|
1
|
Zhan T, Betge J, Schulte N, Dreikhausen L,
Hirth M, Li M, Weidner P, Leipertz A, Teufel A and Ebert MP:
Digestive cancers: Mechanisms, therapeutics and management. Signal
Transduct Target Ther. 10(24)2025.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Bray F, Laversanne M, Sung H, Ferlay J,
Siegel RL, Soerjomataram I and Jemal A: Global cancer statistics
2022: GLOBOCAN estimates of incidence and mortality worldwide for
36 cancers in 185 countries. CA Cancer J Clin. 74:229–263.
2024.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Mousavi SE, Ilaghi M, Elahi Vahed I and
Nejadghaderi SA: Epidemiology and socioeconomic correlates of
gastric cancer in Asia: Results from the GLOBOCAN 2020 data and
projections from 2020 to 2040. Sci Rep. 15(6529)2025.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Ferreira RM, Pereira-Marques J,
Pinto-Ribeiro I, Costa JL, Carneiro F, Machado JC and Figueiredo C:
Gastric microbial community profiling reveals a dysbiotic
cancer-associated microbiota. Gut. 67:226–236. 2018.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Buchta Rosean C, Feng TY, Azar FN and
Rutkowski MR: Impact of the microbiome on cancer progression and
response to anti-cancer therapies. Adv Cancer Res. 143:255–294.
2019.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Singh R, Zogg H, Wei L, Bartlett A,
Ghoshal UC, Rajender S and Ro S: Gut microbial dysbiosis in the
pathogenesis of gastrointestinal dysmotility and metabolic
disorders. J Neurogastroenterol Motil. 27:19–34. 2021.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Asseri AH, Bakhsh T, Abuzahrah SS, Ali S
and Rather IA: The gut dysbiosis-cancer axis: Illuminating novel
insights and implications for clinical practice. Front Pharmacol.
14(1208044)2023.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Rooks MG and Garrett WS: Gut microbiota,
metabolites and host immunity. Nat Rev Immunol. 16:341–352.
2016.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Wang Z, Li L, Wang S, Wei J, Qu L, Pan L
and Xu K: The role of the gut microbiota and probiotics associated
with microbial metabolisms in cancer prevention and therapy. Front
Pharmacol. 13(1025860)2022.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Feng W, Liu J, Cheng H, Zhang D, Tan Y and
Peng C: Dietary compounds in modulation of gut microbiota-derived
metabolites. Front Nutr. 9(939571)2022.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Molinaro A, Wahlström A and Marschall HU:
Role of bile acids in metabolic control. Trends Endocrinol Metab.
29:31–41. 2018.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Barrueto L, Caminero F, Cash L, Makris C,
Lamichhane P and Deshmukh RR: Resistance to checkpoint inhibition
in cancer immunotherapy. Transl Oncol. 13(100738)2020.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Bae J, Park K and Kim YM: Commensal
microbiota and cancer immunotherapy: Harnessing commensal bacteria
for cancer therapy. Immune Netw. 22(e3)2022.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Feng P, Xue X, Bukhari I, Qiu C, Li Y,
Zheng P and Mi Y: Gut microbiota and its therapeutic implications
in tumor microenvironment interactions. Front Microbiol.
15(1287077)2024.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Yang Z, Wang X, Zhou H, Jiang M, Wang J
and Sui B: Molecular complexity of colorectal cancer: Pathways,
biomarkers, and therapeutic strategies. Cancer Manag Res.
16:1389–1403. 2024.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Yang Z, Chang Y, Hu Y, An W, Xing C and
Sui B: A concise review on advancement in molecular targeted
therapy for lung cancer. Period Biol. 126:15–31. 2024.
|
|
17
|
Ryu MH, Lee JL, Chang HM, Kim TW, Kang HJ,
Sohn HJ, Lee JS and Kang YK: Patterns of progression in
gastrointestinal stromal tumor treated with imatinib mesylate. Jpn
J Clin Oncol. 36:17–24. 2006.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Gao X, Yin P, Ren Y, Yu L, Tian F, Zhao J,
Chen W, Xue Y and Zhai Q: Predicting personalized diets based on
microbial characteristics between patients with superficial
gastritis and atrophic gastritis. Nutrients.
15(4738)2023.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Mei S, Deng Z, Chen Y, Ning D, Guo Y, Fan
X, Wang R, Meng Y, Zhou Q and Tian X: Dysbiosis: The first hit for
digestive system cancer. Front Physiol. 13(1040991)2022.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Cruz MS, Tintelnot J and Gagliani N: Roles
of microbiota in pancreatic cancer development and treatment. Gut
Microbes. 16(2320280)2024.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Rinninella E, Raoul P, Cintoni M,
Franceschi F, Miggiano GAD, Gasbarrini A and Mele MC: What is the
healthy gut microbiota composition? A changing ecosystem across
age, environment, diet, and diseases. Microorganisms.
7(14)2019.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Magne F, Gotteland M, Gauthier L, Zazueta
A, Pesoa S, Navarrete P and Balamurugan R: The
firmicutes/bacteroidetes ratio: A relevant marker of gut dysbiosis
in obese patients? Nutrients. 12(1474)2020.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Colombo F, Illescas O, Noci S, Minnai F,
Pintarelli G, Pettinicchio A, Vannelli A, Sorrentino L, Battaglia
L, Cosimelli M, et al: Gut microbiota composition in colorectal
cancer patients is genetically regulated. Sci Rep.
12(11424)2022.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Li N, Bai C, Zhao L, Sun Z, Ge Y and Li X:
The relationship between gut microbiome features and chemotherapy
response in gastrointestinal cancer. Front Oncol.
11(781697)2021.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Kulmambetova G, Kurentay B, Gusmaulemova
A, Utupov T, Auganova D, Tarlykov P, Mamlin M, Khamzina S,
Shalekenov S and Kozhakhmetov A: Association of Fusobacterium
nucleatum infection with colorectal cancer in Kazakhstani
patients. Front Oncol. 14(1473575)2024.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Abdulla MH, Agarwal D, Singh JK, Traiki
TB, Pandey MK, Ahmad R and Srivastava SK: Association of the
microbiome with colorectal cancer development (review). Int J
Oncol. 58(17)2021.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Osman MA, Neoh HM, Ab Mutalib NS, Chin SF,
Mazlan L, Raja Ali RA, Zakaria AD, Ngiu CS, Ang MY and Jamal R:
Parvimonas micra, Peptostreptococcus stomatis,
Fusobacterium nucleatum and Akkermansia muciniphila as a
four-bacteria biomarker panel of colorectal cancer. Sci Rep.
11(2925)2021.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Conde-Pérez K, Buetas E, Aja-Macaya P,
Martin-De Arribas E, Iglesias-Corrás I, Trigo-Tasende N, Nasser-Ali
M, Estévez LS, Rumbo-Feal S, Otero-Alén B, et al: Parvimonas
micra can translocate from the subgingival sulcus of the human oral
cavity to colorectal adenocarcinoma. Mol Oncol. 18:1143–1173.
2024.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Effendi RMRA, Anshory M, Kalim H, Dwiyana
RF, Suwarsa O, Pardo LM, Nijsten TEC and Thio HB: Akkermansia
muciniphila and Faecalibacterium prausnitzii in
immune-related diseases. Microorganisms. 10(2382)2022.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Montgomery TL, Toppen LC, Eckstrom K,
Heney ER, Kennedy JJ, Scarborough MJ and Krementsov DN:
Lactobacillaceae differentially impact butyrate-producing gut
microbiota to drive CNS autoimmunity. Gut Microbes.
16(2418415)2024.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Gomes S, Baltazar F, Silva E and Preto A:
Microbiota-derived short-chain fatty acids: New road in colorectal
cancer therapy. Pharmaceutics. 14(2359)2022.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Liu G, Tang J, Zhou J and Dong M:
Short-chain fatty acids play a positive role in colorectal cancer.
Discov Oncol. 15(425)2024.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Han A, Bennett N, Ahmed B, Whelan J and
Donohoe DR: Butyrate decreases its own oxidation in colorectal
cancer cells through inhibition of histone deacetylases.
Oncotarget. 9:27280–27292. 2018.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Xu Z, Xiao L, Wang S, Cheng Y, Wu J, Meng
Y, Bao K, Zhang J and Cheng C: Alteration of gastric microbiota and
transcriptome in a rat with gastric intestinal metaplasia induced
by deoxycholic acid. Front Microbiol. 14(1160821)2023.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Wang S, Kuang J, Zhang H, Chen W, Zheng X,
Wang J, Huang F, Ge K, Li M, Zhao M, et al: Bile acid-microbiome
interaction promotes gastric carcinogenesis. Adv Sci (Weinh).
9(e2200263)2022.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Ma C, Han M, Heinrich B, Fu Q, Zhang Q,
Sandhu M, Agdashian D, Terabe M, Berzofsky JA, Fako V, et al: Gut
microbiome-mediated bile acid metabolism regulates liver cancer via
NKT cells. Science. 360(eaan5931)2018.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Phelan JP, Reen FJ, Caparros-Martin JA,
O'Connor R and O'Gara F: Rethinking the bile acid/gut microbiome
axis in cancer. Oncotarget. 8:115736–115747. 2017.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Chen C, Shen J, Du Y, Shi X, Niu Y, Jin G,
Liu Y, Shi Y, Lyu J and Lin L: Characteristics of gut microbiota in
patients with gastric cancer by surgery, chemotherapy and lymph
node metastasis. Clin Transl Oncol. 24:2181–2190. 2022.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Dai D, Yang Y, Yu J, Dang T, Qin W, Teng
L, Ye J and Jiang H: Interactions between gastric microbiota and
metabolites in gastric cancer. Cell Death Dis.
12(1104)2021.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Correa P and Piazuelo MB: Helicobacter
pylori infection and gastric adenocarcinoma. US Gastroenterol
Hepatol Rev. 7:59–64. 2011.PubMed/NCBI
|
|
41
|
Yu D, Yang J, Jin M, Zhou B, Shi L, Zhao
L, Zhang J, Lin Z, Ren J, Liu L, et al: Fecal Streptococcus
alteration is associated with gastric cancer occurrence and liver
metastasis. mBio. 12(e0299421)2021.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Jang S, Hansen LM, Su H, Solnick JV and
Cha JH: Host immune response mediates changes in cagA copy number
and virulence potential of Helicobacter pylori. Gut
Microbes. 14(2044721)2022.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Jin D, Huang K, Xu M, Hua H, Ye F, Yan J,
Zhang G and Wang Y: Deoxycholic acid induces gastric intestinal
metaplasia by activating STAT3 signaling and disturbing gastric
bile acids metabolism and microbiota. Gut Microbes.
14(2120744)2022.PubMed/NCBI View Article : Google Scholar
|
|
44
|
Sah DK, Arjunan A, Lee B and Jung YD:
Reactive oxygen species and H. pylori infection: A
comprehensive review of their roles in gastric cancer development.
Antioxidants (Basel). 12(1712)2023.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Blackwood BP, Yuan CY, Wood DR, Nicolas
JD, Grothaus JS and Hunter CJ: Probiotic Lactobacillus
species strengthen intestinal barrier function and tight junction
integrity in experimental necrotizing enterocolitis. J Probiotics
Health. 5(159)2017.PubMed/NCBI View Article : Google Scholar
|
|
46
|
Devi TB, Devadas K, George M, Gandhimathi
A, Chouhan D, Retnakumar RJ, Alexander SM, Varghese J, Dharmaseelan
S, Chandrika SK, et al: Low Bifidobacterium abundance in the
lower gut microbiota is associated with Helicobacter
pylori-related gastric ulcer and gastric cancer. Front
Microbiol. 12(631140)2021.PubMed/NCBI View Article : Google Scholar
|
|
47
|
Park JY, Seo H, Kang CS, Shin TS, Kim JW,
Park JM, Kim JG and Kim YK: Dysbiotic change in gastric microbiome
and its functional implication in gastric carcinogenesis. Sci Rep.
12(4285)2022.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Yuan L, Pan L, Wang Y, Zhao J, Fang L,
Zhou Y, Xia R, Ma Y, Jiang Z, Xu Z, et al: Characterization of the
landscape of the intratumoral microbiota reveals that
Streptococcus anginosus increases the risk of gastric cancer
initiation and progression. Cell Discov. 10(117)2024.PubMed/NCBI View Article : Google Scholar
|
|
49
|
May MS, Park H, Moallem DH, Seeram D,
Dajiang S, Hibshoosh H, Jamison JK, Uhlemann AC and Manji GA: Low
bacterial biomass in human pancreatic cancer and adjacent normal
tissue. Int J Mol Sci. 26(140)2024.PubMed/NCBI View Article : Google Scholar
|
|
50
|
Pushalkar S, Hundeyin M, Daley D,
Zambirinis CP, Kurz E, Mishra A, Mohan N, Aykut B, Usyk M, Torres
LE, et al: The pancreatic cancer microbiome promotes oncogenesis by
induction of innate and adaptive immune suppression. Cancer Discov.
8:403–416. 2018.PubMed/NCBI View Article : Google Scholar
|
|
51
|
Pust MM, Rocha Castellanos DM, Rzasa K,
Dame A, Pishchany G, Assawasirisin C, Liss A, Fernandez-Del
Castillo C and Xavier RJ: Absence of a pancreatic microbiome in
intraductal papillary mucinous neoplasm. Gut. 73:1131–1141.
2024.PubMed/NCBI View Article : Google Scholar
|
|
52
|
Bellotti R, Speth C, Adolph TE, Lass-Flörl
C, Effenberger M, Öfner D and Maglione M: Micro- and mycobiota
dysbiosis in pancreatic ductal adenocarcinoma development. Cancers
(Basel). 13(3431)2021.PubMed/NCBI View Article : Google Scholar
|
|
53
|
Wei X, Mei C, Li X and Xie Y: The unique
microbiome and immunity in pancreatic cancer. Pancreas. 50:119–129.
2021.PubMed/NCBI View Article : Google Scholar
|
|
54
|
Wang S, Li Y, Xing C, Ding C, Zhang H,
Chen L, You L, Dai M and Zhao Y: Tumor microenvironment in
chemoresistance, metastasis and immunotherapy of pancreatic cancer.
Am J Cancer Res. 10:1937–1953. 2020.PubMed/NCBI
|
|
55
|
Nista EC, Del Gaudio A, Del Vecchio LE,
Mezza T, Pignataro G, Piccioni A, Gasbarrini A, Franceschi F and
Candelli M: Pancreatic cancer resistance to treatment: The role of
microbiota. Biomedicines. 11(157)2023.PubMed/NCBI View Article : Google Scholar
|
|
56
|
Saenz C, Fang Q, Gnanasekaran T, Trammell
SAJ, Buijink JDA, Pisano P, Wierer M, Moens F, Lengger B, Brejnrod
A and Arumugam M: Clostridium scindens secretome suppresses
virulence gene expression of Clostridioides difficile in a bile
acid-independent manner. Microbiol Spectr.
11(e0393322)2023.PubMed/NCBI View Article : Google Scholar
|
|
57
|
Li W, Chen H and Tang J: Interplay between
bile acids and intestinal microbiota: Regulatory mechanisms and
therapeutic potential for infections. Pathogens.
13(702)2024.PubMed/NCBI View Article : Google Scholar
|
|
58
|
Wu Z, Guo J, Zhang Z, Gao S, Huang M, Wang
Y, Zhang Y, Li Q and Li J: Bacteroidetes promotes esophageal
squamous carcinoma invasion and metastasis through LPS-mediated
TLR4/Myd88/NF-κB pathway and inflammatory changes. Sci Rep.
14(12827)2024.PubMed/NCBI View Article : Google Scholar
|
|
59
|
Greathouse KL, Stone JK, Vargas AJ,
Choudhury A, Padgett RN, White JR, Jung A and Harris CC:
Co-enrichment of cancer-associated bacterial taxa is correlated
with immune cell infiltrates in esophageal tumor tissue. Sci Rep.
14(2574)2024.PubMed/NCBI View Article : Google Scholar
|
|
60
|
Mostafavi Abdolmaleky H and Zhou JR: Gut
microbiota dysbiosis, oxidative stress, inflammation, and
epigenetic alterations in metabolic diseases. Antioxidants (Basel).
13(985)2024.PubMed/NCBI View Article : Google Scholar
|
|
61
|
Nguyen TT, Ung TT, Li S, Lian S, Xia Y,
Park SY and Do Jung Y: Metformin inhibits lithocholic acid-induced
interleukin 8 upregulation in colorectal cancer cells by
suppressing ROS production and NF-kB activity. Sci Rep.
9(2003)2019.PubMed/NCBI View Article : Google Scholar
|
|
62
|
Sun J, Chen S, Zang D, Sun H, Sun Y and
Chen J: Butyrate as a promising therapeutic target in cancer: From
pathogenesis to clinic (review). Int J Oncol. 64(44)2024.PubMed/NCBI View Article : Google Scholar
|
|
63
|
Xiao T, Wu S, Yan C, Zhao C, Jin H, Yan N,
Xu J, Wu Y, Li C, Shao Q and Xia S: Butyrate upregulates the TLR4
expression and the phosphorylation of MAPKs and NK-κB in colon
cancer cell in vitro. Oncol Lett. 16:4439–4447.
2018.PubMed/NCBI View Article : Google Scholar
|
|
64
|
Kaźmierczak-Siedlecka K, Marano L, Merola
E, Roviello F and Połom K: Sodium butyrate in both prevention and
supportive treatment of colorectal cancer. Front Cell Infect
Microbiol. 12(1023806)2022.PubMed/NCBI View Article : Google Scholar
|
|
65
|
Rodríguez-Enríquez S, Robledo-Cadena DX,
Gallardo-Pérez JC, Pacheco-Velázquez SC, Vázquez C, Saavedra E,
Vargas-Navarro JL, Blanco-Carpintero BA, Marín-Hernández Á,
Jasso-Chávez R, et al: Acetate promotes a differential energy
metabolic response in human HCT 116 and COLO 205 colon cancer cells
impacting cancer cell growth and invasiveness. Front Oncol.
11(697408)2021.PubMed/NCBI View Article : Google Scholar
|
|
66
|
Cornall LM, Mathai ML, Hryciw DH and
McAinch AJ: The therapeutic potential of GPR43: A novel role in
modulating metabolic health. Cell Mol Life Sci. 70:4759–4770.
2013.PubMed/NCBI View Article : Google Scholar
|
|
67
|
Yao T, Dong X, Lv J, Fu L and Li L:
Propionate alleviated colitis by modulating iron homeostasis to
inhibit ferroptosis and macrophage polarization. Int
Immunopharmacol. 162(115151)2025.PubMed/NCBI View Article : Google Scholar
|
|
68
|
Li Y, Zhao M, Lin Y, Jiang X, Jin L, Ye P,
Lu Y, Pei R and Jiang L: Licochalcone A induces
mitochondria-dependent apoptosis and interacts with venetoclax in
acute myeloid leukemia. Eur J Pharmacol. 968(176418)2024.PubMed/NCBI View Article : Google Scholar
|
|
69
|
Kozoni V, Tsioulias G, Shiff S and Rigas
B: The effect of lithocholic acid on proliferation and apoptosis
during the early stages of colon carcinogenesis: differential
effect on apoptosis in the presence of a colon carcinogen.
Carcinogenesis. 21:999–1005. 2000.PubMed/NCBI View Article : Google Scholar
|
|
70
|
Luu TH, Bard JM, Carbonnelle D, Chaillou
C, Huvelin JM, Bobin-Dubigeon C and Nazih H: Lithocholic bile acid
inhibits lipogenesis and induces apoptosis in breast cancer cells.
Cell Oncol (Dordr). 41:13–24. 2018.PubMed/NCBI View Article : Google Scholar
|
|
71
|
Trah J, Arand J, Oh J, Pagerols-Raluy L,
Trochimiuk M, Appl B, Heidelbach H, Vincent D, Saleem MA,
Reinshagen K, et al: Lithocholic bile acid induces apoptosis in
human nephroblastoma cells: A non-selective treatment option. Sci
Rep. 10(20349)2020.PubMed/NCBI View Article : Google Scholar
|
|
72
|
Schwarcz S, Kovács P, Nyerges P, Ujlaki G,
Sipos A, Uray K, Bai P and Mikó E: The bacterial metabolite,
lithocholic acid, has antineoplastic effects in pancreatic
adenocarcinoma. Cell Death Discov. 10(248)2024.PubMed/NCBI View Article : Google Scholar
|
|
73
|
Nguyen TT, Ung TT, Kim NH and Jung YD:
Role of bile acids in colon carcinogenesis. World J Clin Cases.
6:577–588. 2018.PubMed/NCBI View Article : Google Scholar
|
|
74
|
Carino A, Graziosi L, D'Amore C, Cipriani
S, Marchianò S, Marino E, Zampella A, Rende M, Mosci P, Distrutti
E, et al: The bile acid receptor GPBAR1 (TGR5) is expressed in
human gastric cancers and promotes epithelial-mesenchymal
transition in gastric cancer cell lines. Oncotarget. 7:61021–61035.
2016.PubMed/NCBI View Article : Google Scholar
|
|
75
|
Su X, Gao Y and Yang R: Gut
microbiota-derived tryptophan metabolites maintain gut and systemic
homeostasis. Cells. 11(2296)2022.PubMed/NCBI View Article : Google Scholar
|
|
76
|
Zhao P, Chen Y, Zhou S and Li F: Microbial
modulation of tryptophan metabolism links gut microbiota to disease
and its treatment. Pharmacol Res. 219(107896)2025.PubMed/NCBI View Article : Google Scholar
|
|
77
|
Wang Z, Yin M, Zhou R, Li M, Peng J and
Wang Z: Kynurenine promotes the immune escape of colorectal cancer
cells via NAT10-mediated ac4C acetylation of PD-L1.
Clinics (Sao Paulo). 80(100658)2025.PubMed/NCBI View Article : Google Scholar
|
|
78
|
Dehhaghi M, Kazemi Shariat Panahi H, Heng
B and Guillemin GJ: The gut microbiota, kynurenine pathway, and
immune system interaction in the development of brain cancer. Front
Cell Dev Biol. 8(562812)2020.PubMed/NCBI View Article : Google Scholar
|
|
79
|
Ren B, Fang Y, Gu M, You L, Zhang T and
Zhao Y: Microbiota-metabolism-epigenetics-immunity axis in cancer.
Front Immunol. 15(1449912)2024.
|
|
80
|
Wilton J, de Mendonça FL, Pereira-Castro
I, Tellier M, Nojima T, Costa AM, Freitas J, Murphy S, Oliveira MJ,
Proudfoot NJ and Moreira A: Pro-inflammatory polarization and
colorectal cancer modulate alternative and intronic polyadenylation
in primary human macrophages. Front Immunol.
14(1182525)2023.PubMed/NCBI View Article : Google Scholar
|
|
81
|
Li Y, Li Q, Yuan R, Wang Y, Guo C and Wang
L: Bifidobacterium breve-derived indole-3-lactic acid
ameliorates colitis-associated tumorigenesis by directing the
differentiation of immature colonic macrophages. Theranostics.
14:2719–2735. 2024.PubMed/NCBI View Article : Google Scholar
|
|
82
|
Hunzeker ZE, Zhao L, Kim AM, Parker JM,
Zhu Z, Xiao H, Bai Q, Wakefield MR and Fang Y: The role of IL-22 in
cancer. Med Oncol. 41(240)2024.PubMed/NCBI View Article : Google Scholar
|
|
83
|
Liu X, Li S, Wang L and Ma K:
Microecological regulation in HCC therapy: Gut microbiome enhances
ICI treatment. Biochim Biophys Acta Mol Basis Dis.
1870(167230)2024.PubMed/NCBI View Article : Google Scholar
|
|
84
|
Goodwin AC, Destefano Shields CE, Wu S,
Huso DL, Wu X, Murray-Stewart TR, Hacker-Prietz A, Rabizadeh S,
Woster PM, Sears CL and Casero RA Jr: Polyamine catabolism
contributes to enterotoxigenic Bacteroides fragilis-induced
colon tumorigenesis. Proc Natl Acad Sci USA. 108:15354–15359.
2011.PubMed/NCBI View Article : Google Scholar
|
|
85
|
Holbert CE, Cullen MT, Casero RA Jr and
Stewart TM: Polyamines in cancer: Integrating organismal metabolism
and antitumour immunity. Nat Rev Cancer. 22:467–480.
2022.PubMed/NCBI View Article : Google Scholar
|
|
86
|
Schlichtner S, Yasinska IM, Klenova E,
Abooali M, Lall GS, Berger SM, Ruggiero S, Cholewa D, Milošević M,
Gibbs BF, et al: L-Kynurenine participates in cancer immune evasion
by downregulating hypoxic signaling in T lymphocytes.
Oncoimmunology. 12(2244330)2023.PubMed/NCBI View Article : Google Scholar
|
|
87
|
Snezhkina AV, Krasnov GS, Lipatova AV,
Sadritdinova AF, Kardymon OL, Fedorova MS, Melnikova NV, Stepanov
OA, Zaretsky AR, Kaprin AD, et al: The dysregulation of polyamine
metabolism in colorectal cancer is associated with overexpression
of c-Myc and C/EBPβ rather than enterotoxigenic Bacteroides
fragilis infection. Oxid Med Cell Longev.
2016(2353560)2016.PubMed/NCBI View Article : Google Scholar
|
|
88
|
Braccia DJ, Jiang X, Pop M and Hall AB:
The capacity to produce hydrogen sulfide (H2S) via cysteine
degradation is ubiquitous in the human gut microbiome. Front
Microbiol. 12(705583)2021.PubMed/NCBI View Article : Google Scholar
|
|
89
|
Kumar A, Ali A, Kapardar RK, Dar GM,
Nimisha Apurva, Sharma AK, Verma R, Sattar RSA, Ahmad E, et al:
Implication of gut microbes and its metabolites in colorectal
cancer. J Cancer Res Clin Oncol. 149:441–465. 2023.PubMed/NCBI View Article : Google Scholar
|
|
90
|
Blachier F, Andriamihaja M, Larraufie P,
Ahn E, Lan A and Kim E: Production of hydrogen sulfide by the
intestinal microbiota and epithelial cells and consequences for the
colonic and rectal mucosa. Am J Physiol Gastrointest Liver Physiol.
320:G125–G135. 2021.PubMed/NCBI View Article : Google Scholar
|
|
91
|
Wallace JL, Motta JP and Buret AG:
Hydrogen sulfide: An agent of stability at the microbiome-mucosa
interface. Am J Physiol Gastrointest Liver Physiol. 314:G143–G149.
2018.PubMed/NCBI View Article : Google Scholar
|
|
92
|
Lu W and Wen J: Anti-inflammatory effects
of hydrogen sulfide in axes between gut and other organs. Antioxid
Redox Signal. 42:341–360. 2025.PubMed/NCBI View Article : Google Scholar
|
|
93
|
Luu M, Schütz B, Lauth M and Visekruna A:
The impact of gut microbiota-derived metabolites on the tumor
immune microenvironment. Cancers (Basel). 15(1588)2023.PubMed/NCBI View Article : Google Scholar
|
|
94
|
Arya P, Sharma V, Singh P, Thapliyal S and
Sharma M: Bacterial endotoxin-lipopolysaccharide role in
inflammatory diseases: An overview. Iran J Basic Med Sci.
28:553–564. 2025.PubMed/NCBI View Article : Google Scholar
|
|
95
|
Li X, Yang Y, Zhang B, Lin X, Fu X, An Y,
Zou Y, Wang JX, Wang Z and Yu T: Lactate metabolism in human health
and disease. Signal Transduct Target Ther. 7(305)2022.PubMed/NCBI View Article : Google Scholar
|
|
96
|
Zi M, Zhang Y, Hu C, Zhang S, Chen J, Yuan
L and Cheng X: A literature review on the potential clinical
implications of streptococci in gastric cancer. Front Microbiol.
13(1010465)2022.PubMed/NCBI View Article : Google Scholar
|
|
97
|
Fu K, Cheung AHK, Wong CC, Liu W, Zhou Y,
Wang F, Huang P, Yuan K, Coker OO, Pan Y, et al:
Streptococcus anginosus promotes gastric inflammation,
atrophy, and tumorigenesis in mice. Cell. 187:882–896.e17.
2024.
|
|
98
|
Liu H, Pan M, Liu M, Zeng L, Li Y, Huang
Z, Guo C and Wang H: Lactate: A rising star in tumors and
inflammation. Front Immunol. 15(1496390)2024.PubMed/NCBI View Article : Google Scholar
|
|
99
|
Li L, Wang M, Jiang Z, Yi C and Yi Y:
Intratumoral microbial heterogeneity in HCC reveals a potential
therapeutic target. JHEP Rep. 7(101538)2025.PubMed/NCBI View Article : Google Scholar
|
|
100
|
Bi C, Xiao G, Liu C, Yan J, Chen J, Si W,
Zhang J and Liu Z: Molecular immune mechanism of intestinal
microbiota and their metabolites in the occurrence and development
of liver cancer. Front Cell Dev Biol. 9(702414)2021.PubMed/NCBI View Article : Google Scholar
|
|
101
|
Chen Z, Guan D, Wang Z, Li X, Dong S,
Huang J and Zhou W: Microbiota in cancer: Molecular mechanisms and
therapeutic interventions. MedComm (2020). 4(e417)2023.PubMed/NCBI View Article : Google Scholar
|
|
102
|
Liu H, Xiong X, Zhu W, Wang S, Huang W,
Zhu G, Xu H and Yang L: Gut microbial metabolites in cancer
immunomodulation. Mol Cancer. 25(8)2025.PubMed/NCBI View Article : Google Scholar
|
|
103
|
Chandra V and McAllister F: Therapeutic
potential of microbial modulation in pancreatic cancer. Gut.
70:1419–1425. 2021.PubMed/NCBI View Article : Google Scholar
|
|
104
|
Cao W, Zheng C, Xu X, Jin R, Huang F, Shi
M, He Z, Luo Y, Liu L, Liu Z, et al: Clostridium butyricum
potentially improves inflammation and immunity through alteration
of the microbiota and metabolism of gastric cancer patients after
gastrectomy. Front Immunol. 13(1076245)2022.PubMed/NCBI View Article : Google Scholar
|
|
105
|
Zhang G and Sun D: The synthesis of the
novel Escherichia coli toxin-colibactin and its mechanisms
of tumorigenesis of colorectal cancer. Front Microbiol.
15(1501973)2024.PubMed/NCBI View Article : Google Scholar
|
|
106
|
Iftekhar A, Berger H, Bouznad N, Heuberger
J, Boccellato F, Dobrindt U, Hermeking H, Sigal M and Meyer TF:
Genomic aberrations after short-term exposure to
colibactin-producing E. coli transform primary colon
epithelial cells. Nat Commun. 12(1003)2021.PubMed/NCBI View Article : Google Scholar
|
|
107
|
Guragain M, Schmidt JW, Kalchayanand N,
Dickey AM and Bosilevac JM: Characterization of Escherichia
coli harboring colibactin genes (clb) isolated from beef
production and processing systems. Sci Rep. 12(5305)2022.PubMed/NCBI View Article : Google Scholar
|
|
108
|
Koppel N, Maini Rekdal V and Balskus EP:
Chemical transformation of xenobiotics by the human gut microbiota.
Science. 356(eaag2770)2017.PubMed/NCBI View Article : Google Scholar
|
|
109
|
Katati B, Kovacs S, Njapau H, Kachapulula
PW, Zwaan BJ, van Diepeningen AD and Schoustra SE: Aflatoxigenic
Aspergillus modulates aflatoxin-B1 levels through an
antioxidative mechanism. J Fungi (Basel). 9(690)2023.PubMed/NCBI View Article : Google Scholar
|
|
110
|
Bojić M, Debeljak Ž and Guengerich FP:
Principles of xenobiotic metabolism (biotransformation). In:
Pharmacogenomics in Clinical Practice. Primorac D, Höppner W and
Bach-Rojecky L (eds). Springer International Publishing, Cham,
pp13-33, 2024.
|
|
111
|
Pollet RM, D'Agostino EH, Walton WG, Xu Y,
Little MS, Biernat KA, Pellock SJ, Patterson LM, Creekmore BC,
Isenberg HN, et al: An atlas of β-glucuronidases in the human
intestinal microbiome. Structure. 25:967–977.e5. 2017.PubMed/NCBI View Article : Google Scholar
|
|
112
|
El Asri A, Zarrouq B, El Kinany K,
Bouguenouch L, Ouldim K and El Rhazi K: Associations between
nutritional factors and KRAS mutations in colorectal cancer: A
systematic review. BMC Cancer. 20(696)2020.PubMed/NCBI View Article : Google Scholar
|
|
113
|
Zhang M, Yang D and Gold B: The
adenomatous polyposis coli (APC) mutation spectra in different
anatomical regions of the large intestine in colorectal cancer.
Mutat Res. 810:1–5. 2018.PubMed/NCBI View Article : Google Scholar
|
|
114
|
González-Soltero R, Bailén M, de Lucas B,
Ramírez-Goercke MI, Pareja-Galeano H and Larrosa M: Role of oral
and gut microbiota in dietary nitrate metabolism and its impact on
sports performance. Nutrients. 12(3611)2020.PubMed/NCBI View Article : Google Scholar
|
|
115
|
Vermeer ITM, Gerrits MM, Moonen EJC,
Engels LGJB, Dallinga JW, Kleinjans JCS, van Maanen JMS, Kuipers EJ
and Kusters JG: Helicobacter pylori does not mediate the
formation of carcinogenic N-nitrosamines. Helicobacter. 7:163–169.
2002.
|
|
116
|
Elsanhoty RM, Al-Turki IA and Ramadan MF:
Application of lactic acid bacteria in removing heavy metals and
aflatoxin B1 from contaminated water. Water Sci Technol.
74:625–638. 2016.PubMed/NCBI View Article : Google Scholar
|
|
117
|
Assefa S and Köhler G: Intestinal
microbiome and metal toxicity. Curr Opin Toxicol. 19:21–27.
2020.PubMed/NCBI View Article : Google Scholar
|
|
118
|
Darbandi A, Navidifar T, Koupaei M,
Afifirad R, Nezhad RA, Emamie A, Talebi M and Kakanj M: The effect
of the combination of probiotics and heavy metals from various
aspects in humans: A systematic review of clinical trial studies.
Health Sci Rep. 8(e70521)2025.PubMed/NCBI View Article : Google Scholar
|
|
119
|
Haiser HJ, Gootenberg DB, Chatman K,
Sirasani G, Balskus EP and Turnbaugh PJ: Predicting and
manipulating cardiac drug inactivation by the human gut bacterium
Eggerthella lenta. Science. 341:295–298. 2013.PubMed/NCBI View Article : Google Scholar
|
|
120
|
Ting NLN, Lau HCH and Yu J: Cancer
pharmacomicrobiomics: Targeting microbiota to optimise cancer
therapy outcomes. Gut. 71:1412–1425. 2022.PubMed/NCBI View Article : Google Scholar
|
|
121
|
Heshiki Y, Vazquez-Uribe R, Li J, Ni Y,
Quainoo S, Imamovic L, Li J, Sørensen M, Chow BKC, Weiss GJ, et al:
Predictable modulation of cancer treatment outcomes by the gut
microbiota. Microbiome. 8(28)2020.PubMed/NCBI View Article : Google Scholar
|
|
122
|
Weber R, Fleming V, Hu X, Nagibin V, Groth
C, Altevogt P, Utikal J and Umansky V: Myeloid-derived suppressor
cells hinder the anti-cancer activity of immune checkpoint
inhibitors. Front Immunol. 9(1310)2018.PubMed/NCBI View Article : Google Scholar
|
|
123
|
Niu H, Zhou M, Zogona D, Xing Z, Wu T,
Chen R, Cui D, Liang F and Xu X: Akkermansia muciniphila: A
potential candidate for ameliorating metabolic diseases. Front
Immunol. 15(1370658)2024.PubMed/NCBI View Article : Google Scholar
|
|
124
|
Zhang S, Yang Y, Weng W, Guo B, Cai G, Ma
Y and Cai S: Fusobacterium nucleatum promotes chemoresistance to
5-fluorouracil by upregulation of BIRC3 expression in colorectal
cancer. J Exp Clin Cancer Res. 38(14)2019.PubMed/NCBI View Article : Google Scholar
|
|
125
|
Hussain S: On a new proposed mechanism of
5-fluorouracil-mediated cytotoxicity. Trends Cancer. 6:365–368.
2020.PubMed/NCBI View Article : Google Scholar
|
|
126
|
Vande Voorde J, Vervaeke P, Liekens S and
Balzarini J: Mycoplasma hyorhinis-encoded cytidine deaminase
efficiently inactivates cytosine-based anticancer drugs. FEBS Open
Bio. 5:634–639. 2015.PubMed/NCBI View Article : Google Scholar
|
|
127
|
Ratiner K, Ciocan D, Abdeen SK and Elinav
E: Utilization of the microbiome in personalized medicine. Nat Rev
Microbiol. 22:291–308. 2024.PubMed/NCBI View Article : Google Scholar
|
|
128
|
Nakatsu G, Andreeva N, MacDonald MH and
Garrett WS: Interactions between diet and gut microbiota in cancer.
Nat Microbiol. 9:1644–1654. 2024.PubMed/NCBI View Article : Google Scholar
|
|
129
|
Cani PD, Depommier C, Derrien M, Everard A
and de Vos WM: Akkermansia muciniphila: Paradigm for
next-generation beneficial microorganisms. Nat Rev Gastroenterol
Hepatol. 19:625–637. 2022.
|
|
130
|
Myhrstad MCW, Tunsjø H, Charnock C and
Telle-Hansen VH: Dietary fiber, gut microbiota, and metabolic
regulation-current status in human randomized trials. Nutrients.
12(859)2020.PubMed/NCBI View Article : Google Scholar
|
|
131
|
Yang Y, Xia Y, Chen H, Hong L, Feng J,
Yang J, Yang Z, Shi C, Wu W, Gao R, et al: The effect of
perioperative probiotics treatment for colorectal cancer:
Short-term outcomes of a randomized controlled trial. Oncotarget.
7:8432–8440. 2016.PubMed/NCBI View Article : Google Scholar
|
|
132
|
Miller LE, Zimmermann AK and Ouwehand AC:
Contemporary meta-analysis of short-term probiotic consumption on
gastrointestinal transit. World J Gastroenterol. 22:5122–5131.
2016.PubMed/NCBI View Article : Google Scholar
|
|
133
|
Feng K, Ren F and Wang X: Association
between oral microbiome and seven types of cancers in East Asian
population: A two-sample Mendelian randomization analysis. Front
Mol Biosci. 10(1327893)2023.PubMed/NCBI View Article : Google Scholar
|
|
134
|
Hsieh YY, Tung SY, Pan HY, Yen CW, Xu HW,
Lin YJ, Deng YF, Hsu WT, Wu CS and Li C: Increased abundance of
Clostridium and Fusobacterium in gastric microbiota
of patients with gastric cancer in Taiwan. Sci Rep.
8(158)2018.PubMed/NCBI View Article : Google Scholar
|
|
135
|
Silva-García O, Valdez-Alarcón JJ and
Baizabal-Aguirre VM: Wnt/β-catenin signaling as a molecular target
by pathogenic bacteria. Front Immunol. 10(2135)2019.PubMed/NCBI View Article : Google Scholar
|
|
136
|
Dadgar-Zankbar L, Shariati A,
Bostanghadiri N, Elahi Z, Mirkalantari S, Razavi S, Kamali F and
Darban-Sarokhalil D: Evaluation of enterotoxigenic Bacteroides
fragilis correlation with the expression of cellular signaling
pathway genes in Iranian patients with colorectal cancer. Infect
Agent Cancer. 18(48)2023.PubMed/NCBI View Article : Google Scholar
|
|
137
|
Yu Z, Li Y and Wang J: Mesalazine
suppresses colorectal cancer liver metastasis via the
HDAC3/Wnt/β-catenin axis through downregulating Bacteroides
fragilis abundance. APMIS. 133(e70078)2025.PubMed/NCBI View Article : Google Scholar
|
|
138
|
Grąt M, Wronka KM, Krasnodębski M, Masior
Ł, Lewandowski Z, Kosińska I, Grąt K, Stypułkowski J, Rejowski S,
Wasilewicz M, et al: Profile of gut microbiota associated with the
presence of hepatocellular cancer in patients with liver cirrhosis.
Transplant Proc. 48:1687–1691. 2016.PubMed/NCBI View Article : Google Scholar
|
|
139
|
Ferreira-Halder CV, Faria AVDS and Andrade
SS: Action and function of Faecalibacterium prausnitzii in
health and disease. Best Pract Res Clin Gastroenterol. 31:643–648.
2017.
|
|
140
|
Zhang W, Xu X, Cai L and Cai X: Dysbiosis
of the gut microbiome in elderly patients with hepatocellular
carcinoma. Sci Rep. 13(7797)2023.PubMed/NCBI View Article : Google Scholar
|
|
141
|
Hexun Z, Miyake T, Maekawa T, Mori H,
Yasukawa D, Ohno M, Nishida A, Andoh A and Tani M: High abundance
of Lachnospiraceae in the human gut microbiome is related to high
immunoscores in advanced colorectal cancer. Cancer Immunol
Immunother. 72:315–326. 2023.PubMed/NCBI View Article : Google Scholar
|
|
142
|
Castro PR, Bittencourt LFF, Larochelle S,
Andrade SP, Mackay CR, Slevin M, Moulin VJ and Barcelos LS: GPR43
regulates sodium butyrate-induced angiogenesis and matrix
remodeling. Am J Physiol Heart Circ Physiol. 320:H1066–H1079.
2021.PubMed/NCBI View Article : Google Scholar
|
|
143
|
Tacconi E, Palma G, De Biase D, Luciano A,
Barbieri M, de Nigris F and Bruzzese F: Microbiota effect on
trimethylamine N-oxide production: From cancer to fitness-A
practical preventing recommendation and therapies. Nutrients.
15(563)2023.PubMed/NCBI View Article : Google Scholar
|