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Case Report

Superficial spreading squamous cell carcinoma of the cervix involving the endometrium: A case report and literature review

  • Authors:
    • Sirui Song
    • Heng Zheng
    • Xiang He
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610045, P.R. China
  • Article Number: 185
    |
    Published online on: August 5, 2025
       https://doi.org/10.3892/etm.2025.12935
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Abstract

Superficial spreading cervical squamous cell carcinoma (SCC) constitutes a relatively uncommon subtype of cervical cancer, distinguished by the replacement of the endometrium and, in some instances, the epithelial lining of the fallopian tubes with cervical SCC cells that are contiguous with the primary cervical lesion. The present study describes a case involving a 76‑year‑old patient who primarily exhibited symptoms of abdominal pain and pyometra. During a routine cervical ThinPrep cytologic test, which was conducted while the patient was undergoing anti‑infective treatment, high‑grade squamous intraepithelial lesion of the cervix was detected. Following the surgical procedure of total hysterectomy with bilateral salpingo‑oophorectomy, pathological examination indicated a diagnosis of superficial spreading SCC of the cervix, with extensive involvement of the endometrial lining and the mucosal layer of the interstitial portions of both fallopian tubes. This rare case is a reminder that in elderly patients with pyometra where cervical biopsy only indicates cervical intraepithelial neoplasia, merely administering anti‑infective treatment or performing cervical conization may lead to a missed diagnosis of superficial spreading cervical SCC. Currently, there are no standardized diagnostic and therapeutic approaches for superficial spreading cervical SCC. In the present case, radiotherapy was administrated to the patient to delay recurrence. Large‑sample studies are crucial for improving the understanding of this tumor and facilitating advancements in precision medicine treatments.
View Figures

Figure 1

(A) Ultrasound image, with a red arrow
indicating the uterine cavity. (B) H&E staining of cervical
squamous cell carcinoma in situ (magnification, x40). (C)
SCC of the endometrium in situ (H&E; magnification,
x40). (D) SCC in situ of the interstitial region of the
fallopian tubes (H&E; magnification, x40). Scale bars, 200 µm.
Black arrows indicate the lesion. SCC, squamous cell carcinoma.

Figure 2

Immunohistochemical staining for (A)
p16 and (B) Ki-67 in the cervix. Scale bar, 200 µm.
View References

1 

Global Burden of Disease Cancer Collaboration. Fitzmaurice C, Akinyemiju TF, Al Lami FH, Alam T, Alizadeh-Navaei R, Allen C, Alsharif U, Alvis-Guzman N, Amini E, et al: Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990 to 2016: A systematic analysis for the global burden of disease study. JAMA Oncol. 4:1553–1568. 2018.PubMed/NCBI View Article : Google Scholar

2 

Martin-Hirsch PP, Paraskevaidis E, Bryant A, Dickinson HO and Keep SL: Surgery for cervical intraepithelial neoplasia. Cochrane Database Syst Rev: CD001318, 2010.

3 

National Comprehensive Cancer Network (NCCN): NCCN Clinical Practice Guidelines in Oncology: Cervical Cancer (Version 1.2025). NCCN, Plymouth Meeting, PA, 2024.

4 

Siegel RL, Miller KD, Fuchs HE and Jemal A: Cancer statistics, 2021. CA Cancer J Clin. 71:7–33. 2021.PubMed/NCBI View Article : Google Scholar

5 

Lifshitz SG and Buchsbaum HJ: Spread of cervical carcinoma. Obstet Gynecol Annu. 6:341–354. 1977.PubMed/NCBI

6 

Rangankar V, Bokil S and Deshmukh S: Superficial spread of nonkeratinizing squamous cell carcinoma of the cervix to the endometrium: A case report. Cureus. 16(e63931)2024.PubMed/NCBI View Article : Google Scholar

7 

Hallgrímsson JT: Carcinoma in situ of the endocervix, corpus uteri and both oviducts. Acta Obstet Gynecol Scand. 46:268–272. 1967.PubMed/NCBI

8 

Salm R: Superficial intra-uterine spread of intra-epithelial cervical carcinoma. J Pathol. 97:719–723. 1969.PubMed/NCBI View Article : Google Scholar

9 

van Meurs H, Visser O, Buist MR, Ten Kate FJW and van der Velden J: Frequency of pelvic lymph node metastases and parametrial involvement in stage IA2 cervical cancer: A population-based study and literature review. Int J Gynecol Cancer. 19:21–26. 2009.PubMed/NCBI View Article : Google Scholar

10 

Costa S, Marra E, Martinelli GN, Santini D, Casadio P, Formelli G, Pelusi C, Ghi T, Syrjänen K and Pelusi G: Outcome of conservatively treated microinvasive squamous cell carcinoma of the uterine cervix during a 10-year follow-up. Int J Gynecol Cancer. 19:33–38. 2009.PubMed/NCBI View Article : Google Scholar

11 

Razquin S, Mayayo E, Antón E and Alvira R: Squamous cell carcinoma in situ of the endometrium as superficial extension of cervical carcinoma. Gynecol Obstet Invest. 35:190–1902. 1993.PubMed/NCBI View Article : Google Scholar

12 

Pins MR, Young RH, Crum CP, Leach IH and Scully RE: Cervical squamous cell carcinoma in situ with intraepithelial extension to the upper genital tract and invasion of tubes and ovaries: Report of a case with human papilloma virus analysis. Int J Gynecol Pathol. 16:272–278. 1997.PubMed/NCBI View Article : Google Scholar

13 

Kushima M, Fujii H, Murakami K, Ota H, Matsumoto T, Motoyama T, Kiyokawa T and Ishikura H: Simultaneous squamous cell carcinomas of the uterine cervix and upper genital tract: Loss of heterozygosity analysis demonstrates clonal neoplasms of cervical origin. Int J Gynecol Pathol. 20:353–358. 2001.PubMed/NCBI View Article : Google Scholar

14 

Tan GC, Isa MR, Ng SP and Jamil YMA: Unusual form of superficial spreading microinvasive squamous cell carcinoma of uterine cervix involving the endometrium of uterus. J Obstet Gynaecol Res. 30:363–367. 2004.PubMed/NCBI View Article : Google Scholar

15 

Anthuenis J, Baekelandt J, Bourgain C and De Rop C: Squamous cell carcinoma in situ lining the uterine cavity. Eur J Gynaecol Oncol. 37:135–138. 2016.PubMed/NCBI

16 

Nakajima T, Hatta H, Nishida T, Minamisaka T, Miwa S, Terahata S and Imura J: Superficial spread of cervical squamous cell carcinoma to the upper genital tract and dissemination to the omentum. Pathol Int. 69:119–121. 2019.PubMed/NCBI View Article : Google Scholar

17 

Wang W and Zhou F: Cervical HSIL involving the endometrium and adenomyosis: A case report and literature review. J Coll Physicians Surg Pak. 31:337–339. 2021.PubMed/NCBI View Article : Google Scholar

18 

Martín-Vallejo J, Laforga JB, Molina-Bellido P and Clemente-Pérez PA: Superficial spreading cervical squamous cell carcinoma in situ involving the endometrium: A case report and review of the literature. J Med Case Rep. 16(196)2022.PubMed/NCBI View Article : Google Scholar

19 

Shu XY, Dai Z, Zhang S, Yang HX and Bi H: Endometrial squamous cell carcinoma originating from the cervix: A case report. World J Clin Cases. 10:8782–8787. 2022.PubMed/NCBI View Article : Google Scholar

20 

Agusti N, Viveros-Carreño D, Wu CF, Wilke RN, Kanbergs A, Barajas K, Zamorano AS, Pareja R, Melamed A and Rauh-Hain JA: Adjuvant chemoradiotherapy vs radiotherapy alone for patients with intermediate-risk cervical cancer. JAMA Oncol. 11:511–518. 2025.PubMed/NCBI View Article : Google Scholar

21 

Ishida M and Okabe H: Superficial spreading squamous cell carcinoma of the uterine cervix involving the endometrium: Report of two cases with emphasis on the likely molecular mechanism. Oncol Lett. 5:31–34. 2013.PubMed/NCBI View Article : Google Scholar

22 

Zhang Y, Zhang X, Wang H and Shen D: Stage IA1 HPV-associated cervical squamous cell carcinoma metastasizing to ovary by special pathway: A case report and literature review. J Ovarian Res. 15(21)2022.PubMed/NCBI View Article : Google Scholar

23 

Wu PJ, Tsai SCS, Huang JY, Lee MS, Wang PH and Lin FCF: From infection to malignancy: Tracing the impact of human papillomavirus on uterine endometrial cancer in a nationwide population-based cohort study. Viruses. 15(2314)2023.PubMed/NCBI View Article : Google Scholar

24 

Darré T, Aboubakari AS, Sonhaye L, Douaguibe B, Bassowa A and Napo-Koura G: Primary squamous cell carcinoma of the endometrium associated with human papilloma virus in a young woman: A case report. J Med Case Rep. 13(167)2019.PubMed/NCBI View Article : Google Scholar

25 

Jiang X, Han Z, Chun Z, Wen B and Chen T: An unusual pattern of endometrial involvement: Superficial spreading squamous cell carcinoma of the cervix. Front Oncol. 14(1456297)2024.PubMed/NCBI View Article : Google Scholar

26 

Bhatla N and Denny L: FIGO cancer report 2018. Int J Gynaecol Obstet. 143 (Suppl 2):S2–S3. 2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Song S, Zheng H and He X: Superficial spreading squamous cell carcinoma of the cervix involving the endometrium: A case report and literature review. Exp Ther Med 30: 185, 2025.
APA
Song, S., Zheng, H., & He, X. (2025). Superficial spreading squamous cell carcinoma of the cervix involving the endometrium: A case report and literature review. Experimental and Therapeutic Medicine, 30, 185. https://doi.org/10.3892/etm.2025.12935
MLA
Song, S., Zheng, H., He, X."Superficial spreading squamous cell carcinoma of the cervix involving the endometrium: A case report and literature review". Experimental and Therapeutic Medicine 30.4 (2025): 185.
Chicago
Song, S., Zheng, H., He, X."Superficial spreading squamous cell carcinoma of the cervix involving the endometrium: A case report and literature review". Experimental and Therapeutic Medicine 30, no. 4 (2025): 185. https://doi.org/10.3892/etm.2025.12935
Copy and paste a formatted citation
x
Spandidos Publications style
Song S, Zheng H and He X: Superficial spreading squamous cell carcinoma of the cervix involving the endometrium: A case report and literature review. Exp Ther Med 30: 185, 2025.
APA
Song, S., Zheng, H., & He, X. (2025). Superficial spreading squamous cell carcinoma of the cervix involving the endometrium: A case report and literature review. Experimental and Therapeutic Medicine, 30, 185. https://doi.org/10.3892/etm.2025.12935
MLA
Song, S., Zheng, H., He, X."Superficial spreading squamous cell carcinoma of the cervix involving the endometrium: A case report and literature review". Experimental and Therapeutic Medicine 30.4 (2025): 185.
Chicago
Song, S., Zheng, H., He, X."Superficial spreading squamous cell carcinoma of the cervix involving the endometrium: A case report and literature review". Experimental and Therapeutic Medicine 30, no. 4 (2025): 185. https://doi.org/10.3892/etm.2025.12935
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