|
1
|
Yang Y, Lv M, Xu Q, Wang X and Fang Z:
Extracellular vesicles in idiopathic pulmonary fibrosis:
Pathogenesis, biomarkers and innovative therapeutic strategies. Int
J Nanomedicine. 19:12593–12614. 2024.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Richeldi L, Collard HR and Jones MG:
Idiopathic pulmonary fibrosis. Lancet. 389:1941–1952.
2017.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Lederer DJ and Martinez FJ: Idiopathic
pulmonary fibrosis. New Engl J Med. 378:1811–1823. 2018.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Kou M, Jiao Y, Li Z, Wei B, Li Y, Cai Y
and Wei W: Real-world safety and effectiveness of pirfenidone and
nintedanib in the treatment of idiopathic pulmonary fibrosis: A
systematic review and meta-analysis. Eur J Clin Pharmacol.
80:1445–1460. 2024.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Chagas MDSS, Behrens MD, Moragas-Tellis
CJ, Penedo GXM, Silva AR and Goncalves-de-Albuquerque CF: Flavonols
and flavones as Potential anti-inflammatory, antioxidant, and
antibacterial compounds. Oxid Med Cell Longev.
2022(9966750)2022.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Rajesh RU and Sangeetha D: Therapeutic
potentials and targeting strategies of quercetin on cancer cells:
Challenges and future prospects. Phytomedicine.
133(155902)2024.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Godoy MCX, Monteiro GA, Moraes BHD, Macedo
JA, Goncalves GMS and Gambero A: Addition of polyphenols to drugs:
The potential of controlling ‘Inflammaging’ and fibrosis in human
senescent lung fibroblasts in vitro. Int J Mol Sci.
25(7163)2024.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Reyes-Jimenez E, Ramirez-Hernandez AA,
Santos-Alvarez JC, Velázquez-Enríquez JM, González-García K,
Carrasco-Torres G, Villa-Treviño S, Baltiérrez-Hoyos R and
Vásquez-Garzón VR: Coadministration of 3'5-dimaleamylbenzoic acid
and quercetin decrease pulmonary fibrosis in a systemic sclerosis
model. Int Immunopharmacol. 122(110664)2023.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Wiggins Z, Chioma OS, Drake WP and
Langford M: The effect of quercetin on human lung fibroblasts and
regulation of collagen production. Am J Resp Crit Care.
(207)2023.
|
|
10
|
Andres S, Pevny S, Ziegenhagen R, Bakhiya
N, Schäfer B, Hirsch-Ernst KI and Lampen A: Safety aspects of the
use of quercetin as a dietary supplement. Mol Nutr Food Res.
(62)2018.PubMed/NCBI View Article : Google Scholar : doi:
10.1002/mnfr.201700447.
|
|
11
|
Liu X, Liang Q, Qin Y, Chen Z and Yue R:
Advances and perspectives on the Anti-fibrotic mechanisms of the
quercetin. Am J Chin Med. 53:1411–1440. 2025.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Sellares J and Rojas M: Quercetin in
idiopathic pulmonary fibrosis: Another brick in the senolytic wall.
Am J Respir Cell Mol Biol. 60:3–4. 2019.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Amir-Behghadami M and Janati A:
Population, Intervention, Comparison, Outcomes and Study (PICOS)
design as a framework to formulate eligibility criteria in
systematic reviews. Emerg Med J. 37(387)2020.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Ashcroft T, Simpson JM and Timbrell V:
Simple method of estimating severity of pulmonary fibrosis on a
numerical scale. J Clin Pathol. 41:467–470. 1988.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Page MJ, McKenzie JE, Bossuyt PM, Boutron
I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan
SE, et al: The PRISMA 2020 statement: An updated guideline for
reporting systematic reviews. BMJ. 372(n71)2021.PubMed/NCBI View
Article : Google Scholar
|
|
16
|
Hooijmans CR, Rovers MM, de Vries RBM,
Leenaars M, Ritskes-Hoitinga M and Langendam MW: SYRCLE's risk of
bias tool for animal studies. BMC Med Res Methodol.
14(43)2014.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Baowen Q, Yulin Z, Xin W, Wenjing X, Hao
Z, Zhizhi C, Xingmei D, Xia Z, Yuquan W and Lijuan C: A further
investigation concerning correlation between anti-fibrotic effect
of liposomal quercetin and inflammatory cytokines in pulmonary
fibrosis. Eur J Pharmacol. 642:134–139. 2010.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Mehrzadi S, Hosseini P, Mehrabani M,
Siahpoosh A, Goudarzi M, Khalili H and Malayeri A: Attenuation of
Bleomycin-induced pulmonary fibrosis in wistar rats by combination
treatment of two natural phenolic compounds: Quercetin and Gallic
acid. Nutr Cancer. 73:2039–2049. 2021.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Martinez JA, Ramos SG, Meirelles MS,
Verceze AV, Arantes MR and Vannucchi H: Effects of quercetin on
Bleomycin-induced lung injury: A preliminary study. J Bras Pneumol.
34:445–452. 2008.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Kushwah L, Verma R, Gohel D, Patel M,
Marvania T and Balakrishnan S: Evaluating the ameliorative
potential of quercetin against the Bleomycin-induced pulmonary
fibrosis in wistar rats. Pulm Med. 2013:280–289. 2013.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Impellizzeri D, Talero E, Siracusa R,
Alcaide A, Cordaro M, Maria Zubelia J, Bruschetta G, Crupi R,
Esposito E, Cuzzocrea S and Motilva V: Protective effect of
polyphenols in an inflammatory process associated with experimental
pulmonary fibrosis in mice. Brit J Nutr. 114:853–865.
2015.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Park HK, Kim SJ, Kwon DY, Park JH and Kim
YC: Protective effect of quercetin against paraquat-induced lung
injury in rats. Life Sci. 87:181–186. 2010.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Taslidere E, Esrefoglu M, Elbe H, Cetin A
and Ates B: Protective effects of melatonin and quercetin on
experimental lung injury induced by carbon tetrachloride in rats.
Exp Lung Res. 40:59–65. 2014.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Geng F, Xu M, Zhao L, Zhang H, Li J, Jin
F, Li Y, Li T, Yang X, Li S, et al: Quercetin alleviates pulmonary
fibrosis in mice exposed to silica by inhibiting macrophage
senescence. Front Pharmacol. 13(912029)2022.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Geng F, Zhao L, Cai Y, Zhao Y, Jin F, Li
Y, Li T, Yang X, Li S, Gao X, et al: Quercetin alleviates pulmonary
fibrosis in silicotic mice by inhibiting macrophage transition and
TGF-β-Smad2/3 pathway. Curr Issues Mol Biol. 45:3087–3101.
2023.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Hohmann MS, Habiel DM, Coelho AL, Verri
JWA and Hogaboam CM: Quercetin enhances ligand-induced apoptosis in
senescent idiopathic pulmonary fibrosis fibroblasts and reduces
lung fibrosis in vivo. Am J Resp Cell Mol. 60:28–40.
2019.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Wu W, Wu X, Qiu L, Wan R, Zhu X, Chen S,
Yang X, Liu X and Wu J: Quercetin influences intestinal
dysbacteriosis and delays alveolar epithelial cell senescence by
regulating PTEN/PI3K/AKT signaling in pulmonary fibrosis. Naunyn
Schmiedebergs Arch Pharmacol. 397:4809–4822. 2024.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Liu H, Xue J, Li X, Ao R and Lu Y:
Quercetin liposomes protect against Radiation-induced pulmonary
injury in a murine model. Oncol Lett. 6:453–459. 2013.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Verma S, Dutta A, Dahiya A and Kalra N:
Quercetin-3-Rutinoside alleviates radiation-induced lung
inflammation and fibrosis via regulation of NF-κB/TGF-β1 signaling.
Phytomedicine. 99(154004)2022.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Boots AW, Veith C, Albrecht C, Bartholome
R, Drittij MJ, Claessen SMH, Bast A, Rosenbruch M, Jonkers L, van
Schooten FJ and Schins RPF: The dietary antioxidant quercetin
reduces hallmarks of bleomycin-induced lung fibrogenesis in mice.
BMC Pulm Med. 20:112–116. 2020.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Wei QF, Wang XH, Zhang XY, Song LJ, Wang
YM, Wang Q, Lv F and Li XF: Therapeutic effects of quercetin on
bleomycin induced pulmonary fibrosis in rats. Int J Clin Exp Med.
9:5161–5167. 2016.
|
|
32
|
Oka VO, Okon UE and Osim EE: Pulmonary
responses following quercetin administration in rats after
intratracheal instillation of amiodarone. Niger J Physiol Sci.
34:63–68. 2019.PubMed/NCBI
|
|
33
|
Qin M, Chen W, Cui J, Li W, Liu D and
Zhang W: Protective efficacy of inhaled quercetin for radiation
pneumonitis. Exp Ther Med. 14:5773–5778. 2017.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Ding S, Jiang J and Li Y: Quercetin
alleviates PM2.5-induced chronic lung injury in mice by targeting
ferroptosis. PeerJ. 12(e16703)2024.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Malayeri AR, Hemmati AA, Arzi A, Rezaie A,
Ghafurian-Boroojerdnia M and Khalili HR: A comparison of the
effects of quercetin hydrate with those of vitamin E on the levels
of IL-13, PDGF, TNF-α, and INF-γ in bleomycin-induced pulmonary
fibrosis in rats. Jundishapur J Nat Ph. 11(e27705)2016.
|
|
36
|
El-Sayed NS and Rizk SM: The protective
effect of quercetin, green tea or malt extracts against
experimentally-induced lung fibrosis in rats. African J Pharm
Pharmacol. 3:191–201. 2009.
|
|
37
|
Fang Y, Jin W, Guo Z and Hao J: Quercetin
alleviates Asthma-induced airway inflammation and remodeling
through downregulating periostin via blocking TGF-β1/smad pathway.
Pharmacology. 108:432–443. 2023.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Yao J, Li Y, Meng F, Shen W and Wen H:
Enhancement of suppression oxidative stress and inflammation of
quercetin by Nano-decoration for ameliorating silica-induced
pulmonary fibrosis. Environ Toxicol. 38:1494–1508. 2023.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Yang T, Wang H, Li Y, Zeng Z, Shen Y, Wan
C, Wu Y, Dong J, Chen L and Wen F: Serotonin receptors 5-HTR2A and
5-HTR2B are involved in cigarette smoke-induced airway
inflammation, mucus hypersecretion and airway remodeling in mice.
Int Immunopharmacol. 81(106036)2020.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Zhang H, Hua H, Liu J, Wang C, Zhu C, Xia
Q, Jiang W, Cheng X, Hu X and Zhang Y: Integrative analysis of the
efficacy and pharmacological mechanism of Xuefu Zhuyu decoction in
idiopathic pulmonary fibrosis via evidence-based medicine,
bioinformatics, and experimental verification. Heliyon.
10(e38122)2024.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Toker C, Kuyucu Y, Saker D, Kara S,
Guzelel B and Mete UO: Investigation of miR-26b and miR-27b
expressions and the effect of quercetin on fibrosis in experimental
pulmonary fibrosis. J Mol Histol. 55:25–35. 2024.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Geng Q, Yan L, Shi C, Zhang L, Li L, Lu P,
Cao Z, Li L, He X, Tan Y, et al: Therapeutic effects of flavonoids
on pulmonary fibrosis: A preclinical Meta-analysis. Phytomedicine.
132(155807)2024.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Zhang X, Cai Y, Zhang W and Chen X:
Quercetin ameliorates pulmonary fibrosis by inhibiting SphK1/S1P
signaling. Biochem Cell Biol. 96:742–751. 2018.PubMed/NCBI View Article : Google Scholar
|
|
44
|
Xiao C, Tang Y, Ren T, Kong C, You H, Bai
XF, Huang Q, Chen Y, Li LG, Liu MY, et al: Treatment of silicosis
with quercetin depolarizing macrophages via inhibition of
mitochondrial damage-associated pyroptosis. Ecotoxicol Environ Saf.
286(117161)2024.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Zhang H, Yang L, Han Q and Xu W: Original
antifibrotic effects of quercetin on TGF-β1-induced vocal fold
fibroblasts. Am J Transl Res. 14:8552–8561. 2022.PubMed/NCBI
|
|
46
|
Widiatmoko A, Fitri LE, Endharti AT and
Murlistyarini S: The effect of quercetin on phosphorylated p38,
Smad7, Smad2/3 nuclear translocation and collagen type I of keloid
fibroblast culture. J Biotech Res. 16:32–42. 2024.
|
|
47
|
Takano M, Deguchi J, Senoo S, Izumi M,
Kawami M and Yumoto R: Suppressive effect of quercetin against
bleomycin-induced Epithelial-mesenchymal transition in alveolar
epithelial cells. Drug Metab Pharmacokinet. 35:522–526.
2020.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Lee GB, Kim Y, Lee KE, Vinayagam R, Singh
M and Kang SG: Anti-inflammatory effects of quercetin, rutin, and
troxerutin result from the inhibition of NO production and the
reduction of COX-2 levels in RAW 264.7 cells treated with LPS. Appl
Biochem Biotechnol. 196:8431–8452. 2024.PubMed/NCBI View Article : Google Scholar
|
|
49
|
Boots AW, Haenen GRMM and Bast A: Health
effects of quercetin: From antioxidant to nutraceutical. Eur J
Pharmacol. 585:325–337. 2008.PubMed/NCBI View Article : Google Scholar
|
|
50
|
Kostyuk VA, Potapovich AI, Speransky SD
and Maslova GT: Protective effect of natural flavonoids on rat
peritoneal macrophages injury caused by asbestos fibers. Free Radic
Bio Med. 21:487–493. 1996.PubMed/NCBI View Article : Google Scholar
|
|
51
|
Veith C, Drent M, Bast A, van Schooten FJ
and Boots AW: The disturbed redox-balance in pulmonary fibrosis is
modulated by the plant flavonoid quercetin. Toxicol Appl Pharmacol.
336:40–48. 2017.PubMed/NCBI View Article : Google Scholar
|
