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Article

Demographics, cardiopulmonary comorbidities, laboratory data and length of hospital stay in patients with acute exacerbation of chronic obstructive pulmonary disease at high altitude: A comparative study

  • Authors:
    • Yuying Tan
    • Bi Ran
    • Fangying Chen
    • Lin Liu
    • Lei Chen
  • View Affiliations / Copyright

    Affiliations: Department of High Altitude Medicine, Center for High Altitude Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Pulmonary and Critical Care Medicine, 363 Hospital, Chengdu, Sichuan 610041, P.R. China
  • Article Number: 215
    |
    Published online on: September 8, 2025
       https://doi.org/10.3892/etm.2025.12965
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Abstract

Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is known to impose a significant burden on patients, but its demographic and clinical features in patients with AECOPD at high altitude (HA) still need to be addressed. A total of 142 patients with AECOPD at HA [>2,500 meters (m)] and 142 patients with AECOPD at low altitude (LA) (<500 m) as controls, matched 1:1 by age and sex, encountered at West China Hospital of Sichuan University (Chengdu, China) between January 2023 and December 2023, were retrospectively analyzed. Demographics, cardiopulmonary comorbidities, laboratory data and length of hospital stay (LOHS) of patients with AECOPD at HA and LA were comparatively analyzed. Univariate and multivariate binary logistic regression analyses were used to identify factors associated with prolonged LOHS in patients with AECOPD at HA. Compared to the LA group, patients with AECOPD at HA, regardless of sex and age, demonstrate certain different demographic and clinical features, including more Tibetans and non‑smokers, different prevalences of cardiopulmonary comorbidities and indicators in blood routine and biochemical tests, particularly higher hemoglobin levels and eosinophils count, which were negatively associated with LOHS. The present findings highlight that these differences could play an important role in the evaluation and prognosis of AECOPD at HA, and future studies should investigate the mechanisms underlying these differences and explore novel interventions to improve clinical outcomes for patients with AECOPD at HA.
View Figures

Figure 1

Flowchart of patients' selection.
AECOPD, acute exacerbation of chronic obstructive pulmonary
disease; HA, high altitude; LA, low altitude.

Figure 2

Receiver operating characteristic
curve of variables for logistic regression analysis and cut-off of
the variables. AUC, area under the curve; EOS, eosinophil; Hb,
hemoglobin.
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Copy and paste a formatted citation
Spandidos Publications style
Tan Y, Ran B, Chen F, Liu L and Chen L: Demographics, cardiopulmonary comorbidities, laboratory data and length of hospital stay in patients with acute exacerbation of chronic obstructive pulmonary disease at high altitude: A comparative study. Exp Ther Med 30: 215, 2025.
APA
Tan, Y., Ran, B., Chen, F., Liu, L., & Chen, L. (2025). Demographics, cardiopulmonary comorbidities, laboratory data and length of hospital stay in patients with acute exacerbation of chronic obstructive pulmonary disease at high altitude: A comparative study. Experimental and Therapeutic Medicine, 30, 215. https://doi.org/10.3892/etm.2025.12965
MLA
Tan, Y., Ran, B., Chen, F., Liu, L., Chen, L."Demographics, cardiopulmonary comorbidities, laboratory data and length of hospital stay in patients with acute exacerbation of chronic obstructive pulmonary disease at high altitude: A comparative study". Experimental and Therapeutic Medicine 30.5 (2025): 215.
Chicago
Tan, Y., Ran, B., Chen, F., Liu, L., Chen, L."Demographics, cardiopulmonary comorbidities, laboratory data and length of hospital stay in patients with acute exacerbation of chronic obstructive pulmonary disease at high altitude: A comparative study". Experimental and Therapeutic Medicine 30, no. 5 (2025): 215. https://doi.org/10.3892/etm.2025.12965
Copy and paste a formatted citation
x
Spandidos Publications style
Tan Y, Ran B, Chen F, Liu L and Chen L: Demographics, cardiopulmonary comorbidities, laboratory data and length of hospital stay in patients with acute exacerbation of chronic obstructive pulmonary disease at high altitude: A comparative study. Exp Ther Med 30: 215, 2025.
APA
Tan, Y., Ran, B., Chen, F., Liu, L., & Chen, L. (2025). Demographics, cardiopulmonary comorbidities, laboratory data and length of hospital stay in patients with acute exacerbation of chronic obstructive pulmonary disease at high altitude: A comparative study. Experimental and Therapeutic Medicine, 30, 215. https://doi.org/10.3892/etm.2025.12965
MLA
Tan, Y., Ran, B., Chen, F., Liu, L., Chen, L."Demographics, cardiopulmonary comorbidities, laboratory data and length of hospital stay in patients with acute exacerbation of chronic obstructive pulmonary disease at high altitude: A comparative study". Experimental and Therapeutic Medicine 30.5 (2025): 215.
Chicago
Tan, Y., Ran, B., Chen, F., Liu, L., Chen, L."Demographics, cardiopulmonary comorbidities, laboratory data and length of hospital stay in patients with acute exacerbation of chronic obstructive pulmonary disease at high altitude: A comparative study". Experimental and Therapeutic Medicine 30, no. 5 (2025): 215. https://doi.org/10.3892/etm.2025.12965
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