|
1
|
Tonello G, Daglio M, Zaccarelli N,
Sottofattori E, Mazzei M and Balbi A: Characterization and
quantitation of the active polynucleotide fraction (PDRN) from
human placenta, a tissue repair stimulating agent. J Pharm Biomed
Anal. 14:1555–1560. 1996.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Pan SY, Chan MKS, Wong MBF, Klokol D and
Chernykh V: Placental therapy: An insight to their biological and
therapeutic properties. J Med Ther. 1:1–6. 2017.
|
|
3
|
Kim TH, Heo SY, Han JS and Jung WK:
Anti-inflammatory effect of polydeoxyribonucleotides (PDRN)
extracted from red alga (Porphyra sp.) (Ps-PDRN) in RAW 264.7
macrophages stimulated with Escherichia coli
lipopolysaccharides: A comparative study with commercial PDRN. Cell
Biochem Funct. 41:889–897. 2023.PubMed/NCBI View
Article : Google Scholar
|
|
4
|
Shu Z, Ji Y, Liu F, Jing Y, Jiao C, Li Y,
Zhao Y, Wang G and Zhang J: Proteomics analysis of the protective
effect of polydeoxyribonucleotide extracted from sea cucumber
(Apostichopus japonicus) sperm in a hydrogen
peroxide-induced RAW264.7 cell injury model. Mar Drugs.
22(325)2024.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Kim TH, Kim SC, Park WS, Choi IW, Kim HW,
Kang HW, Kim YM and Jung WK: PCL/gelatin nanofibers incorporated
with starfish polydeoxyribonucleotides for potential wound healing
applications. Mater Des. 229(111912)2023.
|
|
6
|
Kim M, Kim WJ, Lee HK, Kwon YS and Choi
YM: Efficacy in vitro antioxidation and in vivo skin barrier
recovery of composition containing mineral-cation-phyto DNA
extracted from Aloe vera adventitious root. Asian J Beauty
Cosmetol. 21:231–246. 2023.
|
|
7
|
Lee KS, Lee S, Wang H, Lee G, Kim S, Ryu
YH, Chang NH and Kang YW: Analysis of skin regeneration and
barrier-improvement efficacy of polydeoxyribonucleotide isolated
from Panax ginseng (C.A. Mey.) adventitious root. Molecules.
28(7240)2023.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Kim E, Choi S, Kim SY, Jang SJ, Lee S, Kim
H, Jang JH, Seo HH, Lee JH, Choi SS and Moh SH: Wound healing
effect of polydeoxyribonucleotide derived from Hibiscus
sabdariffa callus via Nrf2 signaling in human keratinocytes.
Biochem Biophys Res Commun. 728(150335)2024.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Shin J, Park G, Lee J and Bae H: The
effect of polydeoxyribonucleotide on chronic non-healing wound of
an amputee: A case report. Ann Rehabil Med. 42:630–633.
2018.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Yun J, Park S, Park HY and Lee KA:
Efficacy of polydeoxyribonucleotide in promoting the healing of
diabetic wounds in a murine model of streptozotocin-induced
diabetes: A pilot experiment. Int J Mol Sci.
24(1932)2023.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Picciolo G, Mannino F, Irrera N, Altavilla
D, Minutoli L, Vaccaro M, Arcoraci V, Squadrito V, Picciolo G,
Squadrito F and Pallio G: PDRN, a natural bioactive compound,
blunts inflammation and positively reprograms healing genes in an
‘in vitro’ model of oral mucositis. Biomed Pharmacother.
138(111538)2021.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Hwang L, Jin JJ, Ko IG, Kim S, Cho YA,
Sung JS, Choi CW and Chang BS: Polydeoxyribonucleotide attenuates
airway inflammation through A2AR signaling pathway in PM10-exposed
mice. Int Neurourol J. 25 (Suppl 1):S19–S26. 2021.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Noh TK, Chung BY, Kim SY, Lee MH, Kim MJ,
Youn CS, Lee MW and Chang SE: Novel anti-melanogenesis properties
of polydeoxyribonucleotide, a popular wound healing booster. Int J
Mol Sci. 17(1448)2016.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Ko IG, Jin JJ, Hwang L, Kim SH, Kim CJ,
Han JH, Lee S, Kim HI, Shin HP and Jeon JW: Polydeoxyribonucleotide
exerts protective effect against CCl4-induced acute
liver injury through inactivation of NF-κB/MAPK signaling pathway
in mice. Int J Mol Sci. 21(7894)2020.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Kim SE, Ko IG, Jin JJ, Hwang L, Kim CJ,
Kim SH, Han JH and Jeon JW: Polydeoxyribonucleotide exerts
therapeutic effect by increasing VEGF and inhibiting inflammatory
cytokines in ischemic colitis rats. Biomed Res Int.
2020(2169083)2020.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Khan A, Wang G, Zhou F, Gong L, Zhang J,
Qi L and Cui H: Polydeoxyribonucleotide: A promising skin
anti-aging agent. Chin J Plast Reconstr Surg. 4:187–193. 2022.
|
|
17
|
Marini HR, Puzzolo D, Micali A, Adamo EB,
Irrera N, Pisani A, Pallio G, Trichilo V, Malta C, Bitto A, et al:
Neuroprotective effects of polydeoxyribonucleotide in a murine
model of cadmium toxicity. Oxid Med Cell Longev.
2018(4285694)2018.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Lee S, Won KY and Joo S: Protective effect
of polydeoxyribonucleotide against CCl4-induced acute
liver injury in mice. Int Neurourol J. 24 (Suppl 2):S88–S95.
2020.
|
|
19
|
Jo S, Baek A, Cho Y, Kim SH, Baek D, Hwang
J, Cho SR and Kim HJ: Therapeutic effects of
polydeoxyribonucleotide in an in vitro neuronal model of
ischemia/reperfusion injury. Sci Rep. 13(6004)2023.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Baek A, Baek D, Kim SH, Kim J, Notario GR,
Lee DW, Kim HJ and Cho SR: Polydeoxyribonucleotide ameliorates
IL-1β-induced impairment of chondrogenic differentiation in human
bone marrow-derived mesenchymal stem cells. Sci Rep.
14(26076)2024.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Galeano M, Pallio G, Irrera N, Mannino F,
Bitto A, Altavilla D, Vaccaro M, Squadrito G, Arcoraci V, Colonna
MR, et al: Polydeoxyribonucleotide: A promising biological platform
to accelerate impaired skin wound healing. Pharmaceuticals (Basel).
14(1103)2021.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Jung HJ, Cho YW, Lim HW, Choi H, Ji DJ and
Lim CJ: Anti-inflammatory, antioxidant, anti-angiogenic and skin
whitening activities of Phryma leptostachya var. asiatica
Hara extract. Biomol Ther (Seoul). 21:72–78. 2013.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Thring TSA, Hili P and Naughton DP:
Anti-collagenase, anti-elastase and anti-oxidant activities of
extracts from 21 plants. BMC Complement Altern Med.
9(27)2009.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Mandal S, Hazra B, Sarkar R, Biswas S and
Mandal N: Assessment of the antioxidant and reactive oxygen species
scavenging activity of methanolic extract of Caesalpinia
crista leaf. Evid Based Complement Alternat Med.
2011(173768)2011.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Gharibzahedi SMT, Razavi SH and Mousavi M:
Characterizing the natural
canthaxanthin/2-hydroxypropyl-β-cyclodextrin inclusion complex.
Carbohydr Polym. 10:1147–1153. 2014.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Masuda T, Yamashita D, Takeda Y and
Yonemori S: Screening for tyrosinase inhibitors among extracts of
seashore plants and identification of potent inhibitors from
Garcinia subelliptica. Biosci Biotechnol Biochem.
69:197–201. 2005.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Wittenauer J, Mäckle S, Sußmann D,
Schweiggert-Weisz U and Carle R: Inhibitory effects of polyphenols
from grape pomace extract on collagenase and elastase activity.
Fitoterapia. 101:179–187. 2015.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Chattuwatthana T and Okello E:
Anti-collagenase, anti-elastase and antioxidant activities of
Pueraria candollei var. mirifica root extract and
Coccinia grandis fruit juice extract: An in vitro study. Eur
J Med Plants. 5:318–327. 2015.
|
|
29
|
Andrés CMC, Pérez de la Lastra JM, Andrés
Juan C, Plou FJ and Pérez-Lebeña E: Superoxide anion chemistry-its
role at the core of the innate immunity. Int J Mol Sci.
24(1841)2023.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Forman HJ and Zhang H: Targeting oxidative
stress in disease: Promise and limitations of antioxidant therapy.
Nat Rev Drug Discov. 20:689–709. 2021.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Sharma JN, Al-Omran A and Parvathy SS:
Role of nitric oxide in inflammatory diseases.
Inflammopharmacology. 15:252–259. 2007.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Akdeniz N, Aktaş A, Erdem T, Akyüz M and
Özdemir S: Nitric oxide levels in atopic dermatitis. The Pain
Clinic. 16:401–405. 2004.
|
|
33
|
Suschek CV, Feibel D, von Kohout M and
Opländer C: Enhancement of nitric oxide bioavailability by
modulation of cutaneous nitric oxide stores. Biomedicines.
10(2124)2022.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Masum MN, Yamauchi K and Mitsunaga T:
Tyrosinase inhibitors from natural and synthetic sources as
skin-lightening agents. Rev Agric Sci. 7:41–58. 2019.
|
|
35
|
Kim YJ, Kim MJ, Kweon DK, Lim ST and Lee
SJ: Polydeoxyribonucleotide activates mitochondrial biogenesis but
reduces MMP-1 activity and melanin biosynthesis in cultured skin
cells. Appl Biochem Biotechnol. 191:540–554. 2020.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Squadrito F, Bitto A, Irrera N, Pizzino G,
Pallio G, Minutoli L and Altavilla D: Pharmacological activity and
clinical use of PDRN. Front Pharmacol. 8(224)2017.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Belletti S, Uggeri J, Gatti R, Govoni P
and Guizzardi S: Polydeoxyribonucleotide promotes cyclobutane
pyrimidine dimer repair in UVB-exposed dermal fibroblasts.
Photodermatol Photoimmunol Photomed. 23:242–249. 2007.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Irrera N, Bitto A, Vaccaro M, Mannino F,
Squadrito V, Pallio G, Arcoraci V, Minutoli L, Ieni A, Lentini M,
et al: PDRN, a bioactive natural compound, ameliorates
imiquimod-induced psoriasis through NF-κB pathway inhibition and
Wnt/β-catenin signaling modulation. Int J Mol Sci.
21(1215)2020.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Echart CL, Graziadio B, Somaini S, Ferro
LI, Richardson PG, Fareed J and Iacobelli M: The fibrinolytic
mechanism of defibrotide: Effect of defibrotide on plasmin
activity. Blood Coagul Fibrinolysis. 20:627–634. 2009.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Baker DE and Demaris K: Defibrotide. Hosp
Pharm. 51:847–854. 2016.PubMed/NCBI View Article : Google Scholar
|
