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Article Open Access

Efficacy of opioids in combination with gabapentin vs. opioids alone in the treatment of patients with cancer‑related pain due to bone metastases from malignant neoplasms: A meta‑analysis

  • Authors:
    • Hongli Zhou
    • Jun Feng
    • Zuolei Tang
  • View Affiliations / Copyright

    Affiliations: Anesthesia Surgery Center, 363 Hospital, Chengdu, Sichuan 610041, P.R. China, Department of Hematology, Chengdu Sixth People's Hospital, Chengdu, Sichuan 610051, P.R. China, Department of Anesthesiology, Sichuan Tianfu New Area People's Hospital, Chengdu, Sichuan 610200, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 108
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    Published online on: February 12, 2026
       https://doi.org/10.3892/etm.2026.13103
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Abstract

Cancer pain seriously affects the quality of life of patients with malignant tumors, especially the pain caused by bone metastases. In recent years, gabapentin has demonstrated potential value in the treatment of cancer pain from bone metastases, providing promising new ideas for clinical treatment. The aim of the present study was to systematically evaluate the efficacy of opioids combined with gabapentin compared with opioids alone in the treatment of cancer‑related pain due to bone metastases of malignant tumors based on meta‑analysis. PubMed, Embase, Web of Science, China National Knowledge Infrastructure, VIP, Wanfang Data and other databases were searched to collect randomized controlled trials and non‑randomized controlled trials of opioids combined with gabapentin compared with opioids alone for the treatment of cancer pain due to malignant bone metastases. The quality of the included studies was evaluated using the Cochrane Risk of Bias Assessment 2.0 tool and the Newcastle‑Ottawa Scale. Subsequent meta‑analyses were performed using the R language. A total of 25 studies including 1,805 patients were included. Meta‑analysis results showed that gabapentin in combination with opioids exhibited a notable advantage in reducing pain scores compared with opioids alone (mean difference=1.26; 95% CI, 0.88‑1.65). Subgroup analyses by study type, sample size and treatment regimen revealed that heterogeneity was influenced by a number of factors. Sensitivity analyses demonstrated the robustness of the findings. However, limited data on adverse effects precluded comprehensive safety analysis. Gabapentin in combination with opioids may be an effective regimen for the treatment of cancer‑related pain associated with bone metastases from malignant tumors. However, due to the heterogeneity of the included studies and limited safety data, clinical application requires caution and individualized treatment regimens based on patient‑specific conditions.
View Figures

Figure 1

Literature search and screening
flowchart. CNKI, China National Knowledge Infrastructure.

Figure 2

Quality evaluation star and bar chart
of randomized controlled trials.

Figure 3

Quality evaluation traffic map of
randomized controlled trials.

Figure 4

Forest plot of gabapentin combined
with opioids compared with opioids alone for numerical rating scale
score outcomes. IV, inverse-variance.

Figure 5

Funnel chart of studies related to
patient satisfaction.
View References

1 

Zhang Q, Hou L, Liu L, Li H, Chang J and Feng L: Medication rule of modern traditional chinese medicine compound prescriptions for the treatment of cancer-induced bone pain based on data mining. World Chinese Medicine. 18:2815–2819. 2023.

2 

Coleman RE: Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res. 12:6243S–6249S. 2006.PubMed/NCBI View Article : Google Scholar

3 

Mercadante S and Fulfaro F: World Health Organization guidelines for cancer pain: A reappraisal. Ann Oncol. 16 (Suppl 4):iv132–iv135. 2005.PubMed/NCBI View Article : Google Scholar

4 

Chang JY: A preclinical study of bone pain patch for the treatment of bone metastases in prostate cancer. Peking Union Medical College, 2024.

5 

Min QM, Liu C and Liu L: Traditional Chinese emotional nursing alleviates cancer pain in cancer patients: A Meta analysis. Chinese Evidence-based Nursing. 10:2118–2122. 2024.

6 

Wan Y, Deng H, Xia Y, Wen X and Yang G: Qualitative study on perioperative experience of intrathecal morphine pump implantation in patients with cancer pain. Journal of Modern Medicine and Health. 41:113–116. 2025.

7 

Chen X, Zheng L, Zhan L, Ye K, Wang J and Gou B: Comparative study on the analgesic effect of ultrasound-guided quadratus lumborum block combined with oxycodone in different approaches after laparoscopic colorectal-carcinoma surgery. Progress in Modern Biomedicine. 24:3061–3065. 2024.

8 

Xu Y: Efficacy and safety of oxycodone hydrochloride extended-release tablets in analgesia in patients with intermediate and advanced malignant tumors. Chinese Journal of Clinical Rational Drug Use. 18:109–112. 2025.

9 

Yunbo B, Zhigang F and Jin J: Clinical observation of oxycodone hydrochloride sustained-release tablets on neuropathic pain in patients with primary lung cancer during radiotherapy and chemotherapy. China Medicine. 20:47–52. 2025.

10 

Wang XM, Li W, Li M, Shang TZ, Yu ZQ and Zhang CL: Investigation on the Chinese medical staff for the clinical application and cognitive status of transdermal fentanyl patch in the treatment of cancer pain. Herald of Medicine. 42:1248–1254. 2023.

11 

Swarm RA, Paice JA, Anghelescu DL, Are M, Bruce JY, Buga S, Chwistek M, Cleeland C, Craig D, Gafford E, et al: Adult cancer pain, version 3.2019, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 17:977–1007. 2019.PubMed/NCBI View Article : Google Scholar

12 

Yang J, Wahner-Roedler DL, Zhou X, Johnson LA, Do A, Pachman DR, Chon TY, Salinas M, Millstine D and Bauer BA: Acupuncture for palliative cancer pain management: Systematic review. BMJ Support Palliat Care. 11:264–270. 2021.PubMed/NCBI View Article : Google Scholar

13 

Russo M, Graham B and Santarelli DM: Gabapentin-friend or foe? Pain Pract. 23:63–69. 2023.PubMed/NCBI View Article : Google Scholar

14 

Chang CY, Challa CK, Shah J and Eloy JD: Gabapentin in acute postoperative pain management. Biomed Res Int. 2014(631756)2014.PubMed/NCBI View Article : Google Scholar

15 

Xu JY: Evaluation of analgesic effects of the combination of gabapentin or duloxetine with resveratrol. Jiangsu Ocean University, 2022.

16 

Biggs JE, Stemkowski PL, Knaus EE, Chowdhury MA, Ballanyi K and Smith PA: Suppression of network activity in dorsal horn by gabapentin permeation of TRPV1 channels: Implications for drug access to cytoplasmic targets. Neurosci Lett. 584:397–402. 2015.PubMed/NCBI View Article : Google Scholar

17 

Hägg S, Jönsson AK and Ahlner J: Current evidence on abuse and misuse of gabapentinoids. Drug Saf. 43:1235–1254. 2020.PubMed/NCBI View Article : Google Scholar

18 

He YY, Chen ZH, Zhao L and Fan XG: Clinical efficacy of gabapentin combined with amitriptyline in patients with opioid tolerance and severe cancer pain: A retrospective study. Journal of Third Military Medical University. 39:1939–1943. 2017.

19 

Wu YC: Clinical study of gabapentin in combination with opioids in cancer pain. Guangxi Medical University, 2009.

20 

Li XM, Liu DQ, Wu HY, Yang C and Yang L: Controlled-release oxycodone alone or combined with gabapentin for management of malignant neuropathic pain. Chin J Cancer Res. 22:80–86. 2010.

21 

Caraceni A, Zecca E, Bonezzi C, Arcuri E, Tur RY, Maltoni M, Visentin M, Gorni G, Martini C, Tirelli W, et al: Gabapentin for neuropathic cancer pain: A randomized controlled trial from the gabapentin cancer pain study group. J Clin Oncol. 22:2909–2917. 2004.PubMed/NCBI View Article : Google Scholar

22 

Keskinbora K, Pekel AF and Aydinli I: Gabapentin and an opioid combination versus opioid alone for the management of neuropathic cancer pain: A randomized open trial. J Pain Symptom Manage. 34:183–189. 2007.PubMed/NCBI View Article : Google Scholar

23 

Ross JR, Goller K, Hardy J, Riley J, Broadley K, A'Hern R and Williams J: Gabapentin is effective in the treatment of cancer-related neuropathic pain: A prospective, open-label study. J Palliat Med. 8:1118–1126. 2005.PubMed/NCBI View Article : Google Scholar

24 

Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, Cates CJ, Cheng HY, Corbett MS, Eldridge SM, et al: RoB 2: A revised tool for assessing risk of bias in randomised trials. BMJ. 366(l4898)2019.PubMed/NCBI View Article : Google Scholar

25 

Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M, et al: The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa Hospital Research Institute, 2010.

26 

Balduzzi S, Rücker G and Schwarzer G: How to perform a meta-analysis with R: A practical tutorial. Evid Based Ment Health. 22:153–160. 2019.PubMed/NCBI View Article : Google Scholar

27 

Viechtbauer W and Cheung MW: Outlier and influence diagnostics for meta-analysis. Res Synth Methods. 1:112–125. 2010.PubMed/NCBI View Article : Google Scholar

28 

Zhao J: Clinical observation of morphine combined with gabapentin in the treatment of moderate and severe neuropathic cancer pain. China Practical Medicine. 11:105–107. 2016.

29 

Zhao XH and Xia J: Efficacy of fentanyl patch combined with gabapentin in the treatment of cancer pain in pancreatic cancer. Strait Pharm J. 32:150–152. 2020.

30 

Jiang W, Song H and Wang E: Analysis of the clinical effect of oxycodone hydrochloride extended-release tablets combined with gabapentin in the treatment of moderate to severe cancer pain. J Med Theory Pract. 34:438–440. 2021.

31 

Sun L: Clinical Analysis of Gabapentin Combined with Morphine Sulfate Sustained-release Tablets in the Treatment of Cancerous Neuropathic Pain. China Foreign Medical Treatment. 40:101–103. 2021.

32 

Teng L, Dai J, Shao H, Zhao L, Lin S, Zhang W and Zou H: Gabapentin enhances the antinociceptive effect of intrathecal morphine in refractory cancer pain patients. Support Care Cancer. 29:7611–7616. 2021.PubMed/NCBI View Article : Google Scholar

33 

Su L: Clinical observation and care of fentanyl patch combined with gabapentin in the treatment of bone metastasis cancer pain. China Medical Engineering. 21:90–92. 2013.

34 

Liu XC, Ding ZP and Zhou XF: Effects of gabapentin combined with morphine sulfate sustained release tablets on pain of middle-late stage cancer patients after chemotherapy and radiotherapy. The Practical Journal of Cancer. (11):1504–1506. 2014.

35 

Qin XB, Song CJ, Yu T, Li JY, Liu TF and Chen XM: Efficacy observation of oxycodone hydrochloride controlled-release tablets combined with gabapentin for the treatment of malignant neuropathic pain. ACTA Academiae Medicinae Xuzhou. (9):594–597. 2015.

36 

Chen L, Shen W, Han X, Yuan Y, Liang D, Yin Q, et al: Clinical observation of sustained-release morphine sulphate combined with gabapentin in the treatment of cancer pain. Chinese Journal of Pain Medicine. 21:679–683. 2015.

37 

Zhang N: Effect and adverse reactions of gabapentin combined with morphine sulfate controlled-release tablets in the treatment of carcinoneuralgia. Chinese Journal of Practical Nervous Diseases. 19:40–42. 2016.

38 

Zhang LJ, et al: Analysis of the efficacy of gabapentin combined with morphine hydrochloride extended-release tablets in the treatment of patients with severe cancer pain. China Health Care and Nutrition. 26:174–175. 2016.

39 

Chen ZH, et al: Clinical observation of oxycodone hydrochloride extended-release tablets combined with gabapentin capsules in the treatment of cancer pain. Guangdong Medical Journal. 38:136–138. 2017.

40 

Jiang B: Clinical study of opioids in combination with gabapentin in cancer pain. Qinghai University, 2017.

41 

She XH and Jiang LY: A study on the effect of gabapentin and morphine hydrochloride sustained-release tablets in relieving pain in patients with cancer pain. Chinese Remedies and Clinics. 17:1824–1826. 2017.

42 

Yan HM, et al: Clinical observation of gabapentin combined with morphine sulfate extended-release tablets in the treatment of cancerous neuropathic pain. Zhejiang Clinical Medical Journal. 20:1073–1075. 2018.

43 

Ru AZ, et al: Analysis of the effect of gabapentin combined with oxycodone hydrochloride in the treatment of cancerous neuropathic pain. Health Vocational Education. 36:84–86. 2018.

44 

Fu XZ: Effect of the combination of morphine sulfate extended-release tablets and gabapentin capsules in the treatment of cancer pain and its effect on quality of life. Journal of North Pharmacy. 15:104–105. 2018.

45 

Yan QY: Clinical study of opioids combined with gabapentin in the treatment of cancer pain and analysis of real-world cancer pain diagnosis and treatment. Hebei Medical University, 2018.

46 

Zhou H, Zhang H, Qian X and Ge W: Efficacy and safety of gabapentin adjuvant therapy for neuropathic cancer pain. China Pharmacist. 22:1278–1286. 2019.

47 

Meng J: Effect of gabapentin combined with oxycodone hydrochloride on patients with advanced cancer-induced pain and its effect on pain media. Medical Information. 32:146–147. 2019.

48 

Zhu RH: Clinical analysis of gabapentin combined with morphine sulfate extended-release tablets in the treatment of cancerous neuropathic pain. Health Guide. (48)(100)2020.

49 

Zhang X: Analysis of the effect of gabapentin combined with oxycodone hydrochloride extended-release tablets in the treatment of cancerous neuropathic pain. Contemporary Medicine Forum. 19(23)2021.

50 

Jiang W, Wang L, Wu T, Xiu X, Yang X and Zhang S: Clinical efficacy of oxycontin combined with gabapentin on neuropathic cancer pain and its effect on immune function. Int J Clin Exp Med. 14:246–254. 2021.

51 

Qi N: Observation of the efficacy of gabapentin combined with oxycodone hydrochloride extended-release tablets in the treatment of cancerous neuropathic pain. Health Guide. (20):7–9. 2024.

52 

Wu X, Li N, Zhu J, Wu Y, Du Y, et al: Observation of opioid combined with corticosteroids or anticonvulsants for advanced cancer patients with pain. Chinese Clinical Oncology. 16:58–60. 2011.

53 

Shinde S, Gordon P, Sharma P, Gross J and Davis MP: Use of non-opioid analgesics as adjuvants to opioid analgesia for cancer pain management in an inpatient palliative unit: Does this improve pain control and reduce opioid requirements? Support Care Cancer. 23:695–703. 2015.PubMed/NCBI View Article : Google Scholar

54 

Eckhardt K, Ammon S, Hofmann U, Riebe A, Gugeler N and Mikus G: Gabapentin enhances the analgesic effect of morphine in healthy volunteers. Anesth Analg. 91:185–191. 2000.PubMed/NCBI View Article : Google Scholar

55 

Wang X, Peng J and Wang X: Oxycodone hydrochloride controlled-release tablet combined with gabapentin for treatment of advanced cancer with neuropathic pain. Journal of Modern Oncology. 20:1930–1932. 2012.

56 

Gilron I: Gabapentin and pregabalin for chronic neuropathic and early postsurgical pain: Current evidence and future directions. Curr Opin Anaesthesiol. 20:456–472. 2007.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhou H, Feng J and Tang Z: Efficacy of opioids in combination with gabapentin vs. opioids alone in the treatment of patients with cancer‑related pain due to bone metastases from malignant neoplasms: A meta‑analysis. Exp Ther Med 31: 108, 2026.
APA
Zhou, H., Feng, J., & Tang, Z. (2026). Efficacy of opioids in combination with gabapentin vs. opioids alone in the treatment of patients with cancer‑related pain due to bone metastases from malignant neoplasms: A meta‑analysis. Experimental and Therapeutic Medicine, 31, 108. https://doi.org/10.3892/etm.2026.13103
MLA
Zhou, H., Feng, J., Tang, Z."Efficacy of opioids in combination with gabapentin vs. opioids alone in the treatment of patients with cancer‑related pain due to bone metastases from malignant neoplasms: A meta‑analysis". Experimental and Therapeutic Medicine 31.4 (2026): 108.
Chicago
Zhou, H., Feng, J., Tang, Z."Efficacy of opioids in combination with gabapentin vs. opioids alone in the treatment of patients with cancer‑related pain due to bone metastases from malignant neoplasms: A meta‑analysis". Experimental and Therapeutic Medicine 31, no. 4 (2026): 108. https://doi.org/10.3892/etm.2026.13103
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou H, Feng J and Tang Z: Efficacy of opioids in combination with gabapentin vs. opioids alone in the treatment of patients with cancer‑related pain due to bone metastases from malignant neoplasms: A meta‑analysis. Exp Ther Med 31: 108, 2026.
APA
Zhou, H., Feng, J., & Tang, Z. (2026). Efficacy of opioids in combination with gabapentin vs. opioids alone in the treatment of patients with cancer‑related pain due to bone metastases from malignant neoplasms: A meta‑analysis. Experimental and Therapeutic Medicine, 31, 108. https://doi.org/10.3892/etm.2026.13103
MLA
Zhou, H., Feng, J., Tang, Z."Efficacy of opioids in combination with gabapentin vs. opioids alone in the treatment of patients with cancer‑related pain due to bone metastases from malignant neoplasms: A meta‑analysis". Experimental and Therapeutic Medicine 31.4 (2026): 108.
Chicago
Zhou, H., Feng, J., Tang, Z."Efficacy of opioids in combination with gabapentin vs. opioids alone in the treatment of patients with cancer‑related pain due to bone metastases from malignant neoplasms: A meta‑analysis". Experimental and Therapeutic Medicine 31, no. 4 (2026): 108. https://doi.org/10.3892/etm.2026.13103
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