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A rare splenic and pancreatic inflammatory myofibroblastic tumour with left‑sided portal hypertension and gastric varices: A case report

  • Authors:
    • Eleni Zografos
    • Alkistis Papatheodoridi
    • Maria Kaparelou
    • Ioanna Tatouli
    • Andreas Mpozikas
    • Margarita Papatheodoridi
    • Angeliki Andrikopoulou
    • Constantinos G. Zografos
    • Georgia Kafiri
    • Efstathios Manios
    • Meletios-Athanasios Dimopoulos
    • Flora Zagouri
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Therapeutics, Alexandra General Hospital, Medical School of the National and Kapodistrian University of Athens, 11528 Athens, Greece, Academic Department of Gastroenterology, Medical School of National and Kapodistrian University of Athens, Laiko General Hospital, 11527 Athens, Greece, Second Department of Surgery, ‘Aretaieio’ Hospital, 11528 Athens, Greece, Department of Pathology, ‘Hippocrateio’ General Hospital of Athens, 11527 Athens, Greece
    Copyright: © Zografos et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 218
    |
    Published online on: September 11, 2025
       https://doi.org/10.3892/etm.2025.12968
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Abstract

Left‑sided portal hypertension or segmental portal hypertension is a rare cause of upper gastrointestinal bleeding. The present study reports a case of isolated gastric variceal haemorrhage and hypersplenism, due to left‑sided portal hypertension induced by inflammatory myofibroblastic tumour (IMT)‑associated splenic vein compression. IMT is an rare mesenchymal neoplasm of intermediate malignant potential that can develop in any location, frequently remaining entirely asymptomatic until it reaches a size that leads to complications. To the best of our knowledge, this is the first case reported of an IMT involving both the spleen and the pancreas. In this patient, splenectomy and partial pancreatectomy were both diagnostic and curative for IMT, and no adjuvant therapy was followed. This case report, along with a short review of the current knowledge on IMT features, contributes towards the understanding and diagnosis of this rare entity with diverse clinical presentations.6
View Figures

Figure 1

Axial contrast-enhanced abdominal
computed tomography imaging findings, shows an intrasplenic cyst
(black arrow) and a large low-attenuation mass in the enlarged
spleen (red arrow), extending from the portal of the spleen to its
inferior pole and involving the splenic vein.

Figure 2

Ιmmunohistological images of the
inflammatory myofibroblastic tumour for (A) haematoxylin and eosin
(magnification, x4), showing positive staining for (B) vimentin
(magnification, x10) and (C) smooth muscle actin (magnification,
x10). Immunohistochemical analysis also displayed weaker expression
of (D) desmin (magnification, x20) and (E) CD34 (magnification,
x4), as well as (F) low Ki67 expression of <1% (magnification,
x10), which is a widely used marker for cell proliferation.
View References

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Copy and paste a formatted citation
Spandidos Publications style
Zografos E, Papatheodoridi A, Kaparelou M, Tatouli I, Mpozikas A, Papatheodoridi M, Andrikopoulou A, Zografos CG, Kafiri G, Manios E, Manios E, et al: A rare splenic and pancreatic inflammatory myofibroblastic tumour with left‑sided portal hypertension and gastric varices: A case report. Exp Ther Med 30: 218, 2025.
APA
Zografos, E., Papatheodoridi, A., Kaparelou, M., Tatouli, I., Mpozikas, A., Papatheodoridi, M. ... Zagouri, F. (2025). A rare splenic and pancreatic inflammatory myofibroblastic tumour with left‑sided portal hypertension and gastric varices: A case report. Experimental and Therapeutic Medicine, 30, 218. https://doi.org/10.3892/etm.2025.12968
MLA
Zografos, E., Papatheodoridi, A., Kaparelou, M., Tatouli, I., Mpozikas, A., Papatheodoridi, M., Andrikopoulou, A., Zografos, C. G., Kafiri, G., Manios, E., Dimopoulos, M., Zagouri, F."A rare splenic and pancreatic inflammatory myofibroblastic tumour with left‑sided portal hypertension and gastric varices: A case report". Experimental and Therapeutic Medicine 30.5 (2025): 218.
Chicago
Zografos, E., Papatheodoridi, A., Kaparelou, M., Tatouli, I., Mpozikas, A., Papatheodoridi, M., Andrikopoulou, A., Zografos, C. G., Kafiri, G., Manios, E., Dimopoulos, M., Zagouri, F."A rare splenic and pancreatic inflammatory myofibroblastic tumour with left‑sided portal hypertension and gastric varices: A case report". Experimental and Therapeutic Medicine 30, no. 5 (2025): 218. https://doi.org/10.3892/etm.2025.12968
Copy and paste a formatted citation
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Spandidos Publications style
Zografos E, Papatheodoridi A, Kaparelou M, Tatouli I, Mpozikas A, Papatheodoridi M, Andrikopoulou A, Zografos CG, Kafiri G, Manios E, Manios E, et al: A rare splenic and pancreatic inflammatory myofibroblastic tumour with left‑sided portal hypertension and gastric varices: A case report. Exp Ther Med 30: 218, 2025.
APA
Zografos, E., Papatheodoridi, A., Kaparelou, M., Tatouli, I., Mpozikas, A., Papatheodoridi, M. ... Zagouri, F. (2025). A rare splenic and pancreatic inflammatory myofibroblastic tumour with left‑sided portal hypertension and gastric varices: A case report. Experimental and Therapeutic Medicine, 30, 218. https://doi.org/10.3892/etm.2025.12968
MLA
Zografos, E., Papatheodoridi, A., Kaparelou, M., Tatouli, I., Mpozikas, A., Papatheodoridi, M., Andrikopoulou, A., Zografos, C. G., Kafiri, G., Manios, E., Dimopoulos, M., Zagouri, F."A rare splenic and pancreatic inflammatory myofibroblastic tumour with left‑sided portal hypertension and gastric varices: A case report". Experimental and Therapeutic Medicine 30.5 (2025): 218.
Chicago
Zografos, E., Papatheodoridi, A., Kaparelou, M., Tatouli, I., Mpozikas, A., Papatheodoridi, M., Andrikopoulou, A., Zografos, C. G., Kafiri, G., Manios, E., Dimopoulos, M., Zagouri, F."A rare splenic and pancreatic inflammatory myofibroblastic tumour with left‑sided portal hypertension and gastric varices: A case report". Experimental and Therapeutic Medicine 30, no. 5 (2025): 218. https://doi.org/10.3892/etm.2025.12968
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