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Case Report Open Access

Solid pseudopapillary neoplasm of the pancreas: A case report

  • Authors:
    • Lei Zhang
    • Donghui Ji
    • Kuopeng Liang
  • View Affiliations / Copyright

    Affiliations: Department of Ultrasound, Xingtai People's Hospital, Xingtai, Hebei 054001, P.R. China, Department of Ultrasound, Xingtai People's Hospital, Xingtai, Hebei 054001, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 204
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    Published online on: August 22, 2025
       https://doi.org/10.3892/etm.2025.12954
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Abstract

Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare exocrine tumor, accounting for <3% of all pancreatic neoplasms. SPN predominantly occurs in young females and typically presents with nonspecific clinical symptoms, including abdominal discomfort, bloating, abdominal pain and palpable abdominal masses. In certain cases, the tumor is detected incidentally during routine physical examinations. This article reports a case of SPN located in the pancreatic tail, which was initially identified during a routine health examination, subsequently diagnosed using contrast‑enhanced ultrasound and enhanced computed tomography (CT), and ultimately confirmed by surgical pathology. Given that SPN is commonly diagnosed using CT and magnetic resonance imaging, the use of ultrasound for the initial diagnosis in this case renders it particularly noteworthy.
View Figures

Figure 1

Ultrasonographic findings. (A)
Conventional ultrasound examination identifying a cystic-solid
lesion measuring ~48x44 mm located in the tail of the pancreas
(arrow). (B) Color Doppler flow imaging revealing no detectable
intratumoral blood flow (arrow). (C) The lesion demonstrates
moderate enhancement, with clearly delineated non-enhancing regions
during the arterial phase on contrast-enhanced ultrasound (arrow).
(D) Enhanced ultrasound showing persistent low enhancement of the
lesion in the venous phase (arrow).

Figure 2

Radiological findings. (A) Enhanced CT
showing low enhancement of the lesion in the arterial phase
(arrow). (B) Enhanced CT showing low enhancement of the lesion in
the venous phase (arrow). CT, computed tomography.

Figure 3

Representative images of pathological
findings. (A) The cellular morphology presents a relatively uniform
pattern, characterized by oval to elongated nuclei and distinct
nuclear grooves (H&E staining; magnification, x100). (B) The
tumor cell nuclei within a mucinous background exhibit a relatively
uniform morphology, display reduced intercellular cohesion and are
arranged in papillary patterns around small blood vessels (H&E
staining; magnification, x100).
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Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Ji D and Liang K: Solid pseudopapillary neoplasm of the pancreas: A case report. Exp Ther Med 30: 204, 2025.
APA
Zhang, L., Ji, D., & Liang, K. (2025). Solid pseudopapillary neoplasm of the pancreas: A case report. Experimental and Therapeutic Medicine, 30, 204. https://doi.org/10.3892/etm.2025.12954
MLA
Zhang, L., Ji, D., Liang, K."Solid pseudopapillary neoplasm of the pancreas: A case report". Experimental and Therapeutic Medicine 30.4 (2025): 204.
Chicago
Zhang, L., Ji, D., Liang, K."Solid pseudopapillary neoplasm of the pancreas: A case report". Experimental and Therapeutic Medicine 30, no. 4 (2025): 204. https://doi.org/10.3892/etm.2025.12954
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Ji D and Liang K: Solid pseudopapillary neoplasm of the pancreas: A case report. Exp Ther Med 30: 204, 2025.
APA
Zhang, L., Ji, D., & Liang, K. (2025). Solid pseudopapillary neoplasm of the pancreas: A case report. Experimental and Therapeutic Medicine, 30, 204. https://doi.org/10.3892/etm.2025.12954
MLA
Zhang, L., Ji, D., Liang, K."Solid pseudopapillary neoplasm of the pancreas: A case report". Experimental and Therapeutic Medicine 30.4 (2025): 204.
Chicago
Zhang, L., Ji, D., Liang, K."Solid pseudopapillary neoplasm of the pancreas: A case report". Experimental and Therapeutic Medicine 30, no. 4 (2025): 204. https://doi.org/10.3892/etm.2025.12954
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