Treatment of a mandibular molar with primary failure of eruption: A case report

Guo,Ming; Zhang,Weisheng

doi:10.3892/etm.2025.13004

January-2026 Volume 31 Issue 1

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January-2026 Volume 31 Issue 1

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Case Report

Treatment of a mandibular molar with primary failure of eruption: A case report

Authors:
- Ming Guo
- Weisheng Zhang
View Affiliations / Copyright

Affiliations: Department of Orthodontics, Stomatology Center, Peking University Shenzhen Hospital, Futian, Shenzhen 518036, P.R. China
Article Number: 9
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Published online on: October 29, 2025

https://doi.org/10.3892/etm.2025.13004
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Abstract

Primary failure of eruption (PFE) is a rare inherited disorder that is uncommon in dental research. It is characterized by failure of healthy tooth eruption, which may result in unilateral or bilateral posterior open bite. To date, the etiology of PFE has remained elusive. The present study reported the case of a 12‑year‑old patient exhibiting unilateral open bite of the posterior teeth, with no evidence of local or systemic complications. The patient expressed aesthetic and functional concerns regarding the occlusion. Clinical and radiological examinations revealed unerupted mandibular molars with fully formed roots located in concave bone defects, with no anatomical obstruction or other dental anomalies. Based on clinical and imaging manifestations and exclusion diagnosis, PFE was diagnosed. The affected molar was extracted and orthodontic treatment with metal self‑ligating brackets was initiated following diagnosis. Notably, the patient was monitored with regular follow‑up visits. Following treatment, occlusal function and dental aesthetics were improved, demonstrating the efficacy of combined surgical extraction and orthodontic management for PFE. In conclusion, the present study highlighted that patients presenting with posterior open bite should be further evaluated to exclude rare disorders, such as PFE. Early detection and intervention may enhance the management of patients, leading to favourable outcomes. However, further studies are required to establish standardized treatment protocols and to elucidate the underlying genetic mechanisms.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Treatment of a mandibular molar with primary failure of eruption: A case report

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Abstract

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