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Case Report Open Access

Rare co‑occurrence of gastrointestinal stromal tumors and leiomyomas: A case report and review of the literature

  • Authors:
    • Yu Zhang
    • Xiaoqiong Shi
    • Wenfu Xie
    • Meilin He
    • Shan Zhang
    • Xue Peng
    • Hao Lei
    • Xulei Li
    • Haiying Liu
    • Qiao Shu
    • Fangyuan Zou
    • Mingyong Wei
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Sichuan Science City Hospital, Mianyang, Sichuan 621000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 67
    |
    Published online on: January 9, 2026
       https://doi.org/10.3892/etm.2026.13062
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Abstract

Gastrointestinal stromal tumors (GISTs) are recognized as the most common neoplasms originating from gastrointestinal mesenchymal tissue. On the other hand, gastric leiomyomas are a common benign neoplasm within the gastrointestinal tract. In general, GISTs are thought to be unrelated to gastric leiomyomas; however, the findings presented in the current study disprove this. The current case report presents a rare case where both GIST and gastric leiomyoma coexisted in a single subepithelial lesion (SEL) at the gastric cardia. Previous studies have confirmed that GIST can originate from smooth muscle cells with a BRAFV600E mutation, which was detected in the present GIST specimen. Notably, simultaneous expression of the KIT and BRAFV600E gene was also observed, challenging the previous assumption that only wild‑type GIST would carry the BRAFV600E gene. In conclusion, it is proposed that there may be homology between GISTs and gastric leiomyomas, and the BRAFV600E mutation was the critical trigger. Therefore, the incidence of BRAFV600E might have been underestimated in reality. The present study highlights that clinicians should be aware that GIST and gastric leiomyoma can coexist in the same SEL to avoid misdiagnosis and mistreatment. In the face of the escalating drug resistance rate of GIST, researchers may derive some novel insights from the present findings for GIST treatment and management.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Shi X, Xie W, He M, Zhang S, Peng X, Lei H, Li X, Liu H, Shu Q, Shu Q, et al: Rare co‑occurrence of gastrointestinal stromal tumors and leiomyomas: A case report and review of the literature. Exp Ther Med 31: 67, 2026.
APA
Zhang, Y., Shi, X., Xie, W., He, M., Zhang, S., Peng, X. ... Wei, M. (2026). Rare co‑occurrence of gastrointestinal stromal tumors and leiomyomas: A case report and review of the literature. Experimental and Therapeutic Medicine, 31, 67. https://doi.org/10.3892/etm.2026.13062
MLA
Zhang, Y., Shi, X., Xie, W., He, M., Zhang, S., Peng, X., Lei, H., Li, X., Liu, H., Shu, Q., Zou, F., Wei, M."Rare co‑occurrence of gastrointestinal stromal tumors and leiomyomas: A case report and review of the literature". Experimental and Therapeutic Medicine 31.3 (2026): 67.
Chicago
Zhang, Y., Shi, X., Xie, W., He, M., Zhang, S., Peng, X., Lei, H., Li, X., Liu, H., Shu, Q., Zou, F., Wei, M."Rare co‑occurrence of gastrointestinal stromal tumors and leiomyomas: A case report and review of the literature". Experimental and Therapeutic Medicine 31, no. 3 (2026): 67. https://doi.org/10.3892/etm.2026.13062
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Shi X, Xie W, He M, Zhang S, Peng X, Lei H, Li X, Liu H, Shu Q, Shu Q, et al: Rare co‑occurrence of gastrointestinal stromal tumors and leiomyomas: A case report and review of the literature. Exp Ther Med 31: 67, 2026.
APA
Zhang, Y., Shi, X., Xie, W., He, M., Zhang, S., Peng, X. ... Wei, M. (2026). Rare co‑occurrence of gastrointestinal stromal tumors and leiomyomas: A case report and review of the literature. Experimental and Therapeutic Medicine, 31, 67. https://doi.org/10.3892/etm.2026.13062
MLA
Zhang, Y., Shi, X., Xie, W., He, M., Zhang, S., Peng, X., Lei, H., Li, X., Liu, H., Shu, Q., Zou, F., Wei, M."Rare co‑occurrence of gastrointestinal stromal tumors and leiomyomas: A case report and review of the literature". Experimental and Therapeutic Medicine 31.3 (2026): 67.
Chicago
Zhang, Y., Shi, X., Xie, W., He, M., Zhang, S., Peng, X., Lei, H., Li, X., Liu, H., Shu, Q., Zou, F., Wei, M."Rare co‑occurrence of gastrointestinal stromal tumors and leiomyomas: A case report and review of the literature". Experimental and Therapeutic Medicine 31, no. 3 (2026): 67. https://doi.org/10.3892/etm.2026.13062
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