Open Access

Advances in the molecular signaling mechanisms of VEGF/VEGFR2 in fundus neovascularization disease (Review)

  • Authors:
    • Huan Shen Li
    • Xiong Gao Huang
  • View Affiliations

  • Published online on: May 20, 2025     https://doi.org/10.3892/etm.2025.12893
  • Article Number: 143
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Fundus neovascularization disease is a blinding eye disease, and represents an umbrella term for a group of disorders in which VEGF and its receptor VEGFR2 play important roles in promoting neovascularization. Compared with physiological angiogenesis, pathological angiogenesis involves several different regulatory mechanisms, vascular structures and functions, as well as microenvironmental effects. Although the role of VEGF and its receptor in angiogenesis is well documented, research on its major molecular signaling mechanisms is limited. In the present review, a basic overview of the VEGF and VEGFR2 pathways, including their downstream signaling mechanisms and the latest therapeutic advances in the context of fundus neovascularization disease, is provided, and the limitations and future perspectives of current anti‑VEGF therapies are discussed. Overall, the purpose of the current review is to provide information on the molecular signaling mechanisms associated with VEGF and VEGFR2 and to perform an in‑depth examination of these molecular signaling pathways and their interaction mechanisms. These interaction mechanisms are expected to facilitate the development of more targeted and long‑lasting therapeutic regimens and provide novel concepts for the treatment of fundus neovascularization disease.
View Figures
View References

Related Articles

Journal Cover

July-2025
Volume 30 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li HS and Huang XG: Advances in the molecular signaling mechanisms of VEGF/VEGFR2 in fundus neovascularization disease (Review). Exp Ther Med 30: 143, 2025.
APA
Li, H.S., & Huang, X.G. (2025). Advances in the molecular signaling mechanisms of VEGF/VEGFR2 in fundus neovascularization disease (Review). Experimental and Therapeutic Medicine, 30, 143. https://doi.org/10.3892/etm.2025.12893
MLA
Li, H. S., Huang, X. G."Advances in the molecular signaling mechanisms of VEGF/VEGFR2 in fundus neovascularization disease (Review)". Experimental and Therapeutic Medicine 30.1 (2025): 143.
Chicago
Li, H. S., Huang, X. G."Advances in the molecular signaling mechanisms of VEGF/VEGFR2 in fundus neovascularization disease (Review)". Experimental and Therapeutic Medicine 30, no. 1 (2025): 143. https://doi.org/10.3892/etm.2025.12893