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Risk factors for anastomotic leakage after anterior resection of rectal cancer with preservation of the left colic artery

  • Authors:
    • Song Tang
    • Fan Zhuo
    • Zhenyu Chen
    • Huiqiang Cai
    • Weibin Zhang
    • Dan Chen
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, P.R. China, Department of General Surgery, Dianbai District People's Hospital, Maoming, Guangdong 525400, P.R. China
    Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 177
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    Published online on: April 28, 2026
       https://doi.org/10.3892/etm.2026.13172
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Abstract

Anastomotic leakage (AL) is a frequent and severe complication after anterior resection for rectal cancer. Most previous studies compared AL incidence between high and low ligation; however, the present study evaluated risk factors for AL in patients undergoing low ligation with preservation of the left colic artery, which has been associated with improved overall outcomes. Clinical data of patients with rectal cancer treated in the Second Department of General Surgery (Gastrointestinal Surgery) of The First Affiliated Hospital of Guangdong Pharmaceutical University (Guangzhou, China) between 2015 and 2024 were retrospectively reviewed, and patients meeting the inclusion and exclusion criteria were enrolled. Demographic characteristics and perioperative variables were collected. Differences between the AL group and the non‑AL group were assessed using univariate analysis, and independent associations were identified using multivariate analysis to produce odds ratios (ORs). A total of 137 patients were included. Intergroup comparative tests showed significant differences in alcohol consumption, distance from the tumor to the anal verge and distance from the anastomosis to the anal verge between the AL group and the non‑AL group (P<0.05). Multivariate analysis identified alcohol consumption (OR=9.845; P=0.0068) and distance from the tumor to the anal verge (OR=0.485; P=0.0368) as independent factors associated with AL. In conclusion, alcohol consumption and distance from the tumor to the anal verge are independent risk factors for AL after anterior resection with preservation of the left colic artery. The risk of AL is 9.845‑fold higher in patients with alcohol consumption. For each 1 cm decrease in distance from the tumor to the anal verge, the risk of AL increases by 2.060‑fold.
View Figures

Figure 1

Fistulography showing the contrast
agent injected through the drainage tube entering the intestinal
tract.

Figure 2

Forest plot of binary logistic
regression analysis for anastomotic leakage risk factors. OR, odds
ratio; Tumor distance: distance from the tumor to the anal verge
(per 1 cm increase); Anastomotic distance: distance from the
anastomosis to the anal verge (per 1 cm increase, not statistically
significant).
View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021.PubMed/NCBI View Article : Google Scholar

2 

Law WL and Chu KW: Anterior resection for rectal cancer with mesorectal excision: A prospective evaluation of 622 patients. Ann Surg. 240:260–268. 2004.PubMed/NCBI View Article : Google Scholar

3 

Knol J and Keller DS: Total mesorectal excision technique-past, present, and future. Clin Colon Rectal Surg. 33:134–143. 2020.PubMed/NCBI View Article : Google Scholar

4 

Keller DS, Berho M, Perez RO, Wexner SD and Chand M: The multidisciplinary management of rectal cancer. Nat Rev Gastroenterol Hepatol. 17:414–429. 2020.PubMed/NCBI View Article : Google Scholar

5 

Karanjia ND, Corder AP, Bearn P and Heald RJ: Leakage from stapled low anastomosis after total mesorectal excision for carcinoma of the rectum. Br J Surg. 81:1224–1226. 1994.PubMed/NCBI View Article : Google Scholar

6 

Shayimu P, Awula M, Wang CY, Jiapaer R, Pan YP, Wu ZM, Chen Y and Zhao ZL: Serum nutritional predictive biomarkers and risk assessment for anastomotic leakage after laparoscopic surgery in rectal cancer patients. World J Gastrointest Surg. 16:3142–3154. 2024.PubMed/NCBI View Article : Google Scholar

7 

Arezzo A, Migliore M, Chiaro P, Arolfo S, Filippini C, Di Cuonzo D, Cirocchi R and Morino M: REAL Score Collaborators. The REAL (REctal anastomotic leak) score for prediction of anastomotic leak after rectal cancer surgery. Tech Coloproctol. 23:649–663. 2019.PubMed/NCBI View Article : Google Scholar

8 

Lange MM, Buunen M, van de Velde CJH and Lange JF: Level of arterial ligation in rectal cancer surgery: Low tie preferred over high tie. A review. Dis Colon Rectum. 51:1139–1145. 2008.PubMed/NCBI View Article : Google Scholar

9 

Draginov A, Chesney TR, Quereshy HA, Chadi SA and Quereshy FA: Association of high ligation versus low ligation of the inferior mesenteric artery on anastomotic leak, postoperative complications, and mortality after minimally invasive surgery for distal sigmoid and rectal cancer. Surg Endosc. 34:4593–4600. 2020.PubMed/NCBI View Article : Google Scholar

10 

Kruszewski WJ, Szajewski M, Ciesielski M, Buczek T, Kawecki K and Walczak J: Level of inferior mesenteric artery ligation does not affect rectal cancer treatment outcomes despite better cancer-specific survival after low ligation-randomized trial results. Colorectal Dis. 23:2575–2583. 2021.PubMed/NCBI View Article : Google Scholar

11 

Si MB, Yan PJ, Du ZY, Li LY, Tian HW, Jiang WJ, Jing WT, Yang J, Han CW, Shi XE, et al: Lymph node yield, survival benefit, and safety of high and low ligation of the inferior mesenteric artery in colorectal cancer surgery: A systematic review and meta-analysis. Int J Colorectal Dis. 34:947–962. 2019.PubMed/NCBI View Article : Google Scholar

12 

Rahbari NN, Weitz J, Hohenberger W, Heald RJ, Moran B, Ulrich A, Holm T, Wong WD, Tiret E, Moriya Y, et al: Definition and grading of anastomotic leakage following anterior resection of the rectum: A proposal by the international study group of rectal cancer. Surgery. 147:339–351. 2010.PubMed/NCBI View Article : Google Scholar

13 

Shang A, Wang S, Yang Y, Li L, Zhao Z, Li D, Guo Y and Wang M: Effect and safety of intraoperative intraperitoneal chemotherapy on patients suffering from colorectal cancer. World J Surg Oncol. 19(84)2021.PubMed/NCBI View Article : Google Scholar

14 

van Stein RM, Aalbers AGJ, Sonke GS and van Driel WJ: Hyperthermic intraperitoneal chemotherapy for ovarian and colorectal cancer: A review. JAMA Oncol. 7:1231–1238. 2021.PubMed/NCBI View Article : Google Scholar

15 

Hida J, Yasutomi M, Maruyama T, Fujimoto K, Nakajima A, Uchida T, Wakano T, Tokoro T, Kubo R and Shindo K: Indication for using high ligation of the inferior mesenteric artery in rectal cancer surgery. Examination of nodal metastases by the clearing method. Dis Colon Rectum. 41:984–991. 1998.PubMed/NCBI View Article : Google Scholar

16 

Nano M, Dal Corso H, Ferronato M, Solej M, Hornung JP and Dei Poli M: Ligation of the inferior mesenteric artery in the surgery of rectal cancer: Anatomical considerations. Dig Surg. 21:123–127. 2004.PubMed/NCBI View Article : Google Scholar

17 

Seike K, Koda K, Saito N, Oda K, Kosugi C, Shimizu K and Miyazaki M: Laser Doppler assessment of the influence of division at the root of the inferior mesenteric artery on anastomotic blood flow in rectosigmoid cancer surgery. Int J Colorectal Dis. 22:689–697. 2007.PubMed/NCBI View Article : Google Scholar

18 

Lange JF, Komen N, Akkerman G, Nout E, Horstmanshoff H, Schlesinger F, Bonjer J and Kleinrensink GJ: Riolan's arch: Confusing, misnomer, and obsolete. A literature survey of the connection(s) between the superior and inferior mesenteric arteries. Am J Surg. 193:742–748. 2007.PubMed/NCBI View Article : Google Scholar

19 

Lee SY, Kim S, Son GM, Kim HJ, Park SY, Park JS, Kim CH, Ha GW, Lee KH, Kim JS, et al: Anastomotic leak after minimally invasive anterior resection for rectal cancer with high versus low ligation of the inferior mesenteric artery: A study protocol for a multicentre randomized clinical trial. Trials. 23(920)2022.PubMed/NCBI View Article : Google Scholar

20 

Hajibandeh S, Hajibandeh S and Maw A: Meta-analysis and trial sequential analysis of randomized controlled trials comparing high and low ligation of the inferior mesenteric artery in rectal cancer surgery. Dis Colon Rectum. 63:988–999. 2020.PubMed/NCBI View Article : Google Scholar

21 

Zarnescu EC, Zarnescu NO and Costea R: Updates of risk factors for anastomotic leakage after colorectal surgery. Diagnostics (Basel). 11(2382)2021.PubMed/NCBI View Article : Google Scholar

22 

Sripathi S, Khan MI, Patel N, Meda RT, Nuguru SP and Rachakonda S: Factors contributing to anastomotic leakage following colorectal surgery: Why, when, and who leaks? Cureus. 14(e29964)2022.PubMed/NCBI View Article : Google Scholar

23 

Sørensen LT, Jørgensen T, Kirkeby LT, Skovdal J, Vennits B and Wille-Jørgensen P: Smoking and alcohol abuse are major risk factors for anastomotic leakage in colorectal surgery. Br J Surg. 86:927–931. 1999.PubMed/NCBI View Article : Google Scholar

24 

Kim CW, Baek SJ, Hur H, Min BS, Baik SH and Kim NK: Anastomotic leakage after low anterior resection for rectal cancer is different between minimally invasive surgery and open surgery. Ann Surg. 263:130–137. 2016.PubMed/NCBI View Article : Google Scholar

25 

Radek KA, Ranzer MJ and DiPietro LA: Brewing complications: The effect of acute ethanol exposure on wound healing. J Leukoc Biol. 86:1125–1134. 2009.PubMed/NCBI View Article : Google Scholar

26 

Gustafsson UO, Scott MJ, Schwenk W, Demartines N, Roulin D, Francis N, McNaught CE, MacFie J, Liberman AS, Soop M, et al: Guidelines for perioperative care in elective colonic surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations. Clin Nutr. 31:783–800. 2012.PubMed/NCBI View Article : Google Scholar

27 

Lee SG and Russ A: Predicting and preventing postoperative outcomes. Clin Colon Rectal Surg. 32:149–156. 2019.PubMed/NCBI View Article : Google Scholar

28 

Degiuli M, Elmore U, De Luca R, De Nardi P, Tomatis M, Biondi A, Persiani R, Solaini L, Rizzo G, Soriero D, et al: Risk factors for anastomotic leakage after anterior resection for rectal cancer (RALAR study): A nationwide retrospective study of the Italian society of surgical oncology colorectal cancer network collaborative group. Colorectal Dis. 24:264–276. 2022.PubMed/NCBI View Article : Google Scholar

29 

Frasson M, Flor-Lorente B, Rodríguez JL, Granero-Castro P, Hervás D, Alvarez Rico MA, Brao MJ, Sánchez González JM and Garcia-Granero E: ANACO Study Group. Risk factors for anastomotic leak after colon resection for cancer: Multivariate analysis and nomogram from a multicentric, prospective, national study with 3193 patients. Ann Surg. 262:321–330. 2015.PubMed/NCBI View Article : Google Scholar

30 

Matthiessen P, Hallböök O, Rutegård J, Simert G and Sjödahl R: Defunctioning stoma reduces symptomatic anastomotic leakage after low anterior resection of the rectum for cancer: A randomized multicenter trial. Ann Surg. 246:207–214. 2007.PubMed/NCBI View Article : Google Scholar

31 

Hüser N, Michalski CW, Erkan M, Schuster T, Rosenberg R, Kleeff J and Friess H: Systematic review and meta-analysis of the role of defunctioning stoma in low rectal cancer surgery. Ann Surg. 248:52–60. 2008.PubMed/NCBI View Article : Google Scholar

32 

Gastinger I, Marusch F, Steinert R, Wolff S, Koeckerling F and Lippert H: Working Group ‘Colon/Rectum Carcinoma’. Protective defunctioning stoma in low anterior resection for rectal carcinoma. Br J Surg. 92:1137–1142. 2005.PubMed/NCBI View Article : Google Scholar

33 

Akiyoshi T, Ueno M, Fukunaga Y, Nagayama S, Fujimoto Y, Konishi T, Kuroyanagi H and Yamaguchi T: Incidence of and risk factors for anastomotic leakage after laparoscopic anterior resection with intracorporeal rectal transection and double-stapling technique anastomosis for rectal cancer. Am J Surg. 202:259–264. 2011.PubMed/NCBI View Article : Google Scholar

34 

Tortorelli AP, Alfieri S, Sanchez AM, Rosa F, Papa V, Di Miceli D, Bellantone C and Doglietto GB: Anastomotic leakage after anterior resection for rectal cancer with mesorectal excision: Incidence, risk factors, and management. Am Surg. 81:41–47. 2015.PubMed/NCBI

35 

Shiomi A, Ito M, Maeda K, Kinugasa Y, Ota M, Yamaue H, Shiozawa M, Horie H, Kuriu Y and Saito N: Effects of a diverting stoma on symptomatic anastomotic leakage after low anterior resection for rectal cancer: A propensity score matching analysis of 1,014 consecutive patients. J Am Coll Surg. 220:186–194. 2015.PubMed/NCBI View Article : Google Scholar

36 

Abudeeb H, Hammad A, Ugwu A, Darabnia J, Malcomson L, Maung M, Khan K, Mclaughlin C and Mukherjee A: Defunctioning stoma-a prognosticator for leaks in low rectal restorative cancer resection: A retrospective analysis of stoma database. Ann Med Surg (Lond). 21:114–117. 2017.PubMed/NCBI View Article : Google Scholar

37 

Amin AI, Ramalingam T, Sexton R, Heald RJ, Leppington-Clarke A and Moran BJ: Comparison of transanal stent with defunctioning stoma in low anterior resection for rectal cancer. Br J Surg. 90:581–582. 2003.PubMed/NCBI View Article : Google Scholar

38 

Choy KT, Yang TWW, Heriot A, Warrier SK and Kong JC: Does rectal tube/transanal stent placement after an anterior resection for rectal cancer reduce anastomotic leak? A systematic review and meta-analysis. Int J Colorectal Dis. 36:1123–1132. 2021.PubMed/NCBI View Article : Google Scholar

39 

Qu H, Liu Y and Bi DS: Clinical risk factors for anastomotic leakage after laparoscopic anterior resection for rectal cancer: A systematic review and meta-analysis. Surg Endosc. 29:3608–3617. 2015.PubMed/NCBI View Article : Google Scholar

40 

Chang JS, Keum KC, Kim NK, Baik SH, Min BS, Huh H, Lee CG and Koom WS: Preoperative chemoradiotherapy effects on anastomotic leakage after rectal cancer resection: A propensity score matching analysis. Ann Surg. 259:516–521. 2014.PubMed/NCBI View Article : Google Scholar

41 

Marijnen CA, Kapiteijn E, van de Velde CJ, Martijn H, Steup WH, Wiggers T, Kranenbarg EK and Leer JW: Cooperative Investigators of the Dutch Colorectal Cancer Group. Acute side effects and complications after short-term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer: Report of a multicenter randomized trial. J Clin Oncol. 20:817–825. 2002.PubMed/NCBI View Article : Google Scholar

42 

Park JS, Choi GS, Kim SH, Kim HR, Kim NK, Lee KY, Kang SB, Kim JY, Lee KY, Kim BC, et al: Multicenter analysis of risk factors for anastomotic leakage after laparoscopic rectal cancer excision: The Korean laparoscopic colorectal surgery study group. Ann Surg. 257:665–671. 2013.PubMed/NCBI View Article : Google Scholar

43 

Zaborowski AM, Stakelum A and Winter DC: Anastomotic leak risk in complete responders to neoadjuvant therapy for rectal cancer: A systematic review. Int J Colorectal Dis. 36:671–676. 2021.PubMed/NCBI View Article : Google Scholar

44 

Lyall A, Mc Adam TK, Townend J and Loudon MA: Factors affecting anastomotic complications following anterior resection in rectal cancer. Colorectal Dis. 9:801–807. 2007.PubMed/NCBI View Article : Google Scholar

45 

Kawada K and Sakai Y: Preoperative, intraoperative and postoperative risk factors for anastomotic leakage after laparoscopic low anterior resection with double stapling technique anastomosis. World J Gastroenterol. 22:5718–5727. 2016.PubMed/NCBI View Article : Google Scholar

46 

Konishi T, Watanabe T, Kishimoto J and Nagawa H: Risk factors for anastomotic leakage after surgery for colorectal cancer: Results of prospective surveillance. J Am Coll Surg. 202:439–444. 2006.PubMed/NCBI View Article : Google Scholar

47 

Foster ME, Laycock JR, Silver IA and Leaper DJ: Hypovolaemia and healing in colonic anastomoses. Br J Surg. 72:831–834. 1985.PubMed/NCBI View Article : Google Scholar

48 

Peduzzi P, Concato J, Kemper E, Holford TR and Feinstein AR: A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol. 49:1373–1379. 1996.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Tang S, Zhuo F, Chen Z, Cai H, Zhang W and Chen D: Risk factors for anastomotic leakage after anterior resection of rectal cancer with preservation of the left colic artery. Exp Ther Med 31: 177, 2026.
APA
Tang, S., Zhuo, F., Chen, Z., Cai, H., Zhang, W., & Chen, D. (2026). Risk factors for anastomotic leakage after anterior resection of rectal cancer with preservation of the left colic artery. Experimental and Therapeutic Medicine, 31, 177. https://doi.org/10.3892/etm.2026.13172
MLA
Tang, S., Zhuo, F., Chen, Z., Cai, H., Zhang, W., Chen, D."Risk factors for anastomotic leakage after anterior resection of rectal cancer with preservation of the left colic artery". Experimental and Therapeutic Medicine 31.6 (2026): 177.
Chicago
Tang, S., Zhuo, F., Chen, Z., Cai, H., Zhang, W., Chen, D."Risk factors for anastomotic leakage after anterior resection of rectal cancer with preservation of the left colic artery". Experimental and Therapeutic Medicine 31, no. 6 (2026): 177. https://doi.org/10.3892/etm.2026.13172
Copy and paste a formatted citation
x
Spandidos Publications style
Tang S, Zhuo F, Chen Z, Cai H, Zhang W and Chen D: Risk factors for anastomotic leakage after anterior resection of rectal cancer with preservation of the left colic artery. Exp Ther Med 31: 177, 2026.
APA
Tang, S., Zhuo, F., Chen, Z., Cai, H., Zhang, W., & Chen, D. (2026). Risk factors for anastomotic leakage after anterior resection of rectal cancer with preservation of the left colic artery. Experimental and Therapeutic Medicine, 31, 177. https://doi.org/10.3892/etm.2026.13172
MLA
Tang, S., Zhuo, F., Chen, Z., Cai, H., Zhang, W., Chen, D."Risk factors for anastomotic leakage after anterior resection of rectal cancer with preservation of the left colic artery". Experimental and Therapeutic Medicine 31.6 (2026): 177.
Chicago
Tang, S., Zhuo, F., Chen, Z., Cai, H., Zhang, W., Chen, D."Risk factors for anastomotic leakage after anterior resection of rectal cancer with preservation of the left colic artery". Experimental and Therapeutic Medicine 31, no. 6 (2026): 177. https://doi.org/10.3892/etm.2026.13172
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