 cells from rats with EAM. The PPARα antagonist MK886 could reverse the effects in a dose‑dependent manner. PPARα deficiency significantly upregulated IκBζ and pNF‑κBp65 expression in the CD4(+) T cells of PPARα (‑/‑) mice. PPARα activation by three different PPARα agonists significantly inhibited IκBζ and IL‑6 levels. The results suggested that IκBζ plays an important role in the pathogenesis of autoimmune myocarditis, and fenofibrate treatment ameliorates EAM by preventing myocardial inflammation and fibrosis, possibly through the PPARα/IκBζ signaling pathway.
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1 

Manoharan I, Suryawanshi A, Hong Y, Ranganathan P, Shanmugam A, Ahmad S, Swafford D, Manicassamy B, Ramesh G, Koni PA, et al: Homeostatic PPARα signaling limits inflammatory responses to commensal microbiota in the intestine. J Immunol. 196:4739–4749. 2016.PubMed/NCBI View Article : Google Scholar

2 

Riaz F, Wei P and Pan F: PPARs at the crossroads of T cell differentiation and type 1 diabetes. Front Immunol. 14(1292238)2023.PubMed/NCBI View Article : Google Scholar

3 

Balakumar P, Rohilla A and Mahadevan N: Pleiotropic actions of fenofibrate on the heart. Pharmacol Res. 63:8–12. 2011.PubMed/NCBI View Article : Google Scholar

4 

Kodama M, Matsumoto Y, Fujiwara M, Masani F, Izumi T and Shibata A: A novel experimental model of giant cell myocarditis induced in rats by immunization with cardiac myosin fraction. Clin Immunol Immunopathol. 57:250–262. 1990.PubMed/NCBI View Article : Google Scholar

5 

Zhong C, Wu Y, Chang H, Liu C, Zhou L, Zou J and Qi Z: Effect of PKC inhibitor on experimental autoimmune myocarditis in Lewis rats. Oncotarget. 8:54187–54198. 2017.PubMed/NCBI View Article : Google Scholar

6 

Zhong C, Chang H, Wu Y, Zhou L, Wang Y, Wang M, Wu P, Qi Z and Zou J: Up-regulated Cx43 phosphorylation at Ser368 prolongs QRS duration in myocarditis. J Cell Mol Med. 22:3537–3547. 2018.PubMed/NCBI View Article : Google Scholar

7 

Cheng H, Xi Y, Chi X, Wu Y and Liu G: Fenofibrate treatment of rats with experimental autoimmune myocarditis by alleviating Treg/Th17 disorder. Cent Eur J Immunol. 41:64–70. 2016.PubMed/NCBI View Article : Google Scholar

8 

Maruyama S, Kato K, Kodama M, Hirono S, Fuse K, Nakagawa O, Nakazawa M, Miida T, Yamamoto T, Watanabe K and Aizawa Y: Fenofibrate, a peroxisome proliferator-activated receptor alpha activator, suppresses experimental autoimmune myocarditis by stimulating the interleukin-10 pathway in rats. J Atheroscler Thromb. 9:87–92. 2002.PubMed/NCBI View Article : Google Scholar

9 

Chang H, Zhao F, Xie X, Liao Y, Song Y, Liu C, Wu Y, Wang Y, Liu D, Wang Y, et al: PPARα suppresses Th17 cell differentiation through IL-6/STAT3/RORγt pathway in experimental autoimmune myocarditis. Exp Cell Res. 375:22–30. 2019.PubMed/NCBI View Article : Google Scholar

10 

Chang H, Wang Y, Wu Y, Ma P, Song Y, Liu C, Ye Y, Qi JH and Qi Z: Cardiac apoptosis caused by elevated cholesterol level in experimental autoimmune myocarditis. Exp Cell Res. 395(112169)2020.PubMed/NCBI View Article : Google Scholar

11 

Feng Y, Chen Z, Xu Y, Han Y, Jia X, Wang Z, Zhang N and Lv W: The central inflammatory regulator IκBζ: Induction, regulation and physiological functions. Front Immunol. 14(1188253)2023.PubMed/NCBI View Article : Google Scholar

12 

Hövelmeyer N, Schmidt-Supprian M and Ohnmacht C: NF-κB in control of regulatory T cell development, identity, and function. J Mol Med (Berl). 100:985–995. 2022.PubMed/NCBI View Article : Google Scholar

13 

Kakiuchi N, Yoshida K, Uchino M, Kihara T, Akaki K, Inoue Y, Kawada K, Nagayama S, Yokoyama A, Yamamoto S, et al: Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis. Nature. 577:260–265. 2020.PubMed/NCBI View Article : Google Scholar

14 

Choi MC, MaruYama T, Chun CH and Park Y: Alleviation of murine osteoarthritis by cartilage-specific deletion of IκBζ. Arthritis Rheumatol. 70:1440–1449. 2018.PubMed/NCBI View Article : Google Scholar

15 

Bambouskova M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, Korenfeld D, Mathyer ME, Kim H, Huang LH, et al: Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis. Nature. 556:501–504. 2018.PubMed/NCBI View Article : Google Scholar

16 

Slowikowski K, Nguyen HN, Noss EH, Simmons DP, Mizoguchi F, Watts GFM, Gurish MF, Brenner MB and Raychaudhuri S: CUX1 and IκBζ (NFKBIZ) mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblasts. Proc Natl Acad Sci USA. 117:5532–5541. 2020.PubMed/NCBI View Article : Google Scholar

17 

Rao X, Huang X, Zhou Z and Lin X: An improvement of the 2ˆ(-delta delta CT) method for quantitative real-time polymerase chain reaction data analysis. Biostat Bioinforma Biomath. 3:71–85. 2013.PubMed/NCBI

18 

Bansal T, Chatterjee E, Singh J, Ray A, Kundu B, Thankamani V, Sengupta S and Sarkar S: Arjunolic acid, a peroxisome proliferator-activated receptor α agonist, regresses cardiac fibrosis by inhibiting non-canonical TGF-β signaling. J Biol Chem. 292:16440–16462. 2017.PubMed/NCBI View Article : Google Scholar

19 

Yamazaki S: The nuclear NF-κB regulator IκBζ: Updates on its molecular functions and pathophysiological roles. Cells. 13(1467)2024.PubMed/NCBI View Article : Google Scholar

20 

Hawkes JE, Yan BY, Chan TC and Krueger JG: Discovery of the IL-23/IL-17 signaling pathway and the treatment of psoriasis. J Immunol. 201:1605–1613. 2018.PubMed/NCBI View Article : Google Scholar

21 

Park A and Heo TH: IL-17A-targeting fenofibrate attenuates inflammation in psoriasis by inducing autophagy. Life Sci. 326(121755)2023.PubMed/NCBI View Article : Google Scholar

22 

Elaidy SM, Essawy SS, Hussain MA, El-Kherbetawy MK and Hamed ER: Modulation of the IL-23/IL-17 axis by fenofibrate ameliorates the ovalbumin/lipopolysaccharide-induced airway inflammation and bronchial asthma in rats. Naunyn Schmiedebergs Arch Pharmacol. 391:309–321. 2018.PubMed/NCBI View Article : Google Scholar

23 

Cao JW, Duan SY, Zhang HX, Chen Y and Guo M: Zinc deficiency promoted fibrosis via ROS and TIMP/MMPs in the myocardium of mice. Biol Trace Elem Res. 196:145–152. 2020.PubMed/NCBI View Article : Google Scholar

24 

Zhang Y, Ji H, Qiao O, Li Z, Pecoraro L, Zhang X, Han X, Wang W, Zhang X, Man S, et al: Nanoparticle conjugation of ginsenoside Rb3 inhibits myocardial fibrosis by regulating PPARα pathway. Biomed Pharmacother. 139(111630)2021.PubMed/NCBI View Article : Google Scholar

25 

Qiu Z, Zhao Y, Tao T, Guo W, Liu R, Huang J and Xu G: Activation of PPARα ameliorates cardiac fibrosis in Dsg2-deficient arrhythmogenic cardiomyopathy. Cells. 11(3184)2022.PubMed/NCBI View Article : Google Scholar

26 

Bertelsen T, Ljungberg C, Litman T, Huppertz C, Hennze R, Rønholt K, Iversen L and Johansen C: IκBζ is a key player in the antipsoriatic effects of secukinumab. J Allergy Clin Immunol. 145:379–90. 2020.PubMed/NCBI View Article : Google Scholar

27 

Gautam P, Maenner S, Cailotto F, Reboul P, Labialle S, Jouzeau JY, Bourgaud F and Moulin D: Emerging role of IκBζ in inflammation: Emphasis on psoriasis. Clin Transl Med. 12(e1032)2022.PubMed/NCBI View Article : Google Scholar

28 

Bertelsen T, Iversen L and Johansen C: The human IL-17A/F heterodimer regulates psoriasis-associated genes through IκBζ. Exp Dermatol. 27:1048–1052. 2018.PubMed/NCBI View Article : Google Scholar

29 

Mok BR, Kim AR, Baek SH, Ahn JH, Seok SH, Shin JU and Kim DH: PFN1 prevents psoriasis pathogenesis through IκBζ regulation. J Invest Dermatol. 142:2455–2463.e9. 2022.PubMed/NCBI View Article : Google Scholar

30 

Mills KHG: IL-17 and IL-17-producing cells in protection versus pathology. Nat Rev Immunol. 23:38–54. 2023.PubMed/NCBI View Article : Google Scholar

31 

Ohto-Ozaki H, Hayakawa M, Kamoshita N, Maruyama T, Tominaga SI and Ohmori T: Induction of IκBζ augments cytokine and chemokine production by IL-33 in mast cells. J Immunol. 204:2033–2042. 2020.PubMed/NCBI View Article : Google Scholar

32 

Yamamoto M, Yamazaki S, Uematsu S, Sato S, Hemmi H, Hoshino K, Kaisho T, Kuwata H, Takeuchi O, Takeshige K, et al: Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. Nature. 430:218–222. 2004.PubMed/NCBI View Article : Google Scholar

33 

Lorscheid S, Müller A, Löffler J, Resch C, Bucher P, Kurschus FC, Waisman A, Schäkel K, Hailfinger S, Schulze-Osthoff K and Kramer D: Keratinocyte-derived IκBζ drives psoriasis and associated systemic inflammation. JCI Insight. 4(e130835)2019.PubMed/NCBI View Article : Google Scholar

34 

Muromoto R, Sato A, Komori Y, Nariya K, Kitai Y, Kashiwakura JI and Matsuda T: Regulation of NFKBIZ gene promoter activity by STAT3, C/EBPβ, and STAT1. Biochem Biophys Res Commun. 613:61–66. 2022.PubMed/NCBI View Article : Google Scholar

35 

Wang J, Liu T, Chen X, Jin Q, Chen Y, Zhang L, Han Z, Chen D, Li Y, Lv Q and Xie M: Bazedoxifene regulates Th17 immune response to ameliorate experimental autoimmune myocarditis via inhibition of STAT3 activation. Front Pharmacol. 11(613160)2021.PubMed/NCBI View Article : Google Scholar

36 

Zhou Z, Sun W, Liang Y, Gao Y, Kong W, Guan Y, Feng J and Wang X: Fenofibrate inhibited the differentiation of T helper 17 cells in vitro. PPAR Res. 2012(145654)2012.PubMed/NCBI View Article : Google Scholar

37 

Muromoto R, Tawa K, Ohgakiuchi Y, Sato A, Saino Y, Hirashima K, Minoguchi H, Kitai Y, Kashiwakura JI, Shimoda K, et al: IκB-ζ expression requires both TYK2/STAT3 activity and IL-17-regulated mRNA stabilization. Immunohorizons. 3:172–185. 2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Chang H, Wang Y, Wu Y, Shi S and Qi Z: Fenofibrate prevents myocardial inflammation and fibrosis via PPARα/IκBζ signaling pathway in rat autoimmune myocarditis. Exp Ther Med 30: 128, 2025.
APA
Chang, H., Wang, Y., Wu, Y., Shi, S., & Qi, Z. (2025). Fenofibrate prevents myocardial inflammation and fibrosis via PPARα/IκBζ signaling pathway in rat autoimmune myocarditis. Experimental and Therapeutic Medicine, 30, 128. https://doi.org/10.3892/etm.2025.12879
MLA
Chang, H., Wang, Y., Wu, Y., Shi, S., Qi, Z."Fenofibrate prevents myocardial inflammation and fibrosis via PPARα/IκBζ signaling pathway in rat autoimmune myocarditis". Experimental and Therapeutic Medicine 30.1 (2025): 128.
Chicago
Chang, H., Wang, Y., Wu, Y., Shi, S., Qi, Z."Fenofibrate prevents myocardial inflammation and fibrosis via PPARα/IκBζ signaling pathway in rat autoimmune myocarditis". Experimental and Therapeutic Medicine 30, no. 1 (2025): 128. https://doi.org/10.3892/etm.2025.12879
Copy and paste a formatted citation
x
Spandidos Publications style
Chang H, Wang Y, Wu Y, Shi S and Qi Z: Fenofibrate prevents myocardial inflammation and fibrosis via PPARα/IκBζ signaling pathway in rat autoimmune myocarditis. Exp Ther Med 30: 128, 2025.
APA
Chang, H., Wang, Y., Wu, Y., Shi, S., & Qi, Z. (2025). Fenofibrate prevents myocardial inflammation and fibrosis via PPARα/IκBζ signaling pathway in rat autoimmune myocarditis. Experimental and Therapeutic Medicine, 30, 128. https://doi.org/10.3892/etm.2025.12879
MLA
Chang, H., Wang, Y., Wu, Y., Shi, S., Qi, Z."Fenofibrate prevents myocardial inflammation and fibrosis via PPARα/IκBζ signaling pathway in rat autoimmune myocarditis". Experimental and Therapeutic Medicine 30.1 (2025): 128.
Chicago
Chang, H., Wang, Y., Wu, Y., Shi, S., Qi, Z."Fenofibrate prevents myocardial inflammation and fibrosis via PPARα/IκBζ signaling pathway in rat autoimmune myocarditis". Experimental and Therapeutic Medicine 30, no. 1 (2025): 128. https://doi.org/10.3892/etm.2025.12879
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