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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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Case Report Open Access

Hepatic mucinous cystic neoplasm in a male patient: A case report

  • Authors:
    • Zongyuan Zhan
    • Yuandong Zhu
    • Wanneng Pan
    • Xiantu Zhang
    • Qinming Hou
    • Bo Wu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Xixi Hospital, Hangzhou, Zhejiang 310023, P.R. China, Department of Surgery, Xixi Hospital, Hangzhou, Zhejiang 310023, P.R. China, Department of Pathology, Xixi Hospital, Hangzhou, Zhejiang 310023, P.R. China, Department of Radiology, Xixi Hospital, Hangzhou, Zhejiang 310023, P.R. China
    Copyright: © Zhan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 202
    |
    Published online on: August 19, 2025
       https://doi.org/10.3892/etm.2025.12952
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Abstract

Hepatic mucinous cystic neoplasms (MCN) are rare cystic tumors that are predominantly observed in females, with a low incidence rate in males. To date, few cases of aggressive MCN have been reported in male patients. The current study reports the case of a 74‑year‑old male patient who presented to Xixi Hospital with abdominal distension. Results of imaging investigations revealed a cystic lesion in the liver and histopathological examination demonstrated positive staining for caudal type homeobox 2, cytokeratin 20, postmeiotic segregation increased 2‌, progesterone receptor and α‑inhibin, leading to a definitive diagnosis of hepatic mucinous cystadenoma. Collectively, the results of the present article demonstrated that hepatic MCN should be considered in the differential diagnosis of cystic liver lesions, including in male patients. A comprehensive evaluation that integrates clinical characteristics, and imaging and histopathological findings is essential for the optimal management of this condition.
View Figures

Figure 1

Imaging. (A) CT scan indicates that
the common bile duct and the left branch of the portal vein at the
hepatic portal are involved. The yellow arrow indicates the
affected vein. (B) Enhanced CT scan revealing nodular protrusions
in a portion of the cyst wall. The yellow arrow indicates the
nodular protrusion. (C) Calcification was visible in a portion of
the cyst wall. The yellow arrow indicates calcification. (D) On the
T1-weighted magnetic resonance images, heterogeneous signals were
observed in the left liver and the area of the hepatic portal,
consisting primarily of iso-intense and low-intense signals. (E)
T2-weighted images showed a predominantly mixed mass of high
signal. (F) Magnetic resonance cholangiopancreatography revealed
that the bile duct at the hepatic portal was compressed and
narrowed, leading to dilation of the bile ducts in the left
liver.

Figure 2

Pathology. (A) Under the microscope,
the structure of the cyst wall reveals a cuboidal and columnar
epithelium (H&E; x400 magnification). (B) Atypical glandular
structures and atypical nuclei are visible (H&E; x400
magnification). (C) Immunostaining reveals a small number of cells
with positive progesterone receptor expression (x400
magnification). (D) Immunostaining indicates cells expressing
α-inhibin in the stroma (x400 magnification). Scale bars, 50 µm.
H&E, hematoxylin and eosin.
View References

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Copy and paste a formatted citation
Spandidos Publications style
Zhan Z, Zhu Y, Pan W, Zhang X, Hou Q and Wu B: Hepatic mucinous cystic neoplasm in a male patient: A case report. Exp Ther Med 30: 202, 2025.
APA
Zhan, Z., Zhu, Y., Pan, W., Zhang, X., Hou, Q., & Wu, B. (2025). Hepatic mucinous cystic neoplasm in a male patient: A case report. Experimental and Therapeutic Medicine, 30, 202. https://doi.org/10.3892/etm.2025.12952
MLA
Zhan, Z., Zhu, Y., Pan, W., Zhang, X., Hou, Q., Wu, B."Hepatic mucinous cystic neoplasm in a male patient: A case report". Experimental and Therapeutic Medicine 30.4 (2025): 202.
Chicago
Zhan, Z., Zhu, Y., Pan, W., Zhang, X., Hou, Q., Wu, B."Hepatic mucinous cystic neoplasm in a male patient: A case report". Experimental and Therapeutic Medicine 30, no. 4 (2025): 202. https://doi.org/10.3892/etm.2025.12952
Copy and paste a formatted citation
x
Spandidos Publications style
Zhan Z, Zhu Y, Pan W, Zhang X, Hou Q and Wu B: Hepatic mucinous cystic neoplasm in a male patient: A case report. Exp Ther Med 30: 202, 2025.
APA
Zhan, Z., Zhu, Y., Pan, W., Zhang, X., Hou, Q., & Wu, B. (2025). Hepatic mucinous cystic neoplasm in a male patient: A case report. Experimental and Therapeutic Medicine, 30, 202. https://doi.org/10.3892/etm.2025.12952
MLA
Zhan, Z., Zhu, Y., Pan, W., Zhang, X., Hou, Q., Wu, B."Hepatic mucinous cystic neoplasm in a male patient: A case report". Experimental and Therapeutic Medicine 30.4 (2025): 202.
Chicago
Zhan, Z., Zhu, Y., Pan, W., Zhang, X., Hou, Q., Wu, B."Hepatic mucinous cystic neoplasm in a male patient: A case report". Experimental and Therapeutic Medicine 30, no. 4 (2025): 202. https://doi.org/10.3892/etm.2025.12952
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