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Value of hs‑cTnT, sST2, and Lp‑PLA2 in the classification of acute coronary syndrome

  • Authors:
    • Hongxin Peng
    • Nasifu Lubanga
    • Cong Sun
    • Bangshun He
    • Yan-Ping Mei
    • Yishan Wang
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, P.R. China
    Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 233
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    Published online on: September 29, 2025
       https://doi.org/10.3892/etm.2025.12983
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Abstract

The present study aimed to assess the value of high‑sensitivity cardiac troponin T (hs‑cTnT), soluble suppression of tumorigenicity 2 protein (sST2) and lipoprotein‑associated phospholipase A2 (Lp‑PLA2) in the classification of acute coronary syndrome (ACS). A total of 236 patients diagnosed with ACS were enrolled in this retrospective study and were further divided into the non‑ST‑segment‑elevation (NSTE)‑ACS group (n=183) and ST‑segment elevation myocardial infarction (STEMI) group (n=53). The three biomarkers (hs‑cTnT, sST2 and Lp‑PLA2) were measured by electrochemiluminescence. The diagnostic performance of each biomarker in differentiating ACS subtypes was evaluated through receiver operating characteristic curve analysis. The DeLong test was applied to compare the discriminatory abilities of the different markers. The binary logistic regression model was employed to analyze the factors influencing ACS classification. The levels of hs‑cTnT and sST2 in males were significantly higher in the STEMI group than in the NSTE‑ACS group (P<0.05). hs‑cTnT [odds ratio (OR)=1.010, 95%CI: 1.007‑1.014] and sST2 (OR=1.022, 95%CI: 1.011‑1.033) were identified as good predictors for distinguishing STEMI from NSTE‑ACS, whereas Lp‑PLA2 (P=0.470) was not a suitable biomarker to discriminate between the two types of ACS. Additionally, the diagnostic efficacy of hs‑cTnT [area under curve (AUC=0.861)] and the combination of hs‑cTnT and sST2 (AUC=0.863) was higher than that of sST2 alone (AUC=0.833, P<0.05). In conclusion, these findings illustrated that hs‑cTnT and sST2 are promising biomarkers to classify patients with ACS. Compared with sST2 alone, hs‑cTnT and its combined detection demonstrate superior diagnostic efficiency in identifying ACS.
View Figures

Figure 1

Patient inclusion flow chart.
NSTE-ACS, non-ST-segment-elevation acute coronary syndrome; NSTEMI,
non-ST-segment elevation myocardial infarction; UA, unstable angina
pectoris.

Figure 2

ROC curve showing the diagnostic
value of hs-cTnT (AUC=0.861), sST2 (AUC=0.833) and their
combination (AUC=0.863) in classifying ACS subtypes. ROC, receiver
operating characteristic; AUC, area under the curve; hs-cTnT,
high-sensitivity cardiac troponin T; sST2, soluble suppression of
tumorigenicity 2 protein.
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Copy and paste a formatted citation
Spandidos Publications style
Peng H, Lubanga N, Sun C, He B, Mei Y and Wang Y: Value of hs‑cTnT, sST2, and Lp‑PLA2 in the classification of acute coronary syndrome. Exp Ther Med 30: 233, 2025.
APA
Peng, H., Lubanga, N., Sun, C., He, B., Mei, Y., & Wang, Y. (2025). Value of hs‑cTnT, sST2, and Lp‑PLA2 in the classification of acute coronary syndrome. Experimental and Therapeutic Medicine, 30, 233. https://doi.org/10.3892/etm.2025.12983
MLA
Peng, H., Lubanga, N., Sun, C., He, B., Mei, Y., Wang, Y."Value of hs‑cTnT, sST2, and Lp‑PLA2 in the classification of acute coronary syndrome". Experimental and Therapeutic Medicine 30.6 (2025): 233.
Chicago
Peng, H., Lubanga, N., Sun, C., He, B., Mei, Y., Wang, Y."Value of hs‑cTnT, sST2, and Lp‑PLA2 in the classification of acute coronary syndrome". Experimental and Therapeutic Medicine 30, no. 6 (2025): 233. https://doi.org/10.3892/etm.2025.12983
Copy and paste a formatted citation
x
Spandidos Publications style
Peng H, Lubanga N, Sun C, He B, Mei Y and Wang Y: Value of hs‑cTnT, sST2, and Lp‑PLA2 in the classification of acute coronary syndrome. Exp Ther Med 30: 233, 2025.
APA
Peng, H., Lubanga, N., Sun, C., He, B., Mei, Y., & Wang, Y. (2025). Value of hs‑cTnT, sST2, and Lp‑PLA2 in the classification of acute coronary syndrome. Experimental and Therapeutic Medicine, 30, 233. https://doi.org/10.3892/etm.2025.12983
MLA
Peng, H., Lubanga, N., Sun, C., He, B., Mei, Y., Wang, Y."Value of hs‑cTnT, sST2, and Lp‑PLA2 in the classification of acute coronary syndrome". Experimental and Therapeutic Medicine 30.6 (2025): 233.
Chicago
Peng, H., Lubanga, N., Sun, C., He, B., Mei, Y., Wang, Y."Value of hs‑cTnT, sST2, and Lp‑PLA2 in the classification of acute coronary syndrome". Experimental and Therapeutic Medicine 30, no. 6 (2025): 233. https://doi.org/10.3892/etm.2025.12983
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